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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville ng Michelle Newbery Nicole Miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus

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Infectious Diseases of Poverty 2014年第1期3卷 397-413页

作者： Kang yiu Lai Wing yiu George ng Fan Fanny Cheng Department of Intensive Care Queen Elizabeth HospitalHKSARB630 Gascoigne RdKowloonHong Kong SARChina Department of Medicine Queen Elizabeth HospitalHKSARKowloonHong Kong SAR China

The recent outbreak of the human Zaire ebolavirus(EBOV)epidemic is spiraling out of control in West *** EBOV hemorrhagic fever has a case fatality rate of up to 90%.The EBOV is classified as a biosafety level 4 pathogen and is considered a category A agent of bioterrorism by Centers for Disease Control and Prevention,with no approved therapies and vaccines available for its treatment apart from supportive *** several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial,the current epidemic might be outpacing the speed at which drugs and vaccines can be *** all viruses,the EBOV largely relies on host cell factors and physiological processes for its entry,replication,and *** have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal *** of the therapeutic agents in this review are directed against non-mutable targets of the host,which is independent of viral *** medications are approved by the Food and Drug Administration(FDA)for the treatment of other *** are available and stockpileable for immediate *** may also have a complementary role to those therapeutic agents under development that are directed against the mutable targets of the EBOV.

关键词： Ebola virus Non-mutable host cell therapeutic targets for Ebola virus Cocktail therapeutic intervention for RNA virus

The Paradoxes of Student Well-being in Singapore

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ECNU Review of Education 2020年第3期3卷 437-451页

作者： pak Tee ng Nanyang Technological University

Purpose:Singapore’s education system is known for its robust curriculum and excellent *** is also a system of keen competitiveness and high *** article addresses how such an education system responds to the issue of student ***/Approach/Methods:This article analyses the recent initiatives and shift in education philosophy in Singapore’s education system,which have a bearing on the issue of student ***:This article argues that while there are direct efforts to address student well-being,the direction Singapore is taking is to pursue a holistic education paradigm,in which education is engaging,joyful,meaningful,and *** article also argues that such a paradigm goes beyond the current well-being agenda and is aligned with a view that education should be about wholeness and *** there are challenges associated with these changes,the Singapore experience suggests that the more we focus on holistic education,rather than interpret student well-being narrowly,the more wellness the students may actually and eventually ***/Value:This article brings to readers learning points from Singapore regarding student well-being,as the country grapples with change to develop a generation of young people,whose beings are and will continue to be well.

关键词： Competition examination social emotional learning stress student well-being

Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

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Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei ng Xiaoping ZHAng Jianwu CHEN Yongqiang SHI Fuchang ZUO Wenxi PEng Weichun FU Liansheng LI Pengwei LUO Chi-Long TAng Guozheng ZHAng Zhiwu MEI Li WAng Cunhui LI Jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese Long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. Furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B (MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-Hsien CHEN Kam K.H.ng Xin YUAN Cho Yin yiu Human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye tracker Electroencephalogram

High-Resolution Infrared-Vacuum Ultraviolet Photoion and Pulsed Field Ionization-Photoelectron Methods for Spectroscopic Studies of Neutrals and Cations

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Chinese Journal of Chemical Physics 2008年第3期21卷 193-201页

作者： Xi Xing Beth Reed Mi Kyung Bahng Peng Wang Hin Koo Woo Sun Jong Baek Chee Shing Lain Cheuk yiu ng Department of Chemistry University of California Davis Davis California 95616 USA

We show that by scanning the frequency of a single mode infrared （IR） optical parametric oscillator （IR- OPO） laser to excite the molecular species of interest and fixing the frequency of a vacuum ultraviolet （VUV） laser to photoionize the IR excited species, high-resolution IR spectra of polyatomic neutrals can be obtained with high sensitivity. The fact that this IR-VUV-photoion （IR-VUV-PI） method is based on VUV photoionization probe, and thus, allows the identification of the neutral IR absorber, makes it applicable for IR spectroscopy measurements of isotopemers, radicals, and clusters, which usually exist as impure samples. The highly resolved IR-VUV-PI measurements achieved using the single mode IR-OPO laser have made possible the selection of single rovibrational states of CH3X （X=Br and I）, C2H4, and C3H4 for VUV-pulsed field ionization-photoelectron （VUV-PFI-PE） measurements, resulting in rovibrationally resolved photoelectron spectra for these polyatomic molecules. These experiments show that the signal- to-noise ratios of the IR-VUV-PI and IR-VUV-PFI-PE spectra obtained by employing the high-resolution IR-OPO laser are significantly higher than those observed in previous IR-VUV-PI and IR-VUV-PFI-PE studies using a low-resolution IR-OPO laser. Further improvement in sensitivity of IR-VUV-PI and IR- VUV-PFI-PE measurements by using the collinear arrangement of IR-VUV lasers and molecular beam is discussed.

关键词： Vacuum ultraviolet Infrared Pulse-field photoelectron High resolution

Quantum State-to-State Vacuum Ultraviolet Photodissociation Dynamics of Small Molecules

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Chinese Journal of Chemical Physics 2019年第1期32卷 23-34,I0001页

作者： Hong Gao Cheuk-yiu ng Beijing National Laboratory for Molecular Sciences (BNLMS) Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Chemistry University of California Davis CA 95616 USA

The present review focused on selected, recent experimental progress of photodissociation dynamics of small molecules covering the vacuum ultraviolet (VUV) range from 6 eV to 20 eV. These advancements come about due to the available laser based VUV light sources along with the developments of advanced experimental techniques, including the velocitymap imaging (VMI), H-atom Rydberg tagging time-of-flight (HRTOF) techniques, as well as the two-color tunable VUV-VUV laser pump-probe detection method. The applications of these experimental techniques have allowed VUV photodissociation studies of many diatomic and triatomic molecules to quantum state-to-state in detail. To highlight the recent accomplishments, we have summarized the results on several important molecular species, including H2 (D2, HD), CO, N2, NO, O2, H2O (D2O, HOD), CO2, and N2O. The detailed VUV photodissociation studies of these molecules are of astrochemical and atmospheric relevance. Since molecular photodissociation initiated by VUV excitation is complex and is often governed by multiple electronic potential energy surfaces, the unraveling of the complex dissociation dynamics requires state-to-state cross section measurements. The newly constructed Dalian Coherent Light Source (DCLS), which is capable of generating coherent VUV radiation with unprecedented brightness in the range of 50-150 nm, promises to propel the photodissociation experiment to the next level.

关键词： Photodissociation State-to-state Velocity-map imaging

What do we know about housing supply?The case of Hong Kong SAR

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Economic and Political Studies 2020年第1期8卷 6-20页

作者： Charles Ka Yui Leung Joe Cho yiu ng Edward Chi Ho Tang Department of Economics and Finance City University of Hong KongHong Kong SARChina Department of Economics and Finance Hong Kong Shue Yan UniversityHong Kong SARChina

The house price in the Hong Kong SAR of China is well-known to be‘unaffordable’.This paper relates the macroeconomy with the housing market of Hong Kong and argues that the housing supply plays a vital role in explaining the *** paper also shows that there are some practical challenges in understanding the housing supply of Hong Kong,including the potentially complicated ownership structure of real estate *** the discussion centres on the situation of Hong Kong,its lesson may also apply to housing markets in other small open economies.

关键词： New housing supply oligopolistic market structure ownership structure real estate development real estate developers