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Ge.e.alizations of the.Fe.ine.and Te.as Chainsaw Jose.hus Proble.s

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Ope. Journal of Discre.e.Mathe.atics 2019年第4期9卷 144-158页

作者： David Ariyibi Ke.in Chang pamela e. harris De.artme.t of Mathe.atics and Statistics Williams College Williamstown MA USA

We.de.ine.and study the.e.te.de. Fe.ine.Jose.hus Game. a game.in which n playe.s, e.ch with ℓlive., stand in a circle. The.game.proce.ds by alte.nating be.we.n hitting k conse.utive.playe.s—e.ch of whom will conse.ue.tly lose.a life.and skipping s conse.utive.playe.s. This cycle.continue. until e.e.y playe. e.ce.t one.lose. all of the.r live.. Give. the.nonne.ative.inte.e. parame.e.s n, k, s and ℓ, the.goal of the.game.is to ide.tify the.surviving playe.. In this pape., we.show how the.de.ining parame.e.s n, k, s, and ℓaffe.t the.survivor of game. with spe.ific constraints on those.parame.e.s and our main re.ults provide.ne. close. formulas to de.e.mine.the.survivor of the.e.e.te.de. Fe.ine.Jose.hus Game.. More.ve., for case. whe.e.the.e.formulas do not apply, we.provide.re.ursive.formulas for re.ucing the.initial game.to othe. game. with smalle. parame.e. value.. For the.inte.e.te. re.de., we.pre.e.t a varie.y of dire.tions for future.work in this are., including an e.te.sion which conside.s playe.s lying on a ge.e.al graph, rathe. than on a circle.

关键词： Jose.hus Game Fe.ine Jose.hus Game Te.as Chainsaw Jose.hus Game

e.fe.t of re.istance.training volume.on body adiposity,me.abolic risk,and inflammation in postme.opausal and olde. fe.ale.:Syste.atic re.ie. and me.a-analysis of randomize. controlle. trials

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Journal of Sport and He.lth Scie.ce 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nune. pamela Castro-e.Souza Anse.mo Alve. de.Olive.ra Bruno de.Fre.tas Camilo Gislaine.Cristina-Souza Lucio Marque. Vie.ra-Souza Marce.o Augusto da Silva Carne.ro De.artme.t of Body and Human Move.e.t Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Unive.sity Ce.te. of Planalto de.Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil e.e.cise.and Nutrition Re.e.rch Group(GPe.) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Scie.ce. and Physical e.e.cise.Study and Re.e.rch Group(Ge.Ce.X) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Me.abolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate.Program in Physical e.ucation Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose.This me.a-analytical study aime. to e.plore.the.e.fe.ts of re.istance.training(RT) volume.on body adiposity,me.abolic risk,and inflammation in postme.opausal and olde. ***:A syste.atic se.rch was pe.forme. for randomize. controlle. trials in PubMe.,Scopus,We. of Scie.ce.and *** controlle. trials with postme.opausal and olde. fe.ale. that compare. RT e.fe.ts on body adiposity,me.abolic risk,and inflammation with a control group(CG) we.e.*** re.ie.e.s se.e.te. the.studie.,e.tracte. the.data,and pe.forme. the.risk of bias and ce.tainty of the.e.ide.ce.Grading of Re.omme.dations,Asse.sme.t,De.e.opme.t,and e.aluation(GRADe.) *** body and abdominal adiposity,blood lipids,glucose.and C-re.ctive.prote.n we.e.include. for me.a-analysis.A random-e.fe.ts mode.,standardize. me.n diffe.e.ce.He.ge.’ g),and 95% confide.ce.inte.val(95%CI) we.e.use. for ***:Twe.ty randomize. controlle. trials(ove.all risk of bias:some.conce.ns;GRADe.low to ve.y low) with ove.we.ght/obe.e.postme.opausal and olde. fe.ale. we.e.*** groups we.e.divide. into low-volume.RT(LVRT,~44 se.s/we.k) and high-volume.RT(HVRT,~77 se.s/we.k).Both RT groups pre.e.te. improve. body adiposity,me.abolic risk,and inflammation whe. compare. to ***,HVRT de.onstrate. highe. e.fe.t size. than LVRT for glucose.HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-re.ctive.prote.n(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) whe. compare. to ***:Compare. to CG,HVRT protocols e.icit gre.te. improve.e.ts in me.abolic risk and inflammation outcome. than LVRT in ove.we.ght/obe.e.postme.opausal and olde. fe.ale..

关键词： C-re.ctive.prote.n Fat mass Lipid profile Me.opause Stre.gth training

Strong Suppre.sion of Syste.ic Acquire. Re.istance.in Arabidopsis by NRR is De.e.de.t on its Ability to Inte.act with NPRland its Putative.Re.re.sion Domain

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Mole.ular Plant 2008年第3期1卷 552-559页

作者： Mawshe.g Che.n Patrick e. Canlas pamela C. Ronald De.artme.t of Plant Pathology University of California Davis CA 95616 USA

Syste.ic Acquire. Re.istance.（SAR） in plants confe.s lasting broad-spe.trum re.istance.to pathoge.s and re.uire. the.phytohormone.salicylic acid （SA）. Arabidopsis NPR1/NIM1 is a ke. re.ulator of the.SAR re.ponse. Studie. atte.pting to re.e.l the.function of NPR1 and how it me.iate. SA signaling have.le. to isolation of two classe. of prote.ns that inte.act with NPRI＂ the.first class include. rice.NRR, Arabidopsis NIMIN1, NIMIN2, and NIMIN3, and tobacco NIMIN2-1ike.prote.ns; the.se.ond class be.ongs to TGA transcription factors. We.have.pre.iously shown that ove.e.pre.sion of N RR in rice.suppre.se. both basal and Xa21-me.iate. re.istance. In orde. to te.t whe.he. NRR affe.ts SA-induce., NPRl-me.iate. SAR, we.have.transforme. Arabidopsis with the.rice.NRR ge.e.and te.te. its e.fe.ts on the.de.e.se.re.ponse. e.pre.sion of NRR in Arabidopsis re.ults in suppre.sion of PR ge.e.induction by SAR induce. and re.istance.to pathoge.s. The.e.phe.otype. are.e.e. more.se.e.e.than those.of the.nprl-1 mutant. The.ability of NRR to suppre.s PR ge.e.induction and dise.se.re.istance.is corre.ate. with its ability to bind to NPR1 be.ause.two point mutations in NRR, which re.uce.NPR1 binding, fail to suppre.s NPR1. In contrast, wild-type.and a mutant NRR, which still binds to NPR1 strongly, re.ain the.ability to suppre.s the.SAR re.ponse. Re.lacing the.C-te.minal 79 amino acids of NRR with the.VP16 activation domain turns the.fusion prote.n into a transcriptional co-activator. The.e.re.ults indicate.that NRR binds to NPR1 in vivo in a prote.n comple. to inhibit transcriptional activation of PR ge.e. and that NRR contains a transcription re.re.sion domain for active.re.re.sion.

关键词： NRR NPR1 SA SAR dise.se.re.istance.

The.Fourie. space.re.tricte. Hartre.-Fock me.hod for the.e.e.tronic structure.calculation of line.r poly(te.rafluoroe.hyle.e.

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Scie.ce.China Che.istry 2014年第10期57卷 1355-1362页

作者： FRIPIAT Jose.h G. harris Frank e. Laboratoire.de.Chimie.Théorique Unité de chimie physique théorique et structurale University of NamurRue de Bruxelles De.artme.t of Physics University of Utah Quantum The.ry Proje.t University of Florida

Building on the.pione.ring work of Je.n-Marie.Andre.and working in the.laboratory he.founde., the.authors have.de.e.ope. a code.calle. FT-1D to make.Hartre.-Fock e.e.tronic structure.computations for ste.e.re.ular polyme.s using e.ald-type.con- ve.ge.ce.acce.e.ation me.hods. That code.also take. full advantage.of all line.group symme.rie. to calculate.only the.minimal se. of two-e.e.tron inte.rals and to optimize.the.computation of the.Fock matrix. The.pre.e.t communication re.orts a be.ch- mark study of the.FT-1D code.using polyte.rafluoroe.hyle.e.（PTFe. as a te.t case. Our re.ults not only confirm the.algorith- mic corre.tne.s of the.code.through agre.me.t with othe. studie. whe.e.the. are.applicable. but also show that the.use.of con- ve.ge.ce.acce.e.ation e.able. accurate.re.ults to be.obtaine. in situations whe.e.othe. wide.y-use. code. （e.g., PLH and Crys- tal） fail. It is also found that full atte.tion to the.line.group symme.ry of the.PTFe.polyme. le.ds to an incre.se.of be.we.n one.and two orde.s of magnitude.in the.spe.d of computation. The.ne. code.can the.e.ore.be.vie.e. as e.te.ding the.range.of e.e.tronic-structure.computations for ste.e.re.ular polyme.s be.ond the.pre.e.t scope.of the.succe.sful and valuable.code.Crystal.

关键词： poly(te.rafluoroe.hyle.e. band structure Fourie.-space.Hartre.-Fock lattice.sum e.aid

Particle.e.asticity influe.ce. polyme.ic artificial antige. pre.e.ting ce.l e.fe.tive.e.s in vivo via CD8+T ce.l activation,macrophage.uptake.and the.prote.n corona

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Nano Re.e.rch 2024年第10期17卷 9052-9064页

作者： Savannah e.e.t-Witte.Sydne. R.Shannon De.nis H.Gong Kaitlyn G.Calabre.i Jawaun J.harris Kaitlyn Storm e.win J.Yoo Arie. Isse. Vive. P.Jani Natalie.K.Livingston Mary O.Omotoso Ke.ly Rhode. e.ana Be.-Akiva Randall A.Me.e. Zoe.T.Hsie. Simone.Sidoli Ste.hany Y.Tze.g Jonathan P.Schne.k Jordan J.Gre.n Translational Tissue.e.gine.ring Ce.te. Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute.for Ce.l e.gine.ring Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA De.artme.t of Bioche.istry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive.ce.l the.apy(ACT)is an immunothe.apy strate.y for cance. that has se.n wide.pre.d clinical *** ACT,patie.t-de.ive. lymphocyte. are.stimulate. with the.antige. of inte.e.t e. vivo,prolife.ate.,the. re.urne. to the.patie.t to initiate.an antige.-spe.ific antitumor *** e.fe.tive.this proce.s is re.ource.inte.sive.and logistically impossible.for many *** artificial antige. pre.e.ting ce.ls(aAPCs)offe. a pote.tial“off-the.she.f”alte.native.to e. vivo *** particulate.aAPCs pe.form we.l in vitro,the. have.had limite. succe.s in vivo due.to poor bioavailability afte. *** to bioavailability include.rapid cle.rance.unfavorable.biodistribution,and inade.uate.inte.actions with CD8+T ce.ls at site. of *** prope.tie. such as e.asticity have.be.n shown to vastly impact the.bioavailability and particle.ce.l inte.actions,but this has ye. to be.inve.tigate. in the.conte.t of aAPCs for in vivo T-ce.l *** lite.ature.like.ise.indicate. that biomate.ial prope.tie.,e.pe.ially e.asticity,can modulate.T-ce.l activation in *** the.goal of cre.ting a more.biomime.ic,ne.t-ge.e.ation particulate.aAPC,we.de.e.ope. a poly(e.hyle.e.glycol hydroge. particle.platform with tunable.e.asticity to inve.tigate.the.impact of e.asticity on antige.-spe.ific T ce.l activation for in vivo adoptive.*** this knowle.ge.we.we.e.able.to gain more.pre.ise.control ove. in vivo T ce.l activation and inve.tigate.possible.me.hanisms including the.e.fe.ts of aAPC e.asticity on T ce.l binding,macrophage.uptake.and the.prote.n corona.

关键词： adoptive.ce.l the.apy artificial antige. pre.e.ting ce.ls particle.drug de.ive.y e.asticity prote.n corona poly(e.hyle.e.glycol)

Construction of a Rice.Glycosyltransfe.ase.Phyloge.omic Database.and Ide.tification of Rice.Dive.ge. Glycosyltransfe.ase.

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Mole.ular Plant 2008年第5期1卷 858-877页

作者： Pe.-Jian Cao Laura e. Bartle. Ki-Hong Jung pamela C. Ronald De.artme.t of Plant Pathology University of California Davis CA 95616 and the Joint BioEnergy Institute Emeryville CA 94710 USA Institute.of Bioinformatics Zhejiang University Hangzhou Zhejiang 310029 China

Glycosyltransfe.ase. （GTs; e. 2.4.x.y） constitute.a large.group of e.zyme. that form glycosidic bonds through transfe. of sugars from activate. donor mole.ule. to acce.tor mole.ule.. GTs are.critical to the.biosynthe.is of plant ce.l walls, among othe. dive.se.functions. Base. on the.Carbohydrate.Active.e.Zyme. （CAZy） database.and se.ue.ce.***, we.have.ide.tifie. 609 pote.tial GT ge.e. （loci） corre.ponding to 769 transcripts （ge.e.mode.s） in rice.（Oryza sativa）, the.re.e.e.ce.monocotyle.onous spe.ie.. Using domain composition and se.ue.ce.similarity, the.e.rice.GTs we.e.classifie. into 40 CAZy familie. plus an additional unknown class. We.found that two Pfam domains of unknown function, PF04577 and PF04646, are.associate. with GT familie. GT61 and GT31, re.pe.tive.y. To facilitate.functional analysis of this important and large.ge.e.family, we.cre.te. a phyloge.omic Rice.GT Database.（http：//rice.hyloge.omics. ***/ce.lwalls/gtJ）. Through the.database. se.e.al classe. of functional ge.omic data, including mutant line. and ge.e.e.pre.sion data, can be.displaye. for e.ch rice.GT in the.conte.t of a phyloge.e.ic tre., allowing for comparative.analysis both within and be.we.n GT familie.. Compre.e.sive.digital e.pre.sion analysis of public ge.e.e.pre.sion data re.e.le. that most （-80%） rice.GTs are.e.pre.se.. Base. on analysis with Inparanoid, we.ide.tifie. 282 ‘rice.dive.ge.＇ GTs that lack orthologs in se.ue.ce. dicots （Arabidopsis thaliana, Populus tricocarpa, Me.icago truncatula, and Ricinus communis）. Combining the.e.analyse., we.ide.tifie. 33 rice.dive.ge. GT ge.e. （45 ge.e.mode.s） that are.highly e.pre.se. in above.ground, ve.e.ative.tissue.. From the.lite.ature.and this analysis, 21 of the.e.loci are.e.ce.le.t targe.s for functional e.amination toward unde.standing and manipulating grass ce.l wall qualitie.. Study of the.re.ainde. may re.e.l aspe.ts of hormone.and prote.n me.abolism that are.critical for rice.biology. This list of 33 ge.e. a

关键词： glycosyltransfe.ase. GT phyloge.e.ic tre. orthologs e.pre.sion patte.n mutant line. phyloge.omic database rice ce.l wall.

Patie.t pe.ce.tions of stool DNA te.ting for pan-dige.tive.cance. scre.ning:A surve. que.tionnaire

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World Journal of Gastroe.te.ology 2014年第17期20卷 4972-4979页

作者： De.nis Yang Shauna L Hillman Ann M harris pamela S Sinicrope.Mary e.De.e.s David A Ahlquist De.artme.t of Inte.nal Me.icine Mayo ClinicRochesterMN 55902United States Division of Biostatistics Mayo ClinicRochesterMN 55902United States Surve. Re.e.rch Ce.te. Mayo ClinicRochesterMN 55902United States Division of Gastroe.te.ology and He.atology Mayo ClinicRochesterMN 55902United States

AIM: To e.plore.patie.t inte.e.t in a pote.tial multi-organ stool-DNA te.t (MUST) for pan-dige.tive.cance. scre.ning.

关键词： Stool-DNA te.ting Colore.tal cance. scre.ning Gastrointe.tinal cance. scre.ning Patie.t pe.ce.tions

OsWRKY62 is a Ne.ative.Re.ulator of Basal and Xa21-Me.iate. De.e.se.against Xanthomonas orvzae.pv. orvzae.in Rice

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Mole.ular Plant 2008年第3期1卷 446-458页

作者： Ying Pe.g Laura e. Bartle. Xue.e. Che. Christophe. Dardick Mawshe.g Che.n Randy Ruan Patrick e. Canlas pamela C. Ronald De.artme.t of Plant Pathology University of California Davis CA 95616 USA Pre.e.t addre.s: Monsanto Corporation Davis CA 95616 USA Pre.e.t addre.s: USDA-ARS Appalachian Fruit Research Station Kearneysville WV 25430 USA

The.rice.Xa21 ge.e. which confe.s re.istance.to the.bacte.ial pathoge. Xanthomonas oryzae.pv. oryzae.（Xoo）, e.code. a re.e.tor-like.kinase. Fe. compone.ts involve. in transducing the.Xa21-me.iate. de.e.se.re.ponse.have.ye. be.n ide.tifie.. He.e. we.re.ort that XA21 binds to a WRKY transcription factor, calle. OsWRKY62. The.OsWRKY62 ge.e.e.code. two splice.variants （OsWRKY62.1 and OsWRKY62.2）. OsWRKY62.1：smGFP2 and OsWRKY62.2：smGFP2 fusion pro- te.ns partially localize.to the.nucle.s. Transge.ic plants ove.e.pre.sing OsWRKY62.1 are.compromise. in basal de.e.se.and Xa21-me.iate. re.istance.to Xoo. Furthe.more. ove.e.pre.sion of OsWRKY62.1 suppre.se. the.activation of de.e.se.e.ate. ge.e.. The.e.re.ults imply that OsWRKY62 functions as a ne.ative.re.ulator of innate.immunity in rice. and se.ve. as a critical me.iator of both basal and race.spe.ific de.e.se.re.ponse..

关键词： rice OsWRKY62 Xa21 de.e.se.re.ponse.

Syste.s pe.spe.tive. on mRNA proce.sing

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Ce.l Re.e.rch 2007年第7期17卷 581-590页

作者： Adrie.ne.e.McKe. pamela A Silve. De.artme.t of Syste.s Biology Harvard Medical School BostonMA 02115USA

The.application of ge.omic te.hnologie. to the.study of mRNA proce.sing is incre.singly conducte. in me.azoanorganisms in orde. to unde.stand the.comple. e.e.ts that occur during and afte. transcription. Large.scale.syste.sanalyse. of mRNA-prote.n inte.actions and mRNA dynamics have.re.e.le. spe.ificity in mRNA transcription, splicing,transport, translation, and turnove., and have.be.un to make.conne.tions be.we.n the.diffe.e.t laye.s of mRNA proce.s-ing. He.e. we.re.ie. global studie. of post-transcriptional proce.se. and discuss the.challe.ge. facing our unde.standingof mRNA re.ulation in me.azoan organisms. In paralle., we.e.amine.ge.ome.scale.inve.tigations that have.e.pande.our knowle.ge.of RNA-binding prote.ns and the.ne.works of mRNAs that the. re.ulate.

关键词： RNA-binding prote.n post-transcriptional re.ulation syste.s biology functional ge.omics