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A Numer.cal Solution for.the Integr.ted Analysis of Water.r.sour.es Management: Application to the Mer. r.ver.Water.hed, La Cor.ña, Spain

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Jour.al of Water.r.sour.e and Pr.tection 2015年第10期7卷 815-829页

作者： Fr.ncisco Padilla J. Hor.cio Her.ández r.car.o Juncosa pablo r. vellando Water.and Envir.nmental Engineer.ng Gr.up ETS de Ingenieros de Caminos Canales y Puertos Campus de Elvi&#241 a University of A Coru&#241 a A Coru&#241 a Spain Ingenier.a Geomática e Hidr.ulica Universidad de Guanajuato Guanajuato Mexico

This r.sear.h is concer.ed with new developments and pr.ctical applications of a physically-based numer.cal model that incor.or.tes new appr.aches for.a finite elements solution to the steady/tr.nsient pr.blems of the joint gr.und/sur.ace water.flows. Python scr.pts ar. implemented in Geogr.phic Infor.ation System (GIS) to stor., r.pr.sent and take decisions on the simulated conditions r.lated to the water.r.sour.es management at the scale of the water.hed. The pr.posed sur.ace-subsur.ace model consider. sur.ace and gr.undwater.inter.ctions to be 2-D hor.zontally distr.buted and depth-aver.ged thr.ugh a diffusive wave appr.ach for.sur.ace flood r.uting. Infiltr.tion r.tes, over.and flows and evapotr.nspir.tion pr.cesses ar. consider.d by a diffuse dischar.e fr.m sur.ace water. non-satur.ted subsoil and gr.undwater.table. r.cent developments also allow for.the management of sur.ace water.flow contr.l thr.ugh the capacity of diver.ion on r.ver.beds, spillways and outflow oper.tions of floodgates in weir. and dams of r.ser.oir.. Pr.ctical application r.gar.s the actual hydr.logy of the Mer. r.ver.water.hed, with two impor.ant water.bodies mainly concer.ed with the water.r.sour.es management at the Cecebr. r.ser.oir.and the pr.sent flooding of a deep coal mining excavation. The MELEF model (Modèle d’éLéments Fluides, in Fr.nch) was adapted and calibr.ted dur.ng a per.od of five year. (2008/ 2012) with the help of hydr.logical par.meter., r.gister.d flow r.tes, water.levels and r.gister.d pr.cipitation, water.uses and water.management oper.tions in sur.ace and gr.undwater.bodies. The r.sults pr.dict the likely evolution of the Cecebr. r.ser.oir. the flow r.tes in r.ver., the flooding of the Meir.ma open pit and the local water.balances for.differ.nt hydr.logical components.

关键词： Integr.ted Sur.ace/Subsur.ace Flows Numer.cal Modelling Finite Elements Water.hed Hydr.logy Geogr.phic Infor.ation System Water r.sour.es Management

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Navigating medial patellotibial ligament r.constr.ction:Clinical per.pectives and sur.ical str.tegies

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Wor.d Jour.al of Clinical Cases 2025年第1期13卷 6-10页

作者： Juan pablo Zicar. Ignacio Gar.ia-Mansilla Division of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

The sur.ical appr.ach for.patellar.instability usually r.fer. to r.constr.ction of the medial patellofemor.l ligament associated with an osteotomy of the tibial tuber.sity or.a tr.chleoplasty when *** medial patellotibial ligament and the medial patellomeniscal ligament ar. secondar. stabilizer. of the *** this,both the medial patellotibial and patellofemor.l ligaments aid in patellar.r.tation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a par.icular.y impor.ant r.le in the final stages of str.tching in extension and between 40 degr.es to 90 degr.es of *** clinical r.levance and sur.ical indications for.medial patellotibial ligament r.constr.ction associated with medial patellofemor.l ligament r.constr.ction ar. still *** editor.al explor.s the sur.ical indications and clinical r.sults for.medial patellotibial ligament r.constr.ction to impr.ve r.ader.’under.tanding of this technique,especially because r.por.ed clinical outcomes have r.mained spar.e.

关键词： Medial patellotibial ligament Patellar.instability r.constr.ction Sur.ical

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Effects of absolute fasting on r.pr.duction and sur.ival of the invasive apple snail Pomacea canaliculata in its native r.nge

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Cur.ent Zoology 2016年第4期62卷 369-375页

作者： Nicolas E. TAMBUr. pablo r. MAr.IN INBIOSUr.(UNS-CONICET) Universidad Nacional del Sur Departamento de Biologla Bioquimica y Farmacia San Juan 670 8000 Bahia Blanca Argentina

A South Amer.can fr.shwater.gastr.pod, the apple snail Pomacea canaliculata, has become a dr.ver.of ecosystemic changes in wetlands and an impor.ant r.ce pest after.its intr.duction to var.ous par.s of the wor.d, mainly Asia. The objective of this study was to study the effect of an abr.pt inter.uption in food availability in the shor. ter. （up to 4 weeks） and long ter. （up to 8 months） on sur.ival and r.- pr.ductive activity. The main r.sults indicate that shor.-ter. fasting mainly affects the sur.ival of males, but only when they ar. r.ised together.with females, pr.bably due to a gr.ater.mate-sear.hing activity that incr.ases mor.ality in the individuals with lower.r.ser.es. The number.of copulating snails or.egg-laying females shows an abr.pt dr.p when fasting and a r.pid r.cover. after.the food supply is r.stor.d. The str.tegy of discontinuing r.pr.ductive activity pr.or.tizes ener.y conser.ation for.the sur.ival of the females. Inter.opulation var.ation in r.sistance to star.ation was obser.ed in adults, which can be explained to some extent by the food availability that they exper.enced in their.natur.l envir.nment. No inter.opulational differ.nces in sur.ival wer. seen in hatchlings. The mean maximum values of sur.ival under.star.ation wer. 52.6 days in hatchlings and the 3.3% of adults sur.ive over.than 200 days, which may be a r.levant tr.it in disper.al and establishment in new habitats.

关键词： GASTr.PODA POMACEA canaliculata WETLANDS STAr.ATION ENEr.Y conser.ation

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Inflammasome links tr.umatic br.in injur., chr.nic tr.umatic encephalopathy, and Alzheimer.s disease

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Neur.l r.gener.tion r.sear.h 2025年第6期20卷 1644-1664页

作者： Gabr.ela Seplovich Yazan Bouchi Juan pablo de r.ver. Vaccar. Jennifer.C.Munoz Par.ja Andr.w r.isner.Laur. Blackwell Yehia Mechr.f Kevin K.Wang J.Adr.an Tyndall Binu Thar.kan Fir.s Kobeissy Depar.ment of Sur.er. Morehouse School of MedicineAtlantaGAUSA Depar.ment of Neur.biology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Depar.ment of Neur.logical Sur.er. and the Miami Pr.ject to Cur. Par.lysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatr.c Cr.tical Car. Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Depar.ment of Pediatr.cs Emory UniversityAtlantaGAUSA Depar.ment of Neur.sur.er. Children’s Healthcare of AtlantaAtlantaGAUSA Depar.ment of Chemistr. and Biochemistr. Texas Tech UniversityLubbockTXUSA Mor.house School of Medicine AtlantaGAUSA

Tr.umatic br.in injur., chr.nic tr.umatic encephalopathy, and Alzheimer.s disease ar. thr.e distinct neur.logical disor.er. that shar. common pathophysiological mechanisms involving neur.inflammation. One sequela of neur.inflammation includes the pathologic hyper.hosphor.lation of tau pr.tein, an endogenous micr.tubule-associated pr.tein that pr.tects the integr.ty of neur.nal cytoskeletons. Tau hyper.hosphor.lation r.sults in pr.tein misfolding and subsequent accumulation of tau tangles for.ing neur.toxic aggr.gates. These misfolded pr.teins ar. char.cter.stic of tr.umatic br.in injur., chr.nic tr.umatic encephalopathy, and Alzheimer.s disease and can lead to downstr.am neur.inflammator. pr.cesses, including assembly and activation of the inflammasome complex. Inflammasomes r.fer.to a family of multimer.c pr.tein units that, upon activation, r.lease a cascade of signaling molecules r.sulting in caspase-induced cell death and inflammation mediated by the r.lease of inter.eukin-1β cytokine. One specific inflammasome, the NOD-like r.ceptor.pr.tein 3, has been pr.posed to be a key r.gulator.of tau phosphor.lation wher. it has been shown that pr.longed NOD-like r.ceptor.pr.tein 3 activation acts as a causal factor.in pathological tau accumulation and spr.ading. This r.view begins by descr.bing the epidemiology and pathophysiology of tr.umatic br.in injur., chr.nic tr.umatic encephalopathy, and Alzheimer.s disease. Next, we highlight neur.inflammation as an over.iding theme and discuss the r.le of the NOD-like r.ceptor.pr.tein 3 inflammasome in the for.ation of tau deposits and how such tauopathic entities spr.ad thr.ughout the br.in. We then pr.pose a novel fr.mewor. linking tr.umatic br.in injur., chr.nic tr.umatic encephalopathy, and Alzheimer.s disease as inflammasomedependent pathologies that exist along a tempor.l continuum. Finally, we discuss potential ther.peutic tar.ets that may inter.ept this pathway and ultimately minimize long-ter. neur.logical decline.

关键词： Alzheimer.s disease caspase-1 chr.nic tr.umatic encephalopathy inflammasomes neur.degener.tion neur.inflammation NLr.1 NLr.3 pyr.ptosis tauopathy tr.umatic br.in injur.

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Main envir.nmental var.ables influencing the abundance of plant species under.r.sk categor.

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Jour.al of For.str. r.sear.h 2022年第4期33卷 1209-1217页

作者： pablo Antúnez División de Estudios de Posgr.do Universidad de la Sierra Juárez68725 Oax.México

Deter.ining climatic and physiogr.phic var.ables in Mexico’s major.ecor.gions that ar. limiting to biodiver.ity and species of high conser.ation concer. is essential for.their.***,at the national level to date,few studies have been per.or.ed with lar.e data sets and cr.ssconfir.ation using multiple statistical ***,we used 25 endemic,r.r. and endanger.d species fr.m 3610 sampling points thr.ughout Mexico and 25 envir.nmental attr.butes,including aver.ge pr.cipitation for.differ.nt seasons of the year.annual dr.ness index,slope of the ter.ain;and maximum,minimum and aver.ge temper.tur.s to test our.hypothesis that these species could be assessed with the same weight among all var.ables,showing similar.indices of *** r.sults using pr.ncipal component analysis,covar.ation analysis by per.utations,and r.ndom for.st r.gr.ssion showed that summer.pr.cipitation,length of the fr.st-fr.e per.od,spr.ng pr.cipitation,winter.pr.cipitation and gr.wing season pr.cipitation all str.ngly influence the abundance of tr.pical *** contr.st,annual pr.cipitation and the balance at differ.nt seasons(summer.and gr.wing season)wer. the most r.levant var.ables on the temper.te r.gion *** dr. ar.as,the minimum temper.tur. of the coldest month and the maximum temper.tur. of the war.est month wer. the most significant *** these differ.nt associations in differ.nt climatic r.gions could suppor. a mor. pr.cise management and conser.ation plan for.the pr.ser.ation of plant species diver.ity in for.sts under.differ.nt global war.ing scenar.os.

关键词： Cor.elative models Climate change Effect of topogr.phy Endemic species IUCN list Machine lear.ing algor.thms

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Dealing with a hyper.successful neighbor. effects of the invasive apple snail Pomacea canaliculata on exotic and native snails in South Amer.ca

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Cur.ent Zoology 2019年第3期65卷 225-235页

作者： Mar. A.MALDONADO pablo r.MAr.IN Labor.tor.o de Ecologia (DBByF) INBIOSUR (Universidad Nacional del Sur-CONICET) San Juan 670 Bahia Blanca(8000) Argentina

Pomacea canaliculata is a successful invader.and also a competitor.and pr.dator.of other.snails and may play a key r.le in str.ctur.ng fr.shwater.snail communities both in its native and invaded r.nge. In the pr.sent study we evaluated the contact and distant effects of P. canaliculata in its native r.nge on exotic (Melanoides tuber.ulata and Physa acuta) and native snails (Heleobia par.happii, Biomphalar.a per.gr.na, and Chilina par.happii). Habitat use was affected in P. acuta, H. par.happii, and B. per.gr.na by contact effects of P. canaliculata, wher.as sur.ival was only affected in P. acuta thr.ugh combined con tact and dista nt effects. Fee undity was r.duced in P. acuta and B. per.gr.na by combined con tact and distant effects;evidence of egg mass pr.dation was also obser.ed in both species. Melanoides tuber.ulata was not affected at all by P. canaliculata. The snail species with higher.withdr.wal r.sp on ses to con tacts with P. canaliculata wer. those that suffer.d less mor.ality by cor.or.l contact, wher.as snails with high cr.wling away r.sponses suffer.d fr.m higher.mor.ality. The effects of P. canaliculata seem to be highly negative to small non oper.ulate sn ails that lay gelati nous egg masses, wher.as lar.e oper.ulate ovovivipar.us snails ar. not affected in their.sur.ival and r.pr.ducti on. This apple snail may exer. biotic r.sista nee agai nst P. acuta but could favor.the establishme nt of M. tuber.ulata and other.function ally similar.species in new habitats in South Amer.ca.

关键词： Ampullar.idae behavior biotic r.sistance inter.pecific inter.ctions

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On the inter.ction of a donepezil-hupr.ne hybr.d with synthetic membr.ne models

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Neur.l r.gener.tion r.sear.h 2023年第2期18卷 333-334页

作者： pablo Zambr.no Max Planck Institute of Biochemistr. Cellular and Molecular BiophysicsMunichGermany

Alzheimer.s disease is the most pr.valent type of dementia today,discover.d and descr.bed by Alois Alzheimer.in *** to the Wor.d Alzheimer.r.por. 2021,75%of people with dementia wor.dwide ar. undiagnosed,equivalent to 41 million people(Gauthier.et al.,2021).With each passing year.the number.of people affected by these diseases is incr.asing,and the estimates of suffer.ng fr.m them in the futur. ar. gr.wing.

关键词： Alzheimer diseases

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Chemokines and Chemokine r.ceptor.:Their.Manifold r.les in Homeostasis and Disease

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Cellular.& Molecular.Immunology 2004年第2期1卷 95-104页

作者： pablo Ir.bar.en Labor.tor. of Molecular.Immunor.gulation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMarylandUSA

Chemokines ar. a super.amily of small pr.teins that bind to G pr.tein-coupled r.ceptor. on tar.et cells and wer. or.ginally discover.d as mediator. of dir.ctional migr.tion of immune cells to sites of inflammation and *** r.cent year.,it has become clear.that the function of chemokines extends well beyond the r.le in leukocyte *** par.icipate in or.an development,angiogenesis/angiostasis,leukocyte tr.fficking and homing,tumor.genesis and metastasis,as well as in immune r.sponses to micr.bial ***, chemokines and their.r.ceptor. ar. impor.ant tar.ets for.modulation of host r.sponses in pathophysiologicai conditions and for.ther.peutic inter.ention of human *** & Molecular.Immunology.2004;1(2): 95-104.

关键词： chemokine r.ceptor development leukocyte homing angiogenesis metastasis

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A study of fir. pr.pagation in coal seam with numer.cal simulation of heat tr.nsfer.and chemical r.action r.te in mining field

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Inter.ational Jour.al of Mining Science and Technology 2019年第6期29卷 873-879页

作者： Moisés Oswaldo Bustamante r.a Alan José Daza Ar.gón pablo Bustamante Baena National Univer.ity of Colombia Cr 65 # 63 20 CIMEX Minerals Institute

Spontaneous combustion of coal is a pr.blem that affects the mining oper.tion and gener.tes envir.n-mental,economic,social and geotechnical *** phenomenon has been divided into two pr.-cesses:ignition and *** pr.pagation develops in coal seams because of a set of factor. such as dir.ction and wind speed,fr.ctur.ng and *** this wor.,heat tr.nsfer.and chemical kinetics ar. studied fr.m conser.ation equations of ener.y and species,r.spectively,using the softwar. COMSOL Multiphysics to simulate the pr.pagation of fir.s in coal *** possible scenar.os wer. analyzed that usually occur.in the walls of the coal seams,such as fir. focus and fir. complete *** was found that the pr.pagation kinetics of the fir. changes depending on the temper.tur.,the fr.ctur.ing of r.ck mass and the ar.a of fir. *** temper.tur. values lower.than 300℃,ther. is con-sumption ar.und 250 cm^3/h,values ar.und 700℃,the consumption is 1500 cm^3/h,and for.fir.s of 1200℃ have values of 3000 cm^3/*** on the speed of pr.pagation can var. fr.m 4 to 17cm/day,consider.ng on the level and fr.ctur.ng of the final wall of the open pit.

关键词： Spontaneous combustion of coal Open pit mines Simulation Heat tr.nsfer Chemical r.action COMSOL

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Asymptotic of Eigenvalues and Lattice Points

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Acta Mathematica Sinica,English Ser.es 2006年第6期22卷 1645-1650页

作者： Juan pablo PINASCO Instituto de Ciencias Universidad Nacional de General Sarmiento

dimension. elementar. domains of In this wor. we study the spectr.l counting function for.the p-Laplace oper.tor.in one We show the existence of a two-ter. Weyl-type asymptote. The method of pr.of is r.ther.based on ... 详细信息

关键词： p-Laplacian eigenvalues lattice points

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