检索结果-南通市图书馆

Basal insulin and GLP-1 receptor agonists： A complementary approach to achievement of glycemic control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华内分泌代谢杂志 2018年第4期34卷 274-277页

作者： Juan pablo Frias National Research Institute Los Angeles CA USA

时至今日，我们已拥有多种降糖药物来应对2型糖尿病的不同病理缺陷。基于丰富的循证证据和临床实践经验，近期的糖尿病治疗指南推荐及早采用机制互补的药物联合方案，以帮助患者持续达到个体化的血糖控制目标。对于已使用基础胰岛素但... 详细信息

时至今日，我们已拥有多种降糖药物来应对2型糖尿病的不同病理缺陷。基于丰富的循证证据和临床实践经验，近期的糖尿病治疗指南推荐及早采用机制互补的药物联合方案，以帮助患者持续达到个体化的血糖控制目标。对于已使用基础胰岛素但血糖控制尚未达标的2型糖尿病患者，多项临床试验证明对其加用胰升糖素样肽1(GLP-1)受体激动剂有助于安全有效地控制血糖。基础胰岛素联合GLP-1受体激动剂治疗方案，通过互补的作用机制，在优化血糖控制的同时，较基础餐时胰岛素等方案显著降低低血糖风险，改善体重。因此，对于采用基础胰岛素治疗但血糖控制不佳的2型糖尿病患者应考虑增加GLP-1受体激动剂。

关键词：糖尿病胰岛素血糖控制保健知识

Predator-induced physiological responses in tadpoles challenged with herbicide pollution

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2013年第4期59卷 475-484页

作者： pablo BURRACO Lidia Jimenez DUARTe Ivan GOMeZ-MeSTRe ecology Evolution and Development Group Estaci6n Biol6gica de Dofiana (EBD-CSIC) E-41092 Seville Spain Av. Las Ciencias 4 2℃ 41020 Sevilla Spain

Predators induce plastic responses in multiple prey taxa, ranging from morphological to behavioral or physiological changes. In amphibians, tadpoles activate plastic responses to reduce predation risk by reducing their activity rate and altering their morphology, specifically tail depth and pigmentation. Furthermore, there is now evidence that tadpoles＇ defenses are modi- fied when predators combine with other stressful factors such as pollutants or competitors, but our knowledge on the physiologi- cal responses underlying these responses is still scarce. Here we study physiological responses in Pelobates cultripes tadpoles exposed to a natural predator （larvae of the aquatic beetle Dytiscus circumflexus）, non-lethal concentrations of herbicide （gly- phosate, 0.5 mg/L and 1.0 mg/L） or both factors combined. We measured corticosterone levels, standard metabolic rate, oxidative damage （TBARS） and activity of antioxidant enzymes, and immune response （via leukocyte count）. Tadpoles reduced their corti- costerone concentration by ca. 24% in the presence of predator cues, whereas corticosterone did not change in the presence of glyphosate. Two enzymes involved in antioxidant response also decreased in the presence of predators （14.7% and 13.2% respec- tively） but not to glyphosate. Herbicide, however, increased the number of neutrophils and reduced that of lymphocytes, and had an interaction effect with predator presence. Standard metabolic rate did not vary across treatments in our experiment. Thus we show a marked physiological response to the presence of predators but little evidence for interaction between predators and low levels of herbicide. Multiple assessment of the physiological state of animals is important to understand the basis and conse- quences ofphenotypic plasticity

关键词： Inducible defenses Physiological responses Corticosterone Glyphosate Spadefoot toads Oxidative stress

effect of self-weight consolidation on a hydro-sedimentological model for the Río de la Plata estuary

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2019年第5期34卷 444-454页

作者： pablo Santoro Mónica Fossati pablo Tassi Nicolas Huybrechts Damien Pham Van Bang Ismael Piedra-Cueva Instituto de Mecánica de los Fluidos e Ingeniería Ambiental Facultad de Ingeniería Universidad de la República Université Paris-est Laboratory for Hydraulics Saint-Venant (ENPC-EDF/R& D-CEREMA) electricity of France R&D Department Sorbonne Universités Université de Technologie de Compiègne FRE UTC-CNRS 3023 Roberval Centre de Recherche Royallieu Cerema Direction Technique Eau Mer et Fleuves Institut National de la Recherche Scientifique Centre-Eau Terre Environnement

The effect of the consolidation process on the morphodynamics and fine sediment dynamics of the Río de la Plata estuary is explored through a circulation-wave-sediment transport model. The consolidation model is calibrated based on settling column experimental data. Different simulations are done in order to initialize the mud layer distribution and to investigate the impact of different erosion parameter assumptions on the modeled sediment dynamics. Finally a two-year simulation is done with and without the consolidation process and realistic hydrodynamic forcings. Considering the consolidation process, the model correctly reproduces measured vertical density profiles in the Montevideo Bay access channel. The simulated suspended sediment dynamics behavior in Montevideo Bay with the consolidation process provides a more realistic deposition pattern in regard to the dredging activities.

关键词： Cohesive sediment Self-weight consolidation Morphodynamics Numerical modeling

KnowID:An Architecture for efficient Knowledge-Driven Information and Data Access

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Data Intelligence 2020年第4期2卷 487-512页

作者： pablo Rubén Fillottrani C.Maria Keet Departamento de Ciencias e Ingeniería de la Computación Universidad Nacional del SurBahía BlancaBuenos Aires 8000Argentina Comisión de Investigaciones Científicas Provincia de Buenos AiresArgentina Department of Computer Science University of Cape TownRondebosch 7700South Africa

Modern information systems require the orchestration of ontologies,conceptual data modeling techniques,and efficient data management so as to provide a means for better informed decision-making and to keep up with new requirements in organizational needs.A major question in delivering such systems,is which components to design and put together to make up the required“knowledge to data”pipeline,as each component and process has *** this paper,we introduce a new knowledge-to-data architecture,*** pulls together both recently proposed components and we add novel transformation rules between enhanced entity-Relationship(eeR)and the Abstract Relational Model to complete the ***’s main distinctive architectural features,compared to other ontology-based data access approaches,are that runtime use can avail of the closed world assumption commonly used in information systems and of full SQL augmented with path queries.

关键词： extended entity-relationship diagrams Abstract relational model Ontology-based data access

early Paleozoic accretionary orogens along the Western Gondwana margin

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第1期12卷 109-130页

作者： Sebastián Oriolo Bernhard Schulz Silvana Geuna pablo DGonzález Juan e.Otamendi JiíSláma elena Druguet Siegfried Siegesmund CONICeT-Universidad de Buenos Aires Instituto de Geociencias BasicasAplicadas y Ambientales de Buenos Aires(IGEBA)Intendente Güiraldes 2160C1428EHABuenos AiresArgentina Institute of Mineralogy Division of Economic Geology and PetrologyTU Bergakademie FreibergBrennhausgasse 14D-09596FreibergSaxonyGermany Instituto de Investigacion en Paleobiología y Geología(UNRN-CONICeT) Avenida Julio A.Roca 1242R8332EXZGeneral RocaArgentina CONICeT Departamento de GeologíaUniversidad Nacional de Río CuartoCampus UniversitarioX5804BYARío CuartoArgentina Institute of Geology The Czech Academy of SciencesRozvojova 269CZ-16500Prague 6Czech Republic Departament de Geologia Universitat Autonoma de Barcelona08193BellaterraBarcelonaSpain Geoscience Centre Georg-August-Universit€at G€ottingenGoldschmidtstraße 337077GottingenGermany

early Paleozoic accretionary orogens dominated the Western Gondwana margin and were characterized by nearly continuous subduction associated with crustal extension and back-arc basin *** southwestern margin is represented by Famatinian and Pampean basement realms exposed in South America,both related to the protracted Paleozoic evolution of the Terra Australis Orogen,whereas the northwestern margin is mainly recorded in Cadomian domains of europe and adjacent ***,no clear relationships between these regions were so far *** on a compilation and reevaluation of geological,paleomagnetic,petrological,geochronological and isotopic evidence,this contribution focuses on crustal-scale tectonic and geodynamic processes occurring in Western Gondwana accretionary orogens,aiming at disentangling their common early Paleozoic *** show that accretionary orogens were dominated by high-temperature/lowpressure metamorphism and relatively high geothermal gradients,resulting from the development of extended/hyperextended margins and bulk transtensional *** this sense,retreating-mode accretionary orogens characterized the early Paleozoic Gondwana margin,though short-lived pulses of compression/transpression also *** existence of retreating subduction zones favoured mantle-derived magmatism and mixing with relatively young(meta)sedimentary sources in a thin continental *** reworking of previous forearc sequences due to trenchward arc migration thus took place through assimilation and anatexis in the arc/back-arc ***,retreating-mode accretionary orogens were the locus of early Paleozoic crustal growth in Western Gondwana,intimately associated with major flare-up events,such as those related to the Cadomian and Famatian *** roll back,probably resulting from decreasing convergence rates and plate velocities after Gondwana assembly,was a key factor for orogen-scale geodynamic ***

关键词： Retreating accretionary orogen Lower Paleozoic Crustal growth Hf isotopic array Famatinian Cadomian

elastic Smart Contracts in Blockchains

在线全文

学校读者我要写书评

暂无评论

Ieee/CAA Journal of Automatica Sinica 2021年第12期8卷 1901-1912页

作者： Schahram Dustdar pablo Fernández JoséMaría García Antonio Ruiz-Cortés Distributed Systems Group Vienna University of TechnologyWien 1040Austria Smart Computer Systems Research and engineering Lab Research Institute of Computer EngineeringUniversity of SevillaSevilla 41012Spain

In this paper,we deal with questions related to blockchains in complex Internet of Things(IoT)-based *** ecosystems are typically composed of IoT devices,edge devices,cloud computing software services,as well as people,who are decision makers in scenarios such as smart *** decisions related to analytics can be based on data coming from IoT sensors,software services,and ***,they are typically based on different levels of abstraction and *** poses a number of challenges when multiple blockchains are used together with smart *** work proposes to apply our concept of elasticity to smart contracts and thereby enabling analytics in and between multiple blockchains in the context of *** propose a reference architecture for elastic Smart Contracts and evaluate the approach in a smart city scenario,discussing the benefits in terms of performance and self-adaptability of our solution.

关键词： Blockchain elasticity Internet of Things(IoT) smart cities smart contracts virtual chains

Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第28期27卷 4639-4652页

作者： Alberto e Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez pablo Salgado Gustavo Romero Sección Hepatología Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoFacultad de MedicinaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina Instituto de Investigaciones en Salud Pública Facultad de OdontologíaUniversidad de Buenos AiresCiudad Autónoma de Buenos Aires 1122Argentina Unidad Clínica Hospital de Gastroenterología Dr.Carlos Bonorino UdaondoInvestigador Asociado del Gobierno de la Ciudad Autónoma de Buenos AiresCiudad Autónoma de Buenos Aires 1264Argentina

This review summarizes the safety and efficacy of statins in patients with *** to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in *** most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver *** is the most serious and potentially life-threatening *** has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle ***,simvastatin should not be administered to patients with Model for end-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle *** to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something *** these effects,statins could prevent liver-related morbidity and mortality in cirrhotic *** studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and *** few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic *** large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival *** these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies ***,it is advisable to per

关键词： Cirrhosis Liver disease Statins Safety efficiency

Metabolic enzymes in seasonally acclimatized and cold acclimated rufous-collared sparrow inhabiting a Chilean Mediterranean environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2014年第3期60卷 338-350页

作者： Isaac PeNA-VILLALOBOS Monica NUNeZ-VILLeGAS Francisco BOZINOVIC pablo SABAT Departamento de Ciencias ecologicas Facultad de Ciencias Universidad de Chile Casilla 653 Santiago Chile Departamento de ecologia and Center of Applied ecology & Sustainability (CAPeS) Facultad de Ciencias Biol6gicas Pontificia Universidad Cat61ica de Chile Santiago 6513677 Chile

Due to the higher energy requirements of birds during winter, it is predicted that the activities of metabolic enzymes （e.g., citrate synthase, CS and cytochrome C oxidase, COX） should increase in tandem with increases in rates of energy expendi ture （e.g., basal metabolic rate, BMR）. However, there is mixed support for the hypothesis of enzymatic acclimatization. Fur thermore, there is little information about the effect of ambient temperature on energetics and tissue enzyme activity levels in passerines inhabiting seasonal Mediterranean environments. In this study we evaluated the interplay between BMR and enzyme activities of freshly caught individuals of the passerine Zonotrichia capensis in winter and summer in a Mediterranean environment from central Chile, and also in warm （30℃） and cold （15℃） labacclimated birds. The results revealed a lack of seasonal variation in BMR, thermal conductance and in the activity of CS and COX. However, we found higher BMR and lower thermal conductance in coldacclimated than in warmacclimated birds. Also, total CS activity was higher in the flight muscles of coldacclimated than in warmacclimated birds. We found also a significant correlation between BMR and total CS activity in pectoral muscle. Although some authors have suggested that BMR mainly depends on the metabolic intensity and mass of internal organs, our results revealed that skeletal muscles such as the flight muscles may also affect BMR. Finally, differences in the accli mation and acclimatization responses in Rufouscollared sparrows suggest that largescale oscillations in the physical environment might maintain the capacity for flexibility in thermogenic traits through generations .

关键词： Basal metabolic rate Citrate synthase Cytochrome C oxidase Phenotypic flexibility Thermal acclimation,Zonotrichia capensis

Phase separating Rho:a widespread regulatory function of disordered regions in proteins revealed in bacteria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第7期8卷 3203-3205页

作者： eric Schumbera pablo Mier Miguel A.Andrade-Navarro Institute of Organismic and Molecular evolution Faculty of BiologyJohannes Gutenberg University of Mainz55128 MainzGermany

A recent study published in Science by Krypotou et *** the role of an intrinsically disordered region(IDR)in the transcription termination Rho protein from Bacteroides thetaiotaomicron:in response to starvation Rho phase separated,which triggered an increase in Rho activity and expression changes.1 These results demonstrate that a highly conserved protein can acquire new regulatory properties in evolution by gaining an IDR that leads to protein phase separation.

关键词： al. disordered separating