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Estrogen rapid effects:a window of opportunity for the aging brain?

Neural Regeneration Research 2022年第8期17卷 1629-1632页

作者： Ivanny Marchant Jana Stojanova Lilian Acevedo pablo olivero Laboratorio de Modelamiento en Medicina Escuela de MedicinaUniversidad de ValparaísoViña del MarChile Interdisciplinary Centre for Health Studies(CIESAL) Universidad de ValparaísoViña del MarChile Servicio de Neurología Hospital Carlos van Buren ValparaísoChile Laboratorio de Estructura y Función Celular Escuela de MedicinaFacultad de MedicinaUniversidad de ValparaísoValparaísoChile Centro Interoperativo en Ciencias Odontológicas y Médicas Universidad de ValparaísoValparaísoChile

Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective *** therapy has been widely used to treat menopausal estrogen deficiency for more than 80 *** high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health ***,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes *** analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal *** cognitive function,the timing hypothesis is consistent with observations from basic and animal *** is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal *** is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural *** the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.

关键词： aging cardiovascular prevention cognitive function estrogen hormone treatment inflammaging rapid effects timing hypothesis TRPV1 window of opportunity

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TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration

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Neural Regeneration Research 2016年第8期11卷 1204-1207页

作者： Ricardo Ramírez-Barrantes Ivanny Marchant pablo olivero Escuela de Medicina Universidad de Valparaíso

Aging induces physical deterioration,loss of the blood brain barrier,neuronal loss-induced mental and neurodegenerative ***-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated *** steroids support important functions,exert pleiotropic effects in different sensory cells,promote regeneration,plasticity and health of the nervous *** diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative ***,restoring neuroendocrine axes during aging can be key to enhance brain health through neuroprotection and neuroregeneration,depending on the modulation of plasticity ***-dependent transient receptor potential cation channel,subfamily V,member 1（TRPV1） expression induces neuroprotection,neurogenesis and regeneration on damaged *** of TRPV1 can modulate neuroprotection and repair of sensitive neurons,while modulators as other cognitive enhancers may improve the survival rate,differentiation and integration of neural stem cell progenitors in functional neural *** constitutes a relevant clinical model of steroidal production decline associated with progressive cognitive and mental impairment,which allows exploring the effects of hormone therapy in health outcomes such as dysfunction of *** the administration of hormone therapy to virtual menopausal individuals allows assessing its hypothetical impact and sensitivity to conditions that modify the effectiveness and efficiency.

关键词： TRPV1 estrogen hormonal replacent neuroprotection aging

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