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Perfluorooctane sulfonate (PFOS) and other fluorochemicals in viscera and muscle of farmed pigs and chickens in Beijing,China

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Chinese Science Bulletin 2010年第31期55卷 3550-3555页

Eleven perfluorinated compounds(PFCs) were determined in tissue samples from farmed pigs and chickens(n=143) that were purchased in Beijing in March *** total PFCs mean concentration was the highest in pig liver(3.438 ng g-1 wet weight(ww)),followed by pig kidney(0.508 ng g-1(ww)),pig heart(0.167 ng g-1(ww)),chicken liver(0.098 ng g-1(ww)),chicken heart(0.050 ng g-1(ww)),pork loin(0.018 ng g-1(ww)),and chicken breast(0.012 ng g-1(ww)).Among the PFCs analyzed,perfluorooctane sulfonate(PFOS) was the predominant compound in viscera and muscle of farmed pigs and *** addition,a strong linear correlation(r = 0.932) was observed between the concentrations of PFOS and perfluoroundecanoic acid(PFUnDA) in pig *** preliminary conclusion is that there is little potential risk of exposure to PFCs via the consumption of these products in Beijing.

关键词：含氟化合物 PFOS 全氟辛烷猪内脏鸡肝北京养殖磺酸

Recent Progress of Fuel-Driven Temporary Materials

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Chinese Journal of Chemistry 2023年第23期41卷 3358-3372页

作者： Guangtong Wang Mengmeng Nan Kangle Guo yaqi pan Tao Jia Shaoqin Liu School of Medicine and Health Harbin Institute of TechnologyHarbinHeilongjiang150080 China College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbinHeilongjiang150040 China School of Life Science and Technology Harbin Institute of TechnologyHarbinHeilongjiang150000 China

Fuel-driven dissipative self-assembly,which is a well-established concept in recent years,refers to out-of-equilibrium molecular self-assembly initiated and supported by the addition of active molecules (chemical fuel).It widely exists in nature since many temporary,active micro- or nanostructures in living bodies are generated by the dissipative self-assembly of ***,the study on dissipative self-assembly provides a good opportunity to have an insight into the microscopic mechanism of living *** the meantime,dissipative assembly is thought to be a potential pathway to achieve dynamic,temporary supramolecular ***,a number of temporary materials have been developed with the aid of strategies for realizing dissipative *** of their properties,including solubility,stiffness,turbidity,color,or self-healing ability,change upon the addition of chemical fuel but spontaneously restore with chemical fuel *** dynamic of these materials brings them various unprecedented *** this review,the principles of fabricating a fuel-driven temporary material are first ***,recent examples of fuel-driven temporary materials are emphatically summarized,including gels,self-erased inks,nanoreactors,self-healing materials,nanochannels,and ***,the challenges of developing fuel-driven temporary materials and some perspectives on the function and application of such kind of materials are discussed.

关键词： Self-assembly Nonequilibrium processes Temporary materials Chemical fuels Gels

Identification of cancer patients using claims data from health insurance systems: A real-world comparative study

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Chinese Journal of Cancer Research 2019年第4期31卷 699-706页

作者： Hongrui Tian Ruiping Xu Fenglei Li Chuanhai Guo Lixin Zhang Zhen Liu Mengfei Liu yaqi pan Zhonghu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China Anyang Cancer Hospital Anyang 455000China Hua County People’s Hospital Anyang 456400China

Objective: To evaluate the accuracy of identifying cancer patients by use of medical claims data in a health insurance system in China, and provide the basis for establishing the claims-based cancer surveillance system in ***: We chose Hua County, Henan Province as the study site, and randomly selected 300 and 1,200 qualified inpatient electronic medical records(EMRs) as well as the New Rural Cooperative Medical Scheme(NCMS) claims records for cancer patients in Hua County People’s Hospital(HCPH) and Anyang Cancer Hospital(ACH) in 2017. Diagnostic information for NCMS claims was evaluated on an individual level, and sensitivity and positive predictive value(PPV) were calculated taking the EMRs as the gold ***: The sensitivity of NCMS was 95.2%(93.8%-96.3%) and 92.0%(88.3%-94.8%) in ACH and HCPH,respectively. The PPV of the NCMS was 97.8%(96.7%-98.5%) in ACH and 89.0%(84.9%-92.3%) in ***, the weighted and combined sensitivity and PPV of NCMS in Hua County was 93.1% and 92.1%,respectively. Significantly higher sensitivity and PPV in identifying patients with common cancers than noncommon cancers were detected in HCPH and ACH separately(P<0.01).Conclusions: Identification of cancer patients by use of the NCMS is accurate on individual level, and it is therefore feasible to conduct claims-based cancer surveillance in areas not covered by cancer registries in China.

关键词： NCMS claims data cancer surveillance sensitivity positive predictive value

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Chinese Journal of Cancer Research 2018年第2期30卷 240-253页

作者： Hui Wang yaqi pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Laboratory of Genetics Peking University Cancer Hospital & Institute Beijing 100142 China Hua County People's Hospital Anyang 456400 China Anyang Cancer Hospital Anyang 455000 China

Objective： There have been few population-based studies evaluating health related quality of life（HRQOL） in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in ***： From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China（ESECC） trial（Clinical ***：NCT01688908） randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk ***： Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort（25.52%） was the most frequently reported problem followed by anxiety/depression（7.97%）, mobility（5.82%）, usual activities（2.61%） and self-care（1%）. These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic ***： Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial.

关键词： HRQOL EQ-5D rural population China

The Incidence of Lymphoma in Beijing:Comparing Results from MIS-CASS(2019)and Beijing Cancer Registry(2017)

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China CDC weekly 2021年第52期3卷 1118-1125,I0001页

作者： Hongrui Tian Weiping Liu Yuqin Song Lan Mi Zhen Liu Mengfei Liu Chuanhai Guo Fangfang Liu Ying Liu yaqi pan Jun Zhu Zhonghu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijingChina.

Introduction:This study aimed to evaluate the performance of the Medical-Insurance-System-based Cancer Surveillance System(MIS-CASS)in estimating cancer incidence by comparing the results with the Beijing Cancer Registry(BCR),which is one of the highest-quality population-based cancer registries in ***:Using lymphoma as an example,we extracted relevant claims data from the administrative systems of medical insurance in Beijing(2012–2020)and estimated the most current lymphoma incidence in Beijing(2019)using a standard data processing *** absolute number of new cases,crude incidence rate,and age-standardized incidence rate of lymphoma were compared with the latest data reported by the BCR(2017).Results:Both lymphoma incidence rates and age distribution of new cases estimated based on MISCASS were similar to the BCR data(crude incidence rate:9.8/100,000 vs.10.6/100,000).However,because MIS-CASS included more designated hospitals and covered a larger local stationary population irrespective of household registration(hukou),the absolute number of incident lymphoma cases identified by MIS-CASS was 39.1%higher than that reported by the BCR(2,002 vs.1,439).Conclusions:The MIS-CASS approach reflected the actual cancer burden in a more complete and timely manner as compared with the current BCR,providing new insights for improving cancer surveillance strategies in China.

关键词： CASS Registry absolute

Development and validation of a questionnaire-based risk scoring system to identify individuals at high risk for gastric cancer in Chinese populations

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Chinese Journal of Cancer Research 2021年第6期33卷 649-658页

作者： Ren Zhou Hongchen Zheng Mengfei Liu Zhen Liu Chuanhai Guo Hongrui Tian Fangfang Liu Ying Liu yaqi pan Huanyu Chen Zhe Hu Hong Cai Zhonghu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer ***:A gastric cancer risk scoring system(GC-RSS)was developed based on questionnaire-based predictors for gastric cancer derived from systematic literature *** assess the capability of this system for discrimination,risk scores for 8,214 and 7,235 outpatient subjects accepting endoscopic examination in two endoscopy centers,and 32,630 participants in a community-based cohort in China were calculated to plot receiver operating characteristic curves and generate area under the curve(AUC).To evaluate the performance of GC-RSS,the screening proportion,sensitivity and detection rate ratio compared to universal screening were used under different risk score cutoff ***:GC-RSS comprised nine predictors including advanced age,male gender,low body mass index(<18.5 kg/m^(2)),family history of gastric cancer,cigarette smoking,consumption of alcohol,preference for salty food,irregularity of meals and consumption of preserved *** tool performed well in determining the risk of malignant gastric lesions with AUCs of 0.763,0.706 and 0.696 in three validation *** subjects with risk scores≥5 were evaluated with endoscopy,nearly 50%of these endoscopies could be saved with a detection rate of over 1.5 times *** the cutoff was set at 8,only about 10%of subjects with the highest risk would be offered endoscopy,and detection rates for gastric cancer could be increased 2-4 fold compared to universal ***:An effective questionnaire-based GC-RSS was developed and *** tool may play an important role in establishing a tailored screening strategy for gastric cancer in China.

关键词： Cancer screening external validation gastric cancer risk scoring system

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电子证据证明力问题之法律思考

前沿 2010年第23期 83-85页

作者：潘亚奇重庆邮电大学重庆400065

电子证据的证明力关乎其作为证据的证明价值,是运用电子证据解决案件纠纷的关键因素。本文以证据学为视角,分析了电子证据的涵义及影响其证明力的重要因素,归纳出衡量电子证据证明力的基本标准,并试提出电子证据作为一种独立证据形式的... 详细信息

电子证据的证明力关乎其作为证据的证明价值,是运用电子证据解决案件纠纷的关键因素。本文以证据学为视角,分析了电子证据的涵义及影响其证明力的重要因素,归纳出衡量电子证据证明力的基本标准,并试提出电子证据作为一种独立证据形式的可能性。

关键词：电子证据证明力独立证据

An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 258-270页

作者： Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi yaqi pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng MOE Key Laboratory of Carcinogenesis and Translational Research Laboratory of Genetics Peking UniversityCancer Hospital & Institute Beijing University of Chinese Medicine CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences Anyang Cancer Hospital

Esophageal squamous cell carcinoma （ESCC） has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional sam- ples using Sanger sequencing. Whole-genomc SNP arrays were employed to detect copy number alteration （CNA） and loss of heterozygosity （LOH） in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations （NSSMs） in 102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology （GO） analysis. Tumor genomes with TP53 mutations were signifi- cantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B （30.9%）, amplification of 1 1q13.3 covering CCND1 （30.9%）, and TP53 point mutation （50.9%） occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC. Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p 11.2, and 3p 12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes. These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting.

关键词： Esophageal squamous cell carcinoma Genomic subtype somatic mutation Copy number alteration Cell cycle deregulation

Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study

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Chinese Journal of Cancer Research 2020年第6期32卷 742-754页

作者： Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang yaqi pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China Novogene Co. LtdBeijing 100080China Hua County People's Hospital Anyang 456400China Anyang Cancer Hospital Anyang 455000China Department of Non-communicable Disease Epidemiology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK

Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of ***:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in *** oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy *** analysis was performed to identify taxa of differential *** oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression ***:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P***:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs.

关键词： Early warning biomarker esophageal squamous cell carcinoma oral microbiome risk prediction