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Atrial fibrillation： the current epidemic

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Journal of Geriatric Cardiology 2017年第3期14卷 195-203页

作者： Carlos A Morillo Amitava Banerjee pablo Perel David Wood Xavier Jouven Department of Cardiac Sciences Division of Cardiology Libin Cardiovascular Institute University of Calgary Calgary AB Canada Population Health Research Institute Hamilton Health Sciences McMaster University Hamilton ON Canada Farr Institute of Health Informatics Research University College of London London UK Centre for Global NCDs London School of Hygiene & Tropical Medicine London UK World Heart Federation Geneva Switzerland International Centre for Circulatory Health Imperial College London London UK Department of Cardiology European Georges-Pompidou Hospital Paris France Paris Cardiovascular Research Center Paris Descartes University lnserm U970 (PARCC) Paris France

Atrial fibrillation （AF） is the most common arrhythmia diagnosed in clinical practice. The consequences of AF have been clearly estab- lished in multiple large observational cohort studies and include increased stroke and systemic embolism rates if no oral anticoagulation is prescribed, with increased morbidity and mortality. With the worldwide aging of the population characterized by a large influx of ＂baby boomers＂ with or without risk factors for developing AF, an epidemic is forecasted within the next 10 to 20 years. Although not all studies support this evidence, it is clear that AF is on the rise and a significant amount of health resources are invested in detecting and managing AF This review focuses on the worldwide burden of AF and reviews global health strategies focused on improving detection, prevention and risk stratification of AF, recently recommended by the World Heart Federation.

关键词： Aging Anticoagulation Atrial fibrillation Heart failure Hypertension Stroke

A GIS-based methodology for the appraisal of historical,architectural,and social values in historic urban cores

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Frontiers of Architectural Research 2020年第4期9卷 900-913页

作者： Juan A.Garcia-Esparza pablo Altaba Tena Department of Mechanical Engineering and Construction Universitot Jaume I12071Castello de la PlanaSpain

Historic environments represent the evolution of materials and techniques that have been used for the construction these environments over the *** into the study of this field entails working not only on the crafts that have constructed these environ ments but also on the people who made,used,and reinterpreted them by learning about the craftsmen and the idiosyncrasies of the *** study has adopted several methodologies as referenee to examine the material and cultural reality of the rural region of Valencia,*** the adaptation of in ter national methodologies,researchers have carried out a digital database that compiles and maps out the results of the Local Character Assessment of ten Histotiric Urban Cores by incorporating the historical,architectural,and social values to reinforce the Territorial Heritage Action *** of the critical innovations adopted by this form of assessment is the compulsory integration of tangible and intangible heritage through the active involvement of users and *** innovation is to understand the values behind the dynamism and transformation of historic ***,this study advances theory and practice on the transmission of knowledge among artisans,researchers,and the population and how con temporary practices help acquire new meani ngs that overlap the past ones.

关键词： Historic environment Local Character Assessme nt Digital heritage GIS for heritage Heritage values

Metabolic enzymes in seasonally acclimatized and cold acclimated rufous-collared sparrow inhabiting a Chilean Mediterranean environment

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Current Zoology 2014年第3期60卷 338-350页

作者： Isaac PENA-VILLALOBOS Monica NUNEZ-VILLEGAS Francisco BOZINOVIC pablo SABAT Departamento de Ciencias Ecologicas Facultad de Ciencias Universidad de Chile Casilla 653 Santiago Chile Departamento de Ecologia and Center of Applied Ecology & Sustainability (CAPES) Facultad de Ciencias Biol6gicas Pontificia Universidad Cat61ica de Chile Santiago 6513677 Chile

Due to the higher energy requirements of birds during winter, it is predicted that the activities of metabolic enzymes （e.g., citrate synthase, CS and cytochrome C oxidase, COX） should increase in tandem with increases in rates of energy expendi ture （e.g., basal metabolic rate, BMR）. However, there is mixed support for the hypothesis of enzymatic acclimatization. Fur thermore, there is little information about the effect of ambient temperature on energetics and tissue enzyme activity levels in passerines inhabiting seasonal Mediterranean environments. In this study we evaluated the interplay between BMR and enzyme activities of freshly caught individuals of the passerine Zonotrichia capensis in winter and summer in a Mediterranean environment from central Chile, and also in warm （30℃） and cold （15℃） labacclimated birds. The results revealed a lack of seasonal variation in BMR, thermal conductance and in the activity of CS and COX. However, we found higher BMR and lower thermal conductance in coldacclimated than in warmacclimated birds. Also, total CS activity was higher in the flight muscles of coldacclimated than in warmacclimated birds. We found also a significant correlation between BMR and total CS activity in pectoral muscle. Although some authors have suggested that BMR mainly depends on the metabolic intensity and mass of internal organs, our results revealed that skeletal muscles such as the flight muscles may also affect BMR. Finally, differences in the accli mation and acclimatization responses in Rufouscollared sparrows suggest that largescale oscillations in the physical environment might maintain the capacity for flexibility in thermogenic traits through generations .

关键词： Basal metabolic rate Citrate synthase Cytochrome C oxidase Phenotypic flexibility Thermal acclimation,Zonotrichia capensis

Phase separating Rho:a widespread regulatory function of disordered regions in proteins revealed in bacteria

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3203-3205页

作者： Eric Schumbera pablo Mier Miguel A.Andrade-Navarro Institute of Organismic and Molecular Evolution Faculty of BiologyJohannes Gutenberg University of Mainz55128 MainzGermany

A recent study published in Science by Krypotou et *** the role of an intrinsically disordered region(IDR)in the transcription termination Rho protein from Bacteroides thetaiotaomicron:in response to starvation Rho phase separated,which triggered an increase in Rho activity and expression changes.1 These results demonstrate that a highly conserved protein can acquire new regulatory properties in evolution by gaining an IDR that leads to protein phase separation.

关键词： al. disordered separating

Are Antarctic Specially Protected Areas safe from plastic pollution? a survey of plastic litter at Byers Peninsula, Livingston Island, Antarctica

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Advances in Polar Science 2020年第4期31卷 284-290页

作者： pablo ALMELA Sergi GONZALEZ Biology Department Autonomous University of MadridMadridSpain Antarctic Group Spanish Meteorological Service(AEMET)BarcelonaSpain

A number of studies have reported in the last decades the presence of plastics in the Southern Ocean,which are liable to reach the coast and accumulate on the Antarctic *** this,there are few data on the amount of plastic pollution on Antarctic beaches below 60°*** we provide valuable information about the presence of plastic debris in Byers Peninsula,Livingston Island,South Shetland Islands,an Antarctic Specially Protected Area(ASPA)and a hotspot for biodiversity.A total of 129 locations with between 1 and 5 items were recorded among the 3 survey sites on Byers *** of the observed items are likely to derive from fishing and local sources such as tourism and research *** discuss the potential impacts of their presence on local fauna and some of the consequences on the Antarctic *** this survey of plastic accumulation in an ASPA,we propose the implementation of mitigation strategies,such as systematic monitoring of the abundance and distribution of plastic waste,in order to identify trends in marine debris and control the levels of plastic pollution in the Maritime Antarctic region.

关键词： marine debris plastic pollution human impact Antarctic Specially Protected Area(ASPA) management Antarctica

Importance of frailty and comorbidity in elderly patients with severe aortic stenosis

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Journal of Geriatric Cardiology 2017年第6期14卷 379-382页

作者： pablo Díez-Villanueva Jorge Salamanca Antonio Rojas Femando Alfonso Cardiology Department Hospital Universitario La Princesa Universidad Autónoma de Madrid Madrid Spain

The progressive aging of the population has risen awareness and concern about the impact of geriatric syndromes on both clinical outcomes and health-related quality of life in elderly patients, as well as issues regarding the rising economic burden associated with healthcare. Recent studies have demonstrated frailty and other geriatric syndromes such as functionality, dependency and comorbidity can identify the most vulnerable patients, thus allowing to better estimate the individual prognosis in terms of disability, readmission and mortality. Such information should also be considered in the decision making process, ensuring the benefit derived from each treatment in each patient, optimizing the resources and avoiding futility.

关键词： Aortic stenosis Frailty

The elphbolt ab initio solver for the coupled electron-phonon Boltzmann transport equations

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npj Computational Materials 2022年第1期8卷 236-244页

作者： Nakib H.Protik Chunhua Li Miguel Pruneda David Broido pablo Ordejón Catalan Institute of Nanoscience and Nanotechnology(ICN2) CSIC and BISTCampus Bellaterra8193BarcelonaSpain Department of Physics Boston CollegeChestnut HillBostonMA02467USA

elphbolt is a modern Fortran (2018 standard) code for efficiently solving the coupled electron–phonon Boltzmann transport equations from first *** results from density functional and density functional perturbation theory as inputs,it can calculate the effect of the non-equilibrium phonons on the electronic transport (phonon drag) and non-equilibrium electrons on the phononic transport (electron drag) in a fully self-consistent manner and obeying the constraints mandated by *** can calculate the lattice,charge,and thermoelectric transport coefficients for the temperature gradient and electric fields,and the effect of the mutual electron–phonon drag on these transport *** code fully exploits the symmetries of the crystal and the transport-active window to allow the sampling of extremely fine electron and phonon wave vector meshes required for accurately capturing the drag *** coarray feature of modern Fortran,which offers native and convenient support for parallelization,is *** code is compact,readable,well-documented,and extensible by design.

关键词： properties phonon equations

Non-ST elevation acute coronary syndrome in the elderly

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Journal of Geriatric Cardiology 2020年第1期17卷 9-15页

作者： pablo Díez-Villanueva César Jiménez Méndez Fernando Alfonso Cardiology Department Hospital Universitario La Princesa Universidad Autónoma de Madrid

1 Introduction Societies are ageing at an accelerated *** scenario is a well-known challenge for health care systems,as chronic diseases,multiple comorbidities and dependency are all entities that often converge in the ***,there is an issue regarding a reduction in the general incidence of acute coronary syndrome(ACS)together with a delayed in the age of presentation,which,in sum,lead to an increase in both incidence and prevalence of ACS with age,especially non-ST elevation myocardial infarction(NSTEMI).

关键词： Acute coronary syndrome Myocardial infarction The elderly

Characterization of the Genetic Diversity of Trachemys dorbigni and Phrynops hilarii

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Asian Herpetological Research 2015年第3期6卷 213-219页

作者： GUIDETTI Brenda Yamile SIROSKI pablo Ariel AMAVET Patricia Susana Facultad de Humanidades y Ciencias Universidad Nacional del Litoral

The utilization of RAPD and ISSR molecular markers is proposed to initiate studies of genetic variability in Phrynops hilarii（Chelidae） and Trachemys dorbigni（Emydidae）, two species of fresh water turtles distributed in South America. Three primers of RAPD and four of ISSR were selected and the amplified products of these markers were evaluated by electrophoretic runs in agarose and polyacrylamide gels. The levels of heterozygosity, Shannon index and different allele numbers were slightly higher in P. hilarii for both types of markers. Levels of polymorphism were also higher in P. hilarii than T. dorbigni and both were elevated compared to those recorded for other species. The fact that similar results were obtained with both types of markers for all estimates of diversity highlights the usefulness and validity of the RAPD technique. The molecular markers used were found potentially useful for analysing future temporal and spatial distribution of genetic diversity in both species, expanding scales work.

关键词： fresh water turtles variability molecular markers RAPD ISSR