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Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis

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World Journal of Gastroenterology 1998年第2期4卷 61-65页

作者： Zhu, HM Huang, X Deng, CZ Porro, GP pace, f Sangaletti, O Jinan Univ Coll Med Affiliated Hosp 2 Dept Gastroenterol Shenzhen 518001 Guangdong Peoples R China Milan Univ Hosp Div Gastroenterol Milan Italy

AIM To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in the development of esophagitis. METHODS Gastric acid secretory testing and 24 h intraesophageal pH monitoring were performed in 31 patients with esophagitis and concomitant duodenal ulcer (E+DU) and compared with those of 72 patients with esophagitis (E) alone. RESULTS The GAO in patients with E+DU was significantly higher than in patients with E ( P ficant difference between the two groups of patients as to endoscopicl findings and parameters of GER ( P >0 05). A multiple regression analysis with stepwise deletion showed that the pre sence of hiatal hernia (HH), GER in upright position and age appeared to correlate significantly with the presence of esophagitis. CONCLUSIONS No parallel relationship between GAO and severity of GER or esophageal lesions exists in patients with E+DU, and that GAO is not a major pathogenetic factor in GER disease.

关键词： esophagitis/etiology gastric acid/secretion duodenal ulcer/etiology gastroesophageal reflux/etiology hydrogen ion concentration multivariate analysis

Gastroesophageal reflux: the features in elderlypatients

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World Journal of Gastroenterology 1999年第5期5卷 421-423页

作者： Huang X Zhu HM Deng CZ Porro GB Sangaletti O pace f Shenzhen Peoples Hosp Dept Gastroenterol Shenzhen 518001 Guangdong Prov Peoples R China Univ Milan Gastrointestinal Unit Milan Italy

AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger *** Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger *** The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pHflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P flux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P f grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (Pflux and esophageal *** incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients.

关键词： gastroesophageal reflux esophagitis hiatal hernia

Climate change and human health: Last call to arms for us

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World Journal of Clinical Cases 2024年第11期12卷 1870-1874页

作者： Antonio Corrente Maria Caterina pace Marco fiore Department of Anaesthesiology and Intensive Care Medicine The Anastasia Guerriero HospitalMarcianise 81025CasertaItaly Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

Climate change,now the foremost global health hazard,poses multifaceted challenges to human *** editorial elucidates the extensive impact of climate change on health,emphasising the increasing burden of diseases and the exacerbation of health *** highlights the critical role of the healthcare sector,particularly anaesthesia,in both contributing to and mitigating climate *** is a call to action for the medical community to recognise and respond to the health challenges posed by climate change.

关键词： Climate change Carbon footprint Sustainability Greenhouse gases Anaesthetic gases Environmental impact Disposable laryngoscope blades

The Solution of the Einstein’s Equations in the Vacuum Region Surrounding a Spherically Symmetric Mass Distribution

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Journal of Modern Physics 2024年第9期15卷 1353-1374页

作者： Carlo Maria pace ICRANet Pescara Italy

In this article, we address the solution of the Einstein’s equations in the vacuum region surrounding a spherically symmetric mass distribution. There are two different types of mathematical solutions, depending on the value of a constant of integration. These two types of solutions are analysed from a physical point of view. The comparison with the linear theory limit is also considered. This leads to a new solution, different from the well known one. If one considers the observational data in the weak field limit this new solution is in agreement with the available data. While the traditional Schwarzschild solution is characterized by a horizon at r=2GM/c2, no horizon exists in this new solution.

关键词： General Theory of Relativity Schwarzschild Solution Event Horizon Black Hole

The Correct Reissner-Nordstrøm, Kerr and Kerr-Newman Metrics

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Journal of Modern Physics 2024年第10期15卷 1502-1522页

作者： Carlo Maria pace ICRANet Pescara Italy

In a very recent article of mine I have corrected the traditional derivation of the Schwarzschild metric thus arriving to formulate a correct Schwarzschild metric different from the traditional Schwarzschild metric. In this article, starting from this correct Schwarzschild metric, I also propose corrections to the other traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics on the basis of the fact that these metrics should be equal to the correct Schwarzschild metric in the borderline case in which they reduce to the case described by this metric. In this way, we see that, like the correct Schwarzschild metric, also the correct Reissner-Nordstrøm, Kerr and Kerr-Newman metrics do not present any event horizon (and therefore do not present any black hole) unlike the traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics.

关键词： General Theory of Relativity Schwarzschild Reissner-Nordstrøm Kerr Kerr-Newman Metric Event Horizon Black Hole

Review and update on the management of triangular fibrocartilage complex injuries in professional athletes

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World Journal of Orthopedics 2024年第2期15卷 110-117页

作者： Valerio pace francesco Bronzini Giovanni Novello Giuseppe Mosillo Luca Braghiroli Department of Trauma and Orthopaedics AOSP TerniTerni 05100Italy Department of Trauma and Orthopaedics University of PerugiaPerugia 06100Italy Department of Trauma and Orthopaedics Hand UnitAOSP TerniTerni 05100Italy

Triangular fibrocartilage complex injuries are common in amateur and professional *** injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar *** order to treat professional athletes,a detailed specific knowledge of the pathology is ***,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position *** early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be *** procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same *** measures are often used as first line treatment when *** lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic *** procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation.

关键词： Triangular fibrocartilage complex injuries Professional athletes Ulnar sided wrist pain Wrist arthroscopy Wrist debridement

Orthopedic manifestations of Li-fraumeni syndrome:Prevention and treatment of a polymorphic spectrum of malignancies

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World Journal of Clinical Cases 2024年第26期12卷 5839-5844页

作者： Giulia Cenci Valerio pace Department of Trauma and Orthopedics Azienda Ospedaliera Santa Maria HospitalTerni 05100Italy Department of Trauma and Orthopedics AOSP TerniTerni 05100Italy

Li-fraumeni syndrome(LfS)is a rare hereditary cancer predisposition syndrome characterized by a heightened risk of developing various malignancies at an early *** evidence suggests a correlation between LfS and orthopedic manifestations,underscoring the importance of orthopedic screening in individuals with this *** cancer is *** is estimated that more than 10%-15%of tumors are secondary to a pathogenic variant in a cancer predisposition *** than 100 cancer predisposition genes and their association with syndromes or isolated tumors have been *** is one of those who have been most widely *** with this syndrome present a high risk of developing one or more *** knowledge enables the establishment of a follow-up protocol for the patient and affected family members,facilitating early detection of new tumors and reducing tumor and treatment-related morbidity and *** primary objective of this invited editorial article is to provide a thorough review of the existing knowledge of LfS and its polymorphic spectrum of related malignancies,with a focus on aspects directly linked to orthopedic *** objective is to offer an update on the most modern prevention,treatment and follow up guidelines that could be useful for the physicians dealing with this cohort of patients.

关键词： Li-fraumeni syndrome Tumor protein P53 Orthopedic diseases Osteosarcoma Chondrosarcoma Screening Prevention

质子泵抑制剂按需维持治疗非糜烂性胃食管反流病与连续治疗同样有效

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英国医学杂志中文版 2008年第2期11卷 111-112页

作者： pace f Tonini M Pallotta S 高健(译) Systematic review: maintenance treatment of gastro-oesophagealreflux disease with proton pump inhibitors taken on-demand. Aliment Pharmacol Ther 2007 不详

问题：对胃食管反流病（GORD）患者来说，质子泵抑制（PPIs）按需维持治疗是否能有效控制症状，和防止复发？

关键词：非糜烂性胃食管反流病质子泵抑制剂维持治疗连续治疗控制症状防止复发

Pain management in acute musculoskeletal injury: Effect of opioid vs nonopioid medications

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World Journal of Orthopedics 2024年第9期15卷 882-890页

作者： Marco fiore Luigi Aurelio Nasto Eleni McCaffery fannia Barletta Angela Visconti francesca Gargano Enrico Pola Maria Caterina pace Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Orthopaedics University of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine New York Presbyterian-Brooklyn Methodist HospitalNew YorkNY 11215United States Department of Anesthesia and Intensive Care “San Carlo”HospitalPotenza 85100Italy Department of Anaesthesia “San Giuliano”HospitalGiugliano 80014Italy Unit of Anesthesia and Intensive Care The Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy

BACKGROUND The use of opioids for pain is linked to an increased risk of developing opioid use disorder,and has resulted in the emergence of the opioid crisis over the last few *** The systematic review question is“How does the use of opioid medications in pain management,compared with non-opioid medications,affect pain intensity over the short,intermediate,and long-term in adults with acute traumatic pain?”.METHODS The protocol was prospectively registered on the International Prospective Re-gister of Systematic Reviews:*** and Google Scholar were electronically searched for controlled peer-reviewed studies published in full,with the PICO framework:P:Adult patients with traumatic injuries,I:Opioid medications,C:Non-opioid medi-cations,O:A minimum clinically important difference(MCID)in *** After full-text screening,we included 14 studies in the qualitative *** these 14 studies,12 were rando-mized clinical trials(RCTs)and 2 were pseudo-RCTs with a total of 2347 patients *** was heteroge-neity in both medication utilized and outcome in these studies;only two studies were homogeneous regarding the type of study conducted,the opioid used,its comparator,and the outcome *** MCID was evaluated in 8 studies,while in 6 studies,any measured pain reduction was considered as an *** 11 cases,the setting of care was the Emergency Department;in 2 cases,care occurred out-of-hospital;and in one case,the setting was not *** included studies were found to have a low-moderate risk of *** Non-opioids can be considered an alternative to opioids for short-term pain management of acute musculoskeletal *** ketamine may cause more adverse events than other routes of administration.

关键词： Acute musculoskeletal injury Acute traumatic pain Non-opioid analgesia Non-opioid pain control Opioid-sparing analgesia Opioid crisis Opioid disorder Systematic review