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End-of-life care in a cardiology department： have we improved？

Journal of Geriatric Cardiology 2016年第7期13卷 587-592页

作者： Juan Rulz-garcia pablo Dlez-Villanueva Ana Ayesta Vanessa Brufia Lourdes M Figueiras-Graillet Laura Gallego-Parra Francisco Fernandez-Aviles Manuel Martinez-Selles Department of Cardiology Hospital General Universitario Gregorio Maranon Calle Doctor Esquerdo Madrid Spain Department of Cardiology Hospital Universitario de Torrejon Calle Mateo Inurria Torrejon de Ardoz Madrid Spain Universidad Francisco de Vitoria Carretera Pozuelo a Majadahonda Pozuelo de Alareon Madrid Spain Department of Cardiology Hospital Universitario de la Princesa Calle de Diego de Leon Madrid Spain Departmet of Cardiology Hospital Universitario del Sureste Ronda del Sur Arganda del Rey Madrid Spain Universidad Complutense de Madrid Av. Seneca Madrid Spain Universidad Europea de Madrid Urbanizacion E1Bosque Calle Tajo Villaviciosa de Odon Madrid Spain

Background End-of-life care is not usually a priority in cardiology departments. We sought to evaluate the changes in end-of-life care after the introduction of a do-not-resuscitate （DNR） order protocol. Methods ＆ Results Retrospective analysis of all deaths in a cardiology department in two periods, before and after the introduction of the protocol. Comparison of demographic characteristics, use of DNR orders, and end-of-life care issues between both periods, according to the presence in the second period of the new DNR sheet （Group A）, a conven- tional DNR order （Group B） or the absence of any DNR order （Group C）. The number of deaths was similar in both periods （n = 198 vs. n = 197）. The rate of patients dying with a DNR order increased significantly （57.1% vs. 68.5%; P = 0.02）. Only 4% of patients in both periods were aware of the decision taken about cardiopulmonary resuscitation. Patients in Group A received the DNR order one day earlier, and 24.5% received it within the first 24 h of admission （vs. 2.6% in the first period; P 〈 0.001）. All patients in Group A with an implantable cardioverter defibrillator （ICD） had shock therapies deactivated （vs. 25.0% in the first period; P = 0.02）. Conclusions The introduction of a DNR order protocol may improve end-of-life care in cardiac patients by increasing the use and shortening the time of registration of DNR orders. It may also contribute to increase ICD deactivation in patients with these orders in place. However, the introduction of the sheet in late stages of the disease failed to improve patient participation.

关键词： Cardiology Cardiopulmonary resuscitation End-of-life Palliative care

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An ACO-RFD hybrid method to solve NP-complete problems

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Frontiers of Computer Science 2013年第5期7卷 729-744页

作者： pablo RABANAL Ismael RODRIGUEZ Fernando RUBIO Dept. Sistemas Inforrnaiticos y Computacion Facultad de Informatica Universidad Complutense de Madrid Madrid 28040 Spain

In this paper we hybridize ant colony optimiza- tion （ACt） and river formation dynamics （RFD）, two related swarm intelligence methods. In ACt, ants form paths （prob- lem solutions） by following each other＇s pheromone trails and reinforcing trails at best paths until eventually a single path is followed. On the other hand, RFD is based on copy- ing how drops form rivers by eroding the ground and de- positing sediments. In a rough sense, RFD can be seen as a gradient-oriented version of ACt. Several previous experi- ments have shown that the gradient orientation of RFD makes this method solve problems in a different way as ACt. In particular, RFD typically performs deeper searches, which in turn makes it find worse solutions than ACt in the first exe- cution steps in general, though RFD solutions surpass ACt solutions after some more time passes. In this paper we try to get the best features of both worlds by hybridizing RFD and ACt. We use a kind of ant-drop hybrid and consider both pheromone trails and altitudes in the environment. We apply the hybrid method, as well as ACt and RFD, to solve two NP-hard problems where ACt and RFD fit in a different manner： the traveling salesman problem （TSP） and the prob- lem of the minimum distances tree in a variable-cost graph （MDV）. We compare the results of each method and we an- alyze the advantages of using the hybrid approach in each case.

关键词： river formation dynamics ant colony optimization heuristic algorithms NP-hard problems

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Parallel array with axially coded light-sheet microscope

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Light(Science & Applications) 2020年第1期9卷 1387-1388页

作者： pablo Loza-Alvarez ICFO-The Institute of Photonic Sciences The Barcelona Institute of Science and Technology08860 CastelldefelsBarcelonaSpain

A parallel array of frequency modulated light sheets results in a scanning-less light sheet microscope capable of fast volumetric imaging.

关键词： array light axial

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Two haplotype-resolved genome assemblies for AAB allotriploid bananas provide insights into banana subgenome asymmetric evolution and Fusarium wilt control

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Plant Communications 2024年第2期5卷 243-260页

作者： Wen-Zhao Xie Yu-Yu Zheng Weidi He Fangcheng Bi Yaoyao Li Tongxin Dou Run Zhou Yi-Xiong Guo Guiming Deng Wenhui Zhang Min-Hui Yuan pablo Sanz-Jimenez Xi-Tong Zhu Xin-Dong Xu Zu-Wen Zhou Zhi-Wei Zhou Jia-Wu Feng Siwen Liu Chunyu Li Qiaosong Yang Chunhua Hu Huijun Gao Tao Dong Jiangbo Dang Qigao Guo Wenguo Cai Jianwei Zhang Ganjun Yi Jia-Ming Song Ou Sheng Ling-Ling Chen Institute of Fruit Tree Research Guangdong Academy of Agricultural SciencesKey Laboratory of South Subtropical Fruit Biology and Genetic Resource UtilizationMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Tropical and Subtropical Fruit Tree ResearchGuangzhou 510640China College of Informatics Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China

Bananas(Musa spp.)are one of the world’s most important fruit crops and play a vital role in food security for many developing *** banana cultivars are triploids derived from inter-and intraspecific hybrid-izations between the wild diploid ancestor species Musa acuminate(AA)and ***(BB).We report two haplotype-resolved genome assemblies of the representative AAB-cultivated types,Plantain and Silk,and precisely characterize ancestral contributions by examining ancestry mosaics across the *** asymmetric evolution is observed in their subgenomes,which can be linked to frequent homol-ogous exchange *** reveal the genetic makeup of triploid banana cultivars and verify that subge-nome B is a rich source of disease resistance *** 58.5%and 59.4%of Plantain and Silk genes,respectively,are present in all three haplotypes,with>50%of genes being differentially expressed alleles in different *** observed that the number of upregulated genes in Plantain is significantly higher than that in Silk at one-week post-inoculation with Fusarium wilt tropical race 4(Foc TR4),which con-firms that Plantain can initiate defense responses faster than ***,we compared genomic and transcriptomic differences among the genes related to carotenoid synthesis and starch metabolism between Plantain and *** study provides resources for better understanding the genomic architecture of culti-vated bananas and has important implications for Musa genetics and breeding.

关键词： bananas Plantain Silk asymmetric evolution homologous exchange Fusarium wilt

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Recent advances in graphene and other 2D materials

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Nano Materials Science 2022年第1期4卷 3-9页

作者： pablo Ares Kostya S.Novoselov Department of Physics&Astronomy and National Graphene Institute University of ManchesterManchesterM139PLUK Centre for Advanced 2D Materials National University of Singapore117546Singapore Chongqing 2D Materials Institute Lingjiang New Area Chongqing 400714China

The isolation of the first two-dimensional material, graphene-a monolayer of carbon atoms arranged in a hexagonal lattice-opened new exciting opportunities in the field of condensed matter physics and materials. Its isolation and subsequent studies demonstrated that it was possible to obtain sheets of atomically thin crystals and that these were stable, and they also began to show its outstanding properties, thus opening the door to a whole new family of materials, known as two-dimensional materials or 2D materials. The great interest in different 2D materials is motivated by the variety of properties they show, being candidates for numerous ***, the combination of 2D crystals allows the assembly of composite, on-demand materials, known as van der Waals heterostructures, which take advantage of the properties of those materials to create functionalities that otherwise would not be accessible. For example, the combination of 2D materials, which can be done with high precision, is opening up opportunities for the study of new challenges in fundamental physics and novel applications. Here we review the latest fundamental discoveries in the area of 2D materials and offer a perspective on the future of the field.

关键词： 2D materials Graphene Molybdenum disulphide Tarition mebl dichalogenides Hexagonal boron nitride van der waals heterostructus Ulrathin nanomaterials

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Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family Medicine and Community Health 2024年第S3期12卷 43-51页

作者： William B Ventres Leslie A Stone Johanna F Shapiro Cynthia Haq Jéssica R B Leao Donald E Nease Jr Liz Grant Stewart W Mercer John C M Gillies pablo González Blasco Maria Auxiliadora C De Benedetto Graziela Moreto Marcelo R Levites Jennifer E DeVoe William R Phillips Jane M Uygur Thomas R Egnew Colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOBRAMFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘Reflective practice in action’,‘The doctor as drug—Balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

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Bridging Methods for Atomistic-to-Continuum Coupling and Their Implementation

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Communications in Computational Physics 2010年第4期7卷 831-876页

作者： pablo Seleson Max Gunzburger Department of Scientific Computing Florida State UniversityTallahasseeFL 32306-4120USA

Several issues connected with bridging methods for atomistic-to-continuum(AtC)coupling are *** coupling approaches using various energy blending models are studied as well as the influence that model parameters,blending functions,and grids have on simulation *** use the Lagrange multiplier method for enforcing constraints on the atomistic and continuum displacements in the bridge *** also show that continuum models are not appropriate for dealing with problems with singular loads,whereas AtC bridging methods yield correct results,thus justifying the need for a multiscale *** investigate models that involve multiple-neighbor interactions in the atomistic region,particularly focusing on a comparison of several approaches for dealing with Dirichlet boundary conditions.

关键词： Multiscale modeling atomistic-to-continuum coupling boundary treatment

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Diffusion dynamics and characterization of attogram masses in optically trapped single nanoparticles using laser-induced plasma imaging

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Nano Research 2023年第5期16卷 7470-7480页

作者： pablo Purohit Francisco J.Fortes Javier Laserna UMALASERLAB Departamento de Química AnalíticaUniversidad de MálagaC/Jiménez Fraud 4Malaga 29010Spain Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

In the present work,a wavelength-selected plasma imaging analysis system is presented and used to track photons emitted from single-trapped nanoparticles in air at atmospheric *** isolated nanoentities were atomized and excited into plasma state using single nanosecond laser *** use of appropriate wavelength filters alongside time-optimized acquisition settings enabled the detection of molecular and atomic emissions in the *** photon detection efficiency of the imaging line resulted in a signal>400 times larger than the simultaneously-acquired dispersive spectroscopy *** increase in sensitivity outlined the evolution of diverse physicochemical processes at the single particle scale which included heat and momentum transfer from the plasma into the particle as wells as chemical *** imaging detection of excited fragments evidenced different diffusion kinetics and time frames for atoms and molecules and their influence upon both the spectroscopic emission readout and fabrication processes using the plasma as a ***,the origin of molecular species,whether naturally-occurring or derived from a chemical reaction in the plasma,could also be studied on the basis of compositional gradients found on the *** of detection for the inspected species ranged from tens to hundreds attograms,thus leading to an exceptional sensing principle for single nanoentities that may impact several areas of science and technology.

关键词： single nanoparticle inspection wavelength-selected laser-induced plasma imaging laser fabrication attogram characterization atomic/molecular diffusion

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The cold-induced factor CBF3 mediates root stem cell activity,regeneration,and developmental responses to cold

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Plant Communications 2023年第6期4卷 197-211页

作者： pablo Perez-garcia Ornella Pucciariello Alvaro Sanchez-Corrionero Javier Cabrera Cristina del Barrio Juan Carlos del Pozo Mariano Perales Krzysztof Wabnik Miguel A.Moreno-Risueno Centro de Biotecnologíay Genómica de Plantas(Universidad Politécnica de Madrid(UPM)–Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria–CSIC(INIA-CSIC)) MadridSpain

Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well *** stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their *** a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and ***3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR ***3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root *** of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root ***,cold induces CBF3,affecting QC ***,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation *** contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.

关键词： stem cells regeneration organ patterning protein movement cell fate low temperature

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DNAzymes directed to HPV-16 E6/E7 mRNA

DNAzymes directed to HPV-16 E6/E7 mRNA

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24th International Papillomavirus Conference and Clinical Workshop

作者： Alvarez-Salas Luis Reyes-gutierrez pablo Laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav Laboratorio de Terapia Genica Departamento de Genetica y Biologia Molecular.Cinvestav

＜正＞The World Health Organization（WHO）estimates that 400 million Human Papillomavirus（HPV）cases are reported worldwide per *** is a necessary cause of cervical cancer and is responsible for approximately 510,000 cases *** under- developed regions of the world,it is the most common cause of death from cancer in women,accounting for 80% of the cases reported *** Coherence Tomography（OCT）is an optical imaging technique that uses near infrared light to

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