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Tendon stem/progenitor cell ageing: Modulation and rejuvenation

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World Journal of Stem Cells 2019年第9期11卷 677-692页

作者： Guang-Chun Dai Ying-Juan Li Min-Hao Chen pan-pan lu Yun-Feng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing210009Jiangsu ProvinceChina Trauma Center Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Orthopaedic Trauma Institute Southeast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina Department of Geriatrics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina China Orthopedic Regenerative Medicine Group Hangzhou 310000Zhejiang ProvinceChina

Tendon ageing is a complicated process caused by multifaceted pathways and ageing plays a critical role in the occurrence and severity of tendon *** role of tendon stem/progenitor cells(TSPCs)in tendon maintenance and regeneration has received increasing attention in recent *** decreased capacity of TSPCs in seniors contributes to impaired tendon functions and raises questions as to what extent these cells either affect,or cause ageing,and whether these age-related cellular alterations are caused by intrinsic factors or the cellular *** this review,recent discoveries concerning the biological characteristics of TSPCs and age-related changes in TSPCs,including the effects of cellular epigenetic alterations and the mechanisms involved in the ageing process,are *** the ageing process,TSPCs ageing might occur as a natural part of the tendon ageing,but could also result from decreased levels of growth factor,hormone deficits and changes in other related ***,we discuss methods that might induce the rejuvenation of TSPC functions that are impaired during ageing,including moderate exercise,cell extracellular matrix condition,growth factors and hormones;these methods aim to rejuvenate the features of youthfulness with the ultimate goal of improving human health during ageing.

关键词： Tendon stem/progenitor cell Ageing Mechanisms Modulation Rejuvenation

Understanding cellular and molecular mechanisms of pathogenesis of diabetic tendinopathy

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World Journal of Stem Cells 2020年第11期12卷 1255-1275页

作者： pan-pan lu Min-Hao Chen Guang-Chun Dai Ying-Juan Li Liu Shi Yun-Feng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Orthopaedic Trauma Institute(OTI) Southeast UniversityNanjing 210009Jiangsu ProvinceChina Trauma Center Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina Department of Geriatrics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina China Orthopedic Regenerative Medicine Group Hangzhou 310000Zhejiang ProvinceChina

There is accumulating evidence of an increased incidence of tendon disorders in people with diabetes *** tendinopathy is an important cause of chronic pain,restricted activity,and even tendon rupture in *** and tendon stem/progenitor cells(TSPCs)are the dominant cellular components associated with tendon homeostasis,maintenance,remodeling,and *** previous studies have shown alterations in tenocytes and TSPCs in high glucose or diabetic conditions that might cause structural and functional variations in diabetic tendons and even accelerate the development and progression of diabetic *** this review,the biomechanical properties and histopathological changes in diabetic tendons are ***,the cellular and molecular alterations in both tenocytes and TSPCs are summarized,and the underlying mechanisms involved are also analyzed.A better understanding of the underlying cellular and molecular pathogenesis of diabetic tendinopathy would provide new insight for the exploration and development of effective therapeutics.

关键词： Tendinopathy Diabetes Mechanism Tenocyte Tendon stem/progenitor cells

Development of an Efficient Plant Regeneration System for Pelargonium×Citrosum Vanleenii

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Agricultural Science & Technology 2011年第5期12卷 678-682,780页

作者： LIAO Fang-lei DAI Ya-juan WANG pan-pan SONG Qing lu Hong-fei College of Chemistry and Life Science Zhejiang Normal University Jinhua 321004

[Objective]As a mosquito-repelling ornamental plant,Pelargonium×Citrosum Vanleenii(P.× Citrosum Vanleenii)is hard to be acquired because of its hybrid background,the paper was to a new regeneration system of(P.× Citrosum Vanleenii).[Method] By studying the influence of plant growth regulators(PGRs)on explant type(leaves and petioles),the optimal combinations of PGRs to maximize SELSs(somatic embryo-like structure)and buds were established.[Result]0.2 mg/L NAA+1.0 mg/L BA was best for LS(leaves segments)and 0.2 mg/L NAA + 1.5 mg/L BAs was best for PS(petioles segments).Cultured plantlets were successfully acclimatized in soil where they grew normally without any morphological *** both LS and PS were usable,the leaf was a better explant for induction of embryogenic calli,somatic embryo-like structures and buds.[Conclusion]This work offered a rapid and efficient system for plant regeneration of P.×Citrosum Vanleenii.

关键词： Pelargonium×Citrosum Vanleenii Regeneration system Embryo-like embryogenesis Somatic embryo-like structures NAA BA

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

前期东北大西洋-地中海西部海温异常影响河南省干热风的可能途径

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高原气象 2025年第1期44卷 150-162页

作者：竹磊磊苏晓乐潘攀吴璐杨婷中国气象局•河南省农业气象保障与应用技术重点开放实验室河南郑州450003 河南省气候中心河南郑州450003

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温... 详细信息

河南省是中国冬小麦的主产区,也是较易受干热风影响的地区。目前对干热风的研究和预报多在天气尺度,从气候的角度研究干热风是否具有可预报性,具有非常重要的意义。本文基于河南省干热风资料、NCEP/NCAR再分析资料和哈得莱环流中心海温资料,分析了1980-2022年前期海温异常与河南省干热风日数的关系,及其可能影响途径。结果表明:(1)豫北、豫西北和豫中多年平均干热风日数较多,其他地区则相对较少。日干热风出现的概率由南向北、由5月下旬至6月上旬逐渐增加。全省平均干热风日数有显著增加趋势。(2)河南省干热风日数与当年3-4月东北大西洋-地中海西部(关键区)海温在年代际和年际尺度上均存在着密切相关,两者与干热风发生时段500 hPa高度场在去趋势前和去趋势后的显著正相关区在东亚中纬度地区位于新疆北部至贝加尔湖尔湖北部,显著负相关区位于我国东北至日本群岛附近,与850 hPa风场在去趋势前和去趋势后的相关在上述正、负显著相关区分别呈反气旋和气旋分布,气旋后部呈偏北风的显著相关,即3-4月关键区高海温年,出现的蒙古高压脊和东亚大槽造成了河南省的干热风天气。海温与环流场的相关在去趋势前和去趋势后在中纬度地区呈现出一个更明显的由东北大西洋经欧亚大陆至东北亚的纬向遥相关波列。(3)西太平洋副热带高压(以下简称副高)偏南(北)时,干热风日数易偏多(少),而3-4月关键区高(低)海温则可以导致副高偏南(北)。(4)干热风偏多年和偏少年、3-4月关键区高海温年和低海温的干热风发生时段30°N-55°N经向平均的涡度差值,及高、低海温年的干热风发生时段500 hPa准地转流函数距平和波作用通量均显示在中纬度地区存在自东北大西洋至东北亚的纬向波列。也即表明,3-4月关键区海温可以激发出一个后期干热风发生时段的类似波列,经欧亚大陆传至东北亚,而高海温年在东亚中纬度地区的环流分布造成了河南省的干热风天气。

关键词：干热风东北大西洋地中海西部海温遥相关波列

骨巨细胞瘤细胞自噬特征及其对细胞增殖的影响

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临床与实验病理学杂志 2018年第3期34卷 305-309页

作者：张盼盼陆荣柱郝彦明方玲娜何大伟李翀江苏大学附属昆山医院检验科苏州215000 江苏大学医学院预防医学与卫生检验系镇江212013 江苏大学附属昆山医院骨科苏州215000 江苏大学附属昆山医院内分泌科苏州215000 江苏大学附属昆山医院临床试验研究中心苏州215000

目的探讨骨巨细胞瘤细胞自噬特征及其对细胞增殖的作用。方法体外培养骨巨细胞瘤细胞(GCT-0404细胞),分别采用血清饥饿、雷帕霉素以及抑制剂氯喹进行处理,Western blot检测自噬相关蛋白LC3、Beclin 1的表达;免疫荧光显示细胞内自噬体的... 详细信息

目的探讨骨巨细胞瘤细胞自噬特征及其对细胞增殖的作用。方法体外培养骨巨细胞瘤细胞(GCT-0404细胞),分别采用血清饥饿、雷帕霉素以及抑制剂氯喹进行处理,Western blot检测自噬相关蛋白LC3、Beclin 1的表达;免疫荧光显示细胞内自噬体的形成;倒置相差显微镜下观察细胞形态学变化;CCK-8检测细胞的活性。结果血清饥饿、雷帕霉素以及氯喹干预GCT-0404细胞,可使LC3-Ⅰ向LC3-Ⅱ的转化水平明显增高(P<0.05);绿色荧光的斑点增多;而Beclin 1的表达水平无显著变化。同时,干预处理后细胞形态发生了显著变化,并抑制细胞增殖(P<0.05)。结论血清饥饿、雷帕霉素以及抑制剂氯喹干预GCT-0404细胞所致自噬的发生及其自噬流的变化可参与对细胞增殖抑制的调控。

关键词：骨肿瘤自噬骨巨细胞瘤细胞增殖

考虑场地效应的多点地震动作用下边坡永久位移分析

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岩土工程学报 2025年第1期47卷 65-75页

作者：宋健潘驭航陆朱汐姬建张飞高玉峰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 河海大学土木与交通学院江苏南京210024

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土... 详细信息

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土条赋予不同的水平和竖向地震动时程,推导出一种考虑场地效应的圆弧和任意形状滑面的多点地震作用下边坡永久位移分析方法。通过与有限差分软件FLAC的数值模拟结果进行对比,验证了该方法能够合理考虑地震动的场地效应。通过研究不同分布形式的多点地震动及竖向地震动对边坡永久位移的影响,结果表明:场地效应引起的水平地震动放大以及多点地震动不同分布模式会导致整个滑体平均地震惯性力作用位置发生改变,从而影响地震作用下滑动体沿滑面的永久变形量,竖向地震动对边坡地震位移影响较小。将方法应用于Lexington土石坝震后变形案例分析,计算得到的坝坡地震永久位移与实际震后观测值相吻合,证明了考虑场地效应的重要性及本文方法的合理性。

关键词：地震边坡稳定性场地效应永久位移极限平衡条分法多点地震动

连续流动法测定纸张中六价铬的测量不确定度评定

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安徽农业科学 2017年第15期45卷 85-87页

作者：赵攀攀苏燕陆扬潘力余斐朱书秀陆明华浙江中烟工业有限责任公司技术中心浙江杭州310024

[目的]评定连续流动法测定烤烟型卷烟纸张中六价铬的测量不确定度。[方法]分析了测量过程,修订了连续流动法测定纸张中六价铬的测定因果关系图,建立了测量不确定度评定的数学模型。分析样品前处理、标准溶液配制、校准曲线拟合、测量重... 详细信息

[目的]评定连续流动法测定烤烟型卷烟纸张中六价铬的测量不确定度。[方法]分析了测量过程,修订了连续流动法测定纸张中六价铬的测定因果关系图,建立了测量不确定度评定的数学模型。分析样品前处理、标准溶液配制、校准曲线拟合、测量重复性等因素引入的不确定度,确定其测量不确定度的主要来源。[结果]连续流动法测定纸张中六价铬的不确定度的主要来源为样品的浓度和测量重复性。通过对不确定度进行评定,得出连续流动法测定纸张中六价铬测量结果的标准不确定度为0.003 5 mg/kg,在95%的置信度下,取包含因子为k=2,其扩展不确定度为0.007 0 mg/kg。[结论]研究可为充分把握六价铬含量测定的关键影响因素,提高测定结果的准确性提供科学依据。

关键词：连续流动法纸张六价铬不确定度

Monitoring nearest neighbor queries with cache strategies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 529-537页

作者： pan Peng lu Yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

The problem of continuously monitoring multiple K-nearest neighbor (K-NN) queries with dynamic object and query dataset is valuable for many location-based applications. A practical method is to partition the data space into grid cells, with both object and query table being indexed by this grid structure, while solving the problem by periodically joining cells of objects with queries having their influence regions intersecting the cells. In the worst case, all cells of objects will be accessed once. Object and query cache strategies are proposed to further reduce the I/O cost. With object cache strategy, queries remaining static in current processing cycle seldom need I/O cost, they can be returned quickly. The main I/O cost comes from moving queries, the query cache strategy is used to restrict their search-regions, which uses current results of queries in the main memory buffer. The queries can share not only the accessing of object pages, but also their influence regions. Theoretical analysis of the expected I/O cost is presented, with the I/O cost being about 40% that of the SEA-CNN method in the experiment results.

关键词： K-nearest neighbors (K-NNs) Continuous query Object cache Query cache