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Acute and 28-day repeated oral toxicological evaluation of Kuruthi Azhal Chooranam-a Siddha preparation on rodents

Journal of Coastal Life Medicine 2016年第10期4卷 795-801页

作者： Marimuthu Kannadasana Ganesan Sumathy palanivel thirusangu sangeetha Chidambaram Saravanababu Kathirvelu Baskar Department of Toxicology Bioscience Research FoundationPorurChennai 600116Tamil NaduIndia Department of Biochemistry University of MadrasGuidy CampusChennai 600025Tamil NaduIndia Department of Pharmacognosy Mohamed Sathak A.J.College of PharmacyMedavakam RoadSholingnallurChennai 600119Tamil NaduIndia Center for Toxicology and Developmental Research Sri Ramachandra UniversityChennai 600116Tamil NaduIndia Department of Ecotoxicology and Entomology Bioscience Research FoundationPorurChennai 600116Tamil NaduIndia

Objective:To determine the effect of phytochemicals in acute and repeated dose of 28-day oral toxicity of Kuruthi Azhal Chooranam(KAC)in Sprague Dawley rats of both ***:Acute oral toxicity was conducted with 2000 mg/kg body weight of KAC orally and the treated animals were observed for signs of toxicity at 30 min,1,2,4 and 24 h and for up to 14 *** repeated 28-day oral toxicity study,the KAC formulation was administered orally with 600,900 and 1200 mg/kg body weight/day to all the three groups of *** animals were observed for clinical signs of toxicity,mortality and morbidity throughout the *** body weight,feed consumption,haematological,plasma biochemistry and serum electrolytes,gross pathology,weights of the organ and histology were studied for no-observed-adverse-effect *** dose of KAC formulation and control reversal groups were also included for delayed toxic effects ***:In the acute toxicity study of KAC formulation,2000 mg/kg body weight dose exhibited no toxic signs and mortality during *** sub-acute 28-day repeated dose toxicity study,there was no significant difference found between control and KAC treated groups(body weight,haematology,biochemistry and serum electrolytes).No abnormalities was found in gross pathology,organs weight and histological observation after KAC ***:The current study suggests that LD_(50)of KAC was>2000 mg/kg and no-observed-adverse-effect level was>1200 mg/kg/day in *** could be used as Siddha drug for various indications.

关键词： Kuruthi azhal chooranam Hypertension Secondary metabolites Acute oral toxicity 28-Day repeated oral toxicity

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