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秘中关系中的一件大事

当代世界 2021年第11期 79-79页

作者：佩德罗·巴勃罗·库琴斯基不详

编辑朋友:今年6月,当我开始动笔给习近平总书记写信祝贺中国共产党百年华诞时,不禁想起这100年来世界特别是中国所发生的巨变。在这100年间,中国不仅成为世界经济和科技进步的引领者,而且使数亿中国人摆脱贫困并过上了美好生活。在撰写... 详细信息

编辑朋友:今年6月,当我开始动笔给习近平总书记写信祝贺中国共产党百年华诞时,不禁想起这100年来世界特别是中国所发生的巨变。在这100年间,中国不仅成为世界经济和科技进步的引领者,而且使数亿中国人摆脱贫困并过上了美好生活。在撰写这封短信时,我很想知道父亲20世纪20年代中期在中亚和中国工作的情景。虽然他没有给我留下关于那段经历的文字记载,但我知道他直至生命的最后时刻还想着要再到中国去。我对中国所发生的一切抱有的浓厚兴趣或许源于此吧。

关键词：百年华诞科技进步美好生活摆脱贫困引领者动笔习近平总书记

AB045. Prognostic significance and characterization of small epithelioid cell population in uveal melanoma

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Annals of Eye Science 2018年第1期 451-451页

作者： Prisca Bustamante pablo Zoroquiain Evangelina Esposito Ciro Garcia Maria A.Saornil Wiliam April Miguel Burnier Henry C.Witelson Ocular Pathology Laboratory McGill University Health Centre Research InstituteMontrealQCCanada Department of Pathology School of MedicinePontifial Catholic University of ChileSantiagoChile

Background:Uveal melanoma(UM)is a malignant neoplasia that is composed of two main types of cells:spindle and *** is a subset of neoplastic small epithelioid cells located predominantly in the infiltrative tumor margins or surrounding blood *** aim of this study is to characterize and evaluate the correlation between the presence of these small epithelioid cells and clinical ***:The clinical-pathological features of 70 UM patients were *** presence of small epithelioid cells was quantified based on percentage of tumor volume,and they were characterized using melanocytic markers(HMB-45,Melan A and SOX-10),stem cell markers(CD133,CD24 and CD38),and T cell lymphocytes(CD3).Univariate and multivariate analyses were *** follow up was available for all ***:The ratio of small epithelioid cell components of all 70 tumors ranged from 0%to 30%(median,1%).Thirty-nine tumors(55.7%)had areas with small epithelioid *** analysis showed that mixed versus spindle cell,higher lymphocytic infiltration,macrophage infiltration,ciliary body involvement,and>5%of small epithelioid cell component had a significant negative impact on metastasis-free *** epithelioid cell component>5%was present in 24 cases(34.3%).Of these,three were classified as spindle and 21 were *** analysis revealed that a>5%small cell component was the most significant morphological adverse prognostic ***,the small epithelioid cells were negative for HMB45,stem cell markers and CD3,and focally and weakly positive for MELAN A and ***:A high small epithelioid cell component is a strong negative prognostic indicator in patients with UM.

关键词： Uveal melanoma(UM) small epithelioid cell

AB079. HER2 as a possible therapeutic target in squamous cell carcinoma of the conjunctiva

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Annals of Eye Science 2018年第1期 485-485页

作者： Paulina García de Alba Graue Evangelina Esposito pablo Zoroquiain Ana Beatriz Toledo Dias Miguel Burnier MUHC-McGill Ocular Pathology Laboratory McGill UniversityMontrealQCCanada Department of Ophthalmology McGill UniversityMontrealQCCanada

Background:Invasive squamous carcinoma(SCC)is the most frequent malignant neoplasia of the conjunctiva,33%of which will metastasize.C-erbB-2/neu(HER2)is an oncogene associated with poor prognosis,metastatic potential and aggressive behavior in several tumors,including breast,stomach,among ***2 amplification is also associated with the response to anti-HER2 *** aim of this study is to evaluate HER2 expression in the progression of ocular surface squamous neoplasia(OSSN)and as a potential therapeutical ***:Ninety-eight OSSN lesions including 17 papillomas(P),27 conjunctival intraepithelial neoplasia(CIN)I,19 CIN II,13 CIN III,and 11 SCC were *** conjunctivas from normal human eyes(NHE)were also included in the *** was performed to analyze HER2(clone 29D8)expression,which was graded as follows:complete membrane staining in more than 10%of malignant cells(3+);week to moderate complete staining in more than 10%of malignant cells(2+);none or fewer than 10%cells staining(0 to 1+,respectively).Positive HER2 was considered when a score 2+or 3+was *** carcinoma with HER2 amplification was used as a positive *** technique was performed in the positive cases to confirm *** analysis was performed using Fisher’s exact ***:HER2 positive expression was detected in 6%of P(100%score 2+),11%of CIN I(100%score 2+),32%of CIN II(100%score 2+),30%of CIN III(100%score 2+),29%of SCC(50%score 2+and 50%score 3+).Benign lesions showed lower HER2 expression than in situ(P=0.03)and invasive tumors(P=0.02).No correlation between HER2 and age or tumor thickness in SCC was found(P>0.05).Conclusions:HER2 is expressed in conjunctival ***,one third of SCC were graded as 2+or 3+.These results support the evaluation of anti-HER2 therapy in conjunctival ***-clinical trials should be performed to determine the importance of this marker in conjunctival SCC for predicting response

关键词： HER2 invasive squamous carcinoma conjunctiva

太极拳对老年女性下肢静态平衡、本体感觉与功能活动的影响

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中华老年骨科与康复电子杂志 2018年第5期4卷 296-301页

作者：王哲培张凯保罗汪毅白震民北京体育大学运动医学与康复学院 100084 北京体育大学运动人体科学学院 100084 北京体育大学校医院 100084

目的探讨长期太极拳运动对老年女性下肢静态平衡能力、本体感觉以及功能活动的影响。方法对日常生活中长期进行太极拳运动的老年女性、无锻炼习惯的老年女性、无锻炼习惯的普通女大学生(非体育生)各10名进行前瞻性研究,利用Technobody P... 详细信息

目的探讨长期太极拳运动对老年女性下肢静态平衡能力、本体感觉以及功能活动的影响。方法对日常生活中长期进行太极拳运动的老年女性、无锻炼习惯的老年女性、无锻炼习惯的普通女大学生(非体育生)各10名进行前瞻性研究,利用Technobody PK254平衡测试及训练系统对其静态平衡与本体感觉进行评估。运用常用的五次"坐-站"测试(Five Times Sit-to-Stand Test,FTSST)、"计时起立-行走"测试(Time Up and Go Test,TUGT),6 m步行测试与三姿平衡测试下肢功能活动情况。结果长期进行太极拳运动的老年女性的静态运动椭圆面积与动态平均轨迹差明显优于无锻炼习惯的老年女性(左侧:t=3.684,P=0.003;右侧:t=4.812,P=0.001);与女大学生对照组比较,差异无统计学意义。在下肢功能测试中,老年女性太极拳运动人群与无锻炼习惯的老年女性相比,差异有统计学意义(FTSST测试:t=2.435,P=0.026;TUGT测试:t=4.050,P<0.01;6 m常速:t=9.015,P<0.01;6 m快速:t=7.208,P<0.01)。结论长期练习太极拳可能对老年女性下肢平衡能力和功能活动的提高与改善有积极意义。

关键词：太极老年人平衡能力功能活动

G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用:FPR促进胶质瘤细胞的成瘤性

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G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用...

第三届中国肿瘤学术大会

作者：卞修武周烨乐颖英龚旺华张夏 pablo Iribarren Rosalba Salcedo O.M.Zack Howard WilliamFarrar 王吉民第三军医大学西南医院病理学研究所第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院实验免疫学实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院基础研究计划室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚... 详细信息

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚。本研究探讨FPR在胶质瘤生长和血管生成中的作用。方法:本研究首先采用免疫组织（细胞）化学和RT-PCR方法,检测不同分化程度的人胶质瘤组织和细胞系中FPR基因和蛋白表达;采用FMLP结合（激活）FPR后,用细胞趋化试验检测瘤细胞迁移情况,用Western免疫印迹、电泳运动漂移分析（EMSA）、ELASIA等技术检测细胞检测信号转导通路相关信号分子磷酸化改变、HIF1α和NFkB核转位、DNA-NFkB复合物形成以及VEGF产生。应用荧光显微分光技术检测Ca2+流变化,用流式细胞术检测细胞FPR,小管形成试验观察肿瘤细胞诱导内皮细胞HUVEC小管形成情况。用siRNA干扰胶质瘤细胞FPR的功能性表达,观察受干扰细胞在无胸腺裸小鼠的移植瘤形成和生长情况。结果:在人高度恶性的胶质瘤（WHO Ⅲ级和Ⅳ级）组织中的瘤细胞检测到了FPR表达,但在低级别（WHO Ⅱ级）胶质瘤表达阴性;体外研究结果与原位肿瘤相似,即,仅高度恶性起源的胶质瘤细胞系表达该受体（mRNA和蛋白）。激活胶质瘤细胞FPR后,瘤细胞的趋化运动增强,细胞信号转导MAPKs和PI3K通路激活,包括ERK1/2、JNK和Akt.快速磷酸化;FPR激活还诱导了NFkB核转位、形成了DNA-NFkB复合物,并刺激了HIF-1α核转位,使瘤细胞血管内皮细胞生长因子（VEGF）基因和蛋白表达增多。胶质母细胞瘤瘤细胞培养上清能诱导内皮细胞迁移和小管形成,而这种作用可被抗VEGF抗体阻断,提示FPR激活后瘤细胞所产生的VEGF在启动恶性胶质瘤的血管生成中有重要作用。进一步的体内实验显示,高表达FPR的胶质母细胞瘤细胞系U87接种到元胸腺裸小鼠后成瘤性和生长速率高于低表达FPR的SHG-44细胞。采用siRNA干扰FPR表达和功能后,肿瘤生长明显受抑制,进一步验证了上述结果。此外,本研究还证明,坏死的胶质瘤细胞释放出可激活存活胶质瘤细胞所表达的FPR的因子,提示FPR可能还是肿瘤微环境中FPR激动剂的感受器,以利肿瘤生长。结论:高度恶性的胶质瘤细胞表达功能性FPR,并对该瘤成瘤、生长和血管生成有促进作用密切关系。上述结果对于我们认识恶性胶质瘤侵袭生长和血管生成特性以及基于FPR设计治疗措施可能有重要意义。

关键词：胶质瘤坏死小干扰RNA (siRNA)血管生成趋化作用

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高分辨率能谱测井——识别复杂矿物(二)

国外测井技术 2015年第1期35卷 64-69页

作者： Manuel Aboud Rob Badry Jim Grau Susan Herron FaridHamichi Jack Horkowitz James Hemingway Robin MacDonald pablo Saldungaray Don Stachiw Northern Cross Christian Stoller Princeston Junction Richard E.Williams 沙特阿美公司必和必拓公司

中子诱发俘获能谱测井仪能够测量井下岩石中特定元素的含量。岩石物理师可根据这些测量数据得出矿物、岩性和地层骨架等性质。早期能谱测井仪的能谱灵敏度不足以获取总有机碳数据,而总有机碳是认识非常规资源远景区的重要测量数据。一... 详细信息

中子诱发俘获能谱测井仪能够测量井下岩石中特定元素的含量。岩石物理师可根据这些测量数据得出矿物、岩性和地层骨架等性质。早期能谱测井仪的能谱灵敏度不足以获取总有机碳数据,而总有机碳是认识非常规资源远景区的重要测量数据。一种新的测井仪器可提供总碳测量,据此可确定有机碳含量。该仪器在识别复杂岩性方面有着前所未有的精度。

关键词：总有机碳能谱测井 Scanner 远景区高分辨率复杂岩性 Eagle 特定元素孔隙度岩心分析

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什么是自由

What is the optimal level of vitamin D in non-dialysis chronic kidney disease population?

心理医生（上半月版） 2013年第2期 73-73页

作者： Pedro pablo Sacriston 苏相宜

埃利斯小姐的实验作业很有名,在她的课上,每个人都必须设计出能够帮助理解的实验,她的学生很喜欢这种教学形式.这次实验作业就有个很难的主题:自由.为了避免故事太过冗长,埃利斯小姐只让我给大家讲讲她最喜欢的三个实验,即阿曼达、查利...

埃利斯小姐的实验作业很有名,在她的课上,每个人都必须设计出能够帮助理解的实验,她的学生很喜欢这种教学形式.这次实验作业就有个很难的主题:自由.为了避免故事太过冗长,埃利斯小姐只让我给大家讲讲她最喜欢的三个实验,即阿曼达、查利以及安德烈娅的实验.

关键词：

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World Journal of Nephrology 2016年第5期5卷 471-481页

作者： pablo Molina JoséL Górriz Mariola D Molina Sandra Beltrán Belén Vizcaíno Verónica Escudero Julia Kanter Ana Iávila Jordi Bover Elvira Fernández Javier Nieto Secundino Cigarrán Enrique Gruss Gema Fernández-Juárez Alberto Martínez-Castelao Juan F Navarro-González Ramón Romero Luis M Pallardó Department of Nephrology Dr Peset University Hospital46017 ValenciaSpain Department of Medicine Universitat de València46005 ValenciaSpain Department of Mathematics Universidad de AlicanteSan Vicente del Raspeig03690 AlicanteSpain Department of Nephrology FundacióPuigvert080348 BarcelonaSpain Department of Nephrology Hospital Uni-versitari de LleidaIRBlleida(Institut de Reserca Biomèdica de Lleida)25198 LleidaSpain Department of Nephrology Hospital General Universitario de Ciudad Real13005 Ciudad RealSpain Department of Nephrology Hospital da Costa Burela7880 LugoSpain Department of Nephrology Hospital Universitario Fundación Alcorcón28922 MadridSpain Department of Nephrology Hospital Universitario de BeellvitgeIDIBELLL'Hospitalet de Llobregat08907 BarcelonaSpain Research Unit and Department of Nephrology University Hospital Nuestra Senora de Candelaria38010 Santa Cruz de TenerifeSpain Department of Medicine Universitat Autònoma de Barcelona08193 BarcelonaSpain

AIM To evaluate thresholds for serum 25(OH)D concentrations in relation to death, kidney progression and hospitalization in non-dialysis chronic kidney disease(CKD) *** Four hundred and seventy non-dialysis 3-5 stage CKD patients participating in OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into 3 groups according to 25(OH)D levels at enrollment(less than 20 ng/mL, between 20 and 29 ng/mL, and at or above 30 ng/mL), considering 25(OH)D between 20 and 29 ng/mL as reference group. Association between 25(OH)D levels and death(primary outcome), and time to first hospitalization and renal progression(secondary outcomes) over a 3-year followup, were assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. To identify 25(OH)D levels at highest risk for outcomes, receiver operating characteristic(ROC) curves were *** Over 29 ± 12 mo of follow-up, 46(10%) patients dead, 156(33%) showed kidney progression, and 126(27%) were hospitalized. After multivariate adjustment, 25(OH)D < 20 ng/mL was an independent predictor of all-cause mortality(HR = 2.33; 95%CI: 1.10-4.91; P = 0.027) and kidney progression(HR = 2.46; 95%CI: 1.63-3.71; P < 0.001), whereas the group with 25(OH)D at or above 30 ng/mL did not have a different hazard for outcomes from the reference group. Hospitalization outcomes were predicted by 25(OH) levels(HR = 0.98; 95%CI: 0.96-1.00; P = 0.027) in the unadjusted Cox proportional hazards model, but not after multivariate adjusting. ROC curves identified 25(OH)D levels at highest risk for death, kidney progression, and hospitalization, at 17.4 ng/mL [area under the curve(AUC) = 0.60; 95%CI: 0.685-0.69; P = 0.027], 18.6 ng/mL(AUC = 0.65; 95%CI: 0.60-0.71; P < 0.001), and 19.0 ng/m L(AUC = 0.56; 95%CI: 0.50-0.62; P = 0.048), ***25(OH)D < 20 ng/mL was an independent predictor of death and progression in patients with stage 3-5 CKD, with no addit

关键词： Vitamin D Chronic kidney disease Mortality Renal progression Hospitalization

Production of Lettuce Seedlings with Association of Diazotrophic Bacteria and Humic Acids

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American Journal of Plant Sciences 2018年第5期9卷 946-957页

作者： Carlos Augusto Rocha de Moraes Rego Bruna Penha Costa Marinez Carpiski Sampaio Marcos Massuo Kashiwaqui Joao Henrique Silva Caetano Vandeir Francisco Guimaraes Juan López de Herrera pablo Wenderson Ribeiro Coutinho Cláudio Yuji Tsutsumi Maria Soraia Fortado Vera Cruz Thatiane Nepomuceno Alves Shirlene Souza Oliveira Ana Carolina Pinguelli Ristau Hannah Braz Center of Agrarian Sciences State University of Western ParanáMarechal Candido RondonBrazil University School of Agricultural Technical Engineering Polytechnic University of MadridMadridSpain

The objective of this work was to verify the responses in agronomic and physiological characters of lettuce seedlings when submitted to different doses of humic acids and the presence or absence of inoculation of the bacterium Azospirillum brasilense. The experiment was carried out at the Protected Cultivation Station and Biological Control Teacher Mário César Lopes, belonging to the Experimental Stations Nucleus of the State University of the West of Paraná. The experimental design was a randomized block design, in a 5 × 2 factorial scheme, with four repetitions, totaling 40 plots. The first factor consisted of five solutions containing humic acid (100%, 75%, 50%, 25% and 0%) and the second factor was the presence or absence of the diazotrophic bacterium Azospirillum brasilense obtained by commercial product. Germination tests were carried out in addition to the determination of agronomic characters such as the number of fully expanded leaves, plant height, stem diameter, main root length, shoot dry mass, root dry mass, total dry mass, and Dickson quality index. The association of diazotrophic bacteria and humic acids did not influence the emergency rate, mean emergence time, mean speed of emergency, emergence speed index, plant height, and root length of lettuce seedlings. The dilutions of humic acids, regardless of inoculation with bacteria diazotrophic favored the development of the number of leaves, stem diameter and Dickson quality index. Inoculation of lettuce seeds with diazotrophic bacteria associated with the addition of humic acids, favored the development of the dry mass of root and total dry matter.

关键词： Azospirillum brasilense Humic Substances Lactuca sativa L. Productive Characteristics