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A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment:Evidence for erectile restoration and cavernous nerve regeneration

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Asian Journal of Urology 2022年第3期9卷 287-293页

作者： Eric chung AndroUrology Centre BrisbaneQLDAustralia University of Queensland Princess Alexandra HospitalBrisbaneQLDAustralia Macquarie University Hospital SydneyNSWAustralia

Objective:The following article explores our evolving understandings of the role of regenerative technology as an effective penile rehabilitation tool in men with erectile dysfunction(ED)in the setting of prostate cancer(PCa)treatment and PCa ***:This narrative clinical review paper summarizes what is currently known about various modalities of regenerative therapy in restoring spontaneous erectile function(EF)in men following PCa treatment with an emphasis on penile rehabilitation ***:Conventional medical therapy often does not reverse underlying endothelial dysfunction or promote neuro-vasculogenesis to preserve penile health in men with *** the past decade,there has been considerable interest in the role of regenerative therapy to restore endothelial dysfunction and ED without future dependency on medical *** therapy can be classified into cellular-based(immunomodulators,stem cells,and platelet-rich plasma),biomaterials(nerve graft transfer),and device-related technology(low-intensity shockwave).Although published literature shows early promise in the role of regenerative technology for ED,there is a paucity of high-quality clinical trials in the setting of penile rehabilitation and PCa survivorship to support their use as standard care and be adopted in clinical guidelines.

关键词： Regenerative therapy Low-intensity shockwave therapy Stem cell therapy Platelet-rich plasma Immunomodulator Nerve transfer Erectile dysfunction Penile rehabilitation

Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders

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Neuroscience Bulletin 2015年第1期31卷 141-159页

作者： Chunyu Liu Michael chung State Key Laboratory of Medical Genetics of China Department of Psychiatry University of Illinois at Chicago

Circadian rhythm alterations have been implicated in multiple neuropsychiatric disorders,particularly those of sleep,addiction,anxiety,and mood. Circadian rhythms are known to be maintained by a set of classic clock genes that form complex mutual and self-regulatory loops. While many other genes showing rhythmic expression have been identified by genome-wide studies,their roles in circadian regulation remain largely unknown. In attempts to directly connect circadian rhythms with neuropsychiatric disorders,genetic studies have identifi ed gene mutations associated with several rare sleep disorders or sleep-related traits. Other than that,genetic studies of circadian genes in psychiatric disorders have had limited success. As an important mediator of environmental factors and regulators of circadian rhythms,the epigenetic system may hold the key to the etiology or pathology of psychiatric disorders,their subtypes or endophenotypes. Epigenomic regulation of the circadian system and the related changes have not been thoroughly explored in the context of neuropsychiatric disorders. We argue for systematic investigation of the circadian system,particularly epigenetic regulation,and its involvement in neuropsychiatric disorders to improve our understanding of human behavior and disease etiology.

关键词： epigenetics circadian rhythms neuropsychiatry

运动员的正念和主观幸福感:检验认知重新评估的中介效应

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中国运动医学杂志 2015年第5期34卷 475-479页

作者：钟伯光张春青刘靖东香港浸会大学体育学系

本研究的目的是检验认知重新评估是否作为青少年运动员正念和主观幸福感的中介变量。本研究邀请了397名专业运动员（12~23岁）参与问卷调查,结果表明正念与主观幸福感以及认知重新评估都是正向的且显著相关,且认知重评与主观幸福感显著... 详细信息

本研究的目的是检验认知重新评估是否作为青少年运动员正念和主观幸福感的中介变量。本研究邀请了397名专业运动员（12~23岁）参与问卷调查,结果表明正念与主观幸福感以及认知重新评估都是正向的且显著相关,且认知重评与主观幸福感显著相关。然而,在使用结构方程模型进行中介分析时,无论是否控制正念与主观幸福感的关系,认知重新评估到主观幸福感的回归系数不显著。因此本研究未能确定认知重新评估对正念和主观幸福感的中介作用,尚需进一步的研究来确认。

关键词：运动员正念情绪调节主观幸福感认知重新评估中介

Validation of a steel dual-core self-centering brace （DC-SCB） for seismic resistance： from brace member to one-story one-bay braced frame tests

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 303-311页

作者： chung-Che CHOU Ping-Ting chung Tsung-Han WU Alexis Rafael Ovalle BEATO Department of Civil Engineering Taiwan University Taipei Taiwan China Director Center for Earthquake Engineering Research (CEER) Taiwan University Taipei Taiwan China

A steel dual-core self-centering brace （DC-SCB） is an innovative structural member that provides both energy dissipation and self-centering properties to structures, reducing maximum and residual drifts of structures in earthquakes. The axial deformation capacity of the DC-SCB is doubled by a parallel arrangement of two inner cores, one outer box and two sets of tensioning elements. This paper presents cyclic test results of a DC-SCB component and a full- scale one-story, one-bay steel frame with a DC-SCB. The DC-SCB that was near 8 m-long was tested to evaluate its cyclic behavior and durability. The DC-SCB performed well under a total of three increasing cyclic loading tests and 60 low- cycle fatigue loading tests without failure. The maximum axial load of the DC-SCB was near 1700 kN at an interstory drift of 2.5%. Moreover, a three-story dual-core self-centering braced frame （DC-SCBF） with a single-diagonal DC-SCB was designed and its first-story, one-bay DC-SCBF subassembly specimen was tested in multiple earthquake-type loadings. The one-story, one-bay subassembly frame specimen performed well up to an interstory drift of 2% with yielding at the column base and local buckling in the steel beam; no damage of the DC-SCB was found after all tests. The maximum residual drift of the DC-SCBF caused by beam local buckling was 0.5% in 2.0% drift cycles.

关键词： dual-core self-centering brace (DC-SCB) braced frame tests residual deformation

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Q690高强钢及其焊接构件的疲劳性能

钢结构（中英文） 2024年第5期39卷 27-33页

作者：陈韡钟国辉香港理工大学土木与环境工程学院中国香港999077 香港理工大学国家钢结构工程技术研究中心香港分中心中国香港999077

高强钢指屈服强度fy不小于460 MPa的钢材,因其良好的材料性能已被逐步应用于建筑和桥梁中。与普通强度钢材相比,高强钢具有更高的屈服强度,可以减小构件的尺寸,且较薄的钢板厚度可以减少焊接工作量、提高焊接质量,从而避免厚板带来的焊... 详细信息

高强钢指屈服强度fy不小于460 MPa的钢材,因其良好的材料性能已被逐步应用于建筑和桥梁中。与普通强度钢材相比,高强钢具有更高的屈服强度,可以减小构件的尺寸,且较薄的钢板厚度可以减少焊接工作量、提高焊接质量,从而避免厚板带来的焊接问题。疲劳损伤一直以来是桥梁结构最为关键的服役问题之一,在国内外现行的结构设计规范中并没有包含针对高强钢材疲劳性能的设计标准。对Q690高强钢及其焊接件的疲劳性能进行了系统性的试验研究,确定Q690高强钢及其焊后的疲劳强度,以推进Q690高强钢在实际工程中的应用。首先对Q690高强钢及其焊接件的标准试件进行单调拉伸试验,确定其材料性能,在Q690焊接件进行试验前对试件进行了腐蚀处理,目的是更为直观地在试验中观察到焊材、热影响区和母材的分布,试验确定颈缩发生的位置为热影响区。根据单调拉伸试验得到的材料力学性能确定了多级疲劳荷载,并对Q690高强钢及焊接光滑圆棒试件进行系列高周-低应变疲劳试验,确定了Q690高强钢母材及其焊接试件的疲劳寿命,并根据试验值拟合出疲劳曲线(S-N曲线)。疲劳试验得到Q690焊接件的疲劳极限为420.0 MPa,Q690母材的疲劳极限为668.8 MPa,结果表明Q690高强钢焊后疲劳极限有明显降低,但Q690高强钢母材及其焊接试件的疲劳极限均远远高于欧洲规范的设计值(母材:118 MPa,焊接件:82.5 MPa)。对Q690焊接试件进行了硬度试验,确定其沿纵向的硬度分布,发现焊材区的硬度最高约为328 HV,在热影响区有明显的软化现象,硬度为240 HV,说明Q690高强钢焊后硬度差异较大。对疲劳破坏后的Q690焊接件断口试件进行了腐蚀试验,发现疲劳裂纹起源于焊材区而非热影响区。并且对断口试件进行了扫描式电子显微镜观察,在疲劳断面发现非金属夹杂物。根据电镜观察的结果,分析了疲劳断口的微观现象,确定疲劳裂纹源及扩展过程,得到初始缺陷是影响Q690焊接件疲劳性能关键因素的结论。

关键词：高强钢焊接接头疲劳性能

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Design, Synthesis, Photophysical Studies and Electrochemistry of Carbazole-, Oxadiazole-, and Oxadiazole-Triarylamine-Containing Rhenium(Ⅰ) Diimine Alkynyl Complexes

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Chinese Journal of Chemistry 2014年第10期32卷 1015-1021页

作者： Wai-Kin chung Keith Man-chung Wong Vivian Wing-Wah Yam and Department of ChemistryThe University of Hong KongPokfulam RoadHong KongChina

A series of rhenium(I)diimine alkynyl complexes with various electron-and hole-transporting moieties has been synthesized and *** electronic absorption,emission and electrochemical properties have also been studied.

关键词： electrochemistry luminescence metal alkynyl rhenium(Ⅰ)diimine,UV/Vis spectroscopy

ML(n)BiCGStab: Reformulation, Analysis and Implementation

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Numerical Mathematics(Theory,Methods and Applications) 2012年第3期5卷 447-492页

作者： Man-chung Yeung Department of Mathematics University of WyomingLaramieWY 82071USA

With the aid of index functions,we re-derive the ML(n)BiCGStab algorithm in[Yeung and Chan,SIAM ***.,21(1999),pp.1263-1290]*** are n ways to define the ML(n)BiCGStab residual *** definition leads to a different ML(n)BiCGStab *** demonstrate this by presenting a second algorithm which requires less *** theory,this second algorithm serves as a bridge that connects the Lanczos-based BiCGStab and the Arnoldi-based FOM while ML(n)BiCG is a bridge connecting BiCG and *** also analyze the breakdown situation from the probabilistic point of view and summarize some useful properties of ML(n)*** issues are also addressed.

关键词： CGS BiCGStab ML(n)BiCGStab multiple starting Lanczos Krylov subspace iterative methods linear systems

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

A fast and simple system performance emulator for enhanced solid state disks:a case study of long read operations

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 418-424页

作者： Do Yeun KIM Chanik PARK Eui-Young chung Sung Woo chung Division of Computer and Communication Engineering Korea University Seoul 13-713 Korea Samsung Electronics Yongin-City Kyunggi-Do 446-701 Korea School of Electrical and Electronic Engineering Yonsei University Seoul 120-749 Korea

In this paper, we propose a fast and simple system emulator, called a system performance emulator(SPE), to evaluate long read *** SPE estimates how much system-wide performance is enhanced by using a faster solid state disk(SSD).By suspending a CPU for a certain time during direct memory access(DMA) transfer and subtracting this suspended time from the total DMA time, the SPE estimates the improvement in system performance expected from an enhanced SSD prior to its *** also examine the relation between storage performance and system performance using the SPE.

关键词： Solid state disk(SSD) Performance emulator System performance Direct memory access(DMA) Operating system