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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-prieto Darren Wragg Nicole Heiduk Mihyun park Nicole Strittmatter Roland A.Fischer Angela Casini Guillermo Moreno-Alcántar Chair of Medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

Gene Therapy of Cancer:Induction of Anti-Tumor Immunity

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Cellular & Molecular Immunology 2004年第2期1卷 105-111页

作者： Jesus prieto Division

Many malignancies lack satisfactory treatment and new therapeutic options are urgently *** therapy is a new modality to treat both inherited and acquired diseases based on the transfer of genetic material to the *** gene therapy strategies against cancers have been developed.A considerable number of preclinical studies indicate that a great variety of cancers are amenable to gene *** these strategies, induction of anti-tumor immunity is the most promising *** therapy with cytokines has reached unprecedented success in preclinical models of *** rather than additive effects have been demonstrated by combination of gene transfer of cytokines/chemokines,costimulatory molecules or adoptive cell *** progress in vector technology and in imaging techniques allowing in vivo assessment of gene expression will facilitate the development of clinical applications of gene therapy,a procedure which may have a notorious impact in the management of cancers lacking effective *** & Molecular Immunology.2004;1(2):105-111.

关键词： gene therapy anti-tumor immunity cytokines costimulatory molecules dendritic cell

Phylogeny,taxonomy and diversification events in the Caliciaceae

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Fungal Diversity 2017年第1期82卷 221-238页

作者： Maria prieto Mats Wedin Department of Botany Swedish Museum of Natural HistoryPO Box 5000710405 StockholmSESweden Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosC/Tulipan s/n28933 MostolesMadridSpain

Although the high degree of non-monophyly and parallel evolution has long been acknowledged within the mazaediate Caliciaceae(Lecanoromycetes,Ascomycota),a natural re-classification of the group has not yet been *** we constructed a multigene phylogeny of the Caliciaceae-Physciaceae clade in order to resolve the detailed relationships within the group,to propose a revised classification,and to perform a dating *** few characters present in the available fossil and the complex character evolution of the group affects the interpretation of morphological traits and thus influences the assignment of the fossil to specific nodes in the phylogeny,when divergence time analyses are carried *** fossil assignments resulted in very different time estimates and the comparison with the analysis based on a secondary calibration demonstrates that the most likely placement of the fossil is close to a terminal node rather than a basal placement in the Calicium *** dating analysis show two successive events giving rise to main clades of mazaediate taxa within the Caliciaceae,in the Upper-Lower Cretaceous boundary and in the *** a result of this study,Cyphelium is synonymized with Calicium,Acolium is resurrected,and the new genera Allocalicium and Pseudothelomma are *** new combinations are proposed:Acolium karelicum,Acolium marcianum,Allocalicium adaequatum,Calicium carolinianum,Calicium lecideinum,Calicium lucidum,Calicium notarisii,Calicium pinicola,Calicium trachyliodes,Pseudothelomma occidentale,Pseudothelomma ocellatum and Thelomma brunneum.A key for the mazaedium-producing Caliciaceae is included.

关键词： Allocalicium gen nov Calicium fossil Divergence time estimates Lichens Multigene Pseudothelomma gen nov

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases

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中国神经再生研究：英文版 2023年第8期18卷 1713-1714页

作者： Susy prieto Huarcaya Friederike Zunke Department of Molecular Neurology University Hospital ErlangenFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Lysosomes are ubiquitous and dynamic organelles with a central role in degradation and recycling of damaged cell components and misfolded proteins,otherwise known as *** plays a fundamental role in the process of correcting cell homeostasis and cellular ***,this process is essential in the central nervous system,as neurons are not able to easily eliminate altered proteins given their post-mitotic state.

关键词： homeostasis diseases otherwise

Bofedal response to climate variability, local management, and water extraction: A case study of Chucuyo, Northern Chile

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Journal of Mountain Science 2022年第1期19卷 241-252页

作者： URIBE-ÁLVAREZ Monserrat C prieto Manuel MESEGUER-RUIZ Oliver Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáArica 1010069Chile Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáIquique 1101783Chile

Andean high-altitude wetlands are important ecosystems that serve a range of socialecological functions. In the Andes, bofedales, a specific type of peat-producing wetland, are essential for the sustainability of mountain ecosystems and indigenous pastoralist communities. The Chucuyo bofedal in northern Chile is affected by climatic variability and water extraction for agricultural uses via the Lauca canal. Herders in the local community also actively manage this wetland according to their traditional ecological knowledge to ensure permanent fodder for their animals. In this article, we analyze the annual behavior of the Chucuyo bofedal after the wet season. Based on precipitation data, extracted water flows, vegetation vigor from satellite images, and an ethnographic approach, we determined that the bofedal’s productivity was negatively correlated with the amount of precipitation and positively correlated with the surface area of the wetland. However, water extraction via the Lauca channel had no significant relationship with either surface area or vegetation vigor. We identify community practices and traditional ecological knowledge as key elements in the maintenance of these ecosystems. This situation is critical in the context of an aging population and the current pattern of migration out of the region to urban areas. The results provide substantial empirical evidence for future decision-making regarding the conservation of these ecosystems.

关键词： Atacama Bofedales Indigenous people Lauca canal Normalized Difference Vegetation Index

On the road towards the global analysis of human synapses

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Neural Regeneration Research 2017年第10期12卷 1586-1589页

作者： G.Aleph prieto Carl W.Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineCAUSA

Synapses are essential units for the flow of information in the *** the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and *** comparison,the study of human synapses has evolved significantly slower,mainly because of technical ***,three novel methods allowing the analysis of molecular,morphological,and functional properties of human synapses may expand our knowledge of the human ***,we briefly describe these methods,and evaluate how the information provided by each unique approach may contribute to the functional and anatomical analysis of the synaptic component of human brain *** particular,using tissue from cryopreserved human brains,synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation（FASS-LTP）,and subpopulations of synapses can be thoroughly assessed in the ribbons of brain tissue by array tomography（AT）.Currently,it is also possible to quantify synaptic density in the living human brain by positron emission tomography（PET）,using a novel synaptic ***,data provided by FASS-LTP,AT,and PET may significantly contribute to the global understanding of synaptic structure and function in both healthy and diseased human brains,thus directly impacting translational research.

关键词： fluorescence analysis of single-synapse long-term potentiation array tomography positron emission tomography synaptosomes flow cytometry microscopy [11C]UCB-J[(R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3 4 5-trifluorophenyl)pyrrolidin-2-one]

Combination of Interleaved Single-input Multiple-output DC-DC Converters

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 132-142页

作者： Eladio Dur´an Aranda Salvador P´erez Litr´an Mar´ıa Bella Ferrera prieto Electronic Engineering Computer Systems and Automation DepartmentUniversity of HuelvaHuelvaSpain Electrical and Thermal Engineering Design and Projects DepartmentUniversity of HuelvaHuelvaSpain

This paper analyses,simulates and verifies an experimental prototype of a four-phase interleaved DC-DC *** is based on a SEPIC-Cuk *** developed prototype has been used in single-input multiple-output(SIMO)*** combined converter allows obtaining dual output voltages of the same value,from a single input DC voltage and with only a power *** interleaved DC-DC converters achieve a better dynamic response and low ripple,maintaining their *** converter is connected in parallel,thereby managing their losses by distributing them between more components,which facilitates the thermal management of the multiphase converter and allows handling high power values in small sizes with respect to solutions for a single *** control strategies were applied:synchronous operation mode(SOM)and interleaved operation mode(IOM).The simulation results allow the comparison of both operational modes,verifying that the IOM presents advantages with respect to the ripple at the input and output *** experimental prototype was designed for a distributed power architecture and bipolar DC microgrid(MG).

关键词： Bipolar DC DC-DC converter interleaved

Gene therapy of liver cancer

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World Journal of Gastroenterology 2006年第38期12卷 6085-6097页

作者： Ruben Hernandez-Alcoceba Bruno Sangro Jesus prieto Division of Gene Therapy and Hepatology School of Medicine Foundation for Applied Medical Research-CIMA University of Navarra Spain Department of Medicine Clinica Universitaria University of Navarra Spain Division of Gene Therapy and Hepatology School of Medicine Foundation for Applied Medical Research-CIMA University of Navarra Spain Department of Medicine Clinica Universitaria University of Navarra Spain

The application of gene transfer technologies to the treatment of cancer has led to the development of new experimental approaches like gene directed enzyme/pro- drug therapy (GDEPT), inhibition of oncogenes and restoration of tumor-suppressor genes. In addition, gene therapy has a big impact on other fields like cancer immunotherapy, anti-angiogenic therapy and virotherapy. These strategies are being evaluated for the treatment of primary and metastatic liver cancer and some of them have reached clinical phases. We present a review on the basis and the actual status of gene therapy approaches applied to liver cancer.

关键词： Gene therapy Cancer Liver Hepatocellular carcinoma Vector Therapeutic gene

Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures

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Journal of Computer Science & Technology 2013年第3期28卷 508-524页

作者： Andrés Ortiz Julio Ortega Antonio F.Díaz Alberto prieto Department of Communications Engineering University of Málaga Department of Computer Architecture and Technology/CITIC University of Granada

Improving the network interface performance is needed by the demand of applications with high communication requirements （for example, some multimedia, real-time, and high-performance computing applications）, and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present OS network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location （proximity to the memories where the different data structures are stored） and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections.

关键词： interrupt affinity processor affinity network interface offioading, SIMICS

Collaborative learning via social computing

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 265-282页

作者： Ricardo S.ALONSO Javier prieto óscar GARCíA Juan M.CORCHADO BISITE Research Group University of Salamanca

Educational innovation is a field that has been greatly enriched by using technology in its processes, resulting in a learning model where information comes from numerous sources and collaboration takes place among multiple students. One attractive challenge within educational innovation is the design of collaborative learning activities from the social computing point of view, where collaboration is not limited to student-to-student relationships, but includes student-to-machine interactions. At the same time, there is a great lack of tools that give support to the whole learning process and are not restricted to specific aspects of the educational task. In this paper, we present and evaluate context-aware framework for collaborative learning applications(CAFCLA) as a solution to these problems. CAFCLA is a flexible framework that covers the entire process of developing collaborative learning activities, taking advantage of contextual information and social interactions. Its application in the experimental case study of a collaborative WebQuest within a museum has shown that, among other benefits, the use of social computing improves the learning process, fosters collaboration, enhances relationships, and increases engagement.

关键词： Context-awareness Collaborative learning Social computing Virtual organizations Wireless sensor networks Real time location system