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An Underwater Biomimetic Robot that can Swim,Bipedal Walk and Grasp

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Journal of Bionic Engineering 2024年第3期21卷 1223-1237页

作者： Qiuxuan Wu Liwei pan FuLin Du ZhaoSheng Wu XiaoNi Chi FaRong Gao Jian Wang Anton A.Zhilenkov School of Automation Hangzhou Dianzi UniversityHangzhou310018China International Joint Research Laboratory for Autonomous Robotic Systems Hangzhou310018China GEELY Automotive Institute Hangzhou Vocational and Technical CollegeHangzhou310018China Institute of Hydrodynamics and Control Processes Sankt-Petersburg Saint Petersburg State Marine Technical UniversitySankt-PetersburgRussia

In developing and exploring extreme and harsh underwater environments,underwater robots can effectively replace humans to complete *** meet the requirements of underwater flexible motion and comprehensive subsea operation,a novel octopus-inspired robot with eight soft limbs was designed and *** robot possesses the capabilities of underwater bipedal walking,multi-arm swimming,and grasping *** closely interact with the underwater seabed environment and minimize disturbance,the robot employs a cable-driven flexible arm for its walking in underwater floor through a bipedal walking *** multi-arm swimming offers a means of three-dimensional spatial movement,allowing the robot to swiftly explore and navigate over large areas,thereby enhancing its ***,the robot’s walking arm enables it to grasp and transport objects underwater,thereby enhancing its practicality in underwater environments.A simplified motion models and gait generation strategies were proposed for two modes of robot locomotion:swimming and walking,inspired by the movement characteristics of octopus-inspired multi-arm swimming and bipedal *** experimental verification,the robot’s average speed of underwater bipedal walking reaches 7.26 cm/s,while the horizontal movement speed for multi-arm swimming is 8.6 cm/s.

关键词： Underwater soft robots Underwater bipedal walking Multi-arm swimming Cable drive

MiR-30a-5p alleviates LPS-induced HPMEC injury through regulation of autophagy via Beclin-1

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BIOCELL 2024年第3期48卷 431-441页

作者： RAN pan JIAYAN MAO YUELIANG ZHENG WEI CHEN JUNPING GUO LIJUN WANG Rainbowfish Rehabilitation and Nursing School Hangzhou Vocational&Technical CollegeHangzhou310018China Cancer Institute of Integrated Traditional Chinese and Western Medicine Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western MedicineZhejiang Academy of Traditional Chinese MedicineHangzhou310012China Geriatric Medicine Center Department of EndocrinologyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou310015China

Background:Sepsis,a type of systemic disease,can impact nearly all organs,tissues and *** them,endothelial cells are amongst theﬁrst to be affected and respond to the *** this study,we investigated the protective effects of microRNA-30a-5p(miR-30a-5p)on human pulmonary microvascular endothelial cells(HPMECs)treated with lipolysaccharide(LPS).Methods:An in vitro model of sepsis was established in HPMECs with the use of *** with different tools(mimetic and inhibitor)to modify miR-30a-5p *** viability,proliferation and apoptosis were detected by the CCK-8 assay,the EdU kit andﬂuorescence staining,*** autophagy-related protein and mRNA expression,the number of autophagosomes were separately examined through Western blot analysis,qPT-PCR and confocal *** and the luciferase reporter assays were used to probe target genes interacting with ***:LPS caused a reduction in the viability and proliferation of HPMECs,as well as an elevation in the number of apoptotic ***,we observed that miR-30a-5p might play a role in preventing LPS-induced inhibition of cell damage and decreasing HPMEC apoptosis,suggesting the potential function of miR-30a-5p in this injury ***,we conﬁrmed that miR-30a-5p exerts its protective effect by regulating cell autophagy,possibly by targeting ***:Our study provided evidence that autophagy is a crucial aspect in the protective role of miR-30a-5p against LPS-induced HPMEC injury,identifying a promising target for sepsis-related endothelial cell injury.

关键词： Sepsis Endothelial cells MicroRNA Systemic inflammatory response syndrome

Analysis of Urban Public Building Space Design Strategies in the Digital Age

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Journal of World Architecture 2024年第2期8卷 140-145页

作者： pan Liang Sharul Azim Sharudin City University Malaysia Petaling Jaya 46100SelangorMalaysia Lishui vocational and technical college Lishui 323000Zhejiang ProvinceChina

Urban public building spaces involve various aspects of people’s daily activities and interactions,making the rationality and scientific nature of the design of these spaces *** article first discusses the role and impact of digitization in the design of public building spaces,covering aspects such as digital design methods,visual expression and presentation,augmented reality’s spatial interaction experience,and integrated design and *** that,it analyzes the process of digitized urban public building space design by exploring topics like digital space design and modeling,visual representation of digital spaces,digital performance analysis of spaces,and the integration of digital *** article aims to provide insights and references for urban public building space design in the digital era.

关键词： Digital age Public building Space design Strategies

资源基础理论视角下高职院校产业学院可持续竞争优势创建:理论、困境与路径

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职业技术教育 2024年第14期45卷 6-11页

作者：潘燕浙江大学教育学院杭州310000 浙江建设职业技术学院杭州310000

资源基础理论聚焦于企业内部可控资源,提出了企业如何依靠自身可控资源来保持持续竞争优势。高职院校产业学院是高校与产业界深度融合的产物,其创建是为了更好地服务产业人才的培养,推动产业的技术革新。基于资源基础理论,针对目前高职... 详细信息

资源基础理论聚焦于企业内部可控资源,提出了企业如何依靠自身可控资源来保持持续竞争优势。高职院校产业学院是高校与产业界深度融合的产物,其创建是为了更好地服务产业人才的培养,推动产业的技术革新。基于资源基础理论,针对目前高职院校产业学院建设存在的资源共享效率低下、资源聚焦难以落地、资源创新动力不足、资源协同机制不畅等问题,提出高职院校产业学院可以通过资源共享整合、资源集中增效、资源动态创新、资源协同治理等发展路径,以创造有价值的、稀缺的、不可复制的能够在合作过程中被开发利用的资源组合,创建自身的可持续竞争优势,从而实现产业学院的可持续发展。

关键词：资源基础理论高职院校产业学院可持续竞争优势

行星轮系取栽一体化蔬菜移栽机构优化设计及试验

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机械传动 2024年第8期48卷 141-149页

作者：张鹏飞刘冬梅赵雄徐亚丹刘东杭州职业技术学院吉利汽车学院浙江杭州310018 浙江理工大学浙江杭州310018

为简化蔬菜毯苗移栽机构、提高移栽效率,提出了一种非圆齿轮行星轮系和变形椭圆行星轮系组合的取苗挖穴一体化移栽机构,可完成蔬菜毯苗切块、取苗、送苗、挖穴、投苗的工作过程。首先,根据蔬菜毯苗的农艺要求,选取合适的移栽轨迹,设定... 详细信息

为简化蔬菜毯苗移栽机构、提高移栽效率,提出了一种非圆齿轮行星轮系和变形椭圆行星轮系组合的取苗挖穴一体化移栽机构,可完成蔬菜毯苗切块、取苗、送苗、挖穴、投苗的工作过程。首先,根据蔬菜毯苗的农艺要求,选取合适的移栽轨迹,设定精确位姿点,采用运动生成机构综合方法建立取苗机构运动学模型;根据取苗机构的运动轨迹要求,基于求解参数拟合优化,获得输入轴与输出轴转角关系曲线,计算非圆齿轮行星轮系总传动比和非圆齿轮节曲线参数。其次,确定挖穴机构优化目标,获得挖穴机构参数。最后,完成整套机构组合与三维模型装配,并进行仿真和样机试验。结果表明,理论轨迹、仿真轨迹和试验轨迹基本一致,幼苗移栽平均漏栽率为2%,平均倒伏率、伤苗率、埋苗率均为1.5%,均满足农艺要求,验证了机构设计方法的准确性。

关键词：行星轮系非圆齿轮变形椭圆齿轮蔬菜移栽

掺铈Cs_(2)BaBr_(4)晶体的生长和闪烁性能研究

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人工晶体学报 2024年第5期53卷 760-765页

作者：殷洁张小强陈灿潘建国湖南化工职业技术学院株洲412000 宁波大学材料科学与化学工程学院浙江省光电探测材料及器件重点实验室宁波315211

以高纯度BaBr_(2)、CsBr、CeBr_(3)为原料,采用高温固相反应法合成了Cs_(2)BaBr_(4)∶1%Ce^(3+)多晶料,并通过坩埚下降法生长了Cs_(2)BaBr_(4)∶1%Ce^(3+)晶体。将晶体切割研磨抛光后得到不同厚度的Cs_(2)BaBr_(4)∶1%Ce^(3+)晶片。对晶体进行了物相分析,XRD图谱表明晶体为一致熔融物,且无相变。研究了晶体的闪烁性能,测试了光学透射率、光致发光、X射线激发发光、多通道gamma能谱、衰减时间。与LaBr_(3)晶体对比,分析了晶体的吸湿性。结果表明,晶体的光学透过率接近80%,在一定波段的紫外光及X射线的激发下,晶体在349与372 nm波长有发射峰。^(137)Cs源伽马射线的激发下,能量分辨率为11%,在紫外激发下,晶体衰减时间为21.9 ns。晶体的吸湿性比LaBr_(3)晶体有大幅改善。

关键词： Cs_(2)BaBr_(4)∶1%Ce^(3+)晶体坩埚下降法光致发光 X射线激发发光衰减时间吸湿性

Exploring Digital Visualization Methods in Urban Public Building Space Design

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Journal of Architectural Research and Development 2024年第2期8卷 55-61页

作者： pan Liang Sharul Azim Sharudin City University Malaysia Menara 46100Petaling JayaSelangorMalaysia Lishui vocational and technical college Lishui 323000Zhejiang ProvinceChina

Digital technology has driven the innovation of architectural design methods and tools,applying digital techniques to allow greater possibilities for more innovative and scientific design of public building *** article first analyzes the characteristics of digital visualization and its advantages in the design of urban public building spaces,including aspects such as visualizing three-dimensional expression,rational analysis of building space,Virtual Reality Experience,and integration of design and construction ***,by introducing digital design methods such as parametric design,algorithmic generation,nonlinear design,and artificial intelligence-assisted design,it explores the methods and implementation approaches of digital visualization in the design of public building *** aim is to offer insights and references for the deeper integration of digital technology into architectural design practices.

关键词： Public building Space design Digital visualization Methods

利拉鲁肽对脓毒症小鼠急性肺损伤的保护作用及其机制

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中华急诊医学杂志 2024年第8期33卷 1134-1139页

作者：郭君平潘然王丽君郑悦亮张茂王桂荣杭州职业技术学院彩虹鱼康复护理学院杭州310018 浙江省人民医院(杭州医学院附属人民医院)急诊科杭州310015 浙江大学医学院附属第二医院急诊科浙江省严重创伤与烧伤诊治重点实验室浙江省急危重症临床医学研究中心杭州310009 纽约州立大学上州医科大学外科系雪城13210

目的探讨利拉鲁肽对脓毒症小鼠急性肺损伤的保护作用及其可能机制。方法选取8-12周龄、健康清洁级FVB/NJ雄性小鼠36只,随机(随机数字法)分为正常对照组、急性肺损伤组(Acute lung injury group,ALI组)和利拉鲁肽干预组(ALI+LIRA组)三组... 详细信息

目的探讨利拉鲁肽对脓毒症小鼠急性肺损伤的保护作用及其可能机制。方法选取8-12周龄、健康清洁级FVB/NJ雄性小鼠36只,随机(随机数字法)分为正常对照组、急性肺损伤组(Acute lung injury group,ALI组)和利拉鲁肽干预组(ALI+LIRA组)三组,每组12只。采用气管内注射铜绿假单胞菌混悬液制备脓毒症急性肺损伤小鼠模型,正常对照组给予气管内注射等体积生理盐水;利拉鲁肽干预组在造模0.5 h后给予利拉鲁肽(2 mg/kg)皮下注射干预,正常对照组和急性肺损伤组给予等体积生理盐水皮下注射。造模24 h后处死小鼠,收集小鼠肺组织,采用苏木精-伊红染色评估肺脏病理损伤,免疫荧光法检测肺组织表面活性蛋白D(surfactant associated protein D,SP-D)表达;收集支气管肺泡灌洗液(broncho-alveolar lavage fl uid,BALF),BCA法检测总蛋白浓度,酶联免疫吸附试验检测白细胞介素6(interleukin-6,IL-6)和肿瘤坏死因子α(tumor necrosis factorα,TNF-α)水平,Western blot法检测BALF和肺组织中SP-D蛋白表达水平。使用SPSS软件进行统计学分析,组间比较采用单因素方差分析。结果与对照组相比,ALI组小鼠的肺组织病理学损伤评分、BALF中总蛋白浓度、IL-6和TNF-α水平均升高,肺组织中SP-D阳性细胞数减少,分泌到BALF中SP-D和肺组织中的SP-D的蛋白表达下调(均P<0.05)。与ALI组相比,ALI+LIRA组小鼠的肺组织病理学损伤评分、BALF中总蛋白浓度、IL-6和TNF-α水平均下降,肺组织中SP-D阳性细胞数增加,分泌到BALF中SP-D和肺组织中的SP-D的蛋白表达上调(均P<0.05)。结论利拉鲁肽可减轻脓毒症小鼠急性肺损伤程度,其保护作用可能通过与促进SP-D分泌相关。

关键词：利拉鲁肽脓毒症铜绿假单胞菌急性肺损伤小鼠炎症细胞因子肺表面活性物质相关蛋白D 分泌

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职业本科院校思政教育体系研究

湖北开放职业学院学报 2024年第1期37卷 103-104,107页

作者：相江苏叶潘虹浙江广厦建设职业技术大学浙江东阳322100

职业本科院校思政教育工作的目标,是培养有高远价值追求、高雅情趣追求和高尚人格追求的职业本科生。要实现这些目标,就需要建构与职业本科院校相适应的思政教育体系,其由组织体系、课程体系、评价体系和激励体系构成一个协同运转的整... 详细信息

职业本科院校思政教育工作的目标,是培养有高远价值追求、高雅情趣追求和高尚人格追求的职业本科生。要实现这些目标,就需要建构与职业本科院校相适应的思政教育体系,其由组织体系、课程体系、评价体系和激励体系构成一个协同运转的整体。该体系要突出职业教育特色,应将职业理念融入思政教育,坚持学生主体地位,推动教育公平与人的全面发展;坚持数字化改革优化思教体系效能,适应新时代“立德树人”要求;坚持营建适应职业本科教育的思政文化,发挥隐性课程的持久影响力。

关键词：职业本科思政教育体系目标构成挑战