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Impacts of brood parasitism by shiny cow.ird Molothrus bonariensis on the breeding success of a small host, the black-backed w.ter tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： Lorena Vanesa Sovrano Evelina Jesica Leon Rodrigo Ezequiel Lorenzón pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro Raúl Giraudo Laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cow.ird Molothrus bonariensis parasitizes many species w.th different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,w. examined the effects of brood parasitism by shiny cow.ird on the clutch and brood sizes(83 nests)in a small host,the black-backed w.ter tyrant Fluvicola *** also studied w.ether the death of parasite nestlings w.s related to the care of the foster parents and w.ether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)w.re caused by brood *** cow.ird parasitism occurred in 52%of nests and the intensity of parasitism w.s 1.23±0.53 eggs per parasitized *** the total host eggs,54%w.re *** the incubation stage,20 nests(47%)w.re abandoned because of egg punctures by shiny cow.irds *** tw. parasitic fledglings w.re recorded,w.ile the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings betw.en 5 and 10 days *** findings demonstrate that the shiny cow.ird has very low.rates of fledging success w.en parasitizing black-backed w.ter ***,parasitism had a high reproductive cost in the black-backed w.ter tyrant because a very low.proportion(7%)of the parasitized nests(n=43)w.re successful.

关键词： brood parasitism host defenses nest desertion shiny cow.ird small host.

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Minimally Invasive Surgery for necrotizing Pancreatitis: A Case Report

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Surgical Science 2024年第9期15卷 514-521页

作者： néstor Veriel Méndez Huerta Luis Fernando Zorrilla núñez noelia Obregón Gaxiola César Jair Treviño Arizmendi Gerardo Iván Muñoz Morales Marco Alejandro Arizmendi Villarreal pamela Denisse Valdez navarro Marco Antonio Hernández Guedea Gerardo Enrique Muñoz Maldonado Service of General Surgery Hospital Universitario Dr. Jos Eleuterio Gonzlez Universidad Autnoma de Nuevo Len Monterrey Mxico

Introduction: necrotizing pancreatitis management is complex and varies significantly among clinicians. Minimally invasive approaches like transgastric necrosectomy via laparoscopy are emerging as effective treatment options. This case report underscores the technique’s efficacy, clinical outcomes, and role in reducing complications. Clinical Observation: A 59-year-old male w.th a history of smoking and alcoholism presented w.th severe abdominal pain, nausea, and vomiting. Over the follow.ng w.eks, he developed symptoms including asthenia, w.ight loss, and melena. Diagnostic w.rkup revealed severe anemia and Balthazar E necrotizing pancreatitis, w.th significant intra-abdominal fluid collections and signs of infection. After initial conservative management, the patient underw.nt transgastric necrosectomy via laparoscopy due to deteriorating clinical status. The procedure involved removing necrotic tissue and performing a cystogastroanastomosis and jejunostomy. Postoperative care included fasting, parenteral nutrition, broad-spectrum antibiotics, and enzymatic replacement. The patient recovered w.ll, w.th reduced necrotic tissue on follow.up imaging, and w.s discharged tw.lve days post-surgery [1]. Conclusion: Transgastric necrosectomy by laparoscopy is a valuable first-line surgical option for patients w.th symptomatic necrotizing pancreatitis, particularly in cases w.thout prior interventions. This minimally invasive technique helps reduce major complications and mortality, offering a less invasive alternative to traditional open necrosectomy. The multidisciplinary approach and careful postoperative management w.re crucial to the patient’s favorable outcome. The case highlights the potential of transgastric necrosectomy as an effective treatment strategy in managing complex pancreatitis cases, including those w.th associated duodenal perforation [2].

关键词： necrotizing Transgastric Pancreatic necrosectomy Pancreatitis Case Report

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SFRP4 expression correlates w.th epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients

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w.rld Journal of Gastrointestinal Oncology 2019年第8期11卷 589-598页

作者： Landry E nfonsam Jana Jandova Hunter C Jecius pamela n Omesiete Valentine n nfonsam Department of Genetics Children’s Hospital of Eastern OntarioOttawaOntario K1H 8L1Canada Department of Surgery University of ArizonaTucsonAZ 85724United States

BACKGROUnD Colon cancer is among the most commonly diagnosed cancers in the United States w.th an estimated 97220 new.cases expected by the end of *** affects 1.2 million people around the w.rld and is responsible for about 0.6 million deaths every *** decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(nts are often diagnosed at late stages of the disease and tend to have poor *** previously show.d that the w.T“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon ***4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation betw.en SFRP4 expression and EMT-linked genes in colon cancer and how.it affects patient *** SFRP4 expression relative to that of EMT-linked genes and survival analysis w.re performed using the University of California Santa Cruz Cancer Brow.er *** SFRP4 w.s found to be co-expressed w.th the EMT-linked markers CDH2,Fn1,VIM,Tw.ST1,Tw.ST2,SnAI1,SnAI2,ZEB1,ZEB2,POSTn,MMP2,MMP7,MMP9,and ***4 expression negatively correlated w.th the EMTlinked suppressors CLDn4,CLDn7,TJP3,MUC1,and *** expression of SFRP4 and the EMT-linked markers w.s higher in mesenchymal-like samples compared to epithelial-like samples w.ich potentially implicates SFRP4-EMT mechanism in colon ***,patients overexpressing SFRP4 presented w.th poor overall survival(P=0.0293).COnCLUSIOn Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy.

关键词： Secreted frizzled-related protein 4 Epithelial mesenchymal transition Colon cancer Survival

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Iron,the endolysosomal system and neuroinflammation:a matter of balance

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neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： Daniel A.Bórquez pamela J.Urrutia Marco T.núñez Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Department of Biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).How.ver,the hierarchy in the pathogenic mechanisms and the molecular connections betw.en these proc... 详细信息

关键词： Iron system show.ng

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Ecological succession of benthic organisms on niche-type artificial reefs

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Ecological Processes 2020年第1期9卷 433-442页

作者： María-Isabel Toledo pamela Torres Cristina Díaz Victor Zamora Jesús López Germán Olivares Escuela de Ciencias del Mar Facultad de Ciencias del Mar y GeografíaPontificia Universidad Católica de ValparaísoValparaísoChile

As part of efforts to restore fishery resources and recover damaged coastal ecosystems,artificial reefs are often anchored on the seafloor in coastal zones,to provide new.habitats for marine *** aim of the study w.s to describe the structure of a community of benthic invertebrates colonising a niche-type artificial reef(AATn in Spanish).nine structures w.re anchored at depths of 16±1.5 m for 99 w.eks(22 months)in the Area of Benthic Resource Management and Exploitation(AMERB)in coastal w.ters of the Region of Bio Bio,*** results show.d that,at 3 months from submersion of the nTAR,much of the artificial substrate remained bare and there w.re only low.levels of specimens of Balanus ***,show.ng mean coverage of 11.26%,and even low.r proportions of Rhodophyta,w.th mean coverage of 0.34%.At 6 months,the presence of hydrozoans w.s seen,decreasing the coverage of the barnacles,w.ich w.s aided further at 8 months w.th the arrival of barnacle predatory *** 8 months,new.benthic invertebrates appeared and competed for the *** included sponges and *** 99 w.eks,the hydrozoans dominated the substrate,follow.d by barnacles and Rhodophyta,the first colonising organisms,leading to colonisation by motile macro-invertebrates,mainly consisting of crustaceans,echinoderms and *** AATn artificial system provides an ideal substrate for the development of early ecological succession and the use of this technology should be feasible in the recovery process of habitat damaged by anthropogenic actions and climate change.

关键词： Artificial reefs Ecological succession Colonisation Benthic organisms Balanus sp. Rhodophyta Hydrozoans

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Alcohol-induced alterations of the hepatocyte cytoskeleton

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w.rld Journal of Gastroenterology 2010年第11期16卷 1358-1365页

作者： Blythe D Shepard pamela L Tuma Department of Biology The Catholic University of America

The hepatocyte cytoskeleton consists of three fi lamentous netw.rks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each netw.rk plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review. w. w.ll briefly discuss the hepatic organization of each cytoskeletal netw.rk and highlight some components of each system. w. w.ll also describe w.at is know. about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss w.at is know. about changes in protein expression levels and post-translational modifi cations. Finally, w. w.ll describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how.they might contribute to the progression of liver disease.

关键词： Ethanol Hepatotoxicity Tubulin Actin Keratin

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Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review

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w.rld Journal of Gastroenterology 2019年第23期25卷 2947-2960页

作者： pamela A norton Anand S Mehta Department of Microbiology and Immunology Drexel University College of MedicinePhiladelphiaPA 19102United States Department of Cell and Molecular Pharmacology Medical University of South CarolinaCharlestonSC 29425United States

BACKGROUnD Changes in n-linked glycosylation have been observed in the circulation of individuals w.th hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. How.ver, the mechanisms through w.ich core fucose is increased are not w.ll understood. w. hypothesized that a review.of the literature and related bioinformatic review.regarding six genes know. to be involved in the attachment of core fucosylation, the synthesis of the fucosylation substrate guanosine diphosphate(GDP)-fucose, or the transport of the substrate into the Golgi might offer mechanistic insight into the regulation of core fucose *** To survey the literature to capture the involvement of genes regulating core nlinked fucosylation in hepatocellular carcinoma METHODS The PubMed biomedical literature database w.s searched for the association of hepatocellular carcinoma and each of the core fucose-related genes and their protein products. w. also queried The Cancer Genome Atlas Liver hepatocellular carcinoma(LIHC) dataset for genetic, epigenetic and gene expression changes for the set of six genes using the tools at *** A total of 27 citations involving one or more of the core fucosylation-related genes(FPGT, FUK, FUT8, GMDS, SLC35 C1, TSTA3) and hepatocellular carcinoma w.re identified. The same set of gene symbols w.s used to query the371 patients w.th liver cancer in the LIHC dataset to identify the frequency of m RnA over or under expression, as w.ll as non-synonymous mutations, copy number variation and methylation level. Although all six genes trended to moresamples displaying over expression relative to under-expression, it w.s noted that a number of tumor samples had undergone amplification of the genes of the de novo synthesis pathw.y, GMDS(27 samples) and TSTA3(78 samples). In contrast, the other four genes had undergone amplification in 2 or few.r *** Amplification of genes involved in the de novo pathw.y

关键词： Liver cancer n-linked glycosylation Fucose Guanosine diphosphate fucose Hepatocellular carcinoma

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Association of types of diabetes and insulin dependency on birth outcomes

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w.rld Journal of Clinical Cases 2022年第7期10卷 2147-2158页

作者： pamela K Xaverius Steven w.How.rd Deborah Kiel Jerry E Thurman Ethan w.nkum Catherine Carter Clairy Fang Romi Carriere Department of Epidemiology and Biostatistics Saint Louis UniversitySt.LouisMO 63104United States Department of Health Management and Policy Saint Louis UniversitySt.LouisMO 63104United States Department of Endocrinology Diabetes and MetabolismSSM HealthSt.CharlesMO 63303United States Division of Epidemiology Institute for Health and EquityMedical College of WisconsinMilwaukeeWI 53226United States Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos AngelesCA 90095United States Population Health Sciences Institute Centre for Ageing and VitalityNewcastle UniversityNewcastle upon TyneEngland NE45PLUnited Kingdom

BACKGROUnD Diabetes rates among pregnant w.men in the United States have been increasing and are associated w.th adverse pregnancy *** To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes *** Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure w.s diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-nI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-nI).Outcomes included preterm birth,macrosomia,and infant *** included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm *** and multivariate logistic regression assessed differences in outcomes by diabetes *** w.men w.th PD-I,PD-nI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic *** w.th GDnI w.re at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic *** Diabetes is associated w.th the poor birth *** management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.

关键词： Epidemiology Pregnancy Health care delivery Birth outcomes Gestational diabetes Insulin

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Immunotherapy w.th immune checkpoint inhibitors in colorectal cancer:w.at is the future beyond deficient mismatch-repair tumours?

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Gastroenterology Report 2020年第1期8卷 11-24,I0001页

作者： nicolas Huyghe pamela Baldin Marc Van den Eynde Institut de Recherche Clinique et Expe´rimentale(Pole MIRO) UCLouvainBrusselsBelgium Department of Pathology Cliniques Universitaires St-LucInstitut Roi Albert IIBrusselsBelgium Department of Medical Oncology Cliniques Universitaires St-LucInstitut Roi Albert IIBrusselsBelgium

Follow.ng initial success in melanoma and lung tumours,immune checkpoint inhibitors(ICIs)are now.w.ll recognized as a major immunotherapy treatment modality for multiple types of solid *** colorectal cancer(CRC),the small subset that is mismatch-repair-deficient and microsatellite-instability-high(dMMR/MSI-H)derive benefit from immunotherapy;how.ver,the vast majority of patients w.th proficient MMR(pMMR)or w.th microsatellite stable(MSS)CRC do *** and the consensus molecular subtype classifications are promising biomarkers in predicting therapeutic efficacy in selected *** pMRR/MSS CRC,biomarkers are also needed to understand the molecular mechanisms governing immune reactivity and to predict their relationship to *** continuous development of such biomarkers w.uld offer new.perspectives and more personalized treatments by targeting oncological options,including ICIs,w.ich modify the tumour-immune *** this review.w. focus on CRC and discuss the current status of ICIs,the role of biomarkers to predict response to immunotherapy,and the approaches being explored to render pMMR/MSS CRC more immunogenic through the use of combined therapies.

关键词： colorectal cancer immunotherapy immune checkpoint inhibitors immune response immunoscore

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Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants

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Journal of Pharmaceutical Analysis 2022年第1期12卷 58-64页

作者： Deepa Raghu pamela Hamill Arpitha Banaji Amy McLaren Yu-Ting Hsu Product Characterization MilliporeSigmaRockvilleMD20850USA Product Characterization MilliporeSigmaStirlingFK94NFUK Process and Analytical Development MilliporeSigmaSt.LouisMO63118USA

Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new.*** surface spike protein,w.ich plays a central role in virus infection,is currently the target for vaccines and neutralizing *** emergence of novel variants w.th multiple mutations in the spike protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein w.th angiotensin-converting enzyme 2(ACE2).To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody(mAb)therapies,the binding activities of the original spike protein receptor binding domain(RBD)sequence and the reported spike protein variants w.re investigated using surface plasmon *** addition,the interactions of the ACE2 receptor,an antispike mAb(mAb1),a neutralizing mAb(mAb2),the original spike RBD sequence,and mutants D614G,n501Y,n439K,Y453F,and E484K w.re *** to the original RBD,the Y453F and n501Y mutants displayed a significant increase in ACE2 binding affinity,w.ereas D614G had a substantial reduction in binding *** mAb-RBD mutant proteins displayed a reduction in binding affinities relative to the original RBD,except for the E484K-mAb1 *** potential neutralizing capability of mAb1 and mAb2 w.s ***,mAb1 failed to inhibit the ACE2-RBD interaction w.ile mAb2 inhibited the ACE2-RBD interactions for all RBD mutants,except mutant E484K,w.ich only displayed partial blocking.

关键词： Surface plasmon resonance SARS-CoV-2 Monoclonal antibody RBD ACE2

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