检索结果-南通市图书馆

Early testing of insulin resistance: a tale of two lipid ratios in a group of 5th graders screened by the Coronary Artery Risk Detection in Appalachian Communities Project (CARDIAC Project)

引用

World journal of Pediatrics 2019年第4期15卷 398-404页

作者： Charles Ituka Mosimah Christa Lilly Awung-Njia Forbin pamela j.murray Lee Pyles Elloise Elliot William Neal West Virginia University MorgantownUSA University of Yaounde I YaoundeCameroon

Background In West Virginia (WV),47% of fifth-grade children are either overweight or *** is no clear consensus regarding the definition of insulin resistance in children,and directly measuring insulin on the population level is *** proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) *** purpose of this study is to examine the relationship between TRIG/HDL-C ratio,TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN).Methods Between 2007 and 2016,52,545 fifth-grade students in WV were assessed for *** glucose and insulin levels were collected only for a sub-group of students who were AN-positive and was used to determine insulin resistance using the Homeostatic Model for Insulin Resistance (HOMA-IR) *** analysis included t tests and logistic regression with receiver operating characteristic *** Of the students assessed for AN,4.5% (n =2360) tested *** prevalence of insulin resistance was 79% (n =814) among 1030 with AN and complete ***/HDL-C ratio and TRIG/LDL-C ratio were significantly associated with insulin resistance (TRIG/HDL-C:Est.=0.36,P < 0.0001,AUC =0.68;TRIG/LDL-C:Est.=0.87,P < 0.0001,AUC =0.69).Multivariate analysis showed that increased body mass index (Est.=0.05,P < 0.0001),gender (Est.=0.49,p < 0.0001) and TRIG/HDL-C ratio (Est.=0.21,P < 0.0001) were significantly associated with insulin *** TRIG/HDL-C is a better surrogate marker of insulin resistance in AN-positive children compared to TRIG/ LDL-C ratio;so,on a population-level,cholesterol rather than insulin may be obtained for preliminary testing of early insulin resistance in children.

关键词： Acanthosis nigricans CARDIAC Project High-density lipoprotein cholesterol Insulin resistance Low-density lipoprotein cholesterol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Iron regulatory protein 1: the deadly switch of ferroptosis

引用

Neural Regeneration Research 2024年第3期19卷 477-478页

作者： Daniel A.Bórquez pamela j.Urrutia Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Institute of Nutrition&Food Technology(INTA) Universidad de ChileSantiagoChile Geroscience Center for Brain Health and Metabolism SantiagoChile

Ferroptosis,an iron-dependent cell death:Ferroptosis is a type of regulated necrosis,characterized by redox-active iron accumulation and increased free radical production derived by Fenton chemistry,that triggers oxidation of polyunsaturated fatty acids in phospholipids,loss of cellular membranes integrity,and leakage of intracellular contents.

关键词： integrity switch Iron

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management of monogenic diabetes in pregnancy:A narrative review

引用

World journal of Diabetes 2024年第1期15卷 15-23页

作者： Mohammad Sadiq jeeyavudeen Sarah R murray Mark W j Strachan Metabolic Unit Western General HospitalEdinburgh EH42XUUnited Kingdom MRC Centre for Reproductive Health University of Edinburgh Queen’s Medical Research InstituteEdinburgh EH164TJUnited Kingdom

Pregnancy in women with monogenic diabetes is potentially complex,with significant implications for both maternal and fetal *** these,maturity-onset diabetes of the young(MODY)stands out as a prevalent monogenic diabetes subtype frequently encountered in clinical *** subtype of MODY requires a distinct approach tailored to the pregnancy,diverging from management strategies in non-pregnant *** MODY(GCK-MODY)typically does not require treatment outside of pregnancy,but special considerations arise when a woman with GCK-MODY becomes *** glycemic targets in GCK-MODY pregnancies are not exclusively dictated by the maternal/paternal MODY genotype but are also influenced by the genotype of the developing *** pregnancy,the choice between sulfonylurea or insulin for treating hepatocyte nuclear factor 1-alpha(HNF1A)-MODY and HNF4A-MODY depends on the mother’s specific circumstances and the available *** of other rarer MODY subtypes is individu-alized,with decisions made on a case-by-case ***,a collaborative approach involving expert diabetes and obstetric teams is crucial for the compre-hensive management of MODY pregnancies.

关键词： Diabetes Pregnancy Maturity-onset diabetes of the young Insulin Sulphonylurea Glucokinase Hepatocyte nuclear factor 1-alpha,hepatocyte nuclear factor 1-beta,and hepatocyte nuclear factor 4-alpha

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pregnancy stressors and postpartum symptoms of depression and anxiety:the moderating role of a cognitivebehavioural therapy(CBT)intervention

引用

General Psychiatry 2024年第1期37卷 112-121页

作者： Yunxiang Sun Soim Park Abid Malik Najia Atif Ahmed Zaidi Atif Rahman pamela j Surkan Department of International Health Johns Hopkins University Bloomberg School of Public HealthBaltimoreMarylandUSA Department of Public Mental Health Health Services AcademyIslamabadPakistan Human Development Research Foundation RawalpindiPakistan Department of Primary Care and Mental Health Institute of Population HealthUniversity of LiverpoolLiverpoolUK

Background Little is known about the association between stressors(especially positive stressors)during pregnancy and postpartum depression and *** We investigated the association between positive and negative stress events during different stages of pregnancy and postpartum mental health outcomes among low-income pregnant women with symptoms of anxiety in Pakistan and evaluated whether an intervention based on cognitive behavioural therapy(CBT)had a regulatory *** Participants were 621 pregnant Pakistani women with mild *** the Pregnancy Experience Scale-Brief Version,six scores were created to assess positive and negative *** performed a multivariate linear regression to examine whether these six scores,measured both at baseline and in the third trimester,were associated with postpartum anxiety and depressive *** effect of the intervention on this relationship was examined by adding an interaction term to the regression *** Hassles frequency measured in the third trimester was positively associated with depression(B=0.22,95%confidence interval(Cl):0.09 to 0.36)and anxiety(B=0.19,95%Cl:0.08to 0.30).At the same timepoint,uplifts intensity was negatively associated with symptoms of depression(B=-0.82,95%Cl:1.46 to-0.18)and anxiety(B=-0.70,95%Cl:-1.25 to-0.15),whereas hassles intensity was positively related to symptoms of depression(B=1.02,95%Cl:0.36 to 1.67)and anxiety(B=0.90,95%Cl:0.34 to 1.47).The intensity ratio of hassles to uplifts reported in the third trimester was positively related to both depression(B=1.40,95%Cl:0.59 to 2.20)and anxiety(B=1.26,95%Cl:0.57 to 1.96).The intervention strengthened the overall positive effects of uplfts and the negative effects of *** experiences at baseline during early pregnancy to mid-pregnancy were not associated with mental health *** Stressors in the third trimester but not earlier in pregnancy were associated with postpartum symptoms

关键词： postpartum stress behaviour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ocular therapies for neuronal ceroid lipofuscinoses: more than meets the eye

引用

Neural Regeneration Research 2022年第8期17卷 1755-1756页

作者： Samantha j.murray Nadia L.Mitchell Faculty of Agricultural and Life Sciences Lincoln UniversityLincolnNew Zealand

The neuronal ceroid lipofuscinoses(NCLs),also known as Batten disease,are a group of inherited,neurodegenerative,lysosomal storage diseases typically manifesting in *** are currently 13 known forms of NCL resulting from various mutations in the CLN(ceroid lipofuscinoses neuronal)genes(CLN1-8 and CLN10-14).Although varying in onset and severity,the NCLs share several phenotypic features including seizures,motor dysfunction,cognitive decline,and progressive loss of vision(Mole et al.,2011).Current treatment strategies being investigated in pre-clinical studies and early stage clinical trials primarily target the brain and spinal *** these potential therapeutics show promise in attenuating neurological disease,protection against retinal dysfunction and degeneration is generally ineffective or not reported.

关键词： degeneration primarily typically

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Seasonal resource selection of an arboreal habitatspecialist in a human-dominated landscape: A case studyusing red panda

引用

Current Zoology 2023年第1期69卷 1-11页

作者： Damber Bista Greg S.Baxter Nicholas j.Hudson Peter j.murray School of Agriculture and Food Sciences(Wildlife Science Unit) The University of QueenslandGattonQLD 4343Australia School of Agriculture and Environmental Science University of Southern QueenslandDarling HeightsQLD 4350Australia

Human-dominated landscapes provide heterogeneous wildlife habitat. Conservation of habitat specialists, like red pandas Ailurus fulgens, inhabiting such landscapes is challenging. Therefore, information on resource use across spatial and temporal scales could enable informed-decisionmaking with better conservation outcomes. We aimed to examine the effect of geo-physical, vegetation, and disturbance variables on fine-scalehabitat selection of red pandas in one such landscape. We equipped 10 red pandas with GPS collars in eastern Nepal in 2019 and monitoredthem for 1 year. Our analysis was based on a generalized-linear-mixed model. We found the combined effect of geo-physical, vegetation, anddisturbance variables resulted in differences in resource selection of red pandas and that the degree of response to these variables variedacross seasons. Human disturbances, especially road and cattle herding activities, affected habitat utilization throughout the year whereas othervariables were important only during restricted periods. For instance, geo-physical variables were influential in the premating and cub-rearingseasons while vegetation variables were important in all seasons other than premating. Red pandas selected steeper slopes with high solarinsolation in the premating season while they occupied elevated areas and preferred specific aspects in the cub-rearing season. Furthermore,the utilized areas had tall bamboo in the birthing and cub-rearing seasons while they also preferred diverse tree species and high shrub coverin the latter. Our study demonstrates the significance of season-specific management, suggests the importance of specific types of vegetationduring biologically crucial periods, and emphasizes the necessity to minimize disturbances throughout the year.

关键词： Ailurus fulgens anthropogenic disturbances habitat specialists habitat utilization resource use spatio-temporal variation vegetation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽车迈向“即插即用”

引用

工业设计 2007年第8期 30-32,34+36+38页

作者： Charles j.murray

随着汽车设计的重点从机械转向电气,汽车制造商们正在研究如何让司机能够直接在汽车上连接使用移动消费品。

关键词：汽车工程师稳定控制系统汽车制造商移动消费角速度传感器安全系统娱乐化微控制器电子设备模块

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

追踪未来电子业界的“杀手级应用”

引用

工业设计 2007年第3期 35-39,6页

作者： Charles j.murray

未来产业繁荣将可能由那种能俘获男女老少的心,让穷人富人都能为之掏腰包的软件所推动。电子业界下一个“杀手级应用”目前仍是个谜。它可能在硅谷某个极普通的开发实验室内悄悄地展开,也可能在某位夜以继日苦苦思索的印度大学生脑内飞... 详细信息

未来产业繁荣将可能由那种能俘获男女老少的心,让穷人富人都能为之掏腰包的软件所推动。电子业界下一个“杀手级应用”目前仍是个谜。它可能在硅谷某个极普通的开发实验室内悄悄地展开,也可能在某位夜以继日苦苦思索的印度大学生脑内飞速运转着。

关键词：处理器自动驾驶模拟器件电子设备传感器应用软件杀手德州仪器医疗设备

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

电池制造商致力于新型电动车电池的研发

引用

工业设计 2007年第10期 32-34页

作者： Charles j.murray

电动车用电池又回来了,这一次它将面临着严峻的来自成本和安全性的双重挑战。然而它的使命已经不像十年前那样令人望而生畏了。

关键词：电动车电池汽车制造商车用电池纯电动车双重挑战内燃机锂离子电池安全性国家实验室系统公司

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

机器人救生员

引用

工业设计 2007年第5期 32+49-51页

作者： Charles j.murray

有一天,你会看到关于它援救战场伤员的录像。也或许你会在它大步走过拥挤的医院长廊时与它擦肩而过。不管怎样,你有可能在毫无准备的情况下见到“Bear”(战地援助机器人)。毕竟这不是一种全自动喷涂机器人。由马萨诸塞州一家公司为美国... 详细信息

有一天,你会看到关于它援救战场伤员的录像。也或许你会在它大步走过拥挤的医院长廊时与它擦肩而过。不管怎样,你有可能在毫无准备的情况下见到“Bear”(战地援助机器人)。毕竟这不是一种全自动喷涂机器人。由马萨诸塞州一家公司为美国陆军研制的这款机器人只能说是成百上千的商业机器人的后代。在机器人技术等级上,它不像是一个流水线上组装的机器人,更像是星球大战中的C3PO或施瓦辛格饰演的终结者。

关键词：可移动机器人美国陆军微控制器全自动喷涂终结者人性化流水线马萨诸塞州楼梯发电机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：