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Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 65-82页

作者： Xiaojian JIANG Lihong LEI Weilian SUN yingming WEI Jiayin HAN Shuaiqi ZHONG Xianyan YANG Zhongru GOU Lili CHEN Department of Oral Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang–California International Nanosystem InstituteZhejiang UniversityHangzhou310058China

Magnesium-doped calcium silicate(CS)bioceramic scaffolds have unique advantages in mandibular defect repair;however,they lack antibacterial properties to cope with the complex oral ***,for the first time,the CS scaffold was functionally modified with a novel copper-containing polydopamine(PDA(Cu^(2+)))rapid deposition method,to construct internally modified(*P),externally modified(@PDA),and dually modified(*P@PDA)*** morphology,degradation behavior,and mechanical properties of the obtained scaffolds were evaluated in *** results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical *** the prolonged immersion stage,the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained *** in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA,while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis ***,the PDA(Cu^(2+))-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect ***,it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu^(2+))modification,and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.

关键词： Copper-containing polydopamine Modification Antibacterial property Bone regeneration Angiogenesis Bioceramic scaffold

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Time-domain Differential Protection Based on Operating and Restraining Trajectory Indices for Lines Connecting Battery Storage Energy Stations

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1074-1086页

作者： Yingyu Liang Cunyue pan School of Mechanical and Electrical Engineering China University of Mining and Technology(Beijing)BeijingChina

Battery energy storage stations(BESSs)pose sever-al challenges for both phasor-based differential protection and the newly-proposed time-domain differential *** challenges include low sensitivity and even ***,the negative impact of various nonideal conditions,including current transformer(CT)saturation,errors,and outliers,on the security of differential protection remains an important *** by the aforementioned issues,this study ac-counts for the trajectory distribution discrepancy on Cartesian plane under various conditions and proposes a time-domain dif-ferential protection *** this paper,the trajectory formed by operating and restraining current samples is ***,after considering different operating states,the fault severity levels,and nonideal conditions,the variances in trajectory distribution between internal and external faults are extensively *** this basis,the Cartesian plane is divided into operating,uncertainty,and restraining ***-ther,the operating and restraining trajectory indices are meticu-lously designed and a protection criterion based on these indi-ces is formed to accurately separate internal faults from other events,unaffected by CT saturation,errors,and *** exceptional performance of the proposed protection method is extensively validated through PSCAD simulations and a hard-ware-in-the-loop testing *** the dependability,sensitivity,and security,the proposed protection method outper-forms three state-of-the-art differential protection methods.

关键词： Battery energy storage station time-domain differential protection operating trajectory index(OTI) restraining trajectory index(RTI)

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健脾活血汤联合西药治疗脾胃虚弱慢性胃炎随机平行对照研究

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实用中医内科杂志 2015年第9期29卷 108-110页

作者：潘应明湖北省武汉市黄陂区人民医院中医科武汉430300

[目的]观察健脾活血汤联合西药治疗脾胃虚弱型慢性胃炎疗效。[方法]使用随机平行对照方法,将54例门诊及住院患者按掷骰子法简单随机分为两组。对照组27例奥美拉唑,20mg/次,2次/d;阿莫西林,1g/次,2次/d;克拉霉素,0.5g/次,2次/d;7d后用铝... 详细信息

[目的]观察健脾活血汤联合西药治疗脾胃虚弱型慢性胃炎疗效。[方法]使用随机平行对照方法,将54例门诊及住院患者按掷骰子法简单随机分为两组。对照组27例奥美拉唑,20mg/次,2次/d;阿莫西林,1g/次,2次/d;克拉霉素,0.5g/次,2次/d;7d后用铝碳酸镁,1g/次,3次/d;21d后恶心或上腹饱胀多潘立酮,20mg/次,3次/d。治疗组27例健脾活血汤(木香10g,山药、太子参各15g,半夏、白术、砂仁、陈皮、茯苓各10g,甘草6g,蒲黄、五灵脂各10g;腹胀明显加枳壳、厚朴各10g,湿重苔厚腻加苏叶、藿香各10g;恶心呕吐加紫苏梗10g,竹茹15g,生姜10g),1剂/d,水煎200m L,早晚口服;西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、胃黏膜状况、中医证候积分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈8例,显效17例,有效2例,无效0例,总有效率100.00%。对照组痊愈4例,显效13例,有效6例,无效4例,总有效率85.19%。治疗组疗效优于对照组(P<0.05)。幽门螺杆菌转阴率治疗组优于对照组(P<0.05)。[结论]健脾活血汤联合西药治疗脾胃虚弱型慢性胃炎疗效满意,无严重不良反应,值得推广。

关键词：慢性胃炎胃脘痛痞满嘈杂腹胀健脾活血汤脾胃虚弱奥美拉唑阿莫西林克拉霉素铝碳酸镁多潘立酮胃黏膜中医证候积分中西医结合治疗随机平行对照研究

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A Time-Domain Numerical Simulation for Free Motion Responses of Two Ships Advancing in Head Waves

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China Ocean Engineering 2024年第3期38卷 519-530页

作者： pan Su-yong CHENG Yong School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

The constant panel method within the framework of potential flow theory in the time domain is developed for solving the hydrodynamic interactions between two parallel ships with forward *** solving problems within a time domain framework,the free water surface needs to simultaneously satisfy both the kinematic and dynamic boundary conditions of the free water *** provides conditions for adding artificial damping *** the Runge−Kutta method to solve equations related to *** upwind differential scheme is used in the present method to deal with the convection terms on the free surface to prevent waves *** the comparison with the available experimental data and other numerical methods,the present method is proved to have good mesh convergence,and satisfactory results can be *** constant panel method is applied to calculate the hydrodynamic interaction responses of two parallel ships advancing in head *** simulations are conducted on the effects of forward speed,different longitudinal and lateral distances on the motion response of two modified Wigley ships in head *** further investigations are conducted on the effects of different ship types on the motion response.

关键词： ship motions time domain simulation forward speed different distances wave loads

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基于异质在线评论信息的多准则决策方法研究

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系统工程理论与实践 2024年第4期44卷 1349-1364页

作者：何世繁潘晓宏王应明福州大学经济与管理学院福州350108 青岛大学商学院青岛266061

随着信息技术的发展,互联网中积累了大量有价值的信息,这些信息已成为多准则决策重要的信息来源.由于个人知识背景、经验、表达习惯以及不同准则特质的不同,在线评论信息通常由多种形式的信息组成,如实数、区间数和文本信息.这种异质信... 详细信息

随着信息技术的发展,互联网中积累了大量有价值的信息,这些信息已成为多准则决策重要的信息来源.由于个人知识背景、经验、表达习惯以及不同准则特质的不同,在线评论信息通常由多种形式的信息组成,如实数、区间数和文本信息.这种异质信息会给决策过程中的信息处理、融合和方案选择带来新的挑战.为了应对这些挑战,本文提出了一种基于异质在线评论信息的多准则决策方法.首先,通过数据获取与预处理方法,获得与决策问题相关的异质在线评论信息.其次,提出了一种异质信息处理方法,将不同形式的信息统一处理为分布在同一识别框架上的语言分布信息.然后,为了应对在线评论信息中的模糊和不确定性,提出了一种区间权重确定模型和一种基于证据推理算法的信息融合方法.最后,通过一个关于汽车评估的案例分析验证了将所提出的多准则决策方法的实用性和有效性.

关键词：异质在线评论信息多准则决策异质信息处理区间权重确定信息融合

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Cooperative Target Fencing of Multiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of Systems Science & Complexity 2024年第1期37卷 136-151页

作者： pan Zini CHEN Ben M Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem for n-dimensional systems and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull formed by the ***,the dynamics of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the communication network and collision avoidance among the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a numerical example.

关键词： Multi-agent systems networked systems target fencing

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Global Tangentially Analytical Solutions of the 3D Axially Symmetric Prandtl Equations

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Chinese Annals of Mathematics,Series B 2024年第4期45卷 573-596页

作者： Xinghong pan Chaojiang XU School of Mathematics and Key Laboratory of MIIT Nanjing University of Aeronautics and Astronautics Laboratoire de Mathématiques Rapha?l Salem UMR 6085 CNRSUniversité de Rouen Normandie

In this paper,the authors will prove the global existence of solutions to the three dimensional axially symmetric Prandtl boundary layer equations with small initial data,which lies in H1Sobolev space with respect to the normal variable and is analytical with respect to the tangential *** main novelty of this paper relies on careful constructions of a tangentially weighted analytic energy functional and a specially designed good unknown for the reformulated *** result extends that of Paicu-Zhang in[Paicu,*** Zhang,P.,Global existence and the decay of solutions to the Prandtl system with small analytic data,***.,241（1）,2021,403–446].from the two dimensional case to the three dimensional axially symmetric case,but the method used here is a direct energy estimates rather than Fourier analysis techniques applied there.

关键词： Axially symmetric Global existence Prandtl equations Tangentially analytical solutions

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两类脱氢松香胺Schiff碱类衍生物的合成及其离子识别性能

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有机化学 2011年第9期31卷 1468-1474页

作者：雷茜冯少波张业王凯潘英明王恒山广西师范大学化学化工学院药用资源化学与药物分子工程教育部重点实验室桂林541004 广西壮族自治区计量检测研究院理化与医疗检测研究所南宁530022 桂林师范高等专科学校化学与工程技术系桂林541001

以脱氢松香胺和降解脱氢松香胺为起始反应物,通过与一系列醛缩合,得到两个系列的脱氢松香胺Schiff碱类衍生物2a～2f和4a～4e.其结构用1H NMR,13C NMR,MS,IR和元素分析等分析手段进行了确证.随后对所合成的脱氢松香胺Schiff碱类衍生物进... 详细信息

以脱氢松香胺和降解脱氢松香胺为起始反应物,通过与一系列醛缩合,得到两个系列的脱氢松香胺Schiff碱类衍生物2a～2f和4a～4e.其结构用1H NMR,13C NMR,MS,IR和元素分析等分析手段进行了确证.随后对所合成的脱氢松香胺Schiff碱类衍生物进行了阴、阳离子的识别能力研究,并对其结构与离子识别能力的关系进行了探讨.

关键词：脱氢松香胺降解脱氢松香胺 Schiff碱离子识别

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FlowGANAnomaly: Flow-Based Anomaly Network Intrusion Detection with Adversarial Learning

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Chinese Journal of Electronics 2024年第1期33卷 58-71页

作者： Zeyi LI pan WANG Zixuan WANG School of Computer Science Nanjing University of Posts and Telecommunications School of Modern Posts Nanjing University of Posts and Telecommunications School of Internet of Things Nanjing University of Posts and Telecommunications

In recent years, low recall rates and high dependencies on data labelling have become the biggest obstacle to developing deep anomaly detection(DAD) techniques. Inspired by the success of generative adversarial networks(GANs) in detecting anomalies in computer vision and imaging, we propose an anomaly detection model called Flow GANAnomaly for detecting anomalous traffic in network intrusion detection systems(NIDS). Unlike traditional GAN-based approaches, which are composed of a flow encoder, a convolutional encoder-decoder-encoder, a flow decoder and a convolutional encoder, the architecture of this model consists of a generator(G) and a discriminator(D).Flow GANAnomaly maps the different types of traffic feature data from separate datasets to a uniform feature space,thus can capture the normality of network traffic data more accurately in an adversarial manner to mitigate the problem of the high dependence on data labeling. Moreover, instead of simply detecting the anomalies by the output of D, we proposed a new anomaly scoring method that integrates the deviation between the output of two Gs’ convolutional encoders with the output of D as weighted scores to improve the low recall rate of anomaly detection. We conducted several experiments comparing existing machine learning algorithms and existing deep learning methods(Auto Encoder and VAE) on four public datasets(NSL-KDD, CIC-IDS2017, CIC-DDo S2019, and UNSW-NB15). The evaluation results show that Flow GANAnomaly can significantly improve the performance of anomaly-based NIDS.

关键词： Deep learning Machine learning algorithms Computational modeling Network intrusion detection Imaging Telecommunication traffic Generative adversarial networks

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Research Progress on Bio‑inspired Flapping‑Wing Rotor Micro Aerial Vehicle Development

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Journal of Bionic Engineering 2024年第4期21卷 1621-1643页

作者： Yingjun pan Shijun Guo Xun Huang Centre for Aeronautics School of AerospaceTransport and ManufacturingCranfield UniversityBedford MK430ALUK

Flapping-wing rotor(FWR)is an innovative bio-inspired micro aerial vehicle capable of vertical take-off and *** unique design combines active flapping motion and passive wing rotation around a vertical central shaft to enhance aerodynamic *** research on FWR,though relatively new,has contributed to 6%of core journal publications in the micro aerial vehicle field over the past two *** paper presents the first comprehensive review of FWR,analysing the current state of the art,key advances,challenges,and future research *** review highlights FWR’s distinctive kinematics and aerodynamic superiority compared to traditional flapping wings,fixed wings,and rotary wings,discussing recent breakthroughs in efficient,passive wing pitching and asymmetric stroke amplitude for lift *** experiments and remote-controlled take-off and hovering tests of single and dual-motor FWR models have showcased their *** review compares FWR flight performance with well-developed insect-like flapping-wing micro aerial vehicles as the technology readiness level progresses from laboratory to outdoor flight testing,advancing from the initial flight of a 2.6 g prototype to the current free flight of a 60-gram *** review also presents ongoing research in bionic flexible wing structures,flight stability and control,and transitioning between hovering and cruise flight modes for an FWR,setting the stage for potential applications.

关键词： Flapping-wing rotor Micro aerial vehicle Bio-inspiration Flight

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