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Empirical mode decomposition of multiphase flows in porous media:characteristic scales and speed of convergence

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Petroleum Science 2020年第1期17卷 153-167页

作者： Nicolás Echebarrena pablo D.Mininni Gustavo A.Moreno YPF-Technology EnsenadaBuenos AiresArgentina CONICET Buenos AiresArgentina Physics Department IFIBASchool of Exact and Natural SciencesUniversity of Buenos AiresCONICETUniversity Campus1428 Buenos AiresArgentina

We apply a proper orthogonal decomposition(POD)to data stemming from numerical simulations of a fingering instability in a multiphase flow passing through obstacles in a porous medium,to study water injection processes in the production of hydrocarbon *** show that the time evolution of a properly defined flow correlation length can be used to identify the onset of the fingering *** of characteristic lengths for each of the modes resulting from the POD provides further information on the dynamics of the ***,using numerical simulations with different viscosity ratios,we show that the convergence of the POD depends non-trivially on whether the fingering instability develops or *** result has implications on proposed methods to decrease the dimensionality of the problem by deriving reduced dynamical systems after truncating the system’s governing equations to a few POD modes.

关键词： Two-phase flow Empirical mode decomposition Viscous fingering Porous media

Beyond vertebrates:the amphioxus as a relevant model system to explore the formation,organization,and regeneration of neuromuscular synapses

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Neural Regeneration Research 2022年第11期17卷 2425-2426页

作者： Esperanza Martínez Sylvain Marcellini Juan pablo Henríquez Neuromuscular Studies Lab (NeSt Lab) Group for the Study of Developmental Processes (GDeP) Department of Cell BiologyFaculty of Biological SciencesUniversidad de Concepción Laboratory of Development and Evolution (LADE)

The neuromuscular junction(NMJ)is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of *** humans,the mature NMJ is the primary target of morphological disassembly and fu... 详细信息

关键词： system contraction synapse

Automatic counting of microglial cell activation and its applications

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Neural Regeneration Research 2016年第8期11卷 1212-1215页

作者： Beatriz I.Gallego Collado pablo de Gracia Instituto de Investigaciones Oftalmologicas Ramon Castroviejo Universidad Complutense de Madrid Madrid Spain Facultad de Optica y Optometria Departamento de Oftalmologia y Otorrinolaringologia Universidad Complutense de Madrid Madrid Spain Midwestern University Chicago College of Optometry Downers Grove IL USA Department of Neurobiology Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ USA

Glaucoma is a multifactorial optic neuropathy characterized by the damage and death of the retinal ganglion *** disease results in vision loss and *** vision loss resulting from the disease cannot be restored and nowadays there is no available cure for glaucoma; however an early detection and treatment,could offer neuronal protection and avoid later serious damages to the visual function.A full understanding of the etiology of the disease will still require the contribution of many scientific *** activation has been observed in glaucoma,being microglial proliferation a hallmark in this neurodegenerative disease.A typical project studying these cellular changes involved in glaucoma often needs thousands of images- from several animals- covering different layers and regions of the *** gold standard to evaluate them is the manual *** method requires a large amount of time from specialized *** is a tedious process and prone to human *** present here a new method to count microglial cells by using a computer *** counts in one hour the same number of images that a researcher counts in four weeks,with no loss of reliability.

关键词： glaucoma glial cells microglial cells automatic counting image processing inner plexiform layer outer plexiform layer bilateral activation

Use of generated artificial road profiles in road roughness evaluation

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Journal of Modern Transportation 2017年第1期25卷 24-33页

作者： Giuseppe Loprencipe pablo Zoccali Department of Civil Building and Environmental EngineeringSapienza University of RomeVia Eudossiana1800184 RomeItaly

In the evaluation of road roughness and its effects on vehicles response in terms of ride quality, loads induced on pavement, drivers＇ comfort, etc., it is very common to generate road profles based on the equation provided by ISO 8608 standard, according to which it is possible to group road surface profiles into eight different classes. However, real profiles are significantly different from the artificial ones because of the non-stationary fea- ture of the first ones and the not full capability of the ISO 8608 equation to correctly describe the frequency content of real road profiles. In this paper, the international roughness index, the frequency-weighted vertical acceleration awz according to ISO 2631, and the dynamic load index are applied both on artificial and real profiles, highlighting the different results obtained. The analysis carried out in this work has highlighted some limitation of the ISO 8608 approach in the description of performance and conditions of real pavement profiles. Furthermore, the different sensitivity of the various indices to the fitted power spectral density parameters is shown, which should be taken into account when performing analysis using artificial profiles.

关键词： Ride quality International roughness indexDynamic load index Road surface irregularities - ISO2631 ISO 8608 Real road profiles Artificial roadprofiles

TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration

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Neural Regeneration Research 2016年第8期11卷 1204-1207页

作者： Ricardo Ramírez-Barrantes Ivanny Marchant pablo Olivero Escuela de Medicina Universidad de Valparaíso

Aging induces physical deterioration,loss of the blood brain barrier,neuronal loss-induced mental and neurodegenerative ***-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated *** steroids support important functions,exert pleiotropic effects in different sensory cells,promote regeneration,plasticity and health of the nervous *** diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative ***,restoring neuroendocrine axes during aging can be key to enhance brain health through neuroprotection and neuroregeneration,depending on the modulation of plasticity ***-dependent transient receptor potential cation channel,subfamily V,member 1（TRPV1） expression induces neuroprotection,neurogenesis and regeneration on damaged *** of TRPV1 can modulate neuroprotection and repair of sensitive neurons,while modulators as other cognitive enhancers may improve the survival rate,differentiation and integration of neural stem cell progenitors in functional neural *** constitutes a relevant clinical model of steroidal production decline associated with progressive cognitive and mental impairment,which allows exploring the effects of hormone therapy in health outcomes such as dysfunction of *** the administration of hormone therapy to virtual menopausal individuals allows assessing its hypothetical impact and sensitivity to conditions that modify the effectiveness and efficiency.

关键词： TRPV1 estrogen hormonal replacent neuroprotection aging

Peridynamic State-Based Models and the Embedded-Atom Model

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Communications in Computational Physics 2014年第1期15卷 179-205页

作者： pablo Seleson Michael L.Parks Max Gunzburger Institute for Computational Engineering and Sciences 201 East 24th StStop C0200AustinTexas 78712-1229USA. Sandia National Laboratories Computing Research CenterP.O.Box 5800MS 1320AlbuquerqueNM 87185-1320USA. Department of Scientific Computing 400 Dirac Science LibraryFlorida State UniversityTallahasseeFL 32306-4120USA.

We investigate connections between nonlocal continuum models and molecular dynamics.A continuous upscaling of molecular dynamics models of the form of the embedded-atom model is presented,providing means for simulating molecular dynamics systems at greatly reduced *** are presented for structured and structureless material models,supported by computational *** nonlocal continuum models are shown to be instances of the state-based peridynamics *** relating multibody peridynamic models and upscaled nonlocal continuum models are derived.

关键词： Peridynamics multibody potentials embedded-atom molecular dynamics.

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Preliminary results of a new intrastromal corneal ring segment as a tissue saving procedure in photorefractive keratectomy to correct moderate to high myopia

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1955-1960页

作者： Sandro Coscarelli pablo Rodrigues Guilherme Rocha Leonardo Torquetti Ennio Coscarelli Eye Clinic Belo Horizonte 30140-001Brazil Escola Paulista de Medicina Sao Paulo 04023-062Brazil Hospital de Olhos de Brasilia Brasilia 70200-670Brazil Center of Excellence in Ophthalmology Para de Minas 35660-051Brazil

AIM:To evaluate the clinical results after implantation of a new intrastromal corneal ring segment(ICRS)associated with photorefractive keratectomy(PRK)to correct high myopia(HM)patients with thin ***:We evaluated 42 eyes of 23 HM patients that had ICRS implantation followed by *** mean age of patients was 29.1±7.12 y(range 18 to 40 years old).Uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),keratometry,spherical equivalent,pachymetry,and aberrometry were compared using ANOVA with repeated measurements evaluated preoperatively and at last follow-up visit after the *** refractive predictability and simulated/real corneal ablation were also ***:The mean follow-up time after PRK was 6.8±1.6 *** mean preoperative UCVA improved from 20/800 preoperative to 20/100 after ICRS and 20/35 after *** mean preoperative BCVA was 20/25(range from 20/30 to 20/20)and remained unchanged after ICRS *** the PRK the mean BCVA was 20/25(range from 20/30 to 20/20).The mean spherical equivalent decreased from-7.25±1.12(range-5.00 to-9.00)preoperatively to-3.32±1.0(range-2.00 to-5.00)postoperatively(P<0.001)after ICRS implantation and decreased from-2.44±1.51 preoperatively to 0.32±0.45(range-0.625 to 0.875)postoperatively(P<0.001)after *** change in BCVA and topographic astigmatism was statistically significant(P<0.0001).CONCLUSION:ICRS in HM associated with PRK can be a tissue saving procedure and an alternative surgical option for correction of moderate to high myopia.

关键词： high myopia intrastromal corneal ring segments photorefractive keratectomy

Protein Shuttle between Nucleus and Cytoplasm:New Paradigms in the ABI5-dependent ABA Responses

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Molecular Plant 2019年第11期12卷 1425-1427页

作者： Inmaculada Sanchez-Vicente pablo Albertos Oscar Lorenzo Dpto.de Botanica y Fisiologia Vegetal Instituto Hispano-Luso de Investigaciones Agrarias(CIALE)Facultad de BiologiaUniversidad de SalamancaC/Rio Duero 1237185 SalamancaSpain Present address:Biotechnology in Horticultural Crops TU Munchen-WeihenstephanLiesel-Beckmann-Strasse 185354 FreisingGermany

Plant survival depends on seed germination,progression through post-germinative developmental checkpoints,and adaptation to abiotic *** these processes underlie a tightly controlled regulation by the stress hormone abscisic acid(ABA)at different levels,even though the main research focuses on changes in transcript and protein ***,protein fate undergoes complex readjustments that allow signal transduction to be integrated into physiological *** them,protein redox status,stability,capacity of oligomerization,formation of complexes,and subcellular compartmentalization become key points for plant reprogramming against stresses to acquire an optimal *** this Spotlight,we highlight and discuss the latest advances in dissecting the mechanisms driving protein dynamics of nucleocytoplasmic trafficking in the cell and its relevance for regulating the stability of ABI5 and the ABI5-dependent AB A signaling pathway(Figure 1).

关键词： Figure driving programming