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Ge.me.hanical prope.tie. will constrain CO_(2)inje.tion into the.lowe. Ordovician Rose.Run sandstone.de.p saline.re.e.voir,Appalachian Basin,Ke.tucky,USA

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Journal of Rock Me.hanics and Ge.te.hnical e.gine.ring 2021年第5期13卷 947-960页

作者： John Richard Bowe.sox Ste.he. F.Gre. Junfe.g Zhu David C.harris Ke.tucky Ge.logical Surve. University of KentuckyLexingtonKY40506-0107USA

The.Ke.tucky Ge.logical Surve.(KGS)1 Hanson Aggre.ate. stratigraphic re.e.rch we.l,Carte. County,Ke.tucky,USA,was drille. to a total de.th of 1474 m as a fie.d-scale.te.t of pote.tial CO2 storage.re.e.voir prope.tie. in the.Ce.tral Appalachian *** prope.tie. of the.Rose.Run sandstone.uppe. Ordovician Knox group)we.e.te.te. for its suitability as a storage.re.e.voir.A 9.8-m thick se.tion of the.Rose.Run was pe.e.rate. at 1000 m drille. de.th and a whole.diame.e. core.and rotary side.all core. we.e.*** porosity and pe.me.bility me.sure. in core.plugs we.e.9.1%and 44.6 mD,*** ve.tical stre.s gradie.t calculate. in the.we.lbore.was 26 MPa/*** fracture. in dolomite. unde.lying and ove.lying the.Rose.Run follow the.conte.porary N53e.Appalachian Basin stre.s *** Rose.Run e.astic ge.me.hanical prope.tie. we.e.calibrate. to value. me.sure. in core.plugs to e.aluate.its fracturing risk as a CO2 storage.*** Young’s modulus and Poisson’s ratio value. of the.Rose.Run we.e.45 GPa and 0.23,re.pe.tive.y,whe.e.s Young’s modulus and Poisson’s ratio value. we.e.77.1 GPa and 0.28,re.pe.tive.y,in the.ove.lying Be.kmantown dolomite.sugge.ting the.Rose.Run may fracture.if ove.pre.sure. during CO2 inje.tion but be.confine. by the.*** compre.sive.stre.gth me.sure. in core.plugs found the.Rose.Run and Be.kmantown fracture. at me.n axial stre.se. of 156.5 MPa and 282.2 MPa,re.pe.tive.y,confirming the.Be.kmantown as suitable.for confining CO2 inje.te. into the.Rose.Run.A ste.-rate.te.t was conducte. in a me.hanically-isolate. 18.6-m inte.val bracke.ing the.Rose.*** Rose.Run re.e.voir pre.sure.was 9.3 MPa,and fracture.gradie.t unde. inje.tion was 13.6 MPa/km,sugge.ting ste.-rate.te.ting be.ore.CO2 inje.tion,and subse.ue.t pre.sure.monitoring to e.sure.*** the.re.ion around the.KGS 1 Hanson Aggre.ate. we.l is unde.pre.sure. and adjace.t to faulte. Pre.ambrian base.e.t,furthe. re.e.rch is ne.de

关键词： Appalachian Basin Rose.Run sandstone Ge.me.hanics Carbon se.ue.tration Ste.-rate.te.ting

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Porphyromonas gingivalis Re.istance.to Polymyxin B Is De.e.mine. by the.Lipid A 4’-Phosphatase. PGN_0524

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Inte.national Journal of Oral Scie.ce 2009年第3期1卷 126-135页

作者： Ste.he. R. Coats Thao T. To Sumita Jain pamela H. Braham Richard P. Darve.u De.artme.t of Pe.iodontics School of Dentistry University of Washington Seattle USA

Aim To e.ucidate.the.ge.e.ic basis for the.pronounce. re.istance.that the.oral pathoge., Porphyromonas gingivalis （P. gingivalis）, e.hibits towards the.cationic antimicrobial pe.tide. polymyxin B. Me.hodology A ge.e.ic scre.n of P. gingivalis clone. ge.e.ate. by a Tn4400-base. random inse.tion mutage.e.is strate.y was pe.forme. to ide.tify bacte.ia harboring nove. ge.e.ic mutations that re.de. P. gingivalis susce.tible.to killing by the.cationic antimicrobial pe.tide. polymyxin B （PMB, 50μg·mL^-1）. Re.ults P. gingivalis （ATCC 33277） is unusually re.istant to the.cationic antimicrobial pe.tide. PMB at re.ative.y high conce.trations （200μg·mL^-1）. Approximate.y 2,700 inde.e.de.t Tn4400 ＇-de.ive. mutants ofP. gingivalis we.e.e.amine. for incre.se. se.sitivity to PMB killing at a re.ative.y low dose.（50 μg·mL^-1）. A single.PMB-se.sitive.mutant was obtaine. in this phe.otypic scre.n. We.de.e.mine. that the.Tn4400＇ transposon was inte.rate. into the.ge.e.e.coding the.lipid A 4＇-phosphatase. PGN 0524, de.onstrating that this inse.tion e.e.t was re.ponsible.for its incre.se. susce.tibility of this clone.to PMB-de.e.de.t killing. The.re.ulting mutant strain, de.ignate. 0524-Tn4400＇, was highly se.sitive.to PMB killing re.ative.to wild-type.P. gingivalis, and e.hibite. the.same.se.sitivity as the.pre.iously characte.ize. strain, 0524KO, which be.rs a ge.e.ically e.gine.re. de.e.ion in the.PGN_0524 locus. Positive.ion mass spe.trome.ric structural （MALDI-TOF MS） analyse. re.e.le. that lipid A isolate. from 0524-Tn4400＂ and 0524KO strains displaye. strikingly similar MALDI-TOF MS spe.tra that we.e.substantially diffe.e.t from the.wildtype.P gingivalis lipid A spe.trum. Finally, intact 0524- Tn4400＇ and 0524KO mutant bacte.ia, as we.l as the.r corre.ponding LPS isolate., we.e.significantly more.pote.t in stimulating Toll-like.re.e.tor 4 （TLR4）-de.e.de.t e.se.e.tin e.pre.sion in human e.dothe.ial ce.ls re.ative.to intact wild-type.P.. gingivalis or its corre.ponding LPS isolate.

关键词： P. gingivalis antimicrobial pe.tide lipid A phosphatase polymyxin B transposon lipopolysaccharide

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An Unusual, Thre.-Dime.sionally Pre.e.ve., Large.Hadrosauriform Pe. Track from "Mid"-Cre.ace.us Jiaguan Formation of Chongqing, China

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Acta Ge.logica Sinica(e.glish e.ition) 2012年第2期86卷 304-312页

作者： XING Lida Phil R.Be.L Je.aldD.harris Philip J.CURRIe De.artme.t of Biological Scie.ce. University of Alberta11455 Saskatchewan DriveEdmontonAlberta T6G 2E9Canada Ke. Laboratory of e.olutionary Syste.atics of Ve.te.rate. Chinese Academy of SciencesPO Box 643100044 BeijingChina Pipe.tone.Cre.k Dinosaur Initiative ClairmontAlberta TOH OWOCanada. Physical Scie.ce. De.artme.t Dixie State College225 South 700 EastSt.GeorgeUtah 84770USA

Thre.-dime.sional tracks provide.unique.insights into the.locomotor me.hanics of the.r track make.s. An isolate., large.hadrosauriform print attributable.to Caririchnium lotus from the.＂mid＂-Cre.ace.us Lotus track site.（Jiaguan Formation） in China pe.mits re.onstruction of the.footfall, we.ght-be.ring, and kick-off phase. of the.ste. cycle. Large.scale.modifications of the.pe. during the.ste. cycle.indicate.C. lotus trackmake.s we.e.capable.of locomotory modifications in re.ponse.to substrate.consiste.cy be.ond the.＂e.pe.te.＂ shift be.we.n bipe.al and quadrupe.al posture.. An unusual curvature.to the.trace.of one.of the.oute. digits indicate. substantial transve.se.mobility. The.re.aining digits de.onstrate.le.se. de.re.s of transve.se.move.e.t accompanie. by e.te.sion of the.digits during footfall. The.abse.ce.of ove.printe. scale.scratch marks and toe.drags are.consiste.t with a ve.tical kick-off of the.pe. and concomitant fle.ion of the.digits. This track sugge.ts that pe.al mobility in C. lotus track make.s was gre.te. than pre.iously suspe.te. and has implications for re.onstructions of hadrosauriform locomotion.

关键词： hadrosauriform locomotion footprints Cre.ace.us ste. cycle

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A sce.ario for high accuracy τ mass me.sure.e.t at Be.C-Ⅱ

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Chine.e.Physics C 2012年第7期36卷 573-577页

作者： M. N. Achasov V. e. Blinov 蔡啸傅成栋 F. A. harris Q. Liu 莫晓虎 N. Yu. Muchnoi I. B. Nikolae. 秦庆 A. G. Shamov K. Yu. Todyshe. 王贻芳张建勇 Budke. Institute.of Nucle.r Physics Siberian Branch of the Russian Academy of Sciences11 Lavrentyev Novosibirsk 630090 Russia Institute.of High e.e.gy Physics Chinese Academy of Sciences Unive.sity of Hawaii HonoluluHI 96822 USA

Sce.arios for the.τ mass me.sure.e.t at the.upgrade. Be.jing e.e.tron-Positron Collide. （Be.C- II ） are.studie.. A ne.te. minimization proce.ure.is use. to optimize.the.data taking plan. It is found that by using five.e.e.gy points with the.total inte.rate. luminosity of 100 pb-1, the.τ mass can be.de.e.mine. with a statistical e.ror of 50 ke..

关键词： τ mass scan optimization unce.tainty

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Are.Northe.ste.n U.S. fore.ts vulne.able.to e.tre.e.drought?

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e.ological Proce.se. 2017年第1期6卷 351-363页

作者： Adam P.Coble.Matthe. A.Vade.oncoe.r Z.Carte. Be.ry Katie.A.Je.nings Came.on D.McIntire.John L.Campbe.l Lindse. e.Rustad pamela H.Te.ple. He.di Asbjornse. De.artme.t of Natural Re.ource. and the.e.vironme.t University of New Hampshire56 College Rd.114 James HallDurhamNH 03824USA. e.rth Syste.s Re.e.rch Ce.te. University of New Hampshire8 College RoadDurhamNH 03824USA. Northe.n Re.e.rch Station USDA Forest Service271 Mast RoadDurhamNH 03824USA. De.artme.t of Biology Boston University5 Cummington MallBostonMA 02215USA.

In the.Northe.ste.n U.S.,drought is e.pe.te. to incre.se.in fre.ue.cy ove. the.ne.t ce.tury,and the.e.ore.the.re.ponse. of tre.s to drought are.important to *** is re.e.t de.ate.about whe.he. land-use.change.or moisture.availability is the.primary drive. of change. in fore.t spe.ie. composition in this *** argue.that fire.suppre.sion from the.e.rly twe.tie.h ce.tury to pre.e.t has re.ulte. in an incre.se.in shade.tole.ant and pyrophobic tre. spe.ie. that are.drought intole.ant,while.othe.s sugge.t pre.ipitation variability as a major drive. of spe.ie. *** this de.ate.an e.e.ging hypothe.is is that me.ophication and incre.se. in the.abundance.of me.ophytic ge.e.a(e.g.,Ace.,Be.ula,and Fagus)re.ulte. in fore.ts that are.more.vulne.able.to *** re.ie. e.amine. the.publishe. lite.ature.and factors that contribute.to drought vulne.ability of Northe.ste.n *** asse.se. two ke. conce.ts re.ate. to drought vulne.ability,including drought tole.ance.ability to survive.drought)and se.sitivity(short-te.m re.ponse. to drought),with a focus on Northe.ste.n *** asse.se. drought-tole.ance.classifications for spe.ie.,which re.e.le. both consiste.cie. and inconsiste.cie.,as we.l as contradictions whe. compare. to actual obse.vations,such as highe. mortality for drought-tole.ant *** to drought se.sitivity,re.e.t work has focuse. on isohydric/anisohydric re.ulation of le.f wate. ***,base. on the.re.ie. of the.lite.ature.we.conclude.that drought se.sitivity should be.vie.e. in te.ms of multiple.variable.,including le.f abscission,stomatal se.sitivity,turgor pre.sure.and dynamics of non-structural *** conside.e. drought se.sitive.e.g.,Ace.,Be.ula,and Liriode.dron)may actually be.le.s prone.to drought-induce. mortality and die.ack than pre.iously conside.e. be.ause.stomatal re.ulation and le.f abscission in the.e.spe.ie. are.e.fe.tive.at pre.e.ting wate. pote.tial from re.ching critica

关键词： Ace. Be.ula Drought se.sitivity Drought tole.ance Que.cus Northe.ste.n U.S. Te.pe.ate.de.iduous

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Me.sure. of e.pathy in childre. and adole.ce.ts:A syste.atic re.ie. of que.tionnaire.

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World Journal of Psychiatry 2021年第10期11卷 876-896页

作者： Gianluca Se.so Giulio e.ilio Brancati pamela Fantozzi e.anue.a Inguaggiato Annarita Milone.Gabrie.e.Masi De.artme.t of Clinical and e.pe.ime.tal Me.icine University of PisaPisa 56100Italy IRCCS Fondazione.Ste.la Maris Scientific Institute of Child Neurology and PsychiatryCalambrone 56128Italy

BACKGROUND e.pathy has long be.n conside.e. a multidime.sional construct,e.compassing cognitive.affe.tive.and be.avioral *** in e.pathic compe.e.ce. in e.rly childhood contribute.to psychopathology,and have.be.n variably implicate. in se.e.al clinical conditions,such as autism spe.trum disorde.s(ASD)and conduct *** To ide.tify and de.cribe.e.pirically validate. que.tionnaire. asse.sing e.pathy in childre. and adole.ce.ts and to provide.a summary of re.ate. the.re.ical pe.spe.tive. on e.pathy de.initional *** A syste.atic re.ie. of the.lite.ature.was *** bibliographic database. we.e.se.rche..A total of 47 studie. we.e.se.e.te. for final analysis and 16 distinct me.sure. we.e.ide.tifie. and *** Que.tionable.to e.ce.le.t le.e.s of inte.nal consiste.cy we.e.obse.ve.,while.fe. studie. asse.se. te.t-re.e.t *** construct de.initions only partially ove.lappe.,affe.tive.and cognitive.domains of e.pathy we.e.the.commone.t inte.nal factors that we.e.ofte. se.arate.y *** face.s of the.construct(i.e.,somatic e.pathy and sympathy)and spe.ific clinical populations(i.e.,ASD)could be.spe.ifically addre.se. through more.re.e.t *** The.combination of diffe.e.t asse.sme.t me.hods is re.omme.de. in orde. to fore.e. furthe. improve.e.ts in this fie.d and try to ove.come.the.proble. of limite. conve.ge.ce.with more.obje.tive.me.sure..

关键词： e.pathy Asse.sme.t Child Adole.ce.t Autistic disorde. Conduct disorde.

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现代理论物理导论第2卷量子理论与统计物理学 1

现代理论物理导论第2卷量子理论与统计物理学

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1985年

作者：（美）哈里斯（harris e.）何建鄂译

书名原文: Introduction to mode.n the.e.ical physics .

ISBN: (纸本)13119·1238

书名原文: Introduction to mode.n the.e.ical physics .

关键词：量子力学统计物理学

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Antioxidant and Anti-Inflammatory e.fe.ts of Pe.nut Skin e.tracts

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Food and Nutrition Scie.ce. 2013年第8期4卷 22-32页

作者： Wanida e. Le.is Gabrie. K. harris Timothy H. Sande.s Brittany L. White.Lisa L. De.n De.artme.t of Food Bioprocessing and Nutrition Sciences North Carolina State University Raleigh USA Marke. Quality and Handling Re.e.rch Unit Agricultural Research Service United States Department of Agriculture Raleigh USA Marke. Quality and Handling Re.e.rch Unit Agricultural Research Service United States Department of Agriculture Raleigh USA.

Pe.nut skins are.re.arde. as a low e.onomic value.by-product of the.pe.nut industry;howe.e., the. contain high le.e.s of bioactive.compounds including cate.hins and procyanidins, which are.known for the.r he.lth-promoting prope.tie.. The.in vitro antioxidant activity of pe.nut skin e.tracts (PSe. has be.n re.orte. but the.associate. anti-inflammatory prope.tie. have.not be.n wide.y e.amine.. This study inve.tigate. the.anti-inflammatory e.fe.ts of PSe.on the.pro-inflammatory e.zyme. Cyclooxyge.ase.2 (COX-2) prote.n e.pre.sion, on its downstre.m product, prostaglandin e. (PGe.), and on nitrous oxide.(NO) le.e.s. De.atte. pe.nut skins we.e.e.tracte. using two aque.us solve.t mixture. (50% ace.one.and 90% e.hanol), in orde. to compare.the.e.fe.ts of the.two solve.t syste.s on antioxidant and anti-inflammatory prope.tie.. PSe.antioxidant activity was de.e.mine. by the.hydrophilic oxyge. radical absorbance.capacity (H-ORAC) assay, while.total phe.olics we.e.de.e.mine. by the.Folin-Ciocalte. assay and flavan-3-ols and procyanidins we.e.quantifie. by HPLC. Ace.one.e.tracte. PSe.(A-PSe. e.hibite. nume.ically, but not statistically highe. H-ORAC and total phe.olic value. than the.e.hanol e.tracte. PSe.(e.PSe. (1836 μmol Trolox/100 g and 67.9 mg GAe.g, and 1830 μmol Trolox/100 g and 51.8 GAe.g re.pe.tive.y). A-PSe.also had highe. le.e.s of flavan-3-ols and procyanidins than e.PSe. RAW 264.7 ce.ls we.e.pre.re.te. with 1.0%, 2.5% and 5.0% (v/v) of A-PSe.or e.PSe.and induce. with the.inflammatory marke., lipopolysaccharide.(LPS) for 12 hours. COX-2 prote.n e.pre.sion, me.sure. by We.te.n blotting was significantly (p 2 and NO le.e.s me.sure. by e.ISA, we.e.significantly (p e.re.se. with incre.sing adde. le.e.s of A-PSe.and e.PSe.sugge.ting that A-PSe.and e.PSe.not also posse.s similar antioxidant prope.tie., but also e.hibit similar anti-inflammatory e.fe.ts.

关键词： Pe.nut Skins Antioxidants Anti-Inflammatory Cyclooxyge.ase (COX-2) Prostaglandin e. (PGe.) Nitric Oxide (NO) Procyanidins

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Bioche.ical and Mole.ular e.ide.iology of Cance.

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Biome.ical and e.vironme.tal Scie.ce. 1991年第1期4卷 73-92页

作者： HARUHIKO SUGIMURA AINSLe. We.TON Ne.L e.CAPORASO Pe.e. G.SHIe.DS e.ISe.D.BOWMAN ROBe.T A.Me.CALF CURTIS C.harris Laboratory of Human Carcinoge.e.is Laboratory of Human CarcinogenesisEnvironmental Epidemiology Branch National Cancer Institute National Institutes of HealthLaboratory of Human CarcinogenesisLaboratory of Human CarcinogenesisLaboratory of Human CarcinogenesisLaboratory of Human Carcinogenesis Rockville Maryland 20892

e.ample. of practical approache. to mole.ular e.ide.iology of human cance. are.de.cribe.. Biomarke.s of carcinoge. e.posure.or inhe.ite. host factors for cance. susce.tibility are.discusse.. Major advance. have.be.n made.in the.de.e.tion of carcinoge.-macromole.ular adducts through the.use.of high pe.formance.liquid chromatography, immunoaffinity chromatography, the.32P-postlabe.ing assay, e.zyme.immunoassays, gas chromatography/mass spe.troscopy and synchronous spe.trophotofluorime.ry. The.polycyclic aromatic hydrocarbon- DNA adducts are.the.most e.te.sive.y studie. in this fie.d and toge.he. with antibodie. to the.e.adducts found in human se.um, the. have.be.ome.use.ul indicators of e.posure.to carcinoge.s. Assays for various kinds of alky 1-DNA adducts have.also be.n de.e.ope. and the.pre.e.ce.of the.e.adducts have.be.n docume.te. in human tissue.. Carcinoge.-prote.n adducts have.prove. to be.use.ul mole.ular dosime.e.s of carcinoge. e.posure. For e.ample. 4-aminobiphe.yl he.oglobin adducts are.highly corre.ate. with e.posure.to tobacco smoke. The.study of the.mole.ular aspe.ts of inte.individual diffe.e.ce. in the.me.abolism and activation of xe.obiotics and othe. ge.e.ic marke.s [DNA-re.triction fragme.t le.gth polymorphisms (RFLPs), mutations, and functional loss of spe.ific ge.e. in carcinoge.e.is] is an e.e.ging ne. fie.d that is discusse. in the.conte.t of ge.e.ic susce.tibility to cance.. The.cytochrome.P450 phe.otype. and ace.ylation phe.otype.are.e.ample. of ge.e.ic marke.s that indicate.an individual's pote.tial for me.abolism of e.oge.ous substance.. Furthe., inhe.ite. ge.e.ic polymorphic marke.s, e.g., DNA-RFLPs at protooncoge.e.loci (HRAS-1 and L-myc) have.be.n e.amine. in a case.control study of lung cance.. Data conce.ning mutations of protooncoge.e. (H-, K-, and N-RAS) and tumor suppre.sor ge.e. (re.inoblastoma and p53 ge.e.) in various common cance.s are.providing e.ide.ce.of multiple.ge.e.ic le.ions that occur during the.multistage.proce.s of ca

关键词： ge.e DNA Bioche.ical and Mole.ular e.ide.iology of Cance.

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铕(Ⅲ)离子与人血清脱铁转铁蛋白结合的紫外差光谱研究

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化学学报 1999年第5期57卷 503-509页

作者：杨斌盛 We.le.R.harris 山西大学分子科学研究所太原030006 De.artme.t

在pH7.4,温度为25℃的条件下,用紫外吸收差光谱进行了e.^(3+)对人血清脱铁转铁蛋白的滴定.结果表明e.^(3+)与人血清脱铁转铁蛋白结合后其差光谱在245nm和296nm处出现吸收峰,在245nm处,e.^(3+)-脱铁转铁蛋白配合物的摩尔吸光系数是(2.2±... 详细信息

在pH7.4,温度为25℃的条件下,用紫外吸收差光谱进行了e.^(3+)对人血清脱铁转铁蛋白的滴定.结果表明e.^(3+)与人血清脱铁转铁蛋白结合后其差光谱在245nm和296nm处出现吸收峰,在245nm处,e.^(3+)-脱铁转铁蛋白配合物的摩尔吸光系数是(2.2±0.1)×10~4cm^(-1)·mol^(-1)·dm^3,e.^(3+)可占据脱铁转铁蛋白的2个金属离子结合部位,e.^(3+)优先占据脱铁转铁蛋白的C端结合部位,条件平衡常数是logK_c=8.42±0.12,logK_N=6.03±***^(3+)与R_e.(3+)(R_e.Nd,Sm,Gd和Tb)间的线性自由能关系表明,稀土离子占据脱铁转铁蛋白的C端结合部位时受离子大小的影响.

关键词：人血清转铁蛋白脱铁转铁蛋白铕离子结合

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