检索结果-南通市图书馆

Zebrafish as a Model for Human Ciliopathies

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2016年第3期43卷 107-120页

作者： Zhu Song Xiaoli Zhang Shuo Jia pamela C.Yelick Chengtian Zhao Institute of Evolution & Marine Biodiversity College of Marine Life Science Ocean University of China Department of Orthodontics Division of Craniofacial and Molecular Genetics Tufts University Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Cilia, microtubule-based structures found on the surface of almost all vertebrate cells, play an array of diverse biological functions. Abnormal ciliary axonemal structure and function can result in a class of genetic disorders that are collectively termed ciliopathies. Model organisms, including Chlamydomonas reinhardtii and Caenorhabditis elegans have been widely used to study the complex genetic basis of ciliopathies. Here, we review the advantages of the zebrafish as a vertebrate model for human ciliopathies. We summarize the features of zebrafish cilia, and the major findings and contributions of the zebrafish model in recent studies of human ciliopathies. We also discuss the new genome editing approaches being efficiently used in zebrafish, and the exciting prospects of these approaches in modeling human ciliopathies.

关键词： Cilia Zebrafish Ciliopathy Disease model

在线全文

学校读者我要写书评

暂无评论

Windsor Castle

Windsor Castle

Recent Advances in Dissecting Stress-Regulatory Crosstalk in Rice

作者： pamela Hartshorne.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Molecular Plant 2013年第2期6卷 250-260页

作者： Rita Sharma David De Vleesschauwer Manoj K. Sharma pamela C. Ronald Department of Plant Pathology and Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA Laboratory of Phytopathology Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious limitation on crop productivity worldwide. Prior or simultaneous exposure to one type of stress often affects the plant response to other stresses, indicating extensive overlap and cross-talk between stress-response signaling pathways. Systems biology approaches that integrate large genomic and prot-eomic data sets have facilitated identification of candidate genes that govern this stress-regulatory crosstalk. Recently, we constructed a yeast two-hybrid map around three rice proteins that control the response to biotic and abiotic stresses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice ortholog of NPR1, a key regulator of systemic acquired resistance; and the ethylene-responsive transcription factor, SUBIA, which confers tolerance to submergence stress. These studies coupled with transcriptional profiling and co-expression analyses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, including mitogen-activated protein kinase 5 （OsMPK5）, wall-associated kinase 25 （WAK25）, sucrose non-fermenting-l-related protein kinase-1 （SnRK1）, SUBIA binding protein 23 （SAB23）, and several WRKY family tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstalk between biotic and abiotic stresses through a variety of mechanisms, including regulation of cellular energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones salicylic acid, ethylene, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstalk defense response hormone systems biology stress.

Heating Up the Environmental Context of Chemical Pollution： Ecotoxicology in a Changing Global Climate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2015年第4期61卷 614-616页

作者： pamela D. NOYES Sean C. LEMA Guest Editors Department of Environmental & Molecular Toxicology Sinnhuber Aquatic Research Laboratory Oregon State University Corvallis OR USA Biological Sciences Department Center for Coastal Marine Sciences California Polytechnic State University San Luis Obispo CA USA

Humans and wildlife are exposed to an ever-increasing array of man-made chemicals that are now meas-ured in every habitat on our planet from the Earth＇s highest mountain peaks to sediments in the deep ocean （e.g., Farrington and Takada, 2014; Quiroz et al., 2009; Veron et al., 1987; Villa et al., 2006）. In addition to the expanding variety of synthetic chemistries in use, there are many substances that are components of the Earth that may through human activities concentrate at high- levels or be released into the environment in forms that enhance their bioavailability, exposure, and toxicity potential.

关键词：光环境生态毒理学全球气候化学污染加热化学物质人类活动生物利用度

Iron,the endolysosomal system and neuroinflammation:a matter of balance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： Daniel A.Bórquez pamela J.Urrutia Marco T.Núñez Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Department of Biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).However,the hierarchy in the pathogenic mechanisms and the molecular connections between these proc... 详细信息

关键词： Iron system showing

Textual Form and Cultural Affect: William Empson′s Double-Plot and Raymond Williams′s Structure of Feeling

在线全文

学校读者我要写书评

暂无评论

外国文学研究 2005年第1期27卷 32-39页

作者： pamela McCallum is professor of English at Department of English University of Calgary

By insisting on the primacy of double-plot, Empson brackets the sometimes deceptive appearances of a text′s content to uncover and disengage the more fundamental double-plot system at work within the defining structure of the text. Empson′s thinking about the reception of double-plot structures enables Raymond Williams′s early formulations of structure of feeling, in particular the gesturing this perplexing, underdeveloped, but persistent concept makes towards understanding collective response to cultural forms. This article explores the implications of the reception of double-plot structures, drawing out the assumptions inscribed in Empson′s claims about processes at work as an audience engages with these dramatic structures.

关键词：诗歌评论文化影响 Empson 雷蒙德·威廉斯双情节文章结构

On the formation and use of calibration equations in nutritionalepidemiology–Discussion of the Paper by *** and ***

在线全文

学校读者我要写书评

暂无评论

Statistical Theory and Related Fields 2018年第1期2卷 11-13页

作者： Laurence S.Freedman pamela A.Shaw Gertner Institute for Epidemiology and Health Policy Research Tel HashomerIsrael Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA

Prentice and Huang(2018)provide an interesting review of the current and future challenges facing the field of nutritional *** fully concur with their stress on the importance of statistical concepts and methods in meeting these *** welcome the opportunity here to expand in two directions on the approaches suggested in their review:first,to show that in implementing their approach extra statistical steps may be required;and second to highlight some dangers of misuse of the estimator,^(-)x(t),of true dietary intake that is central to their approach.

关键词： steps directions estimator

Art making and expressive art therapy in adult health and nursing care:A scoping review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2021年第1期8卷 102-119,I0007页

作者： Heli Vaartio-Rajalin Regina Santamaki-Fischer pamela Jokisalo Lisbeth Fagerstrom Health Sciences Åbo Akademi UniversityVasaFinland Bachelor of Healthcare/Nursing Novia University of Applied SciencesÅboFinland Health Sciences University of South-Eastern NorwayKongsbergNorway

Objectives:While receptive art engagement is known to promote health and wellbeing,active art engagement has not been fully explored in health and nursing *** review is to describe the existing knowledge on art making and expressive art therapy in adult health and nursing care between 2010 and ***:Relevant studies and grey literature were searched and identified between March 17 and April 10,2020 from EBSCO,CINAHL,Medline and ERIC databases and a general Internet *** data charting and extraction,the data(n=42 papers)were summarized and reported in accordance with PRISMA-ScR ***:In the included papers,both art making and expressive art therapy were seen in different health care and nursing contexts:yet not the home care *** emphasis of art activities were group activities for chronically or terminally ill residents,adults aged 65 years or older.A focus on personal narrative was often seen,which may explain why art activities appear to be linked to acknowledging and building new strengths and skills,making meaning of experiences,personal growth,symptom alleviation,and communication;all used to foster collaboration between patients,patients’near-ones and health care ***:Art activities appear to be suitable for every context and can promote personcenteredness and the measurement of nursing outcomes,and they should be considered an essential part of health and nursing care,nursing education and care for health care personnel.

关键词： Adult Aged Art making Art therapy Health care Nursing care Person-centered care

Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第21期15卷 2609-2616页

作者： Benita L McVicker pamela L Tuma Kusum K Kharbanda Serene ML Lee Dean J Tuma Liver Study Unit Department of Veterans Affairs Medical Center and Department of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center Department of Biology The Catholic University of America Department of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center

AIM： To investigate the role of reactive oxygen species （ROS） in ethanol-mediated cell death of polarized hepatic （WlF-B） cells.METHODS： In this work, WIF-B cultures were treated with pyrazole （inducer of cytochrome P4502E1, CYP2E1） and/or L-buthionine sulfoximine （BSO）, a known inhibitor of hepatic glutathione （GSH）, followed by evaluation of ROS production, antioxidant levels, and measures of cell injury （apoptosis and necrosis）.RESULTS： The results revealed that ethanol treatment alone caused a significant two-fold increase in the activation of caspase-3 as well as a similar doubling in ROS. When the activity of the CYP2E1 was increased by pyrazole pretreatment, an additional two-fold elevation in ROS was detected. However, the CYP2EIrelated ROS elevation was not accompanied with a correlative increase in apoptotic cell injury, but rather was found to be associated with an increase in necrotic cell death. Interestingly, when the thiol status of the cells was manipulated using BSO, the ethanol-induced activation of caspase-3 was abrogated. Additionally, ethanol-treated cells displayed enhanced susceptibility to Fas-mediated apoptosis that was blocked by GSH depletion as a result of diminished caspase-8 activity.CONCLUSION： Apoptotic cell death induced as a consequence of ethanol metabolism is not completely dependent upon ROS status but is dependent on sustained GSH levels,

关键词： WIF-B cells Alcohol Fas/CD95 Glutathi-one Caspase