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Anticoagulant use before COVID-19 diagnosis prevent COVID-19 associated acute venous thromboembolism or not:A systematic review and meta-analysis

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World Journal of Methodology 2024年第3期14卷 141-162页

作者： Kinza Iqbal Akshat Banga Taha Bin Arif Sawai Singh Rathore Abhishek Bhurwal Syeda Kisa Batool Naqvi Muhammad Mehdi Pankaj Kumar Mitali Madhu Salklan Ayman Iqbal Jawad Ahmed Nikhil Sharma Amos Lal Rahul Kashyap Vikas Bansal Juan pablo Domecq Department of Internal Medicine Dow Medical CollegeKarachi 74200Pakistan Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Internal Medicine Dr.Sampurnanand Medical CollegeJodhpur 342003RajasthanIndia Department of Gastroenterology and Hepatology Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States Department of Internal Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Department of Nephrology and Hypertension Mayo ClinicRochesterMN 55905United States Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Research Wellspan HealthYorkPA 17403United States

BACKGROUND Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019(COVID-19)*** is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 *** To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 *** A Literature search was performed on LitCovid PubMed,WHO,and Scopus databases from inception(December 2019)till June 2023 for original studies reporting an association between prior use of anticoagulants and patient outcomes in adults with *** primary outcome was the risk of thromboembolic events in COVID-19 patients taking *** outcomes included COVID-19 disease severity,in terms of intensive care unit admission or invasive mechanical ventilation/intubation requirement in patients hospitalized with COVID-19 infection,and *** random effects models were used to calculate crude and adjusted odds ratios(aORs)with 95%confidence intervals(95%CIs).RESULTS Forty-six observational studies met our inclusion *** unadjusted analysis found no association between prior anticoagulation and thromboembolic event risk[n=43851,9 studies,odds ratio(OR)=0.67(0.22,2.07);P=0.49;I2=95%].The association between prior anticoagulation and disease severity was non-significant[n=186782;22 studies,OR=1.08(0.78,1.49);P=0.64;I2=89%].However,pre-hospital anticoagulation significantly increased all-cause mortality risk[n=207292;35 studies,OR=1.72(1.37,2.17);P<0.00001;I2=93%].Pooling adjusted estimates revealed a statistically non-significant association between pre-hospital anticoagulation and thromboembolic event risk[aOR=0.87(0.42,1.80);P=0.71],mortality[aOR=0.94(0.84,1.05);P=0.31],and disease severity[aOR=0.96(0.72,1.26);P=0.76].CONCLUSION Prehospital anticoagulation was not significantly associated with reduced risk of thromboembolic events,improved survival,and lower disease seve

关键词： Prior anticoagulation COVID-19 Prehospital anticoagulation Chronic anticoagulation Mortality Severity Thromboembolic events

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Myelin lipid deficiency:a new key driver of Alzheimer’s disease

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中国神经再生研究：英文版 2023年第1期18卷 121-122页

作者： Shulan Qiu Juan pablo Palavicini Xianlin Han Barshop Institute for Longevity and Aging Studies Division of DiabetesDepartment of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Lipids play essential biological functions that include acting as components of biological membranes,energy storage,signaling,nutrients,transporters,enzyme activators,among *** with the multiple research methods to assess DNA,RNA,and protein content,location,and function in cells,there are relatively fewer methods to study ***,lipid-oriented mechanistic studies remain rare and challenging.

关键词： Alzheimer rare challenging

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Linking plant metabolism and immunity through methionine biosynthesis

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Molecular Plant 2022年第1期15卷 6-8页

作者： Francisco Escaray Amelia Felipo-Benavent pablo Vera Instituto de Biología Molecular y Celular de Plantas Universidad Politécnica de Valencia-C.S.I.CCiudad Politécnica de la InnovaciónEdificio 8EIngeniero Fausto Elios/n46022 ValenciaSpain

Plants respond to pathogenic cues with a transcriptional reprog-ramming that leads to de novo production of defense-related pro-teins and a huge variety of secondary metabolites(e.g.,phyto-alexins,phenolics,etc.).Activation of these host defenses,which contribute to halt the intruder as part of the resistance,im-plies an increased demand for metabolic energy and carbon skel-etons derived from primary metabolism(Bolton,2009).

关键词： metabolism immunity Bolton

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An ontology model to represent aquaponics 4.0 system’s knowledge

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Information Processing in Agriculture 2022年第4期9卷 514-532页

作者： Rabiya Abbasi pablo Martinez Rafiq Ahmad Aquaponics 4.0 Learning Factory(AllFactory) Department of Mechanical EngineeringUniversity of Alberta9211116 St.EdmontonAB T6G 2G8Canada

Aquaponics,one of the vertical farming methods,is a combination of aquaculture and *** enhance the production capabilities of the aquaponics system and maxi-mize crop yield on a commercial level,integration of Industry 4.0 technologies is *** 4.0 is a strategic initiative characterized by the fusion of emerging technologies such as big data and analytics,internet of things,robotics,cloud computing,and artificial *** realization of aquaponics 4.0,however,requires an efficient flow and inte-gration of data due to the presence of complex biological processes.A key challenge in this essence is to deal with the semantic heterogeneity of multiple data *** ontology that is regarded as one of the normative tools solves the semantic interoperation problem by describing,extracting,and sharing the domains’*** the field of agriculture,several ontologies are developed for the soil-based farming methods,but so far,no attempt has been made to represent the knowledge of the aquaponics 4.0 system in the form of an ontology ***,this study proposes a unified ontology model,AquaONT,to rep-resent and store the essential knowledge of an aquaponics 4.0 *** ontology pro-vides a mechanism for sharing and reusing the aquaponics 4.0 system’s knowledge to solve the semantic interoperation *** is built from indoor vertical farming termi-nologies and is validated and implemented by considering experimental test cases related to environmental parameters,design configuration,and product *** proposed ontology model will help vertical farm practitioners with more transparent decision-making regarding crop production,product quality,and facility layout of the aquaponics *** future work,a decision support system will be developed using this ontology model and artificial intelligence techniques for autonomous data-driven decisions.

关键词： Aquaponics 4.0 Industry 4.0 Ontology modeling Knowledge modeling Decision support system

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Estrogen rapid effects:a window of opportunity for the aging brain?

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Neural Regeneration Research 2022年第8期17卷 1629-1632页

作者： Ivanny Marchant Jana Stojanova Lilian Acevedo pablo Olivero Laboratorio de Modelamiento en Medicina Escuela de MedicinaUniversidad de ValparaísoViña del MarChile Interdisciplinary Centre for Health Studies(CIESAL) Universidad de ValparaísoViña del MarChile Servicio de Neurología Hospital Carlos van Buren ValparaísoChile Laboratorio de Estructura y Función Celular Escuela de MedicinaFacultad de MedicinaUniversidad de ValparaísoValparaísoChile Centro Interoperativo en Ciencias Odontológicas y Médicas Universidad de ValparaísoValparaísoChile

Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective *** therapy has been widely used to treat menopausal estrogen deficiency for more than 80 *** high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health ***,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes *** analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal *** cognitive function,the timing hypothesis is consistent with observations from basic and animal *** is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal *** is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural *** the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.

关键词： aging cardiovascular prevention cognitive function estrogen hormone treatment inflammaging rapid effects timing hypothesis TRPV1 window of opportunity

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Clinical application and management of temporary mechanical circulatory support:A clinical consensus

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Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod Bonde Neel Sodha Pavan Atluri Juan pablo Maureira AndréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki Takami Pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult Surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/B883.

关键词： application statement discussions

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Water evacuations in remote tourist regions: evaluating case studies from natural hazards in North Patagonian lakes, Argentina

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Journal of Mountain Science 2022年第6期19卷 1782-1807页

作者： SALGADO pablo Agustin VILLAROSA Gustavo BEIGT Debora OUTES Valeria IPATEC(Instituto Andino-Patagonico de Tecnologias Biologicas y Geoambientales) CONICET-UNCOAv.de los Pioneros 23508400 S.C.de BarilocheArgentina Centro Regional Uniuersitario Bariloche Universidad Nacional del ComahueQuintral 12508400 S.C.de BarilocheArgentina

The remote North Patagonian region is a sparsely populated territory and a world famous tourist destination located on the leeward side of the Andes Mountains. Recent disasters triggered by various types of geoenvironmental hazards(including volcanic eruptions, mass-wasting processes and extreme weather events) heavily disrupted ground transport networks in a region with already limited territorial accessibilities. All these catastrophes prompted the need to evacuate or assist a number of secluded visitors, locals and livestock extemporaneously on board of coastguards and tourist passenger-ships from the shores of the many glacial lakes that make up part of the regional attraction. Despite the recurrence of these types of events, water evacuations in the region continue to be spontaneous, improvised and hazardous procedures. This contribution reconstructs and assesses a number of recent local-scale cases of lake evacuations and assistances from a number of Patagonian urban centers, rural areas and tourist sites. For each case study, we systematically elaborated on the prime components of an evacuation process, which enabled us to recognize key achievements, failures and conditioning factors for managing emergencies via water transport, most of them inherent to the studied region. Some of the complexities to emerge from case studies referred to: complex hazard-related scenarios;limited ground-based accessibilities and risk of isolation;various inter-and intra-organizational issues, incidental to natural reserves and tourist regions;a wide range of particular demographic features;and the availability and vulnerability of water transport resources. We suggested fundamental and replicable recommendations for developing water evacuation plans, also identifying forthcoming problems to solve in order to improve the management of emergencies through this alternative means of transport.

关键词： Water transport Emergency management Accessibility problems Tourism activities Volcanic crises Mountain area

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Predefined-Time Backstepping Stabilization of Autonomous Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 2020-2022页

作者： Alison Garza-Alonso Michael Basin pablo Cesar Rodriguez-Ramirez the School of Physical and Mathematical Sciences Autonomous University of Nuevo LeonSan Nicolas de los GarzaNuevo Leon 66455Mexico Ningbo Institute of Intelligent Equipment Technology Zhejiang 315032China

Dear Editor,In this letter,the backstepping technique is applied to solve the predefined-time stabilization problem for autonomous nonlinear systems,where nonlinear terms are unknown but satisfy a linear growth condition.A linear time-varying control law is designed to drive all states of an autonomous nonlinear system to the origin for an a priori preassigned time.

关键词： nonlinear autonomous satisfy

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Beyond vertebrates:the amphioxus as a relevant model system to explore the formation,organization,and regeneration of neuromuscular synapses

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Neural Regeneration Research 2022年第11期17卷 2425-2426页

作者： Esperanza Martínez Sylvain Marcellini Juan pablo Henríquez Neuromuscular Studies Lab (NeSt Lab) Group for the Study of Developmental Processes (GDeP) Department of Cell BiologyFaculty of Biological SciencesUniversidad de Concepción Laboratory of Development and Evolution (LADE)

The neuromuscular junction(NMJ)is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of *** humans,the mature NMJ is the primary target of morphological disassembly and fu... 详细信息

关键词： system contraction synapse

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Ultrafast impulsive Raman spectroscopy across the terahertz-fingerprint region

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Advanced Photonics 2022年第1期4卷 80-91页

作者： Walker Peterson Julia Gala de pablo Matthew Lindley Kotaro Hiramatsu Keisuke Goda The University of Tokyo School of ScienceDepartment of ChemistryTokyoJapan The University of Tokyo Research Center for SpectrochemistryTokyoJapan PRESTO Japan Science and Technology AgencySaitamaJapan Japan Science and Technology Agency TokyoJapan University of California Los AngelesDepartment of BioengineeringLos AngelesCaliforniaUnited States Wuhan University Institute of Technological SciencesWuhanChina

Broadband Raman spectroscopy(detection bandwidth>1000 cm^(−1))is a valuable and widely used tool for understanding samples via label-free measurements of their molecular *** important Raman spectral regions are the chemically specific“fingerprint”(200 to 1800 cm^(−1))and“low-frequency”or“terahertz”(THz)(500×enhancement of10×enhancement of fingerprint sensitivity above 1000 cm^(−1)compared with that of SE-ISRS.

关键词： optics photonics spectroscopy Raman spectroscopy terahertz

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