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Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

The Journal of Biomedical Research 2019年第3期33卷 201-207页

作者： Aravind Selvin kumar Ramanathan Balakrishnan Karuppiah Murali Vijayan Kamaraj Raju Dhivakar mani Rathika Chinniah manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja Krishnan Prabha Senguttuvan Department of Pediatric Nephrology Institute of Child Health and Hospital for Children Department of Medical Genetics The Tamil Nadu Dr.M.G.R.Medical University Department of Immunology School of Biological SciencesMadurai Kamaraj University Department of Biotechnology and Genetic Engineering Bharathidasan University Department of Clinical Research Narayana Health City Department of Pediatric Nephrology Dr.Mehta’s Children’s Hospital

Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results.

关键词： angiotensin converting enzyme focal segmental glomerulosclerosis minimal change disease nephrotic syndrome

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Design and Development of Virtual Objects to be Used with Haptic Device for Motor Rehabilitation

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Journal of Software Engineering and Applications 2010年第10期3卷 990-997页

作者： Jatin B. maniya Pushparaj mani Pathak Bhanu kumar Mishra 不详

This paper presents design and development of virtual objects to be used with haptic device PHANTOM Omni for motor rehabilitation by incorporating visual and haptic feedback. Developed predominantly for augmentation of motor skill of patient, the objects could also be used for teaching and enhancing writing skill of children. The virtual objects include English alphabets, numbers, string and mazes, and games. The scheme has been evaluated on children from 11 to 14 years age. The experiment gives good results.

关键词： Haptic Motor Rehabilitation Virtual Environment

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Effect of Coronal Mass Ejection on Earth’s Magnetic Field during Ascending Phase of Solar Cycles 23-24

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International Journal of Astronomy and Astrophysics 2017年第3期7卷 213-220页

作者： Bharti Nigam Prithvi Raj Singh Pramod kumar Chamadia Ajay kumar Saxena Chandra mani Tiwari Govt. Autonamous P. G. Science College Satna India Department of Physics Awadhesh Pratap Singh University Rewa India

We have studied the width and speed of coronal mass ejections (CMEs) and geomagnetic disturbance storm time (Dst) Index during ascending phase of solar cycles 23 and 24. We have classified total CMEs according to angular width and speed for the ascending period 1996-2002 and 2008-2014. We have found that the width of 62% CMEs is narrow, and 3% are Halo for the solar cycle 23 and 73% CMEs are narrow, and 2% CMEs are Halo for the solar cycle 24. The speed distribution of 65% CMEs has speed ≤ 500 km/sec and 4% CMEs has speed > 1000 km/sec for solar cycle 23 and 84% CMEs has speed ≤ 500 km/sec and 1% CMEs has speed > 1000 km/sec in cycle 24. The relationship between width and speed is more pronounced for fast ejecta (>1000 km/sec.), while slower ejecta shows more astronomically immense scatter. We have reported that the correlation between Dst and CMEs for ascending phase of solar cycle 24 is less than as compare to ascending phase of solar cycle 23.

关键词： CME Dst SSN

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Effect of Altitude and Maturity Stages on Quality Attributes of Mandarin (Citrus reticulata Blanco)

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American Journal of Plant Sciences 2016年第6期7卷 958-966页

作者： Pradeep Raj Rokaya Dilli Ram Baral Durga mani Gautam Arjun kumar Shrestha Krishna Prasad Paudyal Agriculture and Forestry University (AFU) Rampur Nepal National Agricultural Research Institute (NARI) NARC Khumaltar Nepal

Mandarin (Citrus reticulata Blanco) is a premier fruit crop which ranks in first position of the total fruit industry in Nepal. Studies were conducted to assess the maturity indices and quality parameters of mandarin at three altitudes i.e. 1300 m·asl, 1000 m·asl, and 700 m·asl with six maturity stages i.e. 11 Oct, 21 Oct, 31 Oct, 10 Nov, 20 Nov, and 30 Nov. The most important and reliable judging criteria of fruit maturity in mandarin i.e. fruit weight, external fruit colour, firmness, TSS, acidity, and TSS/Acid ratio, and vitamin C were experimented. The experiment results revealed that 1000 m·asl location was showed the highest fruit weight (104.9 g) and juice percentage (55.23) followed by 1300 m·asl altitude (99.5 g and 53.75% respectively) at 20th of November. The maturity advanced at lower altitude with 50 percent yellow orange rind colour, 10.98 TSS/acid ratio and 4 kg/cm2 firmness from 10th November at lower altitudes whereas it was appeared in 20th November at higher altitudes. The TSS/acid ratio was significantly higher (10.98) in the fruits of 700 m·asl as compared to 1300 m·asl (9.76) on 10th November, however, on 20th November 1300 m·asl showed the highest ratio (17.76). The fruit weight, juice content, TSS was found in increasing trends up to 20 November and then showed constant and decreasing trend. However, TA, firmness and vitamin C were showed in decreasing trends with time. The 1000 - 1300 m·asl was the best location for the mandarin production and 10-20 November was the best period for the mandarin harvesting for optimum maturity.

关键词： Maturity Physico-Chemical Quality Parameters Firmness Total Soluble Solid

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Effect of Pre-Harvest Application of Gibberellic Acid on Fruit Quality and Shelf Life of Mandarin (Citrus reticulata Blanco)

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American Journal of Plant Sciences 2016年第7期7卷 1033-1039页

作者： Pradeep Raj Rokaya Dilli Ram Baral Durga mani Gautam Arjun kumar Shrestha Krishna Prasad Paudyal Agriculture and Forestry University Rampur Chitwan Nepal National Agricultural Research Institute (NARI) NARC Khumaltar Lalitpur Nepal

Mandarin (Citrus reticulata Blanco) is a promising fruit crop gaining popularity for its human nutrition and economic importance in Nepal. The qualitative losses during pre-harvest stage hinder the productivity and subsequently shorten the on-tree storability. An experiment was conducted to assess the effect of gibberellic acid on quality and shelf life of the mandarin fruit. GA3 at 10, 20, and 30 ppm as against of control were evaluated. Observations on fruit weight (g), fruit firmness (kg/cm2), rind colour (1 - 5 index), juice recovery (%), TSS/acid ratio, PLW (%), decay loss (%), and ascorbic acid (mg/100 ml) were recorded at three harvesting dates i.e. 20 Nov, 5 Dec, and 20 Dec and storage condition. It has been revealed that the fruits treated with GA3 at 20 ppm retained higher fruit weight (128.6 g), more firmness (3.54 kg/cm2), better juice recovery (57.75%), and greater TSS/acid ratio (21.24) at the end of study (20 December). The PLW was found less with GA3 at 30 ppm in both ambient (5.17%) and cellar (6.69%) condition as against untreated fruits (9.52% and 11.76%). Similarly, the decay loss was minimum in the fruits treated with GA3 at 30 ppm both with ambient (1.02%) and cellar condition (8.21%) as against control with ambient (5.54%) and cellar (21.58%).

关键词： Fruit Quality Gibberellic Acid Peel Puncture Resistance Physiological Loss in Weight Postharvest Shelf Life

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Effect of Postharvest Treatments on Quality and Shelf Life of Mandarin (Citrus reticulata Blanco)

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American Journal of Plant Sciences 2016年第7期7卷 1098-1105页

Nepal produces large quantity of mandarin (Citrus reticulata Blanco) annually but faces big losses due to improper postharvest treatments. The experiment was carried out during 2012-2013 with the objective of assessing the effect of different postharvest treatments on quality and shelf life of mandarin. The postharvest treatments were: wax emulsion at 10%, bavistin at 0.1%, wax at 10% with bavistin at 0.1%, calcium chloride at 1%, Jeevatu at 5% along with untreated fruits as a control. The experiment was conducted for four weeks of storage at ambient condition in Nepal Agricultural Research Council, Khumaltar, Kathmandu. Wax in combination with bavistin was found as the most effective in reducing the physiological loss in weight, whereas bavistin proved to reduce decay loss up to four weeks of storage. The fruits treated with wax alone and with combination of bavistin retained maximum firmness, juice percentage, vitamin C and palatability rating during the storage. The minimum total soluble solid and maximum titrable acidity were recorded in the fruits treated with wax plus bavistin. The present findings indicate that mandarin can be stored up to four weeks when treated with wax as well as wax with bavistin in the condition with 14°C - 18°C temperature and 45% - 73% relative humidity.

关键词： Mandarin Fruit Quality Postharvest Treatments Palatability Rating and Postharvest Loss in Weight

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Study of anisotropic variation of cosmic rays intensity with solar activity

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Natural Science 2011年第2期3卷 101-103页

作者： Chandra mani Tiwari Devendra Sharma Lalji Tiwari Ajay kumar Saxena Dadan Prasad Tiwari 不详

The annual average values of amplitudes and phases of first two harmonics of cosmic ray anisotropy have been derived by using the harmonic analysis technique for the period 1989 to 2004, which covers mostly the major period of solar cycles 22 and 23. In this paper we have taken the pressure corrected hourly data for Kiel neutron monitor station (cut off rigidity ≈ 2.29 GV) to derive the harmonic component of cosmic ray daily variation and compared with the data of Halekala neutron monitor (cut off rigidity ≈ 13.2 GV) for the period 1991 to 2004. From the analysis it has been concluded that the diurnal amplitude and phase of daily variation of cosmic rays have been found to be correlated with solar activity. However, the semi-diurnal amplitude and phase are inversely correlated with solar activity for both the stations.

关键词： Cosmic Ray Anisotropic Variation Solar Parameter

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Pattern of Acute Parasitic Diarrhea in Children Under Five Years of Age in Kathmandu, Nepal

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Open Journal of Medical Microbiology 2012年第3期2卷 95-100页

作者： Shamshul Ansari Jeevan Bahadur Sherchand Keshab Parajuli Bharat mani Paudyal Ram Prasad Adhikari Shovita Shrestha Shyam kumar Mishra Rajan kumar Dahal Sarmila Tandukar Rama Khadka Ranju Shreshta Soma Kanta Baral Bharat mani Pokhrel Department of Microbiology Institute of Medicine Tribhuvan University Teaching Hospital (TUTH) Kathmandum Nepal Public Health Research Laboratory Institute of Medicine Tribhuvan University Teaching Hospital (TUTH) Kathmandu Nepal

Diarrheal diseases are major problem of developing countries. Though precise data on childhood mortality associated with diarrheal diseases in Nepal is not available, it has been estimated that approximately 25% of child death are associated with diarrheal disease, particularly acute diarrhea. The purpose of this study was to assess the incidence of parasitic pathogens causing acute diarrhea in children under 5 years of age. A total of 525 children with acute diarrhea in a children’s hospital of Kathmandu, Nepal were enrolled between April 2011 and September 2011. The higher prevalence of diarrhea was in the age group of less than 2 years. Out of total 525 enrolled cases, protozoal parasites were found in 10.7% (56/525) of cases and helminthic parasites were found in 1.3% (7/525) of cases. Highest prevalence of 60.3% (38/63) of parasitic infection was found in the age group of 6 - 24 months followed by 7.9% (5/63) in the age group of less than 6 months. Of the total enrolled cases E. histolytica were 6.7% (35/525) followed by Giardial lamblia 3.4% (18/525) and the least frequency was due to A. lumbricoides constituting 0.6% (3/525). The aim of this study was to know the parasitic agents causing acute diarrhea in children.

关键词： Parasitic Diarrhea Protozoa Helminthes TUTH Nepal

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微创与传统切开治疗急性闭合性跟腱断裂疗效的Meta分析

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中国矫形外科杂志 2013年第24期21卷 2449-2454页

作者：陈柯屹张梦苑杨广忠 Anod mani Regmi Sasi kumar Jha 余凯新疆医科大学第一附属医院

[目的]系统评价微创与传统切开治疗急性闭合性跟腱断裂的临床疗效。[方法]计算机检索Medline、Cochrane Library(2013年1期)、Ovid、EMBASE、中国生物医学、中国期刊全文和万方数据库,以及手工检索国内相关骨科杂志,检索微创与传统切开... 详细信息

[目的]系统评价微创与传统切开治疗急性闭合性跟腱断裂的临床疗效。[方法]计算机检索Medline、Cochrane Library(2013年1期)、Ovid、EMBASE、中国生物医学、中国期刊全文和万方数据库,以及手工检索国内相关骨科杂志,检索微创与传统切开治疗急性闭合性跟腱断裂疗效对比的随机对照研究文献,评价指标包括患者术后满意度、跟腱再次断裂率、AOFAS踝-后足评分、踝关节活动度、浅表感染、深部感染、组织粘连、切口瘢痕形成、手术时间等,并采用RevMan 5.2软件进行Meta分析。[结果]共纳入随机对照研究7篇,共328例,微创组160例,传统切开组168例。Meta分析结果显示:微创组与传统切开组相比,术后患者满意度较高,浅表感染较低(P0.05)。[结论]微创治疗急性闭合性跟腱断裂在患者术后满意度上优于传统切开术,且浅部表皮感染率较低,受纳入研究样本量及方法学质量限制,尚需开展更多大样本、高质量随机对照试验来增加证据的论证强度。

关键词：微创传统切开急性跟腱断裂 Meta分析

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Solar-PV inverter for the overall stability of power systems with intelligent MPPT control of DC-link capacitor voltage

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Protection and Control of Modern Power Systems 2023年第1期8卷 245-264页

作者： Sheetal Singh Sanju Saini SKGupta Rajeev kumar Electrical Engineering Department Deenbandhu Chhotu Ram University of Science and Technology MurthalMurthalIndia Electrical and Electronics Engineering Department KIET Group of InstitutionsGhaziabadIndia

This paper demonstrates the controlling abilities of a large PV-farm as a Solar-PV inverter for mitigating the chaotic electrical,electromechanical,and torsional oscillations including Subsynchronous resonance in a turbogenerator-based power *** oscillations include deviations in the machine speed,rotor angle,voltage fluctuations(lead-ing to voltage collapse),and torsional *** the night with no solar power generation,the PV-plant switches to PV-STATCOM mode and works as a Solar-PV inverter at its full capacity to attenuate the *** full sun in the daytime,on any fault detection,the PV-plant responds instantly and stops generating power to work as a Solar-PV *** PV-farm operates in the same mode until the oscillations are fully *** paper mani-fests the control of the DC-link capacitor voltage of the Solar-PV inverter with a bacterial foraging optimization-based intelligent maximum power point tracking controller for the optimal control of active and reactive ***’s multi-machine model aggregated with PV-plant is modeled in the Matlab/Simulink environment to examine the rotor swing deviations with associated shaft *** results for different test cases of interest demonstrate the posi-tive outcomes of deploying large PV-farms as a smart PV-STATCOM for controlling power system oscillations.

关键词： PV-STATCOM Power oscillations Grid-connected system BFO algorithm Rotor dynamics

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