检索结果-南通市图书馆

脱支处理蜡质玉米淀粉分子重排形成纳米结晶微球的研究

在线全文

学校读者我要写书评

暂无评论

粮食与油脂 2014年第11期27卷 12-15页

作者：周中凯陈晓姗郑排云天津科技大学食品工程与生物技术学院天津300457

利用脱支酶对蜡质玉米淀粉进行不同程度的脱支处理,形成不同分子分布的产物,研究产物中分子结构对结晶体形成及结构的影响。SEM显示随着脱支程度的增加结晶体由棒状网络结构逐渐过渡为完美的球状颗粒,FTIR分析发现该结晶体内部分子排列... 详细信息

利用脱支酶对蜡质玉米淀粉进行不同程度的脱支处理,形成不同分子分布的产物,研究产物中分子结构对结晶体形成及结构的影响。SEM显示随着脱支程度的增加结晶体由棒状网络结构逐渐过渡为完美的球状颗粒,FTIR分析发现该结晶体内部分子排列的有序性也是随着脱支程度的增加而升高,说明与淀粉大分子相比,小分子更易趋于有序排列,而脱支产物中大分子的存在会影响重结晶方式,导致结晶体形态、得率和晶型的不同。

关键词：蜡质玉米淀粉脱支形态结晶

CATALYTIC RESEARCH FOR CLEAN ENERGY AND ULTRA-CLEAN FUELS IN THE 21^(st) CENTURY Future Perspectives

在线全文

学校读者我要写书评

暂无评论

石油学报（石油加工） 2002年第6期18卷 1-19页

作者： Chun-shan SONG (Clean Fuels and Catalysis Program, The Energy Institute, and Department of Energy & Geo-Environmnetal Engineering, Pennsylvania State University, 209 Academic Projects Building, University park, pa 16802, USA) Clean Fuels and Catalysis Program The Energy Institute and Department of Energy & Geo-Environmental Engineering Pennsylvania State University 209 Academic Projects Building University Park 美国

本文系由大连理工大学王祥生教授 (本刊编委 )和郭新闻教授约请美国宾州大学宋春山博士撰写的“2 1世纪清洁能源和超清洁燃料催化研究的未来展望”述评。在本文中笔者系统而扼要地回顾了 2 0世纪全球能源消耗及供求的情况 ,展望了 2 1... 详细信息

本文系由大连理工大学王祥生教授 (本刊编委 )和郭新闻教授约请美国宾州大学宋春山博士撰写的“2 1世纪清洁能源和超清洁燃料催化研究的未来展望”述评。在本文中笔者系统而扼要地回顾了 2 0世纪全球能源消耗及供求的情况 ,展望了 2 1世纪催化研究面临的机遇 ,着重讨论了清洁能源 ,对催化而言应把综合和有效利用能源作为研究方向。笔者结合美国情况介绍了许多有用的统计数字 ,重点结合自己的研究工作比较全面地阐述了能源燃料工业对催化研究的需求及其机遇。它包括了清洁运输燃料、重油轻质化增产中间馏分油、制氢和燃料电池、天然气利用、天然气液化、替代燃料的发展、煤的综合利用、专用化学品的合成以及CO2 的转化和利用等。煤既作为生产清洁燃料的原料 ,又作为生产专用化学品的资源 ,把在炼油化工中已经取得卓越成果的催化技术、分子筛催化过程转移到煤化工领域 ,笔者对此提出了比较完整的方案。这些对于读者都有很大的帮助。

关键词：燃料工业催化作用催化技术清洁催化剂无污染清洁燃料

Correlation of the changes of TLR4/NF-κB pathway function in intrauterine adhesion tissue with the characteristics of cytokine secretion and collagen metabolism

在线全文

学校读者我要写书评

暂无评论

Journal of Hainan Medical University 2019年第1期25卷 36-39页

作者： Ling-Ge Jin shan-shan Li Ping Zheng Hong Zhao Department of Gynecology Beijing Gynecology&Obstetrics Hospital of Capital Medical UniversityBeijing100026

Objective:To study the correlation of the changes of Toll-like receptor 4 (TLR4) / nuclear factorκB (NF-κB) pathway function in intrauterine adhesion (IUAs) tissue with the characteristics of cytokine secretion and collagen ***:The patients with IUAs who were treated in our hospital between February 2015 and March 2018 were selected as the IUAs group, and the patients who underwent hysteroscopy due to infertility and were pathologically confirmed to have normal endometrium during the same period were selected as the control group. The expression levels of TLR4/NF-κB pathway molecules and collagen metabolism genes as well as the contents of cytokines and collagen metabolism markers in the adhesion tissues of IUAs group and the normal endometrial tissue of control group were ***: TLR4, NF-κB, a disintegrin and metalloproteinase 15 (ADAM15), ADAM17, matrix metalloproteinase 9 (MMP9) and plasminogen activator inhibitor 1 (pai-1) mRNA expression as well as transforming growth factor-β1 (TGF-β1), Smad2/3, insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), basic fibroblast growth factor (bFGF), periostin/osteoblast-specific factor 2 (Postn), type I collagen (Col-I) and actin-α (α-SMA) contents in the adhesion tissues of IUAs group were significantly higher than those of control group while urokinase-type plasminogen activator (upa) mRNA expression was significantly lower than that of control group;TLR4 and NF-κB mRNA expression were positively correlated with TGF-β1, Smad2/3, IGF-1, IGF-1R, bFGF, Postn, Col-I,α-SMA, ADAM15, ADAM17, MMP9 and pai-1, and negatively correlated with ***:The excessive activation of TLR4/NF-κB pathway in IUAs is associated with the cytokine secretion and collagen metabolism abnormalities.

关键词： Intrauterine adhesions Toll-like receptor 4 Nuclear factorκB Cytokine Collagen metabolism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铜绿假单胞菌临床分布及耐药机制研究

中国病原生物学杂志 2021年第2期16卷 224-227页

作者：秦柯君曹献芹陈派强郭珊新乡市中心医院河南新乡453000 郑州颐和医院

目的分析铜绿假单胞菌分布及耐药机制,为控制菌株耐药性发展提供指导。方法收集本院患者临床送检标本,采用全自动细菌鉴定仪鉴定病原菌,并采用K-B法进行药敏试验。PCR扩增及测序检测耐药基因分布及变异情况。结果共分离289株铜绿假单胞... 详细信息

目的分析铜绿假单胞菌分布及耐药机制,为控制菌株耐药性发展提供指导。方法收集本院患者临床送检标本,采用全自动细菌鉴定仪鉴定病原菌,并采用K-B法进行药敏试验。PCR扩增及测序检测耐药基因分布及变异情况。结果共分离289株铜绿假单胞菌,其中ICU、神经外科、呼吸内科、儿科、神经内科、胸外科、骨外科中分离菌株分别占28.03%、21.11%、17.99%、11.07%、9.00%、7.96%和4.84%。痰液、分泌物、脓液、血液、腹腔积液中分离菌株分别占59.86%、20.07%、10.03%、5.88%和4.15%。铜绿假单胞菌对头孢他啶、亚胺培南、环丙沙星、头孢吡肟、美罗培南、左氧氟沙星、哌拉西林/他唑巴坦、阿米卡星、氨曲南、庆大霉素的耐药率分别为37.02%、2.77%、33.91%、23.88%、6.23%、31.14%、29.07%、19.03%、47.75%和28.03%。93株多重耐药铜绿假单胞菌中TEM、IMP、VIM、OXA-58、armA、rmtB、aac(6′)-Ⅱ、ant(3″)-Ⅰ、oprD2缺失、gyrA突变、parC突变阳性检测率分别为17.20%、12.90%、8.60%、7.53%、21.51%、12.90%、17.20%、25.81%、12.90%、30.11%和23.66%;196株非多重耐药铜绿假单胞菌阳性检测率分别为11.22%、8.16%、6.12%、3.06%、10.71%、7.65%、12.24%、16.84%、7.65%、16.33%和10.20%。铜绿假单胞菌oprD2发生编码区395~405位11 bp片段缺失,gyrA基因发生83位氨基酸突变(Thr→Ile),parC基因发生87位氨基酸突变(Ser→Leu)。结论铜绿假单胞菌感染患者主要分布在ICU科室,痰液样本中分离率较高。耐药基因是铜绿假单胞菌多重耐药性产生的直接原因,及时监测耐药基因分布及变异情况对耐药株传播控制有重要意义。

关键词：铜绿假单胞菌耐药基因耐药机制

在线全文

学校读者我要写书评

暂无评论

肠道微生物蛋白质的发酵与肠道健康的关系

食品科学 2014年第1期35卷 303-309页

作者：周中凯杨艳郑排云张岩陈晓姗天津科技大学食品工程与生物技术学院天津300457

人体内蛋白质发酵主要发生于结肠末端,会产生一些不利于健康的代谢产物如氨类、胺类、酚类化合物和硫化物等。一些重要的肠道疾病如大肠癌、溃疡性结肠炎的发生都集中于结肠末端,这与在该部位的蛋白质的高度发酵有关。流行病学研究表明... 详细信息

人体内蛋白质发酵主要发生于结肠末端,会产生一些不利于健康的代谢产物如氨类、胺类、酚类化合物和硫化物等。一些重要的肠道疾病如大肠癌、溃疡性结肠炎的发生都集中于结肠末端,这与在该部位的蛋白质的高度发酵有关。流行病学研究表明,高肉类食物通常与大肠癌的发生呈正相关性,这是因为高肉食的摄入不仅增加了蛋白质在大肠中的含量,而且还增加了脂肪、荷尔蒙和杂环胺的摄入,这些物质对大肠癌的发生也起到促进的作用。然而,肠道健康和蛋白质的发酵之间的潜在关系还没有得到充分的研究,本文就蛋白质在肠道发酵所产生的一些潜在危害化合物及其在体内代谢循环的研究进行综述。

关键词：大肠癌遗传毒性益生元益生菌蛋白质发酵

One-stop strategy for treatment of atrial fibrillation:feasibility and safety of combining catheter ablation and left atrial appendage closure in a single procedure

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第12期133卷 1422-1428页

作者： Mu Chen Zhi-Quan Wang Qun-shan Wang Jian Sun Peng-pai Zhang Xiang-Fei Feng Wei Li Ying Yu Bo Liu Bin-Feng Mo Rui Zhang Mei Yang Chang-Qi Gong Ming-Zhe Zhao Yi-Chi Yu Yan Zhao Qiu-Fen Lu Yi-Gang Li Department of Cardiology Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China

Background:Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure(LAAC)is increasingly used for stroke prevention in patients with atrial fibrillation(AF).We aimed to observe the feasibility and safety of performing AF ablation and LAAC in a single(one-stop)***:Consecutive AF patients who underwent the combined procedure of AF ablation and LAAC with WATCHMAN device between March 2017 and September 2018 were prospectively *** and intra-procedural parameters were ***-month and subsequent 1-year follow-up were performed in all and earlier-enrolled subjects,***:A total of 178 AF patients(94 males,68.9±8.1 years)underwent the one-stop procedure with CHA2DS2-VASc score 3.3±1.5 and HAS-BLED score 1.6±1.0,*** vein isolation was achieved in all patients while additional linear ablation was applied if the operator deemed necessary,yielding immediate ablation success rate of 98.9%(176/178).In the subsequent LAAC,satisfactory seal(residual leakpatients,*** stroke and one delayed cardiac tamponade occurred,while no device-related thrombus or device migration was *** the 1-year follow-up for the earlier enrolled subjects,52/72(72.2%)of the patients maintained sinus *** was no stroke or systemic embolism ***:Combining catheter ablation and LAAC in a single procedure can be successfully and safely performed in non-valvular AF patients of Chinese population.

关键词： Atrial fibrillation Left atrial appendage closure Catheter ablation Stroke WATCHMAN One-stop procedure

磁激励RF-PECVD法低温制备类金刚石薄膜及其特性

在线全文

学校读者我要写书评

暂无评论

光电子．激光 2010年第9期21卷 1332-1336页

作者：肖琦杨保和朱珊珊天津理工大学天津市薄膜电子与通信器件重点实验室天津300384

采用磁激励射频等离子体增强化学气相沉积(M-RF-PECVD)方法,室温下分别在玻璃和Si(100)衬底上制备类金刚石(DLC)薄膜,通过扫描电镜(SEM)、傅里叶红外光谱(FTIR)和Raman光谱对不同沉积条件下制备的薄膜进行表征。结果表明,在反应压强为30... 详细信息

采用磁激励射频等离子体增强化学气相沉积(M-RF-PECVD)方法,室温下分别在玻璃和Si(100)衬底上制备类金刚石(DLC)薄膜,通过扫描电镜(SEM)、傅里叶红外光谱(FTIR)和Raman光谱对不同沉积条件下制备的薄膜进行表征。结果表明,在反应压强为30 pa、入射功率为50 W、CH4/Ar=5/90、衬底温度为40℃的实验条件下,制备的含氢DLC薄膜表面平整、结构致密,膜基结合度良好,薄膜中以sp3键为主。

关键词：磁激励射频等离子体增强化学气相沉积(RF-PECVD) 低温类金刚石(DLC) 声表面波(SAW) 气体传感器

Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2021年第1期6卷 12-19页

作者： Qing Fang Linrui Wu Caroline Urwald Morgane Mugat shan Wang Kwaku Kyeremeh Carol Philips Samantha Law d Yongjun Zhou Hai Deng Marine Biodiscovery Centre Department of ChemistryUniversity of AberdeenMeston WalkAberdeenAB243UEScotlandUK ENSAIA 2 avenue de la forêt de Haye54505 vandoeuvre lès NancyFrance Department of Chemistry University of GhanaP.O.Box LG56Legon-AccraGhana NCIMB Ltd Ferguson BuildingCraibstone EstateBucksburnAberdeenAB219YAScotlandUK Research Centre for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127China

Non-ribosomal peptides are a group of structurally diverse natural products with various important therapeutic and agrochemical *** pyrrolizidine alkaloids(pas),containing a scaffold of two fused five-membered ring system with a nitrogen atom at the bridgehead,have been found to originate from a multidomain non-ribosomal peptide synthetase to generate indolizidine intermediates,followed by multistep oxidation,catalysed by single Bayer-Villiger(BV)enzymes,to yield pa *** bacterial pas are rare in natural product inventory,bioinformatics analysis suggested that the biosynthetic gene clusters(BGCs)that are likely to be responsible for the production of pa-like metabolites are widely distributed in bacterial ***,most of the strains containing pa-like BGCs are not deposited in the public domain,therefore preventing further assessment of the chemical spaces of this group of bioactive ***,we report a genomic scanning strategy to assess the potential of pa metabolites production in our culture collection without prior knowledge of genome *** the strains tested,we found fifteen contain the key BV enzymes that are likely to be involved in the last step of pa ring *** one-strain-many-compound(OSMAC)method,supported by a combination of HR-MS,NMR,SMART 2.0 technology,and GNPS analysis,allowed identification and characterization of a new[5+7]heterobicyclic carbamate,legoncarbamate,together with five known pas,bohemamine derivatives,from Streptomyces ***37,a Ghanaian soil *** absolute stereochemistry of legoncarbamate was determined by comparison of measured and calculated ECD *** displays antibacterial activity against *** ATCC 25922 with an MIC value of 3.1μg/***,a biosynthetic model of legoncarbamate and other bohemamines was proposed based on the knowledge we have gained so far.

关键词： Genomic scanning Bayer villiger monooxygenase Carbamate alkaloids Pyrrolizidine alkaloids Non-ribosomal peptide synthetases

Adenosine A2A receptor-expressing neurons in the striatum regulate sleep behaviors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2016年第10期30卷 1025-1026页

作者： YUAN Xiang-shan WANG Lu DONG Hui QU Wei-min LI Rui-xi HUANG Zhi-li Department of Pharmacology Fudan University Department of Anatomy Histology and EmbryologyFudan University State Key Laboratory of Medical Neurobiology Fudan University

OBJECTIVE The high prevalence of sleep disturbance has been found in patients with striatum-related neurodegenerative *** the striatum,there are abundant adenosine A2A receptors(A2ARs)whichhavebeen reported to mediatesleepbehavior for *** hypothesized that the A2AR-expressing neurons in the striatum are involved in sleep-wake *** We employed a chemogenetic technique,designer receptor exclusively activated by designer drug(DREADD),to specifically and non-invasively manipulate the neuron activity based on the principle of Cre/Lox P recombination,EEG/electromyogram recording for sleep-wake behaviors,the neural tracing approach toselectively visualize the perikarya of A2AR-expressing neurons and their axons by adeno-associated virus(AAV)encoding humanized Renilla green fluorescent(hr GFP)as a tracerin A2AR-Cre *** addition,we used immunoelectron microscopy,patch-clamp technique,and optogenetics in A2AR-Cre mice to selectively characterize the synapse and functional connectivity between the A2AR-expressing neurons and the neuron of their downstream targets in *** The activation of A2AR-expressing neurons in rostral,centromedial and centrolateral striatum increased non-rapid eye movement(non-REM,NREM)sleep,concomitant with a reduction in wakefulness,whereas the activation of A2AR-expressing neurons in caudal striatum didn′t alter sleep-wake profiles at *** projections in the sagittal section showed that the axons of A2ARexpressing neurons from rostral striatum distributed in the rostral external globuspallidus(GPe)with a discoidal region paralleled to the striato-pallidal border,while the axons of the A2AR-expressing neurons from the central striatum not only distributed in the rostral GPe,but also in the caudal GPe with a similar distributing pattern as did in rostral ***,the axons of A2ARexpressing neurons from caudal striatum just scattered in the caudal *** on our anatomical findings and pa

关键词： striatum A2AR neuron sleep topographical projection DREADD