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Luminometric Studies of Yea.t Response to Complex Environmenta. Ca.cium Va.ia.ions Demonstra.e Sensing of Externa. Ca.cium Ion Cha.ges

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a.va.ces in Microbiology 2022年第9期12卷 555-567页

作者： a.gustus C. Pa.ker Da.id a. Mintz Fra.cisco J. Solis pamela a. marshall School of Ma.hema.ica. a.d Na.ura. Sciences Arizona State University Glendale USA

The response of yea.t to sha.p environmenta. increa.es in ca.cium concentra.ion ha. been extensively studied. However, systema.ic studies of the response under more genera. cha.ges a.e still la.king. Only limited explora.ion of cellula. responses ha. been conducted where ca.cium concentra.ion is decrea.ed. This a.ticle describes a.set of luminometric experiments tha. monitor the cytosolic ca.cium concentra.ion under cha.ging externa. concentra.ion conditions. a. a.decrea.e in externa. ca.cium concentra.ions requires the use of la.ge sa.ple volumes, the experiments require the use of equipment a.a.ted for this purpose. We describe the modifica.ion of commercia. luminometric equipment to ma.e the explora.ion possible. We explore the yea.t cellula. beha.ior when a. increa.e in externa. ca.cium concentra.ion is followed by a.decrea.e in externa. ca.cium concentra.ion. We compa.e these results with those from the ca.e of a.double pulse of concentra.ion increa.e. Results from the experiment show tha. the first, concentra.ion increa.ing pulse produces the well-known sha.p increa.e in cytosolic ca.cium followed by ca.cium sequestra.ion to return to a.cytosolic concentra.ion nea. its initia. condition. Surprisingly, the ca.cium decrea.e step shows simila. results with a.cytosolic increa.e followed by a.return to lower levels. The results suggest the presence of a.ca.cium sensing mecha.ism regula.ing ca.cium influx from externa. sources. This mecha.ism would produce cha.nel opening a. a.response to a.y cha.ges in externa. concentra.ion, be it a. enha.cement or a.depletion.

关键词： Sa.cha.omyces cerevisia. Ca.cium Homeosta.is Extra.ellula. Ion Cha.ges

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a.a.ysis of Volutin Gra.ule Forma.ion in <i>Sa.cha.omyces cerevisia.</i>

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a.va.ces in Microbiology 2014年第8期4卷 465-473页

作者： pamela a. marshall Da.id B. De La.Rosa.Lorenzo G. Sa.chez Ma.thew L. Sta.r School of Ma.hema.ica. a.d Na.ura. Sciences Arizona State University Glendale USA

The budding yea.t Sa.cha.omyces cerevisia. serves a. a. effective model orga.ism for ma.y cellula. pa.hwa.s including phospha.e tra.sport, a.cumula.ion, a.d stora.e. In S. cerevisia., phospha.e is a.tively tra.sported a.ross the pla.ma.membra.e via.severa. phospha.e ca.riers a.d is then tra.sported into the a.idic va.uole (roughly equiva.ent to the ma.ma.ia. lysosome with degra.a.ive functions but with a.ditiona. stora.e functions, such a. ca.cium) where it is synthesized into volutin, a.stora.e form of polyphospha.e, found in ma.y orga.isms. We ha.e been studying volutin gra.ule forma.ion in wild type cells to determine the physiologica. requirements for forma.ion a.d in muta.ts to determine the pa.hwa. by which the volutin biosynthetic proteins a.e tra.sported to the va.uole. Underta.ing a. a.a.ysis of volutin forma.ion in yea.t va.uoles by blocking va.uole function with pha.ma.ologica. a.ents, such a. ionomycin a.d CCCP, we see tha. va.uole pH a. well a. va.uola. ca.cium seems critica. for volutin forma.ion. Different blocks in va.uola. protein sorting ha.e differentia. effects on volutin gra.ule a.cumula.ion, with volutin gra.ule forma.ion seen in a.l muta.t stra.ns thus fa. tested, except for vps33, a.muta.t cell stra.n la.king a.l va.uola. structure. Our da.a.a.e consistent with pleiotrophic effects of va.uola. physiologica. function blocks lea.ing to a.decrea.e in volutin forma.ion.

关键词： Sa.cha.omyces cerevisia. Va.uole Volutin Polyphospha.e

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Textua. Form a.d Cultura. a.fect: Willia. Empson′s Double-Plot a.d Ra.mond Willia.s′s Structure of Feeling

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外国文学研究 2005年第1期27卷 32-39页

作者： pamela McCa.lum is professor of English a. Depa.tment of English University of Calgary

By insisting on the prima.y of double-plot, Empson bra.kets the sometimes deceptive a.pea.a.ces of a.text′s content to uncover a.d disenga.e the more funda.enta. double-plot system a. work within the defining structure of the text. Empson′s thinking a.out the reception of double-plot structures ena.les Ra.mond Willia.s′s ea.ly formula.ions of structure of feeling, in pa.ticula. the gesturing this perplexing, underdeveloped, but persistent concept ma.es towa.ds understa.ding collective response to cultura. forms. This a.ticle explores the implica.ions of the reception of double-plot structures, dra.ing out the a.sumptions inscribed in Empson′s cla.ms a.out processes a. work a. a. a.dience enga.es with these dra.a.ic structures.

关键词：诗歌评论文化影响 Empson 雷蒙德·威廉斯双情节文章结构

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Frequency regula.ion by fuzzy a.d bina.y control in a.hybrid isla.ded microgrid

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Journa. of Modern Power Systems a.d Clea. Energy 2015年第3期3卷 429-439页

作者： pamela Ma.Ja.RES Om Ma.IK Depa.tment of Electrica. a.d Computer Engineering University of CalgaryCalgaryABCanada

Isla.ded microgrids must be self-sufficient in terms of frequency a.d volta.e control due to their isla.ded opera.ion.a.control stra.egy for frequency regula.ion by combining the opera.ion of a.wind genera.or,a.diesel genera.or,a.ba.tery energy stora.e system a.d a.dump loa. in a.microgrid is proposed in this *** the proposed stra.egy,the control ta.k is pa.titioned into two subta.ks:1)choosing the a.propria.e element to be used for regula.ion,a.d 2)providing frequency regula.ion.a.globa. controller chooses the element to ***,the frequency regula.ion is provided by sepa.a.e individua. *** proposed control stra.egy is tested on a.microgrid with mixed types of genera.ion a.d modeled on *** monitoring the power of individua. elements a.d system frequency,it is shown tha. the proposed control stra.egy opera.es *** proposed stra.egy fa.ilita.es the integra.ion of renewa.le energy sources a.d enha.ces frequency regula.ion.

关键词： Frequency regula.ion Fuzzy control Hybrid microgrid a.toma.ic opera.ion

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Contributions of Trimorphic Life Cycles to Dispersa. a.d Evolutiona.y Trends in La.ge Benthic Fora.inifers

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Journa. of Ea.th Science 2022年第6期33卷 1425-1433页

作者： pamela Ha.lock Cla.re E.Reymond College of Ma.ine Science University of South FloridaSt.PetersburgFL33701USA School of Ea.th Sciences China University of GeosciencesWuhan430074China School of Geosciences The University of SydneySydneyNSW2006Australia

The ba.ic life cycle of Fora.inifera.ha. long been recognized a. a.terna.ion between sexua. a.d a.exua. genera.ions;a.common modifica.ion is severa. successive a.exua. *** a.d relea.e of fla.ella.ed ga.etes a.so ha. been documented a. the ba.ic sexua.-reproductive mode in exta.t *** on popula.ion dyna.ics,loca. spa.ia. distributions,a.d biogeogra.hy of a.phistegina.*** Heterostegina.depressa.ha.e been a.gmented by culture studies over the pa.t 50yea.s,providing insights tha. ha.e been widely used in pa.eoecologica. a.d pa.eoenvironmenta. *** a.e proposed suggesting how sta.es in the life cycle might contribute to understa.ding biogeogra.hic a.d evolutiona.y trends commonly observed in la.ge benthic *** of sexua.ly-produced cryptobiotic propa.ules,followed by successive a.exua. genera.ions(schizogeny),ca. potentia.ly esta.lish via.le,loca.ly-a.a.ted popula.ions within litera.ly yea.s,consistent with the concepts of both a.lopa.ric specia.ion a.d reticula.e evolution a.socia.ed with isola.ion a.d reconnection of loca. *** review concludes with the recommenda.ion tha. future studies utilizing genomics,proteonomics,geochemistries,sca.ning technologies,a.d other a.proa.hes ca. promote grea.er understa.ding of both modern a.d fossil la.ger benthic fora.inifera. linea.es.

关键词： a.phistegina coiling ra.io dia.om symbionts Heterostegina.depressa propa.ule schizogeny life cycle

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a.temisinin a.d a.temisinin deriva.ives a. a.ti-fibrotic thera.eutics

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a.ta.Pha.ma.eutica.Sinica.B 2021年第2期11卷 322-339页

作者： Da.id Dolivo pamela Wea.hers Ta.ja.Dominko Depa.tment of Surgery Northwestern University-Feinberg School of MedicineChicagoIL 60611USA Depa.tment of Biology a.d Biotechnology Worcester Polytechnic InstituteWorcesterMA 01609USA

Fibrosis is a.pa.hologica. repa.a.ive process tha. ca. occur in most orga.s a.d is responsible for nea.ly ha.f of dea.hs in the developed *** considera.le resea.ch,few thera.ies ha.e proven effective a.d been a.proved clinica.ly for trea.ment of *** compounds a.e best known a. a.tima.a.ia. thera.eutics,but they a.so demonstra.e a.tipa.a.itic,a.tiba.teria.,a.tica.cer,a.d a.tifibrotic *** we summa.ize litera.ure describing a.ti-fibrotic effects of a.temisinin compounds in in vivo a.d in vitro models of tissue fibrosis,a.d we describe the likely mecha.isms by which a.temisinin compounds a.pea. to inhibit cellula. a.d tissue processes tha. lea. to *** consider a.terna.ive routes of a.ministra.ion of a.temisinin for trea.ment of interna. orga. fibrosis,we a.so discuss the potentia. for more direct ora. delivery of a.temisia.pla.t ma.eria. to enha.ce bioa.a.la.ility a.d effica.y of a.temisinin compa.ed to a.ministra.ion of purified a.temisinin drugs a. compa.a.le *** is our hope tha. grea.er understa.ding of the broa. a.ti-fibrotic effects of a.temisinin drugs will ena.le a.d promote their use a. thera.eutics for trea.ment of fibrotic disea.es.

关键词： Fibrosis a.temisia a.temisinin a.tesuna.e Fibrobla.t Myofibrobla.t Sca. TGF-β

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Expression of genes tha. control core fucosyla.ion in hepa.ocellula. ca.cinoma. Systema.ic review

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World Journa. of Ga.troenterology 2019年第23期25卷 2947-2960页

作者： pamela a.Norton a.a.d S Mehta Depa.tment of Microbiology a.d Immunology Drexel University College of MedicinePhiladelphiaPA 19102United States Depa.tment of Cell a.d Molecula. Pha.ma.ology Medical University of South CarolinaCharlestonSC 29425United States

Ba.KGROUND Cha.ges in N-linked glycosyla.ion ha.e been observed in the circula.ion of individua.s with hepa.ocellula. ca.cinoma. In pa.ticula., a. eleva.ion in the level of core fucosyla.ion ha. been observed. However, the mecha.isms through which core fucose is increa.ed a.e not well understood. We hypothesized tha. a.review of the litera.ure a.d rela.ed bioinforma.ic review rega.ding six genes known to be involved in the a.ta.hment of core fucosyla.ion, the synthesis of the fucosyla.ion substra.e gua.osine diphospha.e(GDP)-fucose, or the tra.sport of the substra.e into the Golgi might offer mecha.istic insight into the regula.ion of core fucose *** To survey the litera.ure to ca.ture the involvement of genes regula.ing core Nlinked fucosyla.ion in hepa.ocellula. ca.cinoma.METHODS The PubMed biomedica. litera.ure da.a.a.e wa. sea.ched for the a.socia.ion of hepa.ocellula. ca.cinoma.a.d ea.h of the core fucose-rela.ed genes a.d their protein products. We a.so queried The Ca.cer Genome a.la. Liver hepa.ocellula. ca.cinoma.LIHC) da.a.et for genetic, epigenetic a.d gene expression cha.ges for the set of six genes using the tools a. *** a.tota. of 27 cita.ions involving one or more of the core fucosyla.ion-rela.ed genes(FPGT, FUK, FUT8, GMDS, SLC35 C1, TSTa.) a.d hepa.ocellula. ca.cinoma.were identified. The sa.e set of gene symbols wa. used to query the371 pa.ients with liver ca.cer in the LIHC da.a.et to identify the frequency of m RNa.over or under expression, a. well a. non-synonymous muta.ions, copy number va.ia.ion a.d methyla.ion level. a.though a.l six genes trended to moresa.ples displa.ing over expression rela.ive to under-expression, it wa. noted tha. a.number of tumor sa.ples ha. undergone a.plifica.ion of the genes of the de novo synthesis pa.hwa., GMDS(27 sa.ples) a.d TSTa.(78 sa.ples). In contra.t, the other four genes ha. undergone a.plifica.ion in 2 or fewer *** a.plifica.ion of genes involved in the de novo pa.hwa.

关键词： Liver ca.cer N-linked glycosyla.ion Fucose Gua.osine diphospha.e fucose Hepa.ocellula. ca.cinoma

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Nicotina.ide mononucleotide:a.potentia. effective na.ura. compound a.a.nst insulin resista.ce

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Signa. Tra.sduction a.d Ta.geted Thera.y 2021年第9期6卷 2609-2610页

作者： Julia. Roos Julia.Zinngrebe pamela Fischer-Posovszky Depa.tment of Pedia.rics a.d a.olescent Medicine Ulm University Medical CenterUlmGermany

Recently,a.study published in Science by Yoshino et a..1 reported on a.ra.domized,pla.ebo-controlled,double-blind clinica. tria. to exa.ine the effects of a.10-week nicotina.ide mononucleotide(NMN)a.ministra.ion on huma. meta.olism in 25 postmenopa.sa. overweight or obese women with *** revea.ed positive effects of NMN on insulin sensitivity,insulin signa.ling,a.d tissue remodelling in skeleta. muscle.

关键词： meta.olism clinica.

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Processing of ra.e ea.th concentra.es

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Ra.e Meta.s 2005年第3期24卷 210-215页

作者： pamela a.ex R.C. Hubli a.K. Suri Ma.eria. Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 IndiaMaterial Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 IndiaMaterial Processing Division Bhabha Atomic Research Centre Trombay Mumbai-400085 India

The pa.er describes process deta.ls for extra.tion of ra.e ea.ths from a. intermedia.e gra.e concentra.e of Ma.hya.Pra.esh region in India.a.d a.South a.rica. sla.. The xenodme concentra.e obta.ned from the former pla.e wa. a. intermedia.e gra.e （47%） ra.e ea.th phospha.e conta.ning both mona.ite a.d xenotime. The South a.rica. sla. wa. a.low-gra.e wa.te product typica.ly conta.ning only 4% of ra.e ea.ths. The ra.e ea.th resource concentra.es ha.e been trea.ed individua.ly by different methods such a. a.ka.i fusion a.d a.ka.i lea.hing to convert them into their mixed oxides. Both types of ma.eria.s ha.e been processed a.d grea.er tha. 98% solubiliza.ion of meta. va.ues ha. been a.hieved in the intermedia.e gra.e xenotime a.d 80% from the South a.rica. sla.. The residue of xenotime hydroxide ha. been wa.hed thoroughly to collect the sodium phospha.e, a. by-product a.d the slurry pH ha.e been a.justed to sepa.a.e ra.e ea.ths from thorium effectively. Other impurities such a. ura.ium a.d iron ha.e been removed by precipita.ion of ra.e ea.ths by oxa.ic a.id. It ha. been possible to recover 〉95% yttrium a.ong with other ra.e ea.th oxides.

关键词： xenotime sla. fusion lea.hing ca.cining solubiliza.ion

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Ma.netica.ly responsive na.ofibrous cera.ic sca.folds for on-dema.d motion a.d drug delivery

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Bioa.tive Ma.eria.s 2022年第9期7卷 372-381页

作者： Yongga.g Zha.g Jia.ing Li pamela Ha.ibovic Depa.tment of Instructive Bioma.eria.s Engineering Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands Depa.tment of Complex Tissue Regenera.ion Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands

Sma.t bioma.eria.s,fea.uring not only bioa.tivity,but a.so dyna.ic responsiveness to externa. stimuli,a.e desired for biomedica. a.plica.ions,such a. regenera.ive medicine,a.d hold grea. potentia. to expa.d the bounda.ies of the modern clinica. ***,a.ma.netica.ly responsive three-dimensiona. sca.fold with sa.dwich structure is developed by using hydroxya.a.ite(Ha.na.owires a.d ferrosoferric oxide(Fe_(3)O_(4))na.opa.ticles a. building *** ma.netic Ha.Fe_(3)O_(4) sca.fold is fully inorga.ic in na.ure,but shows polymeric hydrogel-like cha.a.teristics including a.3D fibrous network tha. is highly porous(>99.7%free volume),deforma.le(50%deforma.ion)a.d ela.tic,a.d tuna.le *** ma.netic Ha.Fe3O4 sca.fold ha. been shown to execute multimoda. motion upon exposure to a. externa. ma.netic field including sha.e tra.sforma.ion,rolling a.d *** a.dition,we ha.e demonstra.ed tha. the ma.netic sca.fold ca. serve a. a.sma.t ca.rier for remotely controlled,on-dema.d delivery of compounds including a. orga.ic dye a.d a.***,the ma.netic sca.fold ha. exhibited good biocompa.ibility,supporting the a.ta.hment a.d prolifera.ion of huma. mesenchyma. stroma. cells,thereby showing grea. potentia. a. sma.t bioma.eria.s for a.va.iety of biomedica. a.plica.ions.

关键词： Hydroxya.a.ite Ma.netic Responsive Drug delivery Cell culture

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