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在家用器具中CFC_(12)替代的可能性

能源研究与信息 1991年第4期7卷 52-62,51页

作者： L.J.M.Kuijpers J.A.deWit M.J.P.janssen 沈豫铨

讫今为止,在家用制冷器具中,还没有合适的能替代CFC_(12)的制冷剂。这种速冷剂,至少在压力、压缩比、无毒性和不可燃性这些方面能与CFC_(12)相类似。唯一相似的制冷剂估计将是H-FC134a和H-CFC_(22)。但尚有许多未确定的方面和缺点与它... 详细信息

讫今为止,在家用制冷器具中,还没有合适的能替代CFC_(12)的制冷剂。这种速冷剂,至少在压力、压缩比、无毒性和不可燃性这些方面能与CFC_(12)相类似。唯一相似的制冷剂估计将是H-FC134a和H-CFC_(22)。但尚有许多未确定的方面和缺点与它们应用的可能性有关,如速冷系统的重新设计也许是必需的。然而,由于家用器具中的制冷迴路是密封的,因此,也许不可燃性的要求会变为允许一定的可燃性。这样,替代物的范围可以考虑得稍微广一点,

关键词：制冷器具家用制冷剂 CFC12

Next generation MHC multimer technology for detection of antigen-specific T cells

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Next generation MHC multimer technology for detection of ant...

聚乙二醇干扰素α-2b单用或联合拉米夫定治疗HBeAg阳性的慢性乙型肝炎:一项随机研究

第十二届全国免疫学学术大会

作者： Garstka Malgorzata Luimstra Jolien J Roex Marthe CJ Redeker Anke janssen George MC Van Veelen Peter A Arens Ramon Falkenburg Frederik JH Neefjes Jacques Ovaa Huib Xi'an Jiaotong University Second Affiliated Hospital Department of Chemical Immunology Leiden University Medical Center Department of Hematology Leiden University Medical Center Department of Immunohematology and Blood Transfusion Leiden University Medical Center Center for Proteomics and Metabolomics Leiden University Medical Center

Peptide ligand presentation by MHC class I molecules is a key element of immunodominance in antiviral and antitumor immune *** multimers are oligomeric forms of MHC-peptide monomers,generally tagged with a fluorochrom... 详细信息

关键词： MHC multimers cytotoxic T cells immunodiagnostics

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 7-8页

作者： janssen H.L.A. Van Zonneveld M. Senturk H. 姜志茹 Depts. Gastroenterol. and Hepatol. Erasmus MC University Medical Center Rotterdam Rotterdam Netherlands

Background Treatment of HBeAg-positive patients with chronic hepatitis B is not effective in most. A combination of immunomodulatory pegylated interferon alfa-2b and antiviral lamivudine might improve the rate of sustained response. Methods 307 HBeAg-positive patients with chronic hepatitis B were assigned combination therapy (100 μg/week pegylated interferon alfa-2b and 100 mg/day lamivudine) or monotherapy (100 μg/week pegylated interferon alfa-2b and placebo) for 52 weeks. During weeks 32-52 the pegylated interferon dose was 50 μg/week in both treatment groups. The analyses were based on the modified intention-to-treat population after exclusion of 24 patients from one centre withdrawn for misconduct, ten who lost HBeAg before the study start, and seven who received no study medication. All included patients were followed up for 26 weeks after treatment. Findings 49 (36%) of 136 patients assigned monotherapy and 46 (35%) of 130 assigned combination therapy had lost HBeAg at the end of follow-up (p=0.91). More of the combination-therapy than of the monotherapy group had cleared HBeAg at the end of treatment (57 [44%] vs 40 [29%]; p=0.01) but relapsed during follow-up. patterns were similar when response was assessed by suppression of serum hepatitis B virus (HBV) DNA or change in concentrations of alanine aminotransferase. Response rates (HBeAg loss) varied by HBV genotype (p=0.01): A, 42 (47%) patients; B, ten (44%); C, 11 (28%); and D, 26 (25%). Interpretation Treatment with pegylated interferon alfa-2b is effective for HBeAg-positive chronic hepatitis B. Combination with lamivudine in the regimen used is not superior to monotherapy. HBV genotype is an important predictor of response to treatment.

关键词：干扰素α HBeAg阳性乙型肝炎随机研究抗病毒药物丙氨酸转氨酶应答率周和单一用药安慰剂

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膝关节的三维数学模型

力学进展 1982年第2期 187-195页

作者： J.Wismans F.Veldpaus J.janssen A.Huson P.Struben 汤浩

数学模型提供了分析研究复杂生物结构的更大可能性。本文提出的模型用来分析二体节之间的运动和力。人的膝关节由于具有复杂解剖结构和复杂三维运动而被选作研究对象。不仅正常功能的正确描述,而且异常功能的辨别和处理,都对人们提出了... 详细信息

数学模型提供了分析研究复杂生物结构的更大可能性。本文提出的模型用来分析二体节之间的运动和力。人的膝关节由于具有复杂解剖结构和复杂三维运动而被选作研究对象。不仅正常功能的正确描述,而且异常功能的辨别和处理,都对人们提出了许多问题。

关键词：膝关节关节囊接触点韧带运动器官胫骨下肢骨股骨

10-Minute Consultation Chronic chilblains

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英国医学杂志中文版 2011年第5期14卷 317-317页

作者： I H Souwer A L M Lagro-janssen

慢性乙型肝炎患者肝炎突发是由宿主因素还是病毒因素诱发:在聚乙二醇干扰素-α2b治疗期间对治疗应答的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 36-37页

作者： Flink H.J Sprengers D Hansen B.E. H.L.A. janssen 李翔 Department of Gastroenterology and Hepatology Erasmus Medical Centre Dr. Molewaterplein 40 3015 GD Rotterdam NetherlandsDr.

Background and aims: Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). patients: A total of 266 patients, participating in a global randomised controlled study, were assigned to 52wee ks of 100 μg pegylated (Peg)-interferon a-2b weekly, combined with either dai ly lamivudine 100 mg or placebo. Results: Sixty seven patients (25%) exhibited 75 flares, with 38 (51%) flares in the combination therapy and 37 (49%) in the monotherapy groups. Overall, 30%of patients with and 38%of patients without a flare responded to therapy (p = 0.25). In 24 patients (36%) the flare was foll owed by a decrease in hepatitis B virus (HBV) DNA (host induced flare). In 25 (3 8%) patients the flare was preceded by an increase in HBV DNA (virus induced fl are). In 17 (26%) patients the flare did not meet one of these criteria (indete rminate flare). Of patients with host induced flare, 58%responded whereas only 20%of patientswith virus induced flares responded (p = 0.008). Hepatitis B surf ace antigen loss (n = 8) was exclusively seen in patients experiencing a host in duced flare. Multivariate logistic analysis showed that host induced flares was an independent predictor of response (p = 0.043). Conclusion: Flares are not mor e common in responders than in non-responders to Peginterferon α-2b therapy. Virus induced flares, which occur after an increase in HBV DNA level, and most p robably are indicative for increased expression of viral antigens, did not lead to treatment response. In contrast, host induced flares which were followed by a HBV DNA decrease were highly associated with treatment response.

关键词：治疗应答乙型肝炎干扰素-α 宿主因素 DNA 安慰剂高度相关性多变量拷贝数

CDC'S REVISED RECOMMENDATIONS FOR HIV TESTING OF ADULTS,ADOLESCENTS AND PREGNANT WOMEN IN HEALTH CARE SETTINGS

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CDC'S REVISED RECOMMENDATIONS FOR HIV TESTING OF ADULTS,ADOL...

艾滋病伦理和政策问题研究扩大艾滋病检测和咨询专家研讨会

作者： Bernard M．Branson H．Hunter Handsfield Margaret A.Lampe Robert S.janssen Allan W.Taylor Sheryl B.Lyss Jill E.Clark Division of HIV/AIDS Prevention National Center for HIV/AIDSViral HepatitisSTDand TB Prevention MD Division of STD Prevention National Center for HIV/AIDSViral HepatitisSTDand TB Prevention and University of WashingtonSeattleWashington MD Division of HIV/AIDS Prevention National Center for HIV/AIDSViral HepatitisSTDand TB Prevention MPH Northrup Grumman Information Technology MPH

These recommendations for human immunodeficiency virus (HIV) testing are intended for all health-care providers in the public and private sectors,including those working in hospital emergency departments,urgent care clinics,inpatient services, substance abuse treatment clinics,public health clinics,community clinics, correctional health-care facilities,and primary care *** recommendations address HIV testing in health-care settings *** do not modify existing guidelines concerning HIV counseling,testing,and referral for persons at high risk for HIV who seek or receive HIV testing in nonclinical settings (e.g.,community-based organizations,outreach settings,or mobile vans).The objectives of these recommendations are to increase HIV screening of patients,including pregnant women,in health-care settings;foster earlier detection of HIV infection;identify and counsel persons with unrecognized HIV infection and link them to clinical and prevention services;and further reduce perinatal transmission of HIV in the United *** revised recommendations update previous recommendations for HIV testing in health-care settings and for screening of pregnant women

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品字型舞台之后的“新新”舞台

演艺科技 2019年第1期 102-107页

作者：路易斯·杨森钟睿(译) 国际舞美组织

今天我将探讨欧洲过去几个世纪歌剧院和大型剧场'后台'的一些主要变化。经过多年的发展,剧场的后台已经变得更高效、更安全,更能满足布景设计师的想法和公众的期望,更适应繁忙的演出和排练排期,更符合越来越严格的健康和安全法规,当然,... 详细信息

今天我将探讨欧洲过去几个世纪歌剧院和大型剧场'后台'的一些主要变化。经过多年的发展,剧场的后台已经变得更高效、更安全,更能满足布景设计师的想法和公众的期望,更适应繁忙的演出和排练排期,更符合越来越严格的健康和安全法规,当然,也逐渐适应了新的舞台技术。我还将谈到未来'后台'的发展变化,并会把我认为正确并且在将来也都十分重要的一些关键词列出。

关键词：歌剧院德意志剧场设计

绿色等离子遇到黑色纤维——等离子活化环境友好碳纤维

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国际纺织导报 2014年第8期42卷 15-16页

作者： A.Saelhoff C.janssen G.Seide T.Gries N.Moller 于艳婷亚琛工业大学 diener电子公司

碳纤维复合材料(CFRP)质量轻,强度高,在机械制造业可代替钢板,是一种有前途的材料。尽管钢板很重,但在当前仍是最先进的材料。目前,CFRP生产不是为了获得轻质量的终端产品,而是旨在符合航天工程的标准规范(部分已经过时)。这意味着,除... 详细信息

碳纤维复合材料(CFRP)质量轻,强度高,在机械制造业可代替钢板,是一种有前途的材料。尽管钢板很重,但在当前仍是最先进的材料。目前,CFRP生产不是为了获得轻质量的终端产品,而是旨在符合航天工程的标准规范(部分已经过时)。这意味着,除其他问题,纤维与基体之间的黏结性能没有得到优化。表面黏附的最优化可以进一步降低能量消耗,从而产生积极的环境影响,尤其是交通工程应用中。通过开发"绿色加工"达到节约能源的"绿色目标",使这项研究工作更有价值。介绍了通过等离子体处理活化碳纤维表面的方法。

关键词：碳纤维碳纤维复合材料黏合等离子体处理