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The more the messier：centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers

The Journal of Biomedical Research 2016年第6期30卷 441-451页

作者： Monica M.Mahathre padmashree c.g.rida Ritu Aneja Department of Biology Georgia State University Atlanta GA 30303 USA Novazoi Theranostics Inc. Piano TX 75025 USA Institute of Biomedical Sciences Georgia State University Atlanta GA 30303 USA center for Obesity Research Georgia State University Atlanta GA 30303 USA

colon cancer is currently the third most common cancer and second most fatal cancer in the United States,resulting in approximately 600,000 deaths *** colorectal cancer death rates are decreasing by about 3%every year,disease outcomes could be substantially improved with more research into the drivers of colon carcinogenesis,the determinants of aggressiveness in colorectal cancer and the identification of biomarkers that could enable choice of more optimal *** carcinogenesis is notably a slow process that can take *** factors that contribute to the development of colon cancer are mutational,epigenetic and environmental,and risk factors include age,history of polyps and family history of colon *** cancers exhibit heterogeneity in their features and are often characterized by the presence of chromosomal instability,microscopic satellite instability,or cpg island methylator *** this review,we propose that centrosome amplification may be a widespread occurrence in colorectal cancers and could potently influence tumor ***,the quantitation of this cancer-specific anomaly could offer valuable prognostic information and pave the way for further customization of treatment based on the organellar profile of *** stratification models that take into account centrosomal status could thus potentially reduce adverse side effects and result in improved outcomes for colorectal cancer patients.

关键词： centrosome amplification colorectal cancer chromosomal instability aneuploidy biomarker prognostic

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Development and Evaluation of Shelf Stability of Flaxoat Nutty Bar in Different Packaging Materials

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Food and Nutrition Sciences 2013年第5期4卷 538-546页

作者： Ananthan padmashree gopal Kumar Sharma Thimma govindaraj Department of cereals and Pulses Technology Defence Food Research Laboratory Mysore India.

Flaxoat nutty bar, a granola cereal bar was developed using oat and wheat as major cereal ingredients and their shelf life was assessed in polypropylene (PP 75 μ), paper (42 gSM) aluminium foil (20 μ) polyethylene (PFP, 37.5 μ) and metallised polyester (MP, 12 μ) low density/linear low density (150 μ) (with and without vacuum) films and stored under ambient temperature conditions and 37℃. chemical changes in bar under different packaging materials during storage revealed that, the bar remained stable and acceptable for 12 months at ambient conditions irrespective of the packaging materials used, while at 37℃, the bar packed in PP films remained stable for 6 months only and rest of the bars packed in PFP, MP and MP (vacuum) films found stable and acceptable for the entire storage period of 12 months. The effect of aw on lipid peroxidation established the maximum stability of the bar at 0.33 aw. Fourteen fatty acids were identified in which oleic (50.91%), linoleic (22.50%) and palmitic (12.63%) acids were found to be the major fatty acids. Fortification of a bar with vitamin c, B1 and B2 contents to meet 50% RDA enhanced vitamin contents and the maximum retention was observed in bars packed under vacuum in MP films.

关键词： cereal Bar Packaging Water Activity chemical changes Shelf Life

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In VitrAntioxygenic Activity of Ridge gourd (Luffa acutangula) Pulp, Peel and Their Extracts on Peroxidation Models

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American Journal of Plant Sciences 2012年第10期3卷 1413-1421页

作者： Ananthan padmashree gopal Kumar Sharma Anil Dutt Semwal Amarinder Singh Bawa Department of cereals and Pulses Technology Defence Food Research Laboratory Siddarthanagar India

Ridge gourd pulp and peel powders as well as their various solvent fractions were evaluated for antioxygenic activity using different methods. Ridge gourd pulp and peel powders at 2% level and their ethanol/water soluble extracts exhibited strong antioxygenic activity in sunflower oil stored at 37?c. The water soluble extract devoid of any antioxygenic activity in sunflower oil. Ridge gourd pulp and peel powders as well as their extracts were evaluated for their antioxygenic activity using linoleic acid peroxidation, β-carotene-linoleic acid bleaching and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) methods. Ethanol/water extracts from ridge gourd pulp and peel showed highest antioxygenic activity followed by water extracts, while the petroleum ether extract showed moderate antioxygenic activity. Ridge gourd peel powder and its extracts showed slightly higher antioxygenic activity than ridge gourd pulp powder and its extracts. This may be attributed to the presence of higher amounts of phenolics and flavonoids which have been reported as potential antioxidants.

关键词： Ridge gourd Antioxygenic Activity Solvent Extraction Phenolics Flavonoids

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Antioxygenic Activity of Solanum nigrum L.Leaves in Sunflower Oil Model System and Its Thermal Stability

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Food and Nutrition Sciences 2014年第11期5卷 1022-1029页

作者： Ananthan padmashree gopal Kumar Sharma Anil Dutt Semwal chitrashekarachar Mahesh Department of cereals and Pulses Technology Defence Food Research Laboratory Siddarthanagar Mysore India

The antioxygenic activity of Solanum nigrum L. leaves and its various solvent extracts were evaluated using sunflower oil model system. Leaf powder and its methanol/water (80:20) soluble fraction showed strong antioxygenic activity in refined sunflower oil. On the other hand, ethyl acetate fraction exhibited marginal antioxygenic activity, whereas the water soluble fraction was practically devoid of any activity in refined sunflower oil. Thermal stability of different extracts of Solanum nigrum L. leaves heated at 80?c in refined sunflower oil also indicated the strong efficacy of methanol/water (80:20) extract to inhibit thermal oxidation. Solanum nigrum L. contain high levels of magnesium (239.0 mg/100g) and phosphorous (80.3 mg/100g). Fatty acid analysis of the lipid extracted from Solanum nigrum L. leaves indicated the presence of linoleic (59.1%) as a major fatty acid. The result of this study confirmed the presence of antioxygenic compounds in leaves, in particular its methanol/water (80:20) extracts showed great potential as a natural antioxidant to inhibit lipid peroxidation in foods.

关键词： Solanum nigrum L. Antioxygenic Activity Solvent Extraction Thermal Stability Phenolics Flavonoids

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computed Radiography with Isotopes-Suitability for Weld Inspection

Computed Radiography with Isotopes-Suitability for Weld Insp...

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17th World conference on Non-Destructive Testing

作者： V.Manoharan Prasad Thapa Rajashekar Venkatachalam g.K.padmashree Megha Navalgund Debasish Mishra gE global Research center 122 EPIPWhite Field Road Bangalore-560 066KarnatakaIndia

＜正＞computed Radiography（cR）is gaining importance in industries for inspection of welds and castings using *** is preferred because of lesser exposure time,no chemical processing,lesser cost of consumables and advantage of a digital image *** also allows archiving of digital images over many years,which is mandatory as per ***,Heavy engineering industries,manufactures of high-pressure boilers,Oil ＆ gas and Energy industries are interested to use computed Radiography（cR）for testing weld integrity and corrosion monitoring of process *** applications require radiography to be carried out using radioactive isotopes such as Se-75,Ir-192 and ***,industries do not have enough experience of using cR with *** require information on choosing the right isotope for different range of thicknesses of a material,in order to meet the ASME Section-V *** will also be helpful if there exists data on comparative performance of cR with respect to films on image *** authors have done extensive study at various engineering industries and characterized the performance of cR with *** image quality performances were studied using weld specimens with defects like lack of fusion;penetration,cracks,concavity,and *** paper presents the quantitative metrics used for evaluation of cR specific to standards and comparative study of cR with various film systems.

关键词： computed radiography Isotopes Weld inspection

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Development and Quality Evaluation of choco Quinoa Nutri Bar during Storage

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Food and Nutrition Sciences 2018年第7期9卷 899-914页

作者： Ananthan padmashree Neha Negi Soorya Haridas Thimma govindaraj Kandanganth Raghavan Anila Kumar Anil Dutt Semwal gopal Kumar Sharma Defence Food Research Laboratory Siddartha Nagar Mysuru India

choco quinoa nutri bar was developed using quinoa as one of the ingredients to explore its nutritional benefits. Bars were packed in polypropylene (PP, 75 μ) and metallised polyester (12 μ) low density—high density (MP, 100 μ) (with/without vacuum) films, stored under ambient and 37°c temperature conditions for shelf life evaluation. Bar contained 14.43% protein, 14.93% fat with a calorific value of 426.75 k cal/100g. chemical changes were observed significantly (p c than the ones stored at ambient conditions (15°c - 34°c). Bars showed maximum stability at 0.33 aw with less chemical changes. Oleic acid (36.06%) was found to be the major fatty acids in the bar followed by palmitic (29.35%), stearic (17.12%) and linoleic (12.05%) acids. Hardness of the bar enhanced significantly during storage, and was observed significantly (p gher in the samples packed in MP films (with/without vacuum) as compared to bars packed in PP films thus restricting the shelf life of the bar to 6 months in MP films (with/without vacuum) and 9 months in PP films at both the temperature conditions.

关键词： choco Quinoa Nutri Bar Quinoa Packaging Material chemical changes Hardness Shelf Life

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印度亚拉文眼科模式(英文)

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眼视光学杂志 2006年第2期8卷 117-119页

作者： Srinivasan M Thulasiraj RD Preethi Pradhan Veni g Aravind Eye care System Lions Aravind Institute of community Ophthalmology MaduraiIndia

印度亚拉文医院是世界卫生组织合作单位,创造了“大规模、高质量、低成本”的眼科医疗模式,2005年,医院门诊量达163万多,手术超过22万例,其中白内障手术达16万多例,为世界之最。如何有效地借鉴印度亚拉文的模式为我所用,成为中国眼科界... 详细信息

印度亚拉文医院是世界卫生组织合作单位,创造了“大规模、高质量、低成本”的眼科医疗模式,2005年,医院门诊量达163万多,手术超过22万例,其中白内障手术达16万多例,为世界之最。如何有效地借鉴印度亚拉文的模式为我所用,成为中国眼科界同仁日益热烈讨论的一个话题。本刊特邀印度亚拉文医院的主要负责人就该模式的特点撰文介绍。

关键词：医院管理眼科模式亚拉文模式

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