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Dried-leaf Artemisia annua: A practical malaria therapeutic for developing countries?

World Journal of Pharmacology 2014年第4期3卷 39-55页

作者： pamela J Weathers Melissa Towler Ahmed Hassanali Pierre Lutgen Patrick Ogwang Engeu Department of Biologyand Biotechnology Worcester Polytechnic Institute Worcester MA 01609 United States School of Pure and Applied Sciences Kenyatta University IFBV-BELHERB PO Box 98 L-6908 Nieder-anven Luxembourg Natural chemotherapeutics Research Institute Ministry of Health PO Box 4864 Kampala Uganda

Artemisinin from the plant Artemisia annua （A. annua） L., and used as artemisinin combination therapy （AcT）, is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the chinese as a tea to treat “fever”. More recently, investiga-tors have shown that tea infusions and oral consumption of the dried leaves of the plant have prophylactic and therapeutic effcacy. The presence of a complex matrix of chemicals within the leaves seems to enhance both the bioavailability and effcacy of artemisinin. Although about 1000-fold less potent than artemisinin in their antiplasmodial activity, these plant chemicals are mainly small molecules that include other artemisinic compounds, terpenes （mainly mono and sesqui）, favonoids, and polyphenolic acids. In addition, polysaccharide constituents of A. an-nua may enhance bioavailability of artemisinin. Rodent pharmacokinetics showed longer T？ and Tmax and greater cmax and AUc in Plasmodium chabaudi -infected mice treated with A. annua dried leaves than in healthy mice. Pharmacokinetics of deoxyartemisinin, a liver metabolite of artemisinin, was more inhibited in infected than in healthy mice. In healthy mice, artemisinin serum levels were 〉 40-fold greater in dried leaf fed mice than those fed with pure artemisinin. Human trial data showed that when delivered as dried leaves, 40-fold less artemisinin was required to obtain a therapeutic response compared to pure artemisinin. AcTs are still unaffordable for many malaria patients, and cost estimates for A. annua dried leaf tablet production are orders of magnitude less than for AcT, despite improvements in the production capacity. considering that for 〉 2000 years this plant was used in traditional chinese medicine for treatment of fever with no apparent appearance of artemisinin drug resistance, the evidence argues for inclusion of affordable A. annua dried leaf tablets into the a

关键词： Malaria Infectious disease Artemisia annua Artemisinin combination therapy Artemisinin combination therapy

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Lippincott's Advanced skills for nursing assistants

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2010年

作者： pamela J. carter Amy J. Stegen

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cardiac Transplantation : The columbia University Medical center / New York-Presbyterian Hospital Manual 1

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丛书名： contemporary cardiology

2004年

作者： Edwards Niloo M. chen Jonathan M. Mazzeo pamela A.

ISBN: (纸本)1588291812

Leading physicians summarize in this easy-to-use and eminently practical handbook the day-to-day management of transplant donors and recipients at columbia-Presbyterian Medical center. Topics covered range from surgical techniques, pathology, and immunosuppression, to posttransplant management, pediatric heart transplantation, surgical alternatives, and mechanical circulatory assistance as a bridge to transplantation. The authors also discuss congenital transplant techniques, state-of-the-art perioperative management techniques and protocols, and UNOS regulation and nurse coordination

关键词： Heart Transplantation.

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A step forward in laparoscopic hepatectomy:comments on“Expert consensus on Laparoscopic Hepatectomy(2013 Version)by National Hepatic Surgery Group,Society of Surgery,chinese Medical Association”

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Frontiers of Medicine 2013年第4期7卷 520-522页

作者： Eric c.H.Lai Department of Surgery Pamela Youde Nethersole Eastern HospitalChai WanHong KongChina

I read with great interest the consensus and guideline of laparoscopic hepatectomy,which was originated from the experts in china[1].This is a significant step forward in minimally invasive liver *** development of minimally invasive liver surgery over the last 2 decades has a great impact on the surgical practice in china,and the other parts of the *** potential advantages of laparoscopic hepatectomy are those of minimal access surgery(Table 1).

关键词： Surgery hepatectomy surgery

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调查研究手册

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作者： (美)pamela L.·Alreck (美)Robert B.·Settle

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Impact of Prophylactic Betamethasone Indication on the Neonatal Outcome in 38-Week Pregnancies Prior to Elective cesarean Section

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Open Journal of Obstetrics and Gynecology 2020年第10期10卷 1396-1401页

作者： Enrique Valdés Rubio pamela Socías Javiera Urquieta Enrique Valdés M Alvaro Sepúlveda-Martínez Maternal and Fetal Medicine Unit Department of Obstetrics and Gynecology Hospital Clínico de la Universidad de Chile Santiago de Chile Chile Universidad Andrés Bello Concepción Chile

Objective: To assess whether the use of prenatal betamethasone in pregnancies with elective caesarean section (c-section) at 38 weeks has a similar risk of adverse neonatal respiratory outcomes than elective c-section... 详细信息

Objective: To assess whether the use of prenatal betamethasone in pregnancies with elective Caesarean section (C-section) at 38 weeks has a similar risk of adverse neonatal respiratory outcomes than elective C-section at 39 weeks. Methods: Retrospective cohort study of pregnant patients with singleton pregnancies and elective C-section at term in a one-year period. Cases were C-section at 38 weeks of gestation with a complete course of betamethasone started 48-hours before. As a control group, pregnancies with a C-section at 39 weeks without betamethasone were included. Results: During the study period, 186 patients were included. Of these, 91 were delivered at 38 weeks and 95 at 39 weeks. There were no significant differences in maternal age and parity. Moreover, there were no significant differences in respiratory complications (respiratory distress syndrome [RDS] = 0% vs 1.1%;p = 1.0, transitory tachypnea [TT] = 0% vs 0%) and admission to Neonatal Intensive Care Unit (NICU) (8.8% vs 6.3%;p = 0.7) between deliveries at 38 weeks and 39 weeks, respectively. Conclusion: Prophylactic use of betamethasone in early term pregnancies who undergo an elective c-section at 38 weeks is associated with similar a

关键词： Betamethasone corticosteroids Elective cesarean Section Respiratory complications Respiratory Distress Syndrome Transitory Tachypnea

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes pamela castro-e-Souza Anselmo Alves de Oliveira Bruno de Freitas camilo Gislaine cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPcEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(cG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and c-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%cI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%cI:-1.63 to-0.74;LVRT=-0.78;95%cI:-1.15 to-0.41) and c-reactive protein(HVRT=-1.00;95%cI:-1.32 to-0.67;LVRT=-0.34;95%cI,-0.63 to-0.04)) when compared to ***:compared to cG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： c-reactive protein Fat mass Lipid profile Menopause Strength training

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Dissect the rice immune system using a whole-genome sequenced mutant population

Dissect the rice immune system using a whole-genome sequence...

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中国植物病理学会2019年学术年会

作者： Li Guotian Sha Gan Jain Rashmi Jenkins Jerry Shu Shengqiang chern Mawsheng copetti Dario Xing Feng Xie Weibo Wing Rod A Schmutz Jeremy Ronald pamela c State Key Laboratory of Agricultural Microbiology and college of Plant Science and Technology Huazhong Agricultural University Department of Plant Pathology University of California Joint BioEnergy Institute Lawrence Berkeley National Laboratory U.S.Department of Energy Joint Genome Institute Arizona Genomics Institute School of Plant SciencesUniversity of Arizona National Key Laboratory of crop Genetic Improvement National Center of Plant Gene ResearchHuazhong Agricultural University HudsonAlpha Institute for Biotechnology

Rice provides food for more than half of the world’s population and also serves as a model for studies of other monocotyledonous ***,we report the de novo genome sequencing and analysis of an early flowering Geng/japonica variety KitaakeX,which completes its life cycle in 9 *** KitaakeX sequence assembly contains 377.6 Mb,consisting of 33 scaffolds（476 contigs） with a contig N50 of 1.4 *** the assembly are detailed gene annotations of 35 594 protein coding *** high-quality genome of the model rice plant KitaakeX will accelerate rice functional *** further facilitate rice research,we generated and sequenced a fast-neutron-induced mutant population in *** sequenced 1 504 mutant lines at 45-fold coverage and identified 91 513 mutations affecting 32 307 genes,i.e.,58% of all rice *** detected an average of 61 mutations per *** types include single-base substitutions,deletions,insertions,inversions,translocations,and tandem *** observed a high proportion of loss-of-function *** facilitate public access to this genetic resource,we established an open access database called KitBase that provides access to sequence data and seed *** have screened this mutant population for lines altered in plant immunity and identified multiple mutant *** on these mutants will be presented.

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Business research methods 8th ed.

Business research methods

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丛书名： The McGraw-Hill/Irwin series Operations and decision sciences

2003年

作者： Donald R. cooper pamela S. Schindler.

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Maternal and infant vitamin D status during lactation: Is latitude important?

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Health 2013年第12期5卷 2004-2013页

作者： carol L. Wagner cynthia R. Howard Thomas c. Hulsey Ruth A. Lawrence Myla Ebeling Judy Shary pamela G. Smith Kristen Morella Sarah N. Taylor Bruce W. Hollis Department of Pediatrics Medical University of South Carolina Charleston South Carolina USA Department of Pediatrics University of Rochester Rochester New York USA

Background: The effect of latitude on maternal and infant vitamin D status during lactation is presumed to be strongly associated with higher rates of deficiency in those living at higher latitudes, yet with lifestyle changes, this conclusion may no longer be correct. Objective: To ascertain if higher latitude adversely affects the vitamin D status of lactating women and their fully breastfeeding infants. Study Design/Methods: Fully breastfeeding women and their infants were eligible for participation in this study as part of a larger prospective vitamin D supplementation trial. Women were recruited from two sites of differing latitude: charleston, Sc at 32°N and Rochester, NY at latitude 43°N. Maternal and infant baseline vitamin D status, intact parathyroid hormone (IPTH), serum calcium and phosphorus as a function of site/latitude were measured. The primary outcome was maternal and infant total circulating 25(OH)D at baseline by center/latitude, and the secondary outcome was the percent of women and infants who had achieved a baseline concentration of at least 20 ng/mL, meeting the Institute of Medicine’s definition of sufficiency at 4 to 6 weeks postpartum. Statistical analysis was performed using SAS version 9.3. Results: Higher latitude adversely affected vitamin D status only in lactating caucasian women. African American and Hispanic women and infants living in Rochester compared to charleston had improved vitamin D status, an effect that was no longer significant when controlling for socioeconomic factors and season. Overall, there was a significant vitamin D deficiency at baseline in lactating mothers, and a far greater deficiency in their infants. Maternal baseline 25(OH)D concentration remained positively associated with being caucasian, BMI and summer months. Breastfeeding infant vitamin D status mirrored maternal status and remained positively associated with being caucasian and summer months. Those infants who had been on a vitamin D supplement at the

关键词： Vitamin D cholecalciferol Lactation Latitude

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