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Inter-and intra-rater reliability of diffusion tensor imaging parameters in the normal pediatric spinal cord

World Journal of Radiology 2015年第9期7卷 279-285页

作者： Nadia Barakat pallav shah Scott H Faro John P Gaughan Devon Middleton MJ Mulcahey Feroze B Mohamed Department of Radiology Temple University Biostatistics Consulting Center Temple University School of Medicine Thomas Jefferson University School of Health Professions

AIM: To assess inter- and intra-rater reliability(agreement) between two region of interest(ROI) methods in pediatric spinal cord diffusion tensor imaging(DTI). METHODS: Inner-Field-of-View DTI data previously acquired from ten pediatric healthy subjects(mean age = 12.10 years) was used to assess for reliability. ROIs were drawn by two neuroradiologists on each subject data twice within a 3-mo interval. ROIs were placed on axial B0 maps along the cervical spine using free-hand and fixed-size ROIs. Agreement analyses for fractional anisotropy(FA), axial diffusivity, radial diffusivity and mean diffusivity were performed using intra-class-correlation(ICC) and Cronbach's alpha statistical ***: Inter- and intra-rater agreement between the two ROI methods showed moderate(ICC = 0.5) to strong(ICC = 0.84). There were significant differences between raters in the number of pixels selected using free-hand ROIs(P < 0.05). However, no significant differences were observed in DTI parameter values. FA showed highest variability in ICC values(0.10-0.87). Cronbach's alpha showed moderate-high values for raters and ROI methods. CONCLUSION: The study showed that high reproducibility in spinal cord DTI can be achieved, and demonstrated the importance of setting detailed methodology for post-processing DTI data, specifically the placement of ROIs.

关键词： Diffusion tensor imaging Reproducibility Reliabili

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Advances in treatment and prevention of hepatitis B

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第4期12卷 56-78页

作者： Niraj James shah Mark M Aloysius Neil Rohit Sharma Kumar pallav Department of Internal Medicine Digestive DiseaseUniversity of Mississippi Medical CenterJacksonMS 39216United States Department of Internal Medicine The Wright Center for Graduate Medical EducationScrantonPA 18505United States Department of Internal Medicine Interventional Oncology and Surgical EndoscopyParkview Regional Medical CenterParkview Cancer InstituteFort WayneIN 46845United States

Chronic hepatitis B(CHB)continues to contribute to worldwide morbidity and mortality ***,clinicians,pharmaceutical companies,and health organizations have dedicated substantial Intellectual and monetary resources to finding a cure,increasing immunization rates,and reducing the global burden of *** and international health-related organizations including the center for disease control,the national institute of health,the American Association for the study of liver disease(AASLD),The European association for the study of the Liver(EASL),The Asia Pacific association for the study of the Liver(APASL)and the world health organization release periodic recommendations for disease prevention and *** review of the most recent guidelines by EASL,AASLD,APASL,and Taiwan Association for the Study of the Liver revealed that an overwhelming majority of cited studies were published before *** reviewed Hepatitis B-related literature published 2018 onwards to identify recent developments and current barriers that will likely direct future efforts towards eradicating hepatitis *** breakthrough in our understanding of the hepatitis B virus life cycle and resulting drug development is encouraging with significant room for further *** from high-risk populations,most vulnerable to the devastating effects of hepatitis B infection and reactivation remain *** of systems approach,optimization of experimental models,identification and validation of next-generation biomarkers,and precise modulation of the human immune response will be critical for future *** the foreseeable future,new treatments will likely complement conventional therapies rather than replace *** Importantly,pragmatic management of CHB related population health challenges must be prioritized to produce real-world results.

关键词： Chronic hepatitis B Hepatitis B virus Hepatitis B prevention Hepatitis B treatment Hepatitis B vaccination Hepatitis B reactivation

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