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Prospective Assessment of Catheter Migration in Implanted Vascular Access Devices for Adjuvant Colorectal Cancer Chemotherapy

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Journal of Cancer Therapy 2012年第6期3卷 920-925页

作者： Pia Osterlund paivi valta Soren Bondedstam Leena Lindgren Department of Oncology Helsinki University Central Hospital and University of HelsinkiHelsinkiFinland Department of Anaesthesiology Helsinki University Central HospitalJorvi HospitalEspooFinland Department of Radiology Helsinki University Central HospitalHelsinkiFinland Department of Anaesthesia Tampere University Hospital and University of TampereTampereFinland.

Background: Chemotherapy in colorectal cancer is usually administered as continuous infusion of 5-fluorouracil, often in combination with oxaliplatin or irinotecan. Targeted drugs are most efficient and tolerable in conjunction with continuous infusion dosing. Implanted venous access devices (VAD) are the prerequisite for continuous infusion administration. The reported catheter migration frequency with VAD is 0% - 3.5%. The purpose of this case-control study was to evaluate the predisposing factors of catheter migration. Methods: We inserted VADs in 88 radically operated colorectal cancer patients randomized to adjuvant 48-hour-infusion chemotherapy repeated every 14 days, altogether 12 times over 24 weeks. Three out of 88 patients (3.4%) had a symptomatic catheter migration from the superior caval vein into the internal jugular vein. The fourth case had chemotherapy for osteosarcoma. These 4 cases were compared with 12 controls from the same 88 patient study population, matched for age, sex, body mass index (BMI), physical activity level and right subclavian insertion site. Tip position, port model, complications, catheter length and material was studied. The post insertion catheter tip position in the chest X-ray was numbered from 1 (in subclavia) to 8 (in atrium). Results: The four cases, all male, had a median position of 3 (range 3 - 4) and controls 6 (range 4 - 8), P = 0.004, median difference 3 (CI95% 1 - 5). At notification of migration the patients had experienced discomfort in the neck region starting 5 to15 days before at strenuous upper extremities activity with Valsalva maneuvers. Conclusion: Optimal catheter tip position when sitting is in the right atrium or low in the superior vena cava to avoid migration. Patients with VADs should avoid strenuous activity with Valsalva maneuvers.

关键词： Central Venous Catheterization Catheter Migration Complication Colorectal Cancer Vascular Access Device

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Medium-term clinical efficacy and safety of single incision and modified trans-obturator mid-urethral slings for female stress urinary incontinence

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 57-62页

作者： Jerome Melon paivi K.Karjalainen Claire McGannon Joseph K.Lee Anna Rosamilia Pelvic Floor Unit Monash Medical CentreMelbourneVICAustralia Central Finland Central Hospital JyvaskylaFinland Department of Obstetrics and Gynaecology Monash Medical CentreMelbourneVICAustralia University of New South Wales KensingtonNSWAustralia Cabrini Hospital Malvern MelbourneVICAustralia

Aims:To evaluate the medium term efficacy and safety of Altis and Solyx single incision slings(SIS)compared with tension-free vaginal tape(TVT)Abbrevo trans-obturator *** hypothesize that both SIS show little difference in efficacy and safety and perform similarly to TVT ***:We conducted an ambispective comparative cohort study of women with stress urinary incontinence who received a SIS in comparison to matched TVT Abbrevo subjects from a concurrent randomized controlled trial(RCT).Subjects were identified retrospectively,and prospectively invited for examination and questionnaires>12 months *** included intrinsic sphincter deficiency,previous sling surgery,and *** outcome was subjective cure[negative response to International Consultation Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-UI SF)question 6,leakage during coughing/activity].Secondary outcomes include objective cure(negative cough stress test),functional outcomes,and adverse ***:Between 2012 and 2018,a total of 113 women received one of two SIS surgeries;Solyx(n=50)followed by the Altis(n=63);104 were available for final efficacy *** follow-up was 21.7(Altis),46.0(Solyx),and 29.0(Abbrevo)*** characteristics were comparable between the *** was no significant differences in the subjective or objective cure rates between the groups,and no differences in functional outcomes such as patient global impression of improvement,and post-operative ICIQ-UI SF *** was a low rate of mesh related complications and no differences seen between the ***:Despite being an underpowered study,Altis and Solyx SIS have favourable efficacy and safety profiles which are comparable to an established trans-obturator mid-urethral slings(MUS).

关键词： Efficacy Mini-sling Safety Single incision sling Stress urinary incontinence

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是否花斑选择饲养年轻的最佳区域试验

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Current Zoology 2015年第4期61卷 604-613页

作者： Elina MANTYLA paivi M. SIRKIA Tero KLEMOLA Toni LAAKSONEN Section of Ecology Department of Biology University of Turku FI-20014 Turku Finland Institute of Biology Freie Universitat Berlin Haderslebener Str. 9 DE- 12163 Berlin Germany

人们一般认为，鸟类能选择育种的领土，稍后会有雏鸟食物最多。然而，对这一重要问题的研究却很少。我们研究了长途移民地区的选择，染色红喉姬hypoleuca芬兰西南部。在一个研究领域，我们监控的领土选择男性的领土解决的顺序。在另一... 详细信息

人们一般认为，鸟类能选择育种的领土，稍后会有雏鸟食物最多。然而，对这一重要问题的研究却很少。我们研究了长途移民地区的选择，染色红喉姬hypoleuca芬兰西南部。在一个研究领域，我们监控的领土选择男性的领土解决的顺序。在另一个研究领域，男性和领土的质量之间的相关性进行了研究，在另一个研究领域，被删除，不允许男性自由选择的领土。我们定义了几种生境特征和ES估计无脊椎动物猎物的丰度从空中，地面和树从在这两个研究领域的巢址周围适当的陷阱。对期望亲鸟会选择一个节肢动物丰富的领土，无论是男性还是女性都选择那些领土，后来最有食物的雏鸟。有，然而，一些证据表明，更多的鸡蛋放在领土与更多的蚜虫和更多的幼鸟都产生在地区蚂蚁丰度高。因此，我们的研究结果表明，虽然这将是有益的鸟类，能够选择食物丰富的地区，他们可能无法检测到正确的线索，这样做早在繁殖季节。然而随着饲养年轻的可能，最好的前景检测的领土的可能性和重要性，之间和内部的季节和更多的关于这一主题的研究有所不同，显然需要[当前生态61（4）：604-613，2015 ]。

关键词：区域试验饲养花斑繁殖季节无脊椎动物选择育种节肢动物男性

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Sustainable Futures： Comparing Methodologies for Analyzing Citizen Visions in Europe

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Journal of Sociology Study 2017年第5期7卷 246-262页

作者： Petteri Repo Kaisa Matschoss paivi Timonen University of Helsinki Finland

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基于ZSM-5的微孔-中孔催化剂上(-)-异蒲勒醇与苯甲醛Prins环化反应合成药物（英文）

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Chinese Journal of Catalysis 2019年第11期40卷 1713-1720页

作者： Ekaterina Kholkina paivi Maki-Arvela Chloe Lozachmeuer Roman Barakov Nataliya Shcherban Dmitry Yu. Murzin 博阿卡德米大学科学与工程系约翰·盖多林过程化学中心芬兰土尔库20500 乌克兰国家科学院L.V. Pisarzhevsky物理化学研究所乌克兰基辅03028

将数个ZSM-5基微孔-中孔催化剂用于(-)-异蒲勒醇与用作反应物和溶剂的苯甲醛进行Prins环化反应,合成杂环含氧2H-色烯衍生物,其包含四氢吡喃结构并表现出生物活性.采用N2吸附,氨-程序升温还原,吡啶和2,6-二-叔丁基吡啶吸附-脱附的红外光... 详细信息

将数个ZSM-5基微孔-中孔催化剂用于(-)-异蒲勒醇与用作反应物和溶剂的苯甲醛进行Prins环化反应,合成杂环含氧2H-色烯衍生物,其包含四氢吡喃结构并表现出生物活性.采用N2吸附,氨-程序升温还原,吡啶和2,6-二-叔丁基吡啶吸附-脱附的红外光谱表征了所考察的催化剂.当在含适量强酸位和12倍所需产物尺寸的中孔的催化剂上,于70℃下进行Prins反应,(-)-异蒲勒醇完全转化时所需产物产率最高达67%.

关键词：微孔-中孔材料 Prins成环反应四氢吡喃

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Ionic Liquid Assisted Extraction of Nitrogen and Sulphur-Containing Air Pollutants from Model Oil and Regeneration of the Spent Ionic Liquid

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Journal of Environmental Protection 2011年第6期2卷 796-802页

作者： Ikenna Anugwom paivi Maki-Arvela Tapio Salmi Jyri-Pekka Mikkola Industrial Chemistry and Reaction Engineering Process Chemistry CentreAbo Akademi UniversityTurkuFinland Technical Chemistry Department of ChemistryChemical-Biological CenterUmea UniversityUmeaSweden

Removal of air pollutants, such as nitrogen and sulphur containing compounds from a model oil (dodecane) was studied. An ionic liquid (1-ethyl-3-methylimidazolium chloride [C2mim] [Cl]) was used as an extractant. Liquid-liquid extraction by using 1-ethyl-3-methylimidazolium chloride [C2mim] [Cl] was found to be a very promising method for the removal of N- and S-compounds. This was evaluated by using a model oil (dodecane) with indole as a neutral nitrogen compound and pyridine as a basic nitrogen compound. Dibenzothiophene (DBT) was used as a sulphur compound. An extraction capacity of up to 90 wt% was achieved for the model oil containing pyridine, while only 76 wt% of indole in the oil was extracted. The extraction capacity of a model sulphur compound DBT was found to be up to 99 wt%. Regeneration of the spent ionic liquid was carried out with toluene back-extraction. A 1:1 toluene-to-IL wt ratio was performed at room temperature. It was observed that, for the spent ionic liquid containing DBT as a model compound more than 85 wt% (corresponding 3852 mg/kg) could be removed from the oil. After the second regeneration cycle, 86 wt% of the DBT was recovered from the ionic liquid to toluene. In the case of indole as the nitrogen containing species, more than 99 wt%, (corresponding to 2993 mg/kg) of the original indole was transferred from the model oil to the ionic liquid. After the first-regeneration cycle of the spent ionic liquid, 54 wt% of the indole–in-IL was transferred to toluene. Thus, both extractions of nitrogen and sulphur model compounds were successfully carried out from model oil and the back-extraction of these compounds from the ionic liquids to toluene demonstrated the proved the concept of the regeneration point of view.

关键词： Ionic Liquids Extraction Air Pollutants Nitrogen Compound Sulfur Compounds

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A comparison of perinatal and infant mortality rates in British Columbia and Finland:Similarities and differences

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Open Journal of Pediatrics 2013年第1期3卷 35-41页

作者： paivi Rautava Anne Synnes Jennifer Claydon Jaakko Matomaki Mika Gissler Turku Clinical Research Centre Turku University HospitalTurkuFinland British Columbia’s Women’s Hospital VancouverCanada Pediatric Research Unit Department of PediatricsTurku University HospitalTurkuFinland Faculty of Medicine Centre for Child PsychiatryUniversity of TurkuTurkuFinland National Institute for Health and Welfare HelsinkiFinland

Introduction: Despite similarities, perinatal and infant mortality rates between British Columbia, (BC) Canada and Finland differ. Key variables that may influence stillbirth, early neonatal, perinatal and infant mortality rates in BC and Finland were studied. Methods: After standardizing definitions, data for all births between 2001 and 2009 from provincial and national registries were used to compare perinatal outcomes between BC and Finland. Annual change was evaluated with regression analyses. Results: Births before 22 weeks gestation were excluded. All mortality rates per 1000 were lower in Finland vs BC (perinatal: 5.1 vs 6.2, stillbirth: 3.4 vs 3.9, early neonatal 1.7 vs 2.4, infant 2.9 vs 4.0;all p Higher multiple birth and preterm birth rates in BC are affecting mortality rates. Finland’s policy of single embryo transfer is a potential explanation. It is possible to have good perinatal outcomes and low caesarean section rates. Conclusions: The Finnish health care system may suggest possible solutions for improved perinatal outcomes. Lower per capita health care expenditures in Finland do not appear to have adversely affected perinatal outcomes.

关键词： Perinatal Mortality Infant Mortality International Comparative Studies

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Engineered Hydrophobin for Biomimetic Mineralization of Functional Calcium Carbonate Microparticles

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Journal of Biomaterials and Nanobiotechnology 2014年第1期5卷 1-7页

作者： Hanna Heinonen paivi Laaksonen Markus B.Linder Hans-Peter Hentze VTT—Technical Research Centre of Finland EspooFinland

In this study, the modified hydrophobin, engineered for biomimetic mineralization, has been employed as a structure-directing agent for mineralization of calcium carbonate. For the first time amphiphilic calcium carbonate particles have been obtained, using engineered proteins. The mineral microparticles have been characterized by optical microscopy, scanning electron microscopy (SEM) and X-ray diffraction (XRD). While mineralization in the presence of non-modified hydrophobin results in polymorph mineral structures, uniform microspheres with an average particle diameter of one micron are obtained by employing hydrophobin which has been modified with an additional ceramophilic protein sequence. Owing to the tri-functionality of the modified hydrophobin (hydrophilic, hydrophobic and ceramophilic), the obtained mineral microparticles exhibit amphiphilic properties. Potential applications are in the areas of functional fillers and pigments, like biomedical and composite materials. Pickering emulsions have been prepared as a demonstration of the emulsion-stabilizing properties of the obtained amphiphilic mineral microspheres. The structure-directing effects of the studied engineered hydrophobins are compared with those of synthetic polymers (i.e. polycarboxylates) used as crystallization and scaling inhibitors in industrial applications.

关键词： Biomimetic Mineralization Engineered Proteins Hydrophobin Calcium Carbonate Functional Microparticles

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The Cost-Effectiveness of Short-Term Psychodynamic Psychotherapy and Solution-Focused Therapy in the Treatment of Depressive and Anxiety Disorders during a Three-Year Follow-Up

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Open Journal of Psychiatry 2014年第3期4卷 238-250页

作者： Timo Maljanen Tommi Harkanen Esa Virtala Olavi Lindfors paivi Tillman Paul Knekt Social Insurance Institution HelsinkiFinland National Institute for Health and Welfare HelsinkiFinland Biomedicum Helsinki HelsinkiFinland

Background: Various psychotherapies are used extensively in treating different mental disorders, but still relatively little is known about the long-term health and cost effects of different therapies. The aim of this study is to compare the cost-effectiveness of short-term psychodynamic psychotherapy (SPP) and solution-focused therapy (SFT) in the treatment of depressive and anxiety disorders during a three-year follow-up. Methods: A total of 198 outpatients suffering from mood or anxiety disorder were randomized to SPP or SFT. Symptoms were assessed using the Beck Depression Inventory, the Hamilton Depression Rating Scale, the Symptom Check List Anxiety Scale, the Hamilton Anxiety Rating Scale, and the Symptom Check List Global Severity Index. Both direct and indirect costs due to mental health problems were measured. Results: The symptoms of depression and anxiety were reduced statistically significantly according to all 5 psychiatric outcome measures during the first 7 months, after which only minor changes were observed. The differences between the two groups were small and not statistically significant. The direct costs were about equal in both groups but the indirect costs were somewhat higher in the SPP group, although not statistically significantly. The costs of auxiliary treatments were much higher than the cost of SPP or SFT. Conclusions: With regard to cost-effectiveness, there is little difference between SPP and SFT.

关键词： Depression Anxiety Psychotherapy Cost Analysis

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Effect of Equi-Strath<sup>®</sup>on Leucocyte Occurrence in the Haired Skin of Horses

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Agricultural Sciences 2018年第1期9卷 1-7页

作者： Danja D. Wiederkehr Elise Jeannerat paivi Nussbaumer Dominik Burger Hendrika Anette van Dorland School of Agricultural Forest and Food Sciences Bern University of Applied Sciences Bern Switzerland Swiss Institute of Equine Medicine University of Bern and Agroscope Bern Switzerland

Strath?/Bio-Strath? is a plasmolyzed herbal yeast product with malt, honey and orange syrup. Its ability to support the immune system of the human being is well known and was tested in several studies. Equi-Strath?, the adapted product for horses was tested in this study. The aim of the study was to analyze the effects of Equi-Strath? on skin condition in the horse. The study included twenty healthy Franches-Montagnes stallions which were divided into two groups. The study group (SG, n = 10) received 0.06 ml/kg bodyweight of Equi-Strath?, the control group (CG, n = 10) the same amount of placebo, daily. The supplement and the placebo were given from week 1 until week 10 of the trial, orally. Skin biopsies were taken three times, once at the beginning of the study (week 0), once at half time (week 5) and once at the end of the study (week 10), followed by histological analysis including leucocytes count twice in five vision fields of each slide. No alterations of hair, adnexal structures or skin thickness were found. However, the number of perivascular lymphocytes turned out to be increased at the end of the study in 9 out of 10 animals of the study group, whereas number of lymphocytes in biopsies of the control group where increased only in 4 out of 10 animals. The increase of lymphocytes in the study group suggests an activation of the immune system due to the application of Equi-Strath?.

关键词： Equine Skin Biopsies Plasmolyzed Herbal Yeast Lymphocytes

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