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Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with nettle

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Journal of Behavioral and Brain Science 2017年第9期7卷 425-445页

作者： Majda Samih pacome kouadio n’go Sabah Belaaouja Amina Ouazzani Touhami Ahmed Omar Touhami Ahami Unit of Clinic and Cognitive neuroscience Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIbn Tofail UniversityKenitraMorocco Training and Research Unit of Biology Sciences Peleforo Gon Coulibaly UniversityKorhogoIvory Coast Botanical and Plant Protection Unit Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIbn Tofail UniversityKenitraMorocco

Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.

关键词： Dimethoate Dioic nettle Acetylcholinesterase Chelation Memory

Developmental effects of Malathion exposure on locomotor activity and anxiety-like behavior in Wistar rat

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Health 2013年第3期5卷 603-611页

作者： pacome kouadio n’go Fatima-Zahra Azzaoui Ahmed Omar Touhami Ahami Porlo Rigobert Soro Mohamed najimi Fatiha Chigr Unit of Clinic and Cognitive neuroscience Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIBN TOFAILUniversityKenitraMorocco Laboratory of Animal Physiology Department of BiologyFaculty of Sciences and TechnologySultan Moulay Slimane UniversityBeni MellalMorocco

Developmental exposure to organophosphate insecticide is well known to induce neurobeha-vioral impairments, at late period. The present study aims to investigate the effects of chronic exposure to Malathion, from in utero to young adult stage, on locomotor skills and anxiety like- behavior among wistar rat. Four groups of female rats, bred with one non-pesticide exposed male, are used. On gestational day 6, three groups receive daily, by intragastric gavage, 3 different doses of Malathion dissolved in corn oil (100, 200 and 300 mg/kg body weight). The control group receives the corn oil only. On postnatal day 21, weaned offsprings are submitted to the similar treatment until adult age. Spontaneous locomotor activity is evaluated using the Open-Field test (OF) and anxiety-like behavior is measured using both Open-Field (OF) test and Elevate Plus-Maze (EPM). Malathion at 300 mg/kg is toxic to pregnant dams, and pups are stillborns. In males, Malathionlevelat 100 and 200 mg/kg induced significant impairment of spontaneous locomotor activities, which is reflected by high decrease of number of squares crossed in OF. In contrast, no discernible changes are observed within females Malathion-treated-group. However, females exposed to both malathion levels develop further anxiety-like response, expressed by significant reductions of exploratory activities in OF and time spent in open arm of EPM. neurochemistry assay shows that cerebellum and neocortex acetylcholinesterase (AChE) activity inhibition are significantly increased with neurobehavioral deficits in males, relative to females. Overall, neurobehavioral outcomes of current study reveal that developmental exposure to Malathion induces sex-selective effects with greater changes in females.

关键词： AChE Activity Developmental neurotoxicity Malathion neurobehavior Organophosphate Insecticides

Methyl Donors Supplementation Attenuates the Adverse Effects of Maternal High Fructose Diet of Offspring Emotional and Cognitive Behaviors

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Open Journal of Endocrine and Metabolic Diseases 2017年第11期7卷 203-218页

作者： Sidi Mohamed Coulibaly Abdelhalem Mesfioui Ali Ouichou pacome kouadio n’go Amina El Hasnaoui Abdeljabbar nassiri Aboubaker El Hessni Laboratory of Genetics Neuroendocrinology and BiotechnologyFaculty of SciencesUniversity Ibn TofailKenitraMorocco Training and Research Unit of Biology Sciences Peleforo Gon Coulibaly UniversityKorhogoIvory Coast

Free Fatty acid is an end-product of hepatic metabolism of fructose. Most of past studies have demonstrated significant relationship between gestational high fat diet and metabolic and physiology outcomes in offspring. However, there is a scarce of data extended to the effects of high fructose diet-fed dams on juveniles’ progeny. Therefore, the present experiment was designed to examine the later effects of maternal high fructose diet intake during pregnancy and lactation on juvenile offspring rats emotional behaviors and memory abilities. We tested whether methyl donors supplemented to that high fructose diet could reverse the adverse effects. We found at two months of age, anxiety-like behavior and depression-like behavior were elevated in off springs of mother fed to high fructose diet and a sex difference effect with males were more affected than females. In addition, behavioral outcomes indicated that the high fructose diet also impaired spatial working and recognition memories in the Y-maze and object recognition test respectively. Blood glucose intolerance increased significantly in juvenile males rats of dams fed with high fructose diet when compared to females. However, a supplementation of the maternal diet with methyl donors attenuated all these changes. Our study suggested a controlled fructose diet supplemented to methyl donors during critical period of brain developing (in utero and pre-weaning stage), otherwise that could induced irreversible detrimental effects on offspring behavior and cognitive health.

关键词： High Fructose Diet Methyl Donors Anxiety-Like Depressive-Like Memory Glucose Intolerance Rat Offspring

Developmental Effects of Malathion Exposure on Recognition Memory and Spatial Learning in Males Wistar Rats

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Journal of Behavioral and Brain Science 2013年第3期3卷 331-340页

作者： pacome kouadio n’go Fatima-Zahra Azzaoui Porlo Rigobert Soro Majda Samih Ahmed Omar Touhami Ahami Mohamed najimi Fatiha Chigr Unit of Clinics and Cognitives neurosciences Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesUniversity Ibn TofailKenitraMorocco Laboratory of Physiology Animal Department of BiologyFaculty of Sciences and TechnologyUniversity Sultan Moulay SlimaneBeni MellalMorocco

Most cognitive effects of Organophosphate Pesticides (OP) are induced after exposure to parathion, chlorpyrifos and diazinon, which the usage has been restricted because of overt signs of their toxicities. In this study, we investigate whether developmental exposure to Malathion could impair spatial learning and recognition memory in male rats. Animals exposed by intragastric route, from in utero to young adult stage, to incremental doses of Malathion dissolved in corn oil;100, 200 and 300 mg/kg of body weight, and one control group are given corn oil. Then, cognitive and behaveioral abilities are assessed using Barnes maze and object recognition memory task. Malathion administration at 300 mg/kg is toxic to pregnant dams, and pups are stillborns. Rats exposed to 200 mg/kg make a significant working memory error, and require more time to find an escape box during the initial training phase of Barnes maze. However, fewer errors are made in rats exposed to 100 mg/kg. For reversal learning task, the high dose group shows great deficits in spatial strategy to locate the new position of the box. With respect to recognition task, both dose 100 and 200 mg/kg impair significant short-term (2 h after habituation phase) object recognition memory, but long-term (24 h after habituation phase) recognition memory is intact in high dose group. The current study also reveals that all treatments induce high significant neocortex acetylcholinesterase (AChE) activity inhibition, but 100 mg/kg dose is not sufficient to disrupt great hippocampal activity alteration. These results suggest that developmental exposure to Malathion, despite low toxicity described, may induce late-emerging spatial learning and recognition memorialterations. Moreover, Cortical and hippocampal area that support strongly these behaviors remain sensitive to incremental doses of Malathion.

关键词： AChE Developmental neurotoxicity Malathion Organophosphate Pesticide Recognition Memory Spatial Learning

Environmental Change in Agricultural Land in Southwest Cote d’Ivoire:Driving Forces and Impacts

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Journal of Environmental Protection 2013年第12期4卷 1373-1382页

作者： A.Y.n’go J.T.Ama-Abina A.Z.kouadio H.K.Kouassi I.Savane nangui Abrogoua University Environmental and Geosciences LaboratoryCote d’Ivoire Jean Lorougnon Guede University of Daloa Cote d’Ivoire

Environmental conditions change in the Southwest of Cote d’Ivoire has been a major issue in development debates over the last decades. Using remote sensing based on land cover change analysis, climatic data, national statistical data, we analyzed the drivers of environmental change in Southwestern of Cote d’Ivoire. Being part of the perennial crops basin, Southwestern of Cote d’Ivoire has witnessed rapid degradation of environmental conditions caused by the conversion of forest areas to agricultural land during the last 20 - 30 years and by a combination of decline in precipitation, soil degradation, a diversity of policies with little concern for the environment and population pressure. We concluded that while climate variability has influenced environmental change in the area of Sassandra, various types of anthropogenic and State interventions in agriculture appear to have been the main underlying causes of environmental degradation.

关键词： Land Use Climate Variability Environmental Change Population Pressure Sassandra Cote d’Ivoire