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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Thermal Comparison of an Organic Rankine Cycle Activated by a Low-Temperature Geothermal Heat Source

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Journal of Mechanics Engineering and Automation 2018年第7期8卷 309-315页

作者： Vera-Romero Iván Corona-Ruíz Silvia L. Martínez Reyes J. Moreno nava I. Ordaz Murillo O. Méndez á brego Víctor M Department of Energy Engineering University of the Ciénega of Michoacán State Sahuayo 59103 Mexico Department of Multicultural Studies University of the Ciénega of Michoacán State Sahuayo 59103 Mexico

This study compares the results from the thermodynamic analysis at an Organic Rankine Cycle power plant,for first and second law efficiency,operating with 14 different working *** plant—located in the town of Los Negritos,in the municipality of Villamar,in the State of Michoacán,Mexico—uses heat from a low-temperature geothermal source with the purpose of identifying the working fluids that are best suited for the operating conditions at *** v.8.0 software was used to collect the thermodynamic *** all the thermodynamic parameters that were analyzed,the fluid that performed the best had an overall energy efficiency of 5.87%,an overall exergy efficiency of 43.07%,and a net output power of 13.04 kWe.

关键词： Organic Rankine cycle geothermal energy Los Negritos thermodynamic analysis exergy

Geochemical Prospection of the Chapala Ciénega at Michoacán State

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International Journal of Geosciences 2014年第9期5卷 1007-1011页

作者： José Martínez Reyes Ivan Vera Romero Meliton Estrada Jaramillo Agustina Ortiz Soriano Ignacio Moreno nava Francisco Gabriel Montes Ayala Francisco García ávalos Ernesto Mendez Ruiz 1University of the Ciénega of Michoacán State Sahuayo México 2Michoacan Society of History Archaeology and Geography A.C. La Palma de Jesús México Michoacan Society of History Archaeology and Geography A.C. La Palma de Jesús México University of the Ciénega of Michoacán State Sahuayo México

The geochemical prospection as a branch of Applied Geochemistry or “Geochemistry of the Landscape” studies the spatial and temporal location of geochemical anomalies in order to locate geological resources of economic value. The Ciénega de Chapala zone in Michoacán is located east of the Citala rift hosting a geological system that leads to regional hydrothermal activity, mainly the Pajacuaran and Ixtlan failures. The regional geothermics include a superficial hydrothermalism consisting of springs and wells of hot water with temperatures between 48°C and 94°C in Ixtlan de los Hervores and mud volcanoes in the water with temperatures between 48°C and 94°C in Ixtlan de los Hervores and mud volcanoes in the Los Negritos. The waters and gases of these hydrothermal manifestations have physicochemical characteristics that indicate the presence of geothermal fluids. To search for possible presence of minerals of economic value, a study of elemental chemical analysis was performed by scanning electron microscopy in samples of rock of the sierra de Pajacuaran, the result of the analysis is clearly abnormal values which may be indicative a geochemical anomaly as well as the possible presence of minerals of economic value in the region. Given the above, the area of the Ciénega de Chapala in Michoacán is a zone where work can be continued both geothermal and mineralogical exploration by conventional techniques or even totally innovative technologies.

关键词： Geochemical Prospection Ciénega Michoacán

Nitrogen/Ammonium Concentration Response of Vegetable and Flower Crops

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Journal of Agricultural Science and Technology(B) 2014年第4期4卷 261-266页

作者： Armando Hemandez-Perez Oscar Gabriel Villegas-Torres Martha Lilia Dominguez-Patifio Martha Lilia Dominguez-Patino Hector Sotelo-nava Antonio Rodriguez-Martinez Luis Alonso Valdez-Aguilar Iria Alia-Tejacal Faculty of Agricultural Sciences University Autonomous of the State of Morelos Cuernavaca 62209 Mexico Faculty of Chemical Sciences and Engineering University Autonomous of the State of Morelos Cuernavaca 62209 Mexico EngineeringandAppliedScience Research Center UniversityAutonomous of the State ofMorelos Cuernavaca 62209 Mexico Department of Horticulture University Autonomus Agrarian Antonio Narro Saltillo 25315 Mexico

Nitrogen （N） is the element with the greatest influence on the growth of vegetables and ornamentals, however, form of delivery, either as nitrate （NO3） or ammonium （NH4＋） has different effects on plant development. The NO3 is the main form of N that plants absorb, but when it is the only source of N that has slight effects on root growth, no effects over enzymatic activities, and stimulates the absorption and translocation of cations within the plant. The NH4＋ is the easiest way of assimilation but is highly toxic when the only source or with respect to the concentration of NO3 is too high. To avoid toxicity, the NH4＋ must not exceed 20% of the total N amount in the formulation, however, it is important to consider the species, variety and environmental conditions. The N as supplied also affects the resistance or susceptibility of plants to diseases, but depends on the species and the type of pathogen.

关键词： Nitrate ammonium vegetables ornamental toxicity nutrition.

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21世纪的多管膜式磺化反应器

日用化学品科学 2000年第S2期23卷 103-108页

作者： G.F.Moretti I.Adami F.nava E.Molteni BALLESTRAS.P.A-MilanoItaly BALLESTRAS.P.A-MilanoItalyBALLESTRAS.P.A-MilanoItalyBALLESTRAS.P.A-MilanoItaly

在过去的 40年中 ,磺化技术已不断地向高质水平改进。在表面活性剂配方的更新过程中 ,磺化阴离子可能一直保持其统治地位。工程师及制造商都将注意力放在“理想工艺”的反应器的设计和使用上。讨论了现代技术的局限性和不完美性。

关键词：磺化多管膜式反应器设计工艺

A High-Resolution Modeling Strategy to Assess Impacts of Climate Change for Mesoamerica and the Caribbean

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American Journal of Climate Change 2016年第2期5卷 202-228页

作者： Robert Oglesby Clinton Rowe Alfred Grunwaldt Ines Ferreira Franklyn Ruiz Jayaka Campbell Luis Alvarado Francisco Argenal Berta Olmedo Alejandro del Castillo Pilar Lopez Edwards Matos Yosef nava Carlos Perez Joel Perez Department of Earth and Atmospheric Sciences University of Nebraska Lincoln NE USA Climate Change and Sustainability Division Inter-American Development Bank Washington DC USA Instituto de Hidrología Meteorología y Estudios Ambientales de Colombia Bogota Colombia University of the West Indies Kingston Jamaica Instituto Meteorológico Nacional Costa Rica San Jose Costa Rica Servicio Meteorológico Nacional de Honduras Dirección General de Aeronáutica Civil Tegucigalpa Honduras Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Water Center for the Humid Tropics of Latin America and the Caribbean (CATHALAC) Ciudad de Panamá Panamá Unidad de Análisis Meteorológico Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Instituto Nacional de Ecología y Cambio Climático Mexico City Mexico National Weather Service MARN San Salvador El Salvador

Mesoamerica and the Caribbean are low-latitude regions at risk for the effects of climate change. Global climate models provide large-scale assessment of climate drivers, but, at a horizontal resolution of 100 km, cannot resolve the effects of topography and land use as they impact the local temperature and precipitation that are keys to climate impacts. We developed a robust dynamical downscaling strategy that used the WRF regional climate model to downscale at 4 - 12 km resolution GCM results. Model verification demonstrates the need for such resolution of topography in order to properly simulate temperatures. Precipitation is more difficult to evaluate, being highly variable in time and space. Overall, a 36 km resolution is inadequate;12 km appears reasonable, especially in regions of low topography, but the 4 km resolution provides the best match with observations. This represents a tradeoff between model resolution and the computational effort needed to make simulations. A key goal is to provide climate change specialists in each country with the information they need to evaluate possible future climate change impacts.

关键词： Regional Climate Models Dynamical Downscaling Strategy Mesoamerica and Caribbean Climate Change

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化纤及其产品的贸易格局正在改变

国际纺织导报 2009年第2期37卷 6-6,8,10页

作者： N. Bywater D. Collier C. nava R. Lee 李刚泰可荣公司

虽说未来的化纤生产领域将逐渐被中国和亚洲其他国家所主导,但仍有部分产品亚洲化纤生产商是不具备能力涉足的,这部分产品依然由欧洲和北美的化纤生产商控制。针对这一由欧洲和北美生产商控制的市场,应利用化纤产品的核心创新技术,并联... 详细信息

虽说未来的化纤生产领域将逐渐被中国和亚洲其他国家所主导,但仍有部分产品亚洲化纤生产商是不具备能力涉足的,这部分产品依然由欧洲和北美的化纤生产商控制。针对这一由欧洲和北美生产商控制的市场,应利用化纤产品的核心创新技术,并联合当地相关方面的专家学者进行不断的研究和开发。

关键词：化纤产品贸易格局变化

Developing Ontology Systems as a Base of an Environmental Quality Management Model in México

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Journal of Environmental Protection 2015年第9期6卷 1084-1093页

作者： René Bernardo Elías Cabrera-Cruz Erika Alarcón-Ruiz Julio César Rolón-Aguilar Salvador W. nava-Díaz Elena María Otazo-Sánchez Ricardo Pérez Aviléz Division of Postgraduate Studies and Research Faculty of Engineering “Arturo Narro Siller” Autonomous University of Tamaulipas Tamaulipas Mexico Center for Chemical Research Autonomous University of Hidalgo State Hidalgo Mexico Institute of Sciences Autonomous University of Puebla Puebla Mexico

The process of identifying the attributes and relationships considered in an ontology is a complex task because there are many factors involved in the deterioration of environmental quality, the diversity of sources and data dispersion. This work presents an ontology that integrates the data required by an Environmental Quality Synoptic System (EQSS), which to date scatters in different Internet sites and concentrates by different agencies for example INEGI, CONABIO, SEMARNAT, CNA, among others. The methodology process consists of the collection of environmental information in Mexico through the application of computational techniques resulting ontology with environmental knowledge that will be processed by the system EQSS. Among the main advantages is than the selection and structure of information allow the automated generation of results in an environmental statement. The ontology proposal is based on knowledge of EQSS system that is based on the architecture of expert systems and through this important information for decision-making in regard to environmental quality and interaction with Geographic Information System (GIS) is obtained.

关键词： Ontology Software Knowledge Modeling Environmental Quality EIA

Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

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World Journal of Cardiovascular Diseases 2021年第9期11卷 439-444页

作者： Jose Antonio Luna-Alvarez-Amezquita Javier Ivan Armenta-Moreno Joaquin Berarducci Jorge Luis Bermudez-Gonzalez Jose Luis Siller-nava Edson Alberto Escandón-Villalobos Nilda Espinola-Zavaleta Roberto Cano-Zarate Juan Ignacio Straface Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico Department of Magnetic Resonance National Institute of Cardiology Ignacio Chavez Mexico City Mexico

Introduction: Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart disease that encompasses an atrioventricular and ventriculoarterial discordance and accounts for less than 1 percent of congenital heart diseases. Objective: To present an atypical case of a man with complex congenital heart disease and conduction anomalies. Case Presentation: This is a case of a 34-year-old patient who came to the hospital with 1 week of dyspnea on exertion and episodes of lipothymia. The patient was referred to our hospital after an electrocardiogram from his primary care with evidence of blocked atrial fibrillation. During the initial evaluation blocked atrial fibrillation was confirmed with a rescue ventricular rate of 38 bpm. A magnetic resonance confirmed the presence of the atrioventricular and ventriculoarterial discordance, the aorta had a left anterior position, perimembranous ventricular septal defect with a right to left shunt, biventricular systolic dysfunction, moderate tricuspid, and mitral regurgitation, interventricular septal intramyocardial and biatrial fibrosis, left atrial dilation, and dilation of the pulmonary artery. After pacemaker placement, the patient has an improvement in his clinical symptoms and quality of life. Conclusions: Cardiac arrhythmias are CCTGA’s leading cause of death, mostly ventricular tachycardia, and atrial fibrillation. Right bundle branch block is a previously unreported and potentially very rare presentati

关键词： Congenital Heart Disease Congenitally Corrected Transposition of the Great Arteries Cardiac Magnetic Resonance Echocardiography Arrhythmia