检索结果-南通市图书馆

The 5-HT2c receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation

引用

Asian Journal of Andrology 2014年第4期16卷 607-610页

作者： paddy kc janssen Ron van Schaik Berend Olivier Marcel D Waldinger Division of Pharmacology Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands Department of Central Hospital Pharmacy Viecuri Hospital Venlo The Netherlands Department of Clinical Chemistry (Akc) Erasmus University Medical Center (Erasmus MC) Rotterdam The Netherlands Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA Outpatient Department of Neurosexology HagaZiekenhuis The Hague The Netherlands.

It has been postulated that the persistent short intravaginal ejaculation latency time （IELT） of men with lifelong premature ejaculation （LPE） is related to 5-hydroxytryptamine （HT）2c receptor functioning. The aim of this study was to investigate the relationship of Cys23Ser 5-HT2c receptor gene polymorphism and the duration of IELT in men with LPE. Therefore, a prospective study was conducted in 64 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-month period. All men were genotyped for Cys23Ser 5-HT2c receptor gene polymorphism. Allele frequencies and genotypes of Cys and Ser variants of 5-HT2c receptor gene polymorphism were determined. Association between Cys/Cys and Ser/Ser genotypes and the natural logarithm of the IELT in men with LPE ***. As a result, the geometric mean, median and natural mean IELT were 25.2, 27.0, 33.9s, respectively. Of all men, 20.0%, 10.8%, 23.1% and 41.5% ejaculated within 10, 10-20, 20-30 and 30-60s after vaginal penetration. Of the 64 men, the Cys/Cys and Ser/Ser genotype frequency for the Cys23Ser polymorphism of the 5-HT2c receptor gene was 81% and 19%, respectively. The geometric mean IELT of the wildtypes （Cys/Cys） is significantly lower （22.6s; 95% CI 18.3-27.8s） than in male homozygous mutants （Ser/Ser）（40.4s; 95% CI 20.3-80.4s）（P = 0.03）. It is concluded that Cys23Ser 5-HT2c receptor gene polymorphism is associated with the IELT in men with LPE. Men with Cys/Cys genotype have shorter IELTs than men with Ser/Ser genotypes.

关键词： 5-HT2c receptor gene Cys23Ser polymorphism intravaginal ejaculation latency time lifelong premature ejaculation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Re： Gene mapping of serotoninergic system polymorphisms provides insight on pathology and treatment of men with lifelong premature ejaculation

引用

Asian Journal of Andrology 2014年第4期16卷 643-643页

作者： paddy kc janssen Ron van Schaik Berend Olivier Marcel D Waldinger Department of Pharmaceutical Sciences Division of Pharmacology Utrecht University Utrecht The Netherlands.

We appreciate and thank Drs Saitz and Serefoglu for their positive and sympathetic words on our article.1 Indeed, our genetic studies have shown that 5-HTTLPR polymorphism, 5-HT1A receptor gene polymorphism and 5-HT2c receptor gene polymorphism are associated with the duration of the intravaginal ejaculatory latency time in men with lifelong premature ejaculation. In line with the remarks） we hope that our stopwatch method will be used by other investigators to investigate the role of serotonergic gene polymorphisms on the duration of the intravaginal ejaculatory latency time.

关键词： @@

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hardy Weinberg Equilibrium in Genetic PE Research Remains Critical to Avoid Misinterpretation

引用

Asian Journal of Andrology 2009年第4期11卷 524-524页

作者： Marcel D. Waldinger paddy K.C. janssen Dave H. Schweitzer Department of Psychiatry and Neurosexology HagaHospital Leyenburg Leyweg 275 2545 CH The Hague the Netherlands 不详

Dear Sir.With interest we have read the article of Ozbek et al. [ 1 ] regarding a possible association of the 5-HTTLPR gene polymorphism and lifelong premature ejaculation （PE） in Turkish men. However, by performing a reanalysis of their data in Table 1, we found major insufficiencies that seriously diminish the validity of their conclusion that there is a higher prevalence of SS genotype in men with lifelong PE. Apart from the fact that in Table 1, the total number of patients and controls should be 69 instead of 70, our reanalysis of their patient data showed that the observed number of genotypes in their patients is not in Hardy Weinberg equilibrium, as the authors have erroneously suggested. This becomes evident by calculating the fraction of observed genotypes in their patients （SS 0.53, SL 0.30,

关键词： no English key word

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：