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Lygodium flexuosum extract down regulates the expression of proinflammatory cytokines in CCl_4 -induced hepatotoxicity

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 421-426页

作者： pallara janardhanan wills Velikkakathu Vasumathi Asha Plant Based Bioactives and Disease Biology Laboratory Rajiv Gandhi Centre for BiotechnologyThiruvananthapuramKerala 695014India MIMS Research Foundation Malabar Institute of Medical SciencesCalicut-673007KeralaIndia

Objective:To examine the downregulalion of proinflammatory cytokines in a time dependant manner on carbon tetrachloride induced toxicity in experimental ***:CCl4（150μL/100 g） was dissolved in com oil（1:1 v/v%） and administered orally,GroupⅠwas treated as normal control and received corn oil on 8th ***Ⅱwas toxic control and was given a single dose of CCl4 on 8th ***Ⅲwas treated with Lygodium flexuosum（***） n-hexane extract（200 mg/kg） for 8 days and on 8th day a single dose of CCl4 was ***Ⅳ（negative contnil） received *** n-hexane extract（200 mg/kg） alone for 8 ***:Treatment with n-hexane extract prior to the administration of CCl4 significantly prevented an increase in serum AST,ALT,LDH activity and lipid peroxidation and prevented the depletion of glutathione （GSH）.Rats treated with *** had reduced mRNA levels of TGF-β1,TNF-αand IL-1βgenes in liver of CCl4 intoxicated rats when compared to CCl4 control as evidenced by RT-PCR. Conclusions:The data suggest that ***,a widely available fem,significantly reduces CCl4 induced acute hepatotoxicily by down-regulating the expression of pro-inflammatory cytokines in rats.

关键词： Lygodium flexuosum Carbon tetrachloride mRNA TGF-β1 TNF-α IL-1β

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Protective effect of Amorphophallus campanulatus(Roxb.) *** against thioacetamide induced oxidative stress in rats

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Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 870-877页

作者： Puthuparampil Nazarudeen Ansil Anand Nitha Santhibhavan Prabhakaran Prabha pallara janardhanan wills Vahab Jazaira Mukalel Sankunni Latha Biochemistry and Pharmacognosy Research Laboratory School of BiosciencesM.G.UniversityP.O.Hills.P.O.KottayamKerala-686560India

Objective:To identify the phytochemical constituents of Amorphopkallus campanulatus(A. campanulatus) tuber and to evaluate its antioxidant potential through in vitro and in vivo models. Methods:Phytochemical screening and in vitro antioxidant activities of *** tuber n-hexane extract(ACHE) and methanolic extract(ACME) were evaluated using DPPH,hydroxyl radical,reducing power and total antioxidant capacity *** total phenolic and flavonoid contents were also *** protective potential of two different doses of ACME(125 and 250 mg/kg) was also evaluated against thioaeetamide(TAA) induced oxidative stress in rats. Silymarin used as a standard drug *** was assessed by quantifying the serum levels of aspartate aminotransferase(AST),alanine aminotransferase(AIT),alkaline phosphatase (ALP) and lactate dehydrogenase(LDH).The antioxidant potential of ACME were also evaluated by the estimation of catalase(CAT),glutathione peroxidase(GPx),glutathione reductase (OR),glutathione-S-transferase(GST),reduced glutathione(GSH) and lipid peroxidation (Thiobarbituric acid reactive substances) in hepatic and renal *** changes of liver were also ***:In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE,which may be attributed to its higher phenolic and flavonoid *** significandy prevented the elevation of serum AST,***,LDH,and tissue malondialdehyde levels(P < 0.05).Hepatic and renal ***,GPx,and catalase levels were remarkably increased by the treatment with the *** of histopathological changes also supported the dose dependent protective effects of ***:The results do suggest that *** tuber could be considered as a potential source of natural antioxidant.

关键词： Amorphophallus campanulatus Thioacetamide DPPH Hepatotoxicity Hepatoprotective Antioxidant aclivily Silymarin

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