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Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging

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World Journal of Gastroenterology 2018年第18期24卷 2024-2035页

作者： shen pan Xiao-Qi Wang Qi-yong Guo Department of Radiology Shengjing Hospital of China Medical University Department of Clinical Science Philips Health-care

AIM To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(GdEOB-DTPA)-enhanced magnetic resonance imaging(MRI) for staging liver fibrosis in chronic hepatitis B/C(CHB/C).METHODS We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions(He F) and relaxation time reduction rate(RE) were measured for staging liver fibrosis. A receiver operating characteristic analysis using the area under the receiver operating characteristic curve(AUC) was used to compare thediagnostic performance in predicting liver fibrosis between He F and *** A total of 73 patients had both pathological results and MRI information. The number of patients in each fibrosis stage was evaluated semiquantitatively according to the METAVIR scoring system: F0, n = 23(31.5%); F1, n = 19(26.0%); F2, n = 13(17.8%); F3, n = 6(8.2%), and F4, n = 12(16.4%). He F by EOB enhancement imaging was significantly correlated with fibrosis stage(r =-0.808, P < 0.05). AUC values for diagnosis of any(≥ F1), significant(≥ F2) or advanced(≥ F3) fibrosis, and cirrhosis(F4) using He F were 0.837(0.733-0.913), 0.890(0.795-0.951), 0.957(0.881-0.990), and 0.957(0.882-0.991), respectively. He F measurement was more accurate than use of RE in establishing liver fibrosis staging, suggesting that calculation of He F is a superior noninvasive liver fibrosis staging *** A T1 mapping-based He F method is an efficient diagnostic tool for the staging of liver fibrosis.

关键词： Liver fibrosis Gd-EOB-DTPA Look-Locker hepatocyte fraction liver function magnetic resonance imaging relative enhancement

Metal-decorated defective BN nanosheets as hydrogen storage materials

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Frontiers of physics 2011年第2期6卷 224-230页

作者： Ming LI Ya-fei LI Zhen ZHOU pan-wen shen College of Chemical Engineering and Biological Technology Hebei Polytechnic University Tangshan 063009 China Institute of New Energy Material Chemistry Key Laboratory of Advanced Energy Materials Chemistry （Ministry of Education） Nankai University Tianjin 300071 China

Density functional theory computations were performed to investigate hydrogen adsorption in metaldecorated defective BN nanosheets. The binding energies of Ca and Sc on pristine BN nanosheets are much lower than the corresponding cohesive energies of the bulk metals; however, B vacancies in BN nanosheets enhance the binding of Ca and Sc atoms dramatically and avoid the clustering of the metal atoms on the surface of BN nanosheets. Ca and Sc strongly bind to defective BN nanosheets due to charge transfer between metal atoms and BN nanosheets. So-decorated BN nanosheets with B vacancies demonstrate promising hydrogen adsorption performances with a hydrogen adsorption energy of -0.19 - -0.35 eV/H2.

关键词： BN nanosheets hydrogen storage first principles

Synthesis and Crystal Structure of a Novel Binuclear Cu(Ⅱ) Complex with Tetradentate Schiff-base Ligand

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1095-1099页

作者： ZHAO Hai-Yan QIU Xiao-Hang TONG Xiao-Lan shen pan-Wen Department of Chemistry Nankai University Tianjin 300071 China College of Science Hebei University of Science and Technology Shijiazhuang 050018 China

A novel binuclear complex （[Cu^2（μ2-shed）（hshed）].（CIO4）,H2O, h2shed = N-salicylidene-N＇-（2-hydroxyethyl）ethylenediamine） has been synthesized and structurally characterized by X-ray diffraction analysis. It crystallizes in monoclinic, space group P21/c with a = 12.511（10）, b = 15.750（12）, c = 14.281 （12） A, β = 100.564（14）°, C22H31CIN4O9Cu2, Mr = 658.04, V = 2766（4） A^3, Z = 4, Dc = 1.580 g/cm^3,μ（MoKα = 1.689 mm^-1, F（000） = 1352, the final R = 0.0528 and wR = 0.1433 for 4880 independent reflections with Rint = 0.0577. The complex is a binuclear copper compound, and two Cu（Ⅱ） ions in the binuclear cation are in different coordination environments. The Cu（1） ion adopts a distorted square pyramidal geometry （x = 0.22） with four donor atoms （N2O2） of the ligand in the basal plane, and one hydroxyl oxygen atom with protonated form occupying the apical position. The Cu（2） ion assumes the geometry of a distorted square plane with four donor atoms （N2O2） of the ligand. The Cu...Cu separation is 3.103 A,. In addition, N-H…O and C-H…O intermolecular hydrogen bonding interactions link these binuclear cations into a quasi one-dimensional chain along the a axis.

关键词： Schiff base copper (Ⅱ) complex crystal structure hydrogen bonds

Binding Equilibrium Studies Between Co^(2+) and HSA or BSA

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Chemical Research in Chinese Universities 2000年第3期16卷 276-279页

作者： BIAN He dong LIANG Hong TU Chu qiao ZHANG Hong zhi shen pan wen Research Institute of Bioinorganic Chemistry Department of Chemistry and Chemical EngineeringGuangxi Normal UniversityGuilin 541004P.R.China Department of Chemistry Nankai UniversityTianjinP.R.China

The interaction of HSA and BSA with Co2+ and a carboxyl atom of Asp is investigated. The number of binding sites and the cooperation among the binding sites are analyzed. According to the equilibrium dialysis results and the study of competition between Co2+ and Cu2+, Ca2+ or Zn2+ to be bound to HSA or BSA, it is suggested that there are three strong binding sites of in both HSA and BSA.

关键词： Co 2+ serum albumin Equilibrium dialysis Coordination analysis Positive cooperative effect

Synthesis and One-dimensional Structure of Cobalt(Ⅱ) Complex [(NaOC_2H_5)CoL_2]_n

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Chemical Research in Chinese Universities 2003年第4期19卷 379-382页

作者： LI Ling GU Wen YAN Shi-ping CHENG Peng LIAO Dai-zheng JIANG Zong-hui shen pan-wen Department of Chemistry Nankai UniversityTianjin 300071P.R.China

The treatment of bis(2-hydroxybenzyl)-amine(HL) with NaOH and Co(Ⅱ)(NO) 2 gives isostructural one-dimensional coordination polymers [(NaOC2H5)CoL2]n(1). The cobalt ions have an octahedral geometry and are coordinated by two crystallographically independent ligands which are further linked by μ -O\-\{phenol\} bridged Co and Na atoms to give a one-dimentional structure.

关键词： Crystal structure Sodium Cobalt complex One\|dimension Bis(2-hydroxybenzyl)amine

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迎接高敏感方法检测心肌肌钙蛋白时代的到来

中华心血管病杂志 2011年第8期39卷 689-692页

作者：潘柏申复旦大学附属中山医院检验科上海200032

心脏标志物的临床应用可追溯到半个多世纪前。1954年，天冬氨酸氨基转移酶（AST，旧称GOT）作为诊断急性心肌梗死（AMI）的第一个心脏标志物用于临床，随后乳酸脱氢酶（LD）和肌酸激酶（CK）在AMI时的变化引起人们兴趣。十多年后，肌酸... 详细信息

心脏标志物的临床应用可追溯到半个多世纪前。1954年，天冬氨酸氨基转移酶（AST，旧称GOT）作为诊断急性心肌梗死（AMI）的第一个心脏标志物用于临床，随后乳酸脱氢酶（LD）和肌酸激酶（CK）在AMI时的变化引起人们兴趣。十多年后，肌酸激酶MB同工酶（CK—MB）在AMI时的异常变化得到广泛关注HJ，曾一度被誉为诊断AMI的“金标准”，

关键词：心肌肌钙蛋白敏感方法肌酸激酶MB同工酶天冬氨酸氨基转移酶心脏标志物检测急性心肌梗死临床应用

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心肌肌钙蛋白测定在临床应用中的一些问题

中华心血管病杂志 2008年第10期36卷 870-871页

作者：潘柏申复旦大学附属上海中山医院检验科 200032

心肌肌钙蛋白（cardia ctroponin，cTn）在心肌损伤诊断中的重要作用已经得到了普遍认同，在急性冠状动脉综合征（ACS）中的其他方面如心电图（ECG）非ST段抬高的心肌梗死（NSTEMI）的应用也得到重视。

关键词：心肌肌钙蛋白临床应用蛋白测定急性冠状动脉综合征非ST段抬高心肌损伤心肌梗死心电图

STRUCTURAL STUDIES OF THE METAL HYDRIDE Ti2Cu0.8Ni0.2H0.65

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结构化学 1989年第3期 192-196页

作者： Wang Gen-Shi shen pan-Wen Huang Jie-shengDepartment of Chemistry,Nankai University , Tianjin

The metal hydride Ti2Cu0.8Ni0.2H0.65, studied by X-ray diffraction and EXAFS speetroscopy, was found to have the same phase as Ti2Cu,both belonging to the tetragonal system and the I 4/mmm space group. The nearest-neighbour distance of Cu-Ti was found to be considerably shorter than, while the those of Cu-Cu and Cu-Ni almost equal to,the corresponding values in unhydrided alloy *** results suggest that the hydrogen atom occupies the tetrahedral interstitial site defined by four Ti atoms in a unit cell of *** H-Ti nearest-neighbour distance of 1. 86A is much shorter than the sum of the atomic radii of H and Ti, indicating a strong H-Ti bond . This may be an important reason for the high thermal stability of the title hydride.

关键词： EXAFS Ti STRUCTURAL STUDIES OF THE METAL HYDRIDE Ti2Cu Ni

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桩承式加筋路堤张力膜效应模型试验研究

岩土力学 2016年第7期37卷 1825-1831页

作者：徐超林潇沈盼盼同济大学地下建筑与工程系上海200092 同济大学岩土工程与地下结构教育部重点实验室上海200092

在桩承式加筋路堤设计计算及工程实践中,筋材的受力计算是具有争议且亟待解决的问题,然而,现有的研究很少关注桩承式加筋路堤中筋材应变的空间分布形式和三维模式下筋材的受力特征。采用自行研制的设备,以桩间距为变量,针对桩承式加筋... 详细信息

在桩承式加筋路堤设计计算及工程实践中,筋材的受力计算是具有争议且亟待解决的问题,然而,现有的研究很少关注桩承式加筋路堤中筋材应变的空间分布形式和三维模式下筋材的受力特征。采用自行研制的设备,以桩间距为变量,针对桩承式加筋路堤中筋材张力膜效应进行了物理模拟试验。试验中通过气压施加荷载,对筋材竖向变形和不同位置筋材应变进行观测。结果表明,张力膜效应下筋材应变和受力很不均匀。正方形布桩情形下,加筋材料的空间变形形态可采用空间抛物面与抛物柱面的组合来模拟。正方形布桩情形下假定筋材上所有荷载全部由相邻桩之间的4条筋带承担,得到的筋材受力计算值明显偏大。在模拟试验结果基础上,初步提出了考虑筋材三维空间变形的拉力计算方法。

关键词：桩承式加筋路堤加筋材料张力膜效应模型试验