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Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

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World Journal of Clinical Oncology 2024年第6期15卷 717-729页

作者： Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala Amelia Maria Găman Camelia Cristina Diaconu Faculty of Medicine “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Department of Hematology Center of Hematolog Department of Cellular and Molecular pathology Stefan S Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Basic Medical Sciences School of Medicine of Taizhou UniversityTaizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Medicine North Bengal Medical College and HospitalWest Bengal 734012India Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation TrustSheffield S57AUUnited Kingdom Lecom at Seton Hill GreensburgPA 15601United States Faculty of Medicine Services HospitalLahore 54000Pakistan Department of Human Anatomy and Physiology University of NairobiNairobi 00100Kenya Faculty of Medicine Udayana UniversityDenpasarBali 80361Indonesia Department of General Surgery Dr.NTR University of Health SciencesVijayawada 520008Andhra PradeshIndia Department of pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania Department of Internal Medicine Faculty of Medicine“Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 105402Romania

Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral *** suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of ***,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic ***,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关键词： Polycythemia vera Essential thrombocythemia Myelofibrosis Cardiovascular disease Hypercholesterolemia Hypertriglyceridemia Obesity Diabetes Inflammation Oxidative stress

In vivo antiplasmodial activities of ethanolic exract and fractions of Eleucine indica

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Asian pacific Journal of Tropical Medicine 2012年第9期5卷 673-676页

作者： Ettebong EO Nwafor pa Okokon JE Department of Pharmacology and Toxicology Faculty of PharmacyP.M.B.1017University of UyoUyoNigeria

Objective:To evaluate the in rivo antiplasmodial activities of the extract and fractions(n-hexane. chloroform,***) of the whole plant in Plasmodium berghei berghei infected ***:Oral administrations of the extract(200.400,and 600 my/kg) of Eleacine indica and fractions(400 mg/kg) were screened in the *** and curative tests. Chloroquine(5 mg/kg).pyrimethamine(1.2 mg/kgi and artesunate(5 mg/kgi were used as controls. Results:The extract showed significant[P< 0.05-0.001) dose-dependent,antiplasmodial activity in the *** and curative tests and increased the survival times of the infected mice. All the fractions exhibited significant antiplasmodial activity with the highest being ethylacetate ***:Eleucine indica extract and fractions possess antimalarial activity which confirms the ethnobotanical use of this plant as a malarial remedy and opens a new highway to further investigate its potentials in the on-going fight against malaria.

关键词： Antimalarial activity Alkaloid Plasmodium berghei berghei Eleucine indica

Transcriptomic signatures decode Th17 cell pathogenicity

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Cellular & Molecular Immunology 2016年第5期13卷 557-559页

作者： pa Reyfman ET Bartom BD Singer Northwestern University Feinberg School of Medicine Department of Medicine Division of Pulmonary and Critical Care Medicine Chicago IL 60611 USA Northwestern University Feinberg School of Medicine Department of Biochemistry and Molecular Genetics Chicago IL 60611 USA

Systems immunology is a growing field that attempts to integrate high-throughput experiments with sophisticated computational analysis and modeling approaches. In the field of systems immunology, single-cell transcrip- tomic profiling （RNA-seq） is an experimental technique that has proven effective for delineating molecular heterogeneity within immune cell subtypes.

关键词： Transcriptomic signatures decode

Evaluation of the anticonvulsant and muscle relaxant effects of the methanol root bark extracts of Annona senegalensis

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Asian pacific Journal of Tropical Medicine 2010年第1期3卷 25-28页

作者： Okoye TC Akah pa Omeke CP Department of Pharmacology and Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

Objective:To investigate the potentials of the root bark of Annona（A.） senegalensis in the control of seizure and related hypnotic and motor incoordination effects in mice using experimental ***:The methanol extract（ME） of the root bark of *** was studied in mice using pentylenetetrazole（PTZ） induced convulsions,phenobarbitone induced sleeping time and motor coordination test on rota-rod *** toxicity and lethality（LD50） lest as well as phytochemical analysis were also carried ***:The extract（200,400,800 mg/ kg） exhibited a non- dose dependent significant（P50 of 1 2%mg/kg,while the phytochemical studies showed the presence of alkaloids, resins,glycosides,carbohydrate,reducing sugar,flavonoids,terpenoids,saponins and tannins. Conclusion:The extract of A senegalensis possessed anticonvulsant activity with pronounced hypnotic and muscle relaxant effects.

关键词： Annona senegalensis Hypnosis Anticonvulsant Muscle relaxant

A New Compound from the Bud of Chrysanthemum indicum L.

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Chinese Chemical Letters 2005年第10期16卷 1341-1342页

作者： Wen Ming CHENG Tian pa YOU Jun LI Department of Chemistry University of Science and Technology of China Hefei 230026 School of Pharmacy Anhui Medical University Hefei 230032

A new bicyclic spiroketone was isolated from the bud of Chrysanthemum indicum L. The chemical structure was elucidated as （1R, 9S, 10S）-10-hydroxyl-8 （2＇, 4＇-diynehexylidene）- 9-isovaleryloxy-2, 7-dioxaspiro [5,... 详细信息

关键词： Chrysanthemum indicum L. X-ray crystallography bicyclic spiroketone (1R 9S,10S)-10-hydroxyl-8 (2' 4'-diynehexylidene)-9-isovaleryloxy-2 7-dioxaspiro[5 4]decane.

Laryngopharyngeal reflux in patients with reflux esophagitis

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World Journal of Gastroenterology 2008年第28期14卷 4523-4528页

作者： Yung-Chih Lai pa-Chun Wang Jun-Chen Lin Division of Gastroenterology Department of Internal Medicine Cathay General Hospital School of Medicine National Taiwan University School of Medicine Taipei Medical University Taipei 10630 Taiwan China Department of Otolaryngology Cathay General Hospital School of Medicine Fu Jen Catholic University Taipei 10630 School of Public Health China Medical University Taichung 40402 Taiwan China Department of Otolaryngology Cathay General Hospital Taipei 10630 Taiwan China

AIM: To assess the prevalence of laryngopharyngeal reflux (LPR) in patients with reflux esophagitis and dis-close factors contributing to the development of LPR. METHODS: A total of 167 patients who proved to have reflux esophagitis by endoscopy were enrolled. They received laryngoscopy to grade the reflux find-ings for the diagnosis of LPR. We used validated ques-tionnaires to identify the presence of laryngopharyn-geal symptoms, and stringent criteria of inclusion to increase the specificity of laryngoscopic findings. The data of patients were analyzed statistically to find out factors related to LPR. RESULTS: The prevalence rate of LPR in studied sub-jects with reflux esophagitis was 23.9%. Age, hoarse- ness and hiatus hernia were factors significantly as-sociated with LPR. In 23 patients with a hiatus hernia, the group with LPR was found to have a lower trend of esophagitis grading. CONCLUSION: Laryngopharyngeal reflux is present in patients with reflux esophagitis, and three predicting factors were identified. However, the development of LPR might be different from that of reflux esophagi-tis. The importance of hiatus hernia deserves further study.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease Reflux esophagitis

Incidence and histopathology of encysted progenetic metacercaria of Clinostomum complanatum(Digenea:Clinostomidae) in Channa punctatus and its development in experimental host

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Asian pacific Journal of Tropical Biomedicine 2012年第6期2卷 421-426页

作者： pa Ahammed Shareef SMA Abidi Section of parasitology Department of Zoology Aligarh Muslim University

Objective:To study the incidence of encysted progenetic metacercariae of Clinostomum complanatum(C. complanatum) in Channa punctatus(C. punctatus), associated histopathology and the experimental infection to laboratory chicken to obtain ovigerous adult ***:Live C. punctatus were brought from local fish market of Aligarh, India, dissected and examined on a monthly basis for the presence of C. complanatumcysts. For histochemistry, infected tissue sections with attached cysts were processed for haematoxylene and eosin staining. Cysts were aseptically fed to 4 day old leghorn chicken to obtain adult worms. Mechanically excysted metacercaria and the ovigerous adult worms were stained in carmine to prepare permanent ***:One year survey for the infection of encysted progenetic metacercaria of ***. punctatusrevealed the prevalence, intensity and abundance of 24.7%, 2.27and 0.608, respectively. Histopathology showed heavy infiltration of immune cells at the site of cyst attachment and some tissue damage was also evident. Following feeding to experimental chicken, about 41.07% of the encysted metacercariae were able to excyst and migrate back to bucco-pharyngeal region where they tenaciously attached and fed on blood, and transformed into ovigerous adult worms from 62 hours onwards of post ***:The parasite is potentially pathogenic to the host, and the availability of a suitable intermediate host can be a contributing factor for the occurrence of C. complanatummetacercaria either in the excysted or encysted form, indicating loose host specificity and zoonotic potential.

关键词： Clinostomum complanatum Encysted progenetic metacercaria Channa punctatus Histopathology Experimental infection Ovigerous adult worm Incidence Host-parasite interaction Metacercarial transformation

Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine

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BIOCELL 2015年第2期39卷 1-3页

作者： Anna paŃCZYSZYN Anna KROP-WATOREK Maciej WIECZOREK University of Opole Department of Biotechnology and Molecular BiologyOpolePoland Ludwik Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of SciencesWroclawPoland

Carcinoembryonic antigen(CEA)is a surface glycoprotein expressed in human epithelial cells and is released from their surface,especially during colorectal ***,colorectal cancer is accompanied by inflammation,where tumor-infiltrating neutrophils play an important *** was also found to be a strong chemotactic agent for *** purpose of this study was to find out if CEA can enhance neutrophil priming and *** neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine(formyl-MLP)and the resulting oxidative burst was measured ***,in vitro priming of neutrophils by CEA,alone or preceded by LPS,inhibited subsequent activation of these cells by *** may have anti-inflammatory properties in vivo.

关键词： CEA oxidative burst formyl-MLP

A thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene

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World Journal of Gastroenterology 2005年第11期11卷 1634-1638页

作者： Theeraphong Pho-Iam Wanna Thongnoppakhun pa-thai Yenchitsomanus Chanin Limwongse Division of Molecular Genetics Division of Medical Genetics

AIM: To investigate mutation of serine protease 1-cationic trypsinogen (CT, PRSS1) gene in members of a thai family with hereditary pancreatitis and pancreatic cancer. METHODS: Polymerase chain reaction and direct sequencing were performed to analyze the PRSS1 gene in two members of the family affected by pancreatitis. Allele specific amplification (ASA) method was then developed to detect the mutation of the PRSS1 gene in all available members of the family and normal control subjects. RESULTS: A cytosine (C) to thymine (T) mutation at position 2441 (g.2441C>T) of the PRSS1 gene, which results in a substitution of arginine by cysteine at position 116 (R116C) of CT, was identified by direct sequencing in both clinically affected members of the family but was not found in the unaffected member. This mutation, which might be arising from deamination of methylated cytosine in CpG dinucleotide of codon 116 (CGT>TGT), was also detected by the ASA method in the two affected members and a proband's brother but was not observed in unaffected members and 54 normal control subjects. CONCLUSION: Autosomal dominant pancreatitis with increased cancer risk in the studied thai family is most likely due to missense (R116C) mutation in the PRSS1 gene.

关键词： PRSS1 Hereditary pancreatitis pancreatic cancer thai R116C