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A tribo-chemical view on astringency of plant-based food substances

Friction 2024年第7期12卷 1392-1407页

作者： Samuel S.GAMANIEL paloma S.DUEÑAS ROBLES Hans TROMP Els H.A.de HOOG Sissi de BEER Emile van der HEIDE Laboratory for Surface Technology and Tribology Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 LWthe Netherlands NIZO Food Research B.V. Ede6710 BAthe Netherlands Department of Molecules and Materials MESA+Institute for Nanotechnology University of TwenteEnschede 7500 AEthe Netherlands

Consumption of plant-based food products having high composition of polyphenols leads to the sensation of *** sliding oral surfaces,friction is an essential property during the oral perception of roughness and dryness which are attributes associated with *** factors including the chemical composition of interacting layers,structure and operation of interfaces have an effect on the astringency development *** manner of interactions occurring at oral interfaces suggest there is a system dependence of astringency and highlights the importance of adopting a tribosystems *** measurement techniques have shown an existing relationship between salivary protein-polyphenol interaction and an astringent ***,the tribo-chemistry involved in this multifaceted sensation remains largely unexplored in a comprehensive *** this review the underlying tribo-chemical processes useful in understanding the mechanism of astringency are highlighted and discussed considering current techniques employed to investigate astringency *** of lubrication on oral surfaces owing to the tribo-chemical interactions involving saliva and astringent plant proteins requires subsequent deformations of oral tissues which are significant enough to induce strains at mechanoreceptor locations,leading to the sensation of *** is proposed that micro-scale contact modelling on the interaction of food particles/aggregates,boundary layers and oral surfaces shows potential in addressing the knowledge gap between tribo-chemical measurement techniques and panel tests,making it possible to attain a predictor for astringency.

关键词： oral lubrication astringency tribo-chemistry tribology

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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： paloma martinez-redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João Lucas Penteado Gomes paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo Stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

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星星西班牙丝绸亭

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室内设计与装修 2024年第1期 138-139页

作者： [捷克]paloma Ca'izares Office coco(编译) Josema Cutillas(摄影) Asier Rua(摄影) paloma Ca?izares Office

丝绸亭是paloma Ca'izares Office对编织物进行研究的初步成果,旨在深入挖掘硬质织物的结构潜力。项目于2023年春在洛格罗尼奥(西班牙)国际建筑与设计节(Concentrico)期间展出,地点包括位于洛格罗尼奥的拉里奥哈官方建筑学院和马德里城... 详细信息

丝绸亭是paloma Ca'izares Office对编织物进行研究的初步成果,旨在深入挖掘硬质织物的结构潜力。项目于2023年春在洛格罗尼奥(西班牙)国际建筑与设计节(Concentrico)期间展出,地点包括位于洛格罗尼奥的拉里奥哈官方建筑学院和马德里城市议程部。

关键词：编织物丝绸西班牙马德里初步成果

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Pyrenetetraone-based covalent organic framework as an effective electrocatalyst for oxygen reduction reaction

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Nano Research 2022年第5期15卷 3907-3912页

作者： paloma Garcia-Arroyo Emiliano martinez-Perinan Jorge J.Cabrera-Trujillo Elena Salagre Enrique G.Michel Jose I.martinez Encarnacion Lorenzo Jose L.Segura Departamento de Quimica Organica I Facultad de CC.QuimicasUniversidad Complutense de Madrid28040 MadridSpain Departamento de Quimica Analitica y Analisis Instrumental Facultad de CienciasUniversidad Autónoma de Madrid28049 MadridSpain Departamento de Fisica de la Materia Condensada Universidad Autónoma de Madrid28049 MadridSpain Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de Madrid28049 MadridSpain Departamento de Nanoestructuras SuperficiesRecubrimientos y Astrofisica MolecularInstituto de Ciencia de Materiales de Madrid(ICMMCSIC)28049 MadridSpain Instituto Madrileno de Estudios Avanzados en Nanociencia(IMDEA-Nanociencia) 28049 MadridSpain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autonoma de Madrid28049 MadridSpain

A novel porous and crystalline two-dimensional(2D)electrochemically active covalent organic framework(COF)based on ortho-quinone units has been prepared as an innovative approach towards the development of organic cathode materials with multiple redox sites as an efficient electrocatalyst for the oxygen reduction reaction(ORR).In contrast with most of the previously reported COFs as electrocatalysts for the ORR,the electrocatalytic application of this material towards ORR has been investigated without adding any metal or conductive supporting material and avoiding any additional carbonization ***,the electrochemical properties of the COF material have been compared with two analogue amorphous frameworks with similar chemical composition,which points out the important role of the enhanced crystallinity and porosity of the COF network in its superior performance as an electrocatalyst towards ORR.

关键词： electrocatalysis oxygen reduction reaction metal free pyrenetetraone covalent organic framework

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PANoptosis:new insights in regulated cell death in ischemia/reperfusion models

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Neural Regeneration Research 2023年第2期18卷 342-343页

作者： paloma González-Rodríguez Arsenio Fernández-López Área de Biología Celular Instituto de BiomedicinaUniversidad de LeónSpain

See related article,pp 357-363The first study describing the cell death and destruction of tissues,organs,and organ systems as programmed events during the development of multicellular organisms was performed by JW Saunders Jr in *** term apoptosis was introduced by Kerr,Wyllie,and Currie in 1972 to describe a programmed phenomenon opposite to mitosis in the regulation of animal cell ***,a description of ectodermal cell lineages as programmed cell death in the worm Caenorhabditis elegans was publishedby JE Sulston and HR Horvitz in 1976.

关键词： organs insight opposite

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Development of a modified predicted heat strain model for hot work environments

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International Journal of Mining Science and Technology 2020年第4期30卷 477-481页

作者： paloma Lazaro Moe Momayez Department of Mining and Geological Engineering The University of ArizonaTucsonAZ 85750USA

Excessive exposure to heat can lead to injuries,illness,and death among *** actual cost of heat-related injuries and illnesses is unknown because of underreporting and lack of symptom ***-factorial,evidence-based,and field-ready guidelines for identifying–and predicting–physiolo gical markers of heat strain are currently *** predicted heat strain(PHS)model,is the latest attempt by mining companies to aid in the evaluation and management of occupational heat *** adopted algorithm relies on worksite environmental measurements and an estimate of individual metabolic rate for mine workers to provide an estimate of the workers’core temperature during a work *** are several known limitations of the PHS model,including the assumption that the subject worker is hydrated and fit.A modified PHS model was presented based on eight physical parameters that are measured at different intervals during a work shift;these parameters are air temperature,relative humidity,air velocity,radiation,metabolic rate,acclimatization,clothing insulation and *** validate the results,the predictions from the modified PHS model were compared with direct physiological measurements obtained from ingestible pills and heat stress monitors under different environmental and working conditions.

关键词： Predicted heat strain Hot underground mines Heat strain Heat stress

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Short and long term corneal biomechanical analysis after overnight orthokeratology

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1128-1134页

作者： Amelia Nieto-Bona paloma Porras-Ángel Adela Elena Ayllón-Gordillo Gonzalo Carracedo David P Piñero Department of Optometry&Vision Optics and Optometry FacultyComplutense University of MadridMadrid 28037Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain

AIM: To investigate the short and long term corneal biomechanical changes after overnight orthokeratology(OK) and compare them with those occurring in subjects not wearing contact ***: Retrospective case control study enrolling 54 subjects that were divided into three groups 18 subjects each: control group(CG), short term(15 nights) OK(STOK) group, and long term(more than 1 y of OK wear) OK(LTOK) group. Corneal biomechanics were characterized using the Cor Vis? ST system(Oculus), recording parameters such as time [first/second applanation time(AT1, AT2)], speed [velocity of corneal apex at the first/second applanation time(AV1, AV2)], and amplitude of deformation(AD1, AD2) in the first and second corneal flattening, corneal stiffness(SPA1), biomechanically corrected intraocular pressure(b IOP) and corneal(CBI) and tomographic biomechanical indices(TBI).RESULTS: Significantly lower AD1 and standard deviate on of Ambrosio’s relational average thickness related to the horizontal profile(ARTh) values were found in the OK groups compared to CG(P<0.05). Likewise, significantly higher values of CBI were found in STOK and LTOK groups compared to CG(P<0.01). No significant differences between groups were found in integrated radius index(P=0.24), strain stress index(P=0.22), tomographic biomechanical index(P=0.91) and corneal stif fness parameter(SPA1, P=0.97). Significant inverse correlations were found between corneal thickness and CBI in STOK(r=-0.90, P<0.01) and LTOK groups(r=-0.71, P<0.01).CONCLUSION: OK does not seem to alter significantly the corneal biomechanical properties, but special care should be taken when analyzing biomechanical parameters influenced by corneal thickness such as amplitude of deformation, ARTh or CBI, because they change significantly after treatment but mainly due to the reduction and pachymetric progression induced by the corneal molding secondary to OK treatment.

关键词： overnight orthokeratology corneal biomechanics pachymetry corneal biomechanical index CorVis?ST tomographic biomechanical index

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Newly Described Components and Regulatory Mechanisms of Circadian Clock Function in Arabidopsis thaliana

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Molecular Plant 2012年第3期5卷 545-553页

作者： Manuel Adrian Troncoso-Ponce and paloma Mas Center for Research in Agricultural Genomics （CRAG） Parc de Recerca UAB Edifici CRAG Barcelona 08193 Spain

The circadian clock temporally coordinates plant growth and metabolism in close synchronization with the diurnal and seasonal environmental changes. Research over the last decade has identified a number of clock components and a variety of regulatory mechanisms responsible for the rhythmic oscillations in metabolic and physiological activities. At the core of the clock, transcriptional/translational feedback loops modulate the expression of a significant proportion of the genome. In this article, we briefly describe some of the very recent advances that have improved our understanding of clock organization and function in Arabidopsis thaliana. The new studies illustrate the role of clock protein complex for- mation on circadian gating of plant growth and identify alternative splicing as a new regulatory mechanism for clock function. Examination of key clock properties such as temperature compensation has also opened new avenues for func- tional research within the plant clockwork. The emerging connections between the circadian clock and metabolism, hor- mone signaling and response to biotic and abiotic stress also add new layers of complexity to the clock network and underscore the significance of the circadian clock regulating the daily life of plants.

关键词： circadian clock circadian rhythms Arabidopsis thaliana feedback loops.

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Photonics of time-varying media

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Advanced Photonics 2022年第1期4卷 30-61页

作者： Emanuele Galiffi Romain Tirole Shixiong Yin Huanan Li Stefano Vezzoli paloma A.Huidobro Mário G.Silveirinha Riccardo Sapienza Andrea Alù J.B.Pendry City University of New York Photonics InitiativeAdvanced Science Research CenterNew YorkUnited States Imperial College London Blackett LaboratoryDepartment of PhysicsLondonUnited Kingdom Nankai University School of PhysicsTianjinChina Instituto de Telecomunicações Instituto Superior Técnico-University of LisbonLisboaPortugal City University of New York Physics ProgramGraduate CenterNew YorkUnited States

Time-varying media have recently emerged as a new paradigm for wave manipulation,due to the synergy between the discovery of highly nonlinear materials,such as epsilon-near-zero materials,and the quest for wave applications,such as magnet-free nonreciprocity,multimode light shaping,and ultrafast *** this review,we provide a comprehensive discussion of the recent progress achieved with photonic metamaterials whose properties stem from their modulation in *** review the basic concepts underpinning temporal switching and its relation with spatial scattering and deploy the resulting insight to review photonic time-crystals and their emergent research avenues,such as topological and non-Hermitian *** then extend our discussion to account for spatiotemporal modulation and its applications to nonreciprocity,synthetic motion,giant anisotropy,amplification,and many other ***,we conclude with a review of the most attractive experimental avenues recently demonstrated and provide a few perspectives on emerging trends for future implementations of time-modulation in photonics.

关键词： time-varying media temporal modulation metamaterials switching optics photonics light

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