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Pathological progression of osteoarthritis:a perspective on subchondral bone

Frontiers of Medicine 2024年第2期18卷 237-257页

作者： Xuefei li Wenhua Chen Dan liu Pinghua Chen Shiyun Wang Fangfang li Qian Chen Shunyi Lv Fangyu li Chen Chen Suxia Guo Weina Yuan pan li Zhijun Hu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai200032China Research and Development Center of Chinese Medicine Resources and Biotechnology Shanghai University of Traditional Chinese MedicineShanghai201203China

Osteoarthritis(OA)is a degenerative bone disease associated with aging.The rising global aging population has led to a surge in OA cases,thereby imposing a significant socioeconomic burden.Researchers have been keenly investigating the mechanisms underlying OA.Previous studies have suggested that the disease starts with synovial inflammation and hyperplasia,advancing toward cartilage degradation.Ultimately,subchondral-bone collapse,sclerosis,and osteophyte formation occur.This progression is deemed as“top to bottom.”However,recent research is challenging this perspective by indicating that initial changes occur in subchondral bone,precipitating cartilage breakdown.In this review,we elucidate the epidemiology of OA and present an in-depth overview of the subchondral bone’s physiological state,functions,and the varied pathological shifts during OA progression.We also introduce the role of multifunctional signal pathways(including osteoprotegerin(OPG)/receptor activator of nuclear factor-kappa B ligand(RANKL)/receptor activator of nuclear factor-kappa B(RANK),and chemokine(CXC motif)ligand 12(CXCL12)/CXC motif chemokine receptor 4(CXCR4))in the pathology of subchondral bone and their role in the“bottom-up”progression of OA.Using vivid pattern maps and clinical images,this review highlights the crucial role of subchondral bone in driving OA progression,illuminating its interplay with the condition.

关键词： osteoarthritis subchondral bone OPG/RANKL/RANK CXCL12/CXCR4

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Wearable and interactive multicolored photochromic fiber display

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light(Science & Applications) 2024年第3期13卷 454-465页

作者： pan li Yuwei Wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan liu Hang Wei Yu Wang Xiaoling Lu Qian Ji Xinyuan Cai li liu Chong Hou Ning Zhou Shaowu pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and Engineering and Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging(HUST) Ministry of EducationWuhan 430030China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Performing Arts Wuhan Conservatory of MusicWuhan 430060China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhan 430074China School of Fashion Beijing Institute of Fashion TechnologyBeijing 100029China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive devices.However,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware.Here,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light control.We designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the fiber.The impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission direction.In addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single fiber.We prepared fibers on mass-produced kilometer-long using the thermal drawing method.The fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as needed.This work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration.

关键词： fiber interactive colored

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Anti-skin-aging effect of fish gelatin from Cynoscion acoupa by maintaining collagen matrix homeostasis on D-galactose induced aging mice

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Food Science and Human Wellness 2024年

作者： Jianxin Tian Jingru liao Biluan Zhong pan li Xiaoqian liu Bing Du Guanzhan Fish Maw Nutrition and Security Research Center College of Food Science South China Agricultural University Guangdong Shenzhiyuan Health Technology Co. Ltd.

Delaying skin-aging through diet is a hot research topic in recent years， but the anti-aging effects of fish gelatin and related mechanisms are not well understood. In this study， we prepared edible fish gelatin from the swim bladder of Cynoscion acoupa using three different processing methods， namely dried (DCM)， soaked (SCM) and instanted (ICM)， to investigate its anti-aging effects and mechanisms on D-galactose induced skin aging in mice， as well as its effects on the gut microbiota. The results demonstrated that fish gelatin significantly increased water content， collagen， hyaluronic acid (HA) and hyaluronic acid (HYP) content， and skin integrity of mice skin， as well as enhanced the antioxidative ability and anti-inflammatory capacity of the skin. In terms of protein and mRNA expression levels in skin tissue， CMs treated with different treatments can up-regulate the expression of EGFR and TIMP1， down-regulating the expression of MMP1 and MMP3， and increase the expression of COL3A1 and COL1A2. CMs attenuated the D-galactose-mediated inhibition collagen expression by stimulating the TGF-β/Smad signaling pathway， thereby maintaining collagen matrix homeostasis. In addition， we revealed that CMs reversed gut micribiota by increase the abundance of intestinal flora. In conclusion， we demonstrated that CMs， especially for ICM， as an effective dietary supplement， have potential anti-aging and skin health benefits.

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Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao pan li Shao-Xing Guan Wen Xie Xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of thiopurines.Dose optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia prediction.AIM To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite concentrations.Late leucopenia was defined as a leukocyte countlizers.In patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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预处理温度对NiCoCrAlYHf涂层氧化行为及表面粗化机制的影响

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表面工程与再制造 2024年第1期24卷 61-62页

作者： pan li Xueling Fan Pin Lu Han Wang Xiaochao Jin Xi'an Key Laboratory of Extreme Environmental and Protection Technology School of Aerospace Engineering Xi'an Jiaotong University Xi'an 710049 China

NiCoCrAlYHf涂层作为热障涂层体系中的粘结层已得到广泛应用,其服役过程中的氧化行为和表面粗化机制受预处理温度的影响较大。为明确预处理温度的影响,对预处理涂层和等温暴露涂层的特性进行了表征和分析,包括微观结构、重量变化、热生... 详细信息

NiCoCrAlYHf涂层作为热障涂层体系中的粘结层已得到广泛应用,其服役过程中的氧化行为和表面粗化机制受预处理温度的影响较大。为明确预处理温度的影响,对预处理涂层和等温暴露涂层的特性进行了表征和分析,包括微观结构、重量变化、热生长氧化物(TGO)厚度和表面粗糙度。

关键词：粗化机制热障涂层预处理温度表面粗糙度氧化行为 NiCoCrAlY 粘结层重量变化

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Solution-Processed Hybrid Europium (Ⅱ) lodide Scintillator for Sensitive X-Ray Detection

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Research 2024年第1期2024卷 49-57页

作者： Xue Zhao Pengfei Fu pan li Hainan Du Jinsong Zhu Ciyu Ge Longbo Yang Boxiang Song Haodi Wu Tong Jin Qingxun Guo liang Wang Jinghui li Zewen Xiao Jingjing Chang Guangda Niu Jiajun Luo Jiang Tang School of Microelectronics Xidian UniversityXi'an 710071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China China Optics Valley Laboratory Wuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Lead halide perovskite nanocrystals have recently demonstrated great potential as x-ray scintillators,yet they stll suffer toxicity issues,inferior light yield(LY)caused by severe self-absorption.Nontoxic bivalent europium ions(Eu^(2+))with intrinsically efficient and self-absorption-free d-f transition are a prospective replacement for the toxic Pb^(2+).Here,we demonstrated solution-processed organic-inorganic hybrid halide BA_(10)Eul_(12)(BA denotes C_(4)H_(9)NH_(4)^(+))single crystals for the first time.

关键词： absorption halide perovskite

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FlowGANAnomaly: Flow-Based Anomaly Network Intrusion Detection with Adversarial Learning

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Chinese Journal of Electronics 2024年第1期33卷 58-71页

作者： Zeyi li pan WANG Zixuan WANG School of Computer Science Nanjing University of Posts and Telecommunications School of Modern Posts Nanjing University of Posts and Telecommunications School of Internet of Things Nanjing University of Posts and Telecommunications

In recent years, low recall rates and high dependencies on data labelling have become the biggest obstacle to developing deep anomaly detection(DAD) techniques. Inspired by the success of generative adversarial networks(GANs) in detecting anomalies in computer vision and imaging, we propose an anomaly detection model called Flow GANAnomaly for detecting anomalous traffic in network intrusion detection systems(NIDS). Unlike traditional GAN-based approaches, which are composed of a flow encoder, a convolutional encoder-decoder-encoder, a flow decoder and a convolutional encoder, the architecture of this model consists of a generator(G) and a discriminator(D).Flow GANAnomaly maps the different types of traffic feature data from separate datasets to a uniform feature space,thus can capture the normality of network traffic data more accurately in an adversarial manner to mitigate the problem of the high dependence on data labeling. Moreover, instead of simply detecting the anomalies by the output of D, we proposed a new anomaly scoring method that integrates the deviation between the output of two Gs’ convolutional encoders with the output of D as weighted scores to improve the low recall rate of anomaly detection. We conducted several experiments comparing existing machine learning algorithms and existing deep learning methods(Auto Encoder and VAE) on four public datasets(NSL-KDD, CIC-IDS2017, CIC-DDo S2019, and UNSW-NB15). The evaluation results show that Flow GANAnomaly can significantly improve the performance of anomaly-based NIDS.

关键词： Anomaly detection Unsupervised learning Generative adversarial network Intrusion detection system

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The Al_(2)O_(3)and Mn/Al_(2)O_(3)sorbents highly utilized in destructive sorption of NF_(3)

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Chinese Journal of Chemical Engineering 2024年第1期65卷 54-62页

作者： Yanfei pan Hejian li li Zheng Xiufeng Xu School of Chemistry and Chemical Engineering Yantai UniversityYantai 264005China

NF_(3)is commonly used as an etching and cleaning gas in semiconductor industry,however it is a strongly greenhouse gas.Therefore,the destruction of disposal NF_(3)is an urgent task to migrate the greenhouse effect.Among the technologies for NF_(3)abatement,the destructive sorption of NF_(3)over metal oxides sorbents is an effective way.Thus,the search for a highly reactive and utilized sorbent for NF_(3)destruction is in great demand.In this work,AlOOH supported on carbon-sphere(AlOOH/CS)as precursors were synthesized hydrothermally and heat-treated to prepare the Al_(2)O_(3)sorbents.The influence of AlOOH/CS hydrothermal temperatures on the reactivity of derived Al_(2)O_(3)sorbents for NF_(3)destruction was investigated,and it is shown that the Al2O3 from AlOOH/CS hydro-thermalized at 120℃is superior to others.Subsequently,the optimized Al_(2)O_(3)was covered by Mn(OH)x to prepare Mn/Al_(2)O_(3)sorbents via changing hydrothermal temperatures and Mn loadings.The results show that the Mn/Al_(2)O_(3)sorbents are more utilized than bare Al_(2)O_(3)in NF_(3)destructive sorption due to the promotional effect of Mn_(2)O_(3)as surface layer on the fluorination of Al_(2)O_(3)as substrate,especially the optimal 5%Mn/Al2O3(160℃)exhibits a utilization percentage as high as 90.4%,and remarkably exceeds all the sorbents reported so far.These findings are beneficial to develop more efficient sorbents for the destruction of NF_(3).

关键词： Greenhouse gas NF_(3)destructive sorption Sorbents Al_(2)O_(3) Mn/Al_(2)O_(3) Reactivity

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Channel Estimation for Reconfigurable Intelligent Surface Aided Multiuser Millimeter-Wave/THz Systems

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China Communications 2024年第3期21卷 91-103页

作者： Chu Hongyun pan Xue li Baijiang School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China

It is assumed that reconfigurable intelligent surface(RIS)is a key technology to enable the potential of mmWave communications.The passivity of the RIS makes channel estimation difficult because the channel can only be measured at the transceiver and not at the RIS.In this paper,we propose a novel separate channel estimator via exploiting the cascaded sparsity in the continuously valued angular domain of the cascaded channel for the RIS-enabled millimeter-wave/Tera-Hz systems,i.e.,the two-stage estimation method where the cascaded channel is separated into the base station(BS)-RIS and the RIS-user(UE)ones.Specifically,we first reveal the cascaded sparsity,i.e.,the sparsity exists in the hybrid angular domains of BS-RIS and the RIS-UEs separated channels,to construct the specific sparsity structure for RIS enabled multi-user systems.Then,we formulate the channel estimation problem using atomic norm minimization(ANM)to enhance the proposed sparsity structure in the continuous angular domains,where a low-complexity channel estimator via Alternating Direction Method of Multipliers(ADMM)is proposed.Simulation findings demonstrate that the proposed channel estimator outperforms the current state-of-the-arts in terms of performance.

关键词： atomic norm minimization cascaded channel estimation convex optimization mmWave/THz reconfigurable intelligent surface(RIS) sparsity

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Flow Field Simulation and Parameter Analysis of Hydraulic Unbalanced Bionic Self-recovery Actuator for Rotary Equipment

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Journal of Bionic Engineering 2024年第1期21卷 325-343页

作者： Wei li Xin pan Dehong Ge Jinji Gao Key Laboratory of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of High-End Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China

The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty equipment.To accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite positions.It can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment performance.The composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed theoretically.The fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery experiments.The experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.

关键词： Engineering self-recovery-Bionics Simulation analysis Self-recovery regulation

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