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Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel Teixeira Proenca Jessica Marinho pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann Viviane Rostirola Elsner Programa de Pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Programa de Pos Graduacao em Ciencias Biologicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Programa de Pos Graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

Parkinson's disease is a neurodegenerative *** stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this *** exercise can regulate oxidative *** purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's *** aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise *** results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's *** with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first *** results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme *** results could better help understand the target of oxidative stress in Parkinson's *** study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease

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T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets

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World Journal of Gastroenterology 2014年第46期20卷 17416-17425页

作者： Luis A Videla Virginia Fernández pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileIndependencia 1027SantiagoChile School of Medical Technology Faculty of MedicineDiego Portales UniversityEjército 141SantiagoChile

AIM: To investigate the redox dependency and promotion of downstream targets in thyroid hormone (T3)-induced AMP-activated protein kinase (AMPK) signaling as cellular energy sensor to limit metabolic stresses in the l... 详细信息

关键词： Liver Thyroid hormone N-acetylcysteine AMP-activated protein kinase Fatty acid oxidation

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Tale of two kinases:Protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase Ⅱ in pre-diabetic cardiomyopathy

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World Journal of Diabetes 2021年第10期12卷 1704-1718页

作者： pamela Gaitán-González Rommel Sánchez-Hernández José-Antonio Arias-Montaño Angélica Rueda Department of Biochemistry Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalCiudad de México 07360Mexico Department of Physiology Biophysics and NeurosciencesCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalCiudad de México 07360Mexico

Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations,including insulin resistance,visceral fat accumulation,and dyslipidemias,which increase the risk for developing cardiovascular *** syndrome is associated with augmented sympathetic tone,which could account for the etiology of pre-diabetic *** review summarizes the current knowledge of the pathophysiological consequences of enhanced and sustainedβ-adrenergic response in pre-diabetes,focusing on cardiac dysfunction reported in diet-induced experimental models of pre-diabetic *** research reviewed indicates that both protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase Ⅱ play important roles in functional responses mediated byβ1-adrenoceptors;therefore,alterations in the expression or function of these kinases can be *** review also outlines recent information on the role of protein kinase A and Ca^(2+)/calmodulin-dependent protein kinase Ⅱ in abnormal Ca^(2+)handling by cardiomyocytes from diet-induced models of pre-diabetic cardiomyopathy.

关键词： Ca^(2+)/calmodulin-dependent protein kinase II Protein kinase A Metabolic syndrome Pre-diabetes Pre-diabetic cardiomyopathy β-Adrenoceptors

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Good Dog

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小学生时代（大嘴英语） 2020年第3期 22-24页

作者： pamela Kapchinske Sue Cornelison(图) 不详

Zoey tells her dog to STAY!But Sam jumps up and runs to *** tells her dog to SPEAK!But silently,he licks her *** shouts,"Sam,ROLL OVER!"And he sits down upon the flower.

关键词： And OVER silent

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网络结构与权力分配:要素论的解释

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社会学研究 2011年第2期25卷 134-166,245页

作者：刘军 David Willer pamela Emanuelson 哈尔滨工程大学社会学系美国南卡罗来纳大学社会学系美国北达科他州立大学社会学系

中国的社会网研究很少关注网络结构与权力分配之间的关系,这恰是要素论的贡献。在介绍影响、社会关系、社会行动者等基本"要素"之后,本文分析了要素论的建模原理及多种结构条件,并简析其优势所在。要素论研究发现,权力的分配取决于行动... 详细信息

中国的社会网研究很少关注网络结构与权力分配之间的关系,这恰是要素论的贡献。在介绍影响、社会关系、社会行动者等基本"要素"之后,本文分析了要素论的建模原理及多种结构条件,并简析其优势所在。要素论研究发现,权力的分配取决于行动者的偏好、信念、关系类型及诸多结构条件,因此,核心点未必有权。要素论根据网络结构预测权力的分配,这是其独特之处。该理论的其他优势有:坚持理论导向的实验研究,揭示了权力来源于"排除"机制,运用分析—组合法,可用于研究大型的、复杂的社会历史结构。本文最后讨论了要素论的未来方向,包括考虑到行动者的属性和结构的转换以及关系的要素论研究会加深对中国社会的认识等。

关键词：权力要素论网络结构关系研究网络交换论社会网络分析

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Use of Residual Material in Biobanking： Solidarity, Common Good, and Informed Consent

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Journal of Philosophy Study 2012年第8期2卷 560-566页

作者： Luciana Caenazzo pamela Tozzo Renzo Pegoraro University of Padova Fondazione Lanza

Biological residual materials can be obtained from surgical activities or from pathological waste material collected for analysis and stored in formalin. This material can be stored in biobanks with the purpose of future research. Formalin-fixed tissue and also formalin-fixed paraffin embedded tissues are not suitable for all kinds of genetic studies on DNA or RNA, as formalin solution is well known for damaging nucleic acids. Therefore, for the purpose of conducting genetic studies, samples should be frozen in order to maintain a good quality of DNA/RNA over time Biobanks, in which waste samples are frozen, are undoubtedly expensive to maintain; however, it could be useful and important to consider their possible implication in particular research, regarding for example the tumor cells growth process, or when the procurement of samples is difficult. Regarding the relationship between informed consent and tissue collection, storage and research, two choices are possible： irreversible or reversible sample anonymization. These procedures involve different approaches and possible solutions that we will seek to define. Also, an important ethical aspect in regard to the role of biobanks is encouraging sample donation. For donors, seeing human sample being kept rather than discarded and seeing them become useful for research highlight the importance of the human body and improve the attitude towards donation. This process might also facilitate the giving of informed consent more trustfully and willingly.

关键词： residual materials biobanks common good informed consent anonymization solidarity

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意大利中高端时装品牌在中日市场的品牌形象比较

意大利中高端时装品牌在中日市场的品牌形象比较

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作者： pamela Mezzanotte 华东师范大学

学位级别：硕士

可以说这篇论文是我在华留学三年的成果。在参与意大利时装品牌的进口贸易工作的实习中,本人发现意大利品牌在不同国家的市场反应是不一样的,值得研究。本论文从品牌形象的角度来研究意大利中高端时装品牌。研究分析在中日两国市场中意... 详细信息

可以说这篇论文是我在华留学三年的成果。在参与意大利时装品牌的进口贸易工作的实习中,本人发现意大利品牌在不同国家的市场反应是不一样的,值得研究。本论文从品牌形象的角度来研究意大利中高端时装品牌。研究分析在中日两国市场中意大利中高端时装品牌是通过什么样的方式建设及加强自身的品牌形象。论文的结构包括三个部分：论文导论,论文主体和论文结论。论文导论里我将介绍论文的起源与背景介绍。然后第二个部分里来介绍品牌形象的中外文献,来解释品牌形象的五个主要因素：品牌个性,品牌标志,企业形象,COO效应与商店。然后来介绍意大利品牌在中日市场的品牌形象状态：按照我的品牌形象体系来分析两个意大利中高端时装品牌的品牌形象。为了提供具有现实价值的案例我选了Harry & Sons和Vezzo为例。第三部分里按照案例分析的结果来给意大利中高端时装品牌一些建议,比较意大利对中日的贸易交流数据,会给意大利时装品牌些建议。

关键词：意大利时装品牌形象 Made in Italy 中日市场比较中高端时装品牌

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The Volatilization of Pollutants from Soil and Groundwater: Its Importance in Assessing Risk for Human Health for a Real Contaminated Site

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Journal of Environmental Protection 2011年第9期2卷 1192-1206页

作者： pamela Morra Laura Leonardelli Gigliola Spadoni 不详

Pollution of different elements (air, water, soil and subsoil) resulting both from accidental events and from ordinary industrial and civil activities causes negative effects on the human health and on the environment. The present paper examines the analysis of a contaminated site, focusing the attention on the negative effects for receptors exposed to soil and groundwater contamination caused by industrial activities. The case study investigated is a contaminated area located in the industrial district of Trento North once occupied by the Italian Carbochimica plant. Pollution in that area is mainly due to contamination of soil and groundwater with polycyclic aromatic hydrocarbons. The methodology applied is the risk evaluation for human health, in terms of individual cancer risk and hazard index. In particular the attention has been focused on a specific migration way: if pollutants in the soil or in the groundwater undergo a phase change, they spread and get to the soil surface, causing a dispersion of vapors in the atmosphere. In this case risk assessment calls for the evaluation of volatilization factor. Among the different models dealing with the estimation of volatilization factor, those mostly known and used in the national and international field of Human Health Risk Assessment were chosen: Jury’s and Farmer’s models. A sensitivity analysis of models was performed, in order to identify the most significant parameters to estimate the volatilization factors among the wide range of input parameters for the application of models. Performing an accurate selection and data processing of the contaminated site, models for the volatilization factors calculation are applied, thus evaluating air concentrations and Human Health Risk. The analysis of the resulting estimates is an excellent aid to draw interesting conclusions and to verify if the soil and groundwater pollutants volatilization affects the human health considerably.

关键词： Human Health Risk Assessment Volatilization Models Soil Contamination Groundwater Contamination Cancer Risk Hazard Index

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The Fiji Tide-Gauge Stations

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International Journal of Geosciences 2017年第4期8卷 536-544页

作者： Nils-Axel Morner pamela Matlack Klein Paleogeophysics&Geodynamics StockholmSweden The Portuguese Sea Level Project AppomattoxVirginiaUSA

We analyse the location, stability and continuity of the two tide-gauge stations in Fiji. Both stations are awkwardly placed on heavy harbour constructions resting on soft sediments susceptible to serious compaction problems. The nearby GPS stations resting on a bedrock hill offer no solution to the stability problems. The Suva tide-gauge has been moved three times, and must accordingly be analysed in segments. Even the last location covering years 1989 to 2917 provides a mixed picture of 16 years of stability, 10 years of rapid rise, and 4 years of rapid fall in relative sea level. This suggests the interaction of subsidence and cyclic changes in sea level. Any application of mean trends would produce meaningless values rather misguiding than assisting in the handling of estimation of on-going absolute sea level changes. We find this vital for the discussions of local sea level changes to be held at the UN conference on “Our Oceans, Our Future” in June in New York and at the main COP23 conference in November in Bonn.

关键词： Fiji Islands Relative and Absolute Sea Level Changes Tide-Gauges Sediment Compaction Coastal Stability GPS-Stations COP23

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Coastal Erosion in Yasawa Islands,Fiji

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Natural Science 2017年第5期9卷 136-142页

作者： Nils-Axel Morner pamela Matlack Klein Paleogeophysics&Geodynamics StockholmSweden The Portuguese Sea Level Project AppomattoxVirginiaUSA

Coastal erosion may have many different causes. Wherever we came across erosion problems on the Yasawa Islands in Fiji, they had causes other than sea level rise. We present two case studies. At one site, the beach erosion was caused by the construction of a stonewall diverting the currents in a gyre that hit the shore causing local beach erosion. At another site, extensive erosion caused removal and lateral re-deposition of huge quantities of sand. From the Google Earth images we can infer a date between 2005 and 2009 for this change in shore conditions. We suggest that the shallow-water sand was destabilized by the commercial harvesting of thousands of sea cucumbers (Holothuria scabra). These animals, by their sheer numbers and ecological behavior, were exerting a stabilizing influence on the shallow-water sandy deposits off the beach at Yageta Village. In both cases, the erosion was caused by human action. The coasts all along the Yasawa Islands are characterized by coastal stability. The presence of extensive rock-cut platforms and notches, as well as the occurrence of corals grown into “mini-atolls” are indicative of a stable sea level throughout the islands.

关键词： Coastal Erosion Currents Jetties Sea Cucumbers Stable Sea Level Fiji

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