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Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

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World Journal of Gastroenterology 2012年第22期18卷 2805-2812页

作者： Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow INSERM U577(National Institute of Health and Medical Research) Inra Cnam University of Paris 13 (UREN) SMBH 74 rue Marcel Cachin F-93017 Bobigny France Department of Biochemistry Jean Verdier Hospital F-93140 Bondy France INSERM U698 University of Paris 13 F-93017 Bobigny France Department of Public Health Avicenne Hospital (AP-HP) University of Paris 13 F-93017 Bobigny France Department of Nutrition Ambroise Paré Hospital (AP-HP) University of Versailles Saint Quentin F-92100 Boulogne-Billancourt France

AIM： To examine the relationships between pre-diag- nostic biomarkers and colorectal cancer risk and assess their relevance in predictive ***： A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplemen- tation en VItamines et Min^raux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases （n = 50） were matched with two randomly selected con- trols （n = 100）. Conditional logistic regression models were used to investigate the associations between pre- diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 （sVCAM-1）, soluble intercellular adhesion molecule-I, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves （AUC） and relative integrated discrimination improvement （RIDI） statistics were used to assess the discriminatory poten- tial of the models. RESULTS： Plasma adiponectin level was associated with decreased colorectal cancer risk （P for linear trend -- 0.03）. Quartiles of sVCAM-1 were associated with increased colorectal cancer risk （P for linear trend = 0.02）. No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction （P for AUC improve- ment = 0.01, RIDI = 26.5%）. CONCLUSION： These results suggest that pre-diag- nostic plasma adiponectin and sVCAM-1 levels are as- sociated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies.

关键词： Colorectal cancer Adiponectin Soluble vascu-lar cell adhesion molecule-l Nested case-control study Prospective study

Levodopa/Carbidopa Intestinal Gel for Treatment of Advanced Parkinson’s Disease: An Update on the Effects of Cognitive Functions

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Advances in Parkinson's Disease 2017年第1期6卷 13-23页

作者： pame.a latino Stefania Tagliente Clelia Pellicano Morena Giovannelli Francesco E. Pontieri Department of Neuroscience Mental Health and Sensory Organs (NeSMOS) “Sapienza” University Rome Italy Department of Clinical and Behavioral Neurology “Santa Lucia Foundation” IRCCS Rome Italy Unit of Neurology Sant’Andrea Hospital Rome Italy

Cognitive impairment is a frequent non-motorsymptom of Parkinson’s disease (PD). In early disease stage, this takes the features of dysexecutive syndrome, and is mostly dependent on derangement of frontostriatal circuitries. In advanced stages, worsening of dysexecutive symptoms is accompanied by disorientation and memory deficit leading to dementia in 30% of cases, due to multiple neurotransmitter derangement. Dysexecutive symptoms in the early stages of PD may benefit from dopamine replacement therapy (DRT). Conversely, severe cognitive symptoms in more advanced stages are frequently aggravated by DRT. In particular, pulsatile stimulation of dopaminergic receptors by orally administered levodopa (LD) plays a significant negative role on cognitive and neuropsychiatric symptoms in advanced PD. The introduction of a gel of LD-carbidopa for continuous intestinal administration (LCIG) allows marked stabilization of plasma LD concentrations and provides benefit on motor fluctuations and dyskinesia of significantly greater magnitude than conventional oral administration in advanced PD patients. The results from several preliminary studies suggest that efficacy of LCGI on motor symptoms may be accompanied by good tolerability and potential benefit on several non-motor symptoms, including cognitive impairment. Future studies with longer observation period and larger cohorts are advised to confirm these preliminary observations.

关键词： Cognition Dementia Dopamine Replacement Therapy Duodopa Levodopa Parkinson’s Disease

Prevalence of refractive errors in Villa Maria,Córdoba,Argentina

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Eye Science 2016年第2期31卷 68-77页

作者： Victoria M.Sainchez Rafael Iribarren Santiago G.latino Victor E.Torres Anal L.Gramajo Maria N.Artal Maria B.Yadarola Patricia R.Garay Jose D.Luna Claudio P.Juarez Fundacion VER Centro Privado de Ojos RomagosaCordobaArgentina Department of Ophthalmology Centro Medico San LuisBuenos AiresArgentina CIES(Conicet y UNC) Facultad de Ciencias EconornicasUNCCordobaArgentina

Background:Refractive errors are among the most frequent reasons for demand of eye-care *** on refractive errors prevalence in our country are *** study has the purpose to assess the prevalence of refractive errors in an adult population of Villa Maria,Córdoba,***:The Villa Maria Eye Study is a population-based cross-sectional study conducted in the city of Villa Maria,Córdoba,Argentina from May 2008 to November ***’s aged 40+received a demographic interview and complete ophthalmological *** acuity was obtained with an ETDRS *** auto refraction was *** spherical equivalent was highly correlated between right and left eyes,so only data of right eyes are *** and hyperopia were defined with a±0.50 diopters(D)criterion and astigmatism>1 ***:This study included 646 subjects,aged 40 to 90(mean age:59.6±10.3 years old).Four hundred and sixty two(71.5%)were *** mean spherical equivalent was+0.714±2.41 D(range,-22.00 to+8.25 D)and the power of the cylinder was,on average,-0.869±0.91 D(range,0 to-6.50 D).In this sample,61.6%subjects were hyperopic,and 13.5%were *** prevalence was lower in men(9.8%versus14.9%)but this difference among genders was not statistically *** were 141 subjects(21.8%)with anisometropia greater than 1 D,and 168 subjects(26.0%)with astigmatism greater than 1 ***:The present study shows the prevalence of cycloplegic refractive errors in an adult population of *** prevalence of hyperopia was high,while myopia prevalence was very low.

关键词：屈光不正患病率玛丽亚阿根廷别墅平均年龄近视眼屈光度

意大利陆缘海底峡谷内小规模周期性滑坡对人类的影响扩大

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海洋地质 2009年第1期25卷 50-50页

作者： Alessandro Bosman Domenico Ridente Francesco latino Chiocci 杨丽娟（译）闫章存（校对）罗马大学环境地质和工程地质研究所意大利罗马大学意大利不详

意大利陆缘是中地中海构造活动强烈、复杂的地段，地貌演化非常迅速。沿意大利陆缘，火山活动、断裂活动以及陆坡失稳等地质作用活动频繁，是有人类居住、活动的，具有潜在地质灾害的地区。因此，阐明那些在海底可见的并与地质灾害有关... 详细信息

意大利陆缘是中地中海构造活动强烈、复杂的地段，地貌演化非常迅速。沿意大利陆缘，火山活动、断裂活动以及陆坡失稳等地质作用活动频繁，是有人类居住、活动的，具有潜在地质灾害的地区。因此，阐明那些在海底可见的并与地质灾害有关的地质特征是海洋地质领域重要的内容之一。

关键词：海底峡谷人类居住意大利陆缘周期性小规模滑坡地质灾害