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冠状动脉严重狭窄的稳定型心绞痛患者侧支循环与内皮祖细胞的关系研究

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中国医师杂志 2011年第9期13卷 1177-1180页

作者：祁学文刘海峰马龙乐王孟赞泰山医学院聊城临床学院心内科山东省聊城252000 泰山医学院聊城临床学院保健科

目的探讨冠状动脉严重狭窄的稳定型心绞痛患者冠状动脉侧支循环形成与循环内皮祖细胞（EPcs）的关系。方法将2008年12月至2010年3月期间入院的稳定性心绞痛患者，经冠状动脉造影检查冠脉有重度狭窄的，将其分为侧支循环良好组（coil＋... 详细信息

目的探讨冠状动脉严重狭窄的稳定型心绞痛患者冠状动脉侧支循环形成与循环内皮祖细胞（EPcs）的关系。方法将2008年12月至2010年3月期间入院的稳定性心绞痛患者，经冠状动脉造影检查冠脉有重度狭窄的，将其分为侧支循环良好组（coil＋组，／7,=42）和侧支循环不良组（coll一组，n=50）。采集研究对象外周血40m1进行EPcs的分离培养，计数EPcs的数量，测定其体外成血管能力，并用酶联免疫吸附法检测92例入选者血浆sDF－1d水平。结果coll＋组EPcs数量显著高于coll一组[（22．10±4．69）cFUs／10。EPcsVs（16．90±3．66）cFUs／10。EPcs，P〈0．01]，其体外成血管能力也明显强于coil一组（25．3±3．2Vfi17．4±2．6，P〈0．01），血浆sDF—1a水平显著高于coll一组[（243．7±19．2）ng／mlvs（203．1±17．8）ng／ml，P〈0．01]。EPcs的数量、体外成血管能力、血浆sDF－1d水平与侧支循环程度呈正相关（r=0．74，0．69，0．82，P〈0．01），同时EPcs的数量、体外成血管能力与血浆sDF－10【水平呈正相关（r=0．81，0．64，P〈0．01）。结论冠脉严重狭窄的冠心病患者其冠脉侧支良好者循环内皮祖细胞数量增多、体外成血管能力增强，这种变化可能与血浆sDF－1“水平升高有关，提高内皮祖细胞的数量、功能以及sDF－1仅活性的治疗方法将对冠心病患者有益。

关键词：冠状动脉狭窄/并发症心绞痛/并发症/病理学侧支循环内皮细胞

Tumor cell-intrinsic PD-L1 promotes tumor-initiating cellgeneration and functions in melanoma and ovarian cancer

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signal Transduction and Targeted Therapy 2016年第1期1卷 1-9页

作者： Harshita B Gupta curtis A clark Bin Yuan Gangadhara sareddy srilakshmi pandeswara Alvaro s padron Vincent Hurez Jose conejo-Garcia Ratna Vadlamudi Rong Li Tyler J curiel Department of Medicine University of Texas Health Science CenterSan AntonioTXUSA The Graduate school of Biomedical sciences University of Texas Health Science CenterSan AntonioTXUSA Department of Molecular Medicine University of Texas Health Science CenterSan AntonioTXUSA Department of Obstetrics and Gynecology University of Texas Health Science CenterSan AntonioTXUSA Tumor Microenvironment and Metastasis Program The Wistar InstitutePhiladelphiaPAUSA cancer Therapy and Research center University of Texas Health Science CenterSan AntonioTXUSA Department of Microbiology and Immunology University of Texas Health Science CenterSan AntonioTXUSA

As tumor PD-L1 provides signals to anti-tumor PD-1^(+)T cells that blunt their functions,αPD-1 andαPD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling ***,tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor cell proliferation and mTOR signals,among other important ***-initiating cells(TIcs)generate carcinomas,resist treatments and promote *** show here that in murine B16 melanoma and ID8agg ovarian carcinoma cells,TIcs express more PD-L1 versus *** PD-L1 in B16 and ID8agg cells by shRNA(‘PD-L1lo’)reduced TIc numbers,the canonical TIc genes nanog and pou5f1(oct4),and functions as assessed by tumorosphere development,immune-dependent and immune-independent tumorigenesis,and serial transplantability in ***,tumor PD-L1 sensitized TIc to interferon-γand rapamycin in ***-intrinsic PD-L1 similarly drove functional TIc generation,canonical TIc gene expression and sensitivity to interferon-γand rapamycin in human Es2 ovarian cancer ***,tumor-intrinsic PD-L1 signals promote TIc generation and virulence,possibly by promoting canonical TIc gene expression,suggesting that PD-L1 has novel signaling effects on cancer pathogenesis and treatment responses.

关键词： melanoma interferon initiating

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红斑狼疮性脑病16例cT表现分析

新疆医科大学学报 2013年第9期36卷 1351-1353页

作者：赵丽萍王红王云玲马景旭贾文霄新疆医科大学第二附属医院影像中心乌鲁木齐830063

目的探讨红斑狼疮性脑病的cT征象及其临床诊断价值。方法回顾性分析1995—2013年共计16例系统性红斑狼疮脑损害患者的颅脑cT检查结果,16例患者均表现出不同程度的神经或精神症状(其中10例患者符合神经精神性红斑狼疮),均行头颅cT检查。... 详细信息

目的探讨红斑狼疮性脑病的cT征象及其临床诊断价值。方法回顾性分析1995—2013年共计16例系统性红斑狼疮脑损害患者的颅脑cT检查结果,16例患者均表现出不同程度的神经或精神症状(其中10例患者符合神经精神性红斑狼疮),均行头颅cT检查。结果红斑狼疮性脑病的cT检查阳性率达93.75%(15/16)。8例患者表现为颞、顶叶或者顶、枕叶单侧或双侧皮层下白质内低密度灶;6例患者表现为双侧或单侧基底节区脑梗塞;9例患者表现为弥漫性中度以下的脑萎缩;1例患者表现为对称性基底节区钙化;2例患者表现为脑出血。结论 cT检查对红斑狼疮性脑病具有较高的敏感性,可以明确病变的部位、性质和范围,且cT扫描速度快,利于患者快速检查。但由于cT征象缺乏特异性,该病的最终确诊仍然需要密切结合临床病史及相关实验室检查。

关键词：系统性红斑狼疮脑病断层摄影术 X线计算机

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班钦释迦乔登对藏传因明学的贡献

青海师范大学学报（藏文版） 2021年第3期 95-110页

作者：玛久杰日本广岛大学 7398527

班钦释迦乔登是萨迦通达显密二教三贤之一,也是藏族历史文化发展中颇具影响力的人物,但是有关客观评价他的因明成就的文章至今还没有。鉴于此,文章以班钦释迦乔登对藏传因明学所做的贡献为主线,较为系统地阐明了班钦释迦乔登在其8~28岁... 详细信息

班钦释迦乔登是萨迦通达显密二教三贤之一,也是藏族历史文化发展中颇具影响力的人物,但是有关客观评价他的因明成就的文章至今还没有。鉴于此,文章以班钦释迦乔登对藏传因明学所做的贡献为主线,较为系统地阐明了班钦释迦乔登在其8~28岁期间,分别学习以绒顿•释迦坚参和桑杰钦均为主的萨迦因明法脉和俄译师因明法脉,并在18~80岁之间,游学桑浦寺、色多坚为主的众多寺院,广泛传播和讲述因明学说,先后著述14部各类因明论著的情况。

关键词：班钦释迦乔登因明桑普寺色多坚寺

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不同类型阵发性房颤的频率分析

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 43-43页

作者： Lin Y. - J. Tai c. - T. Kao T. Dr. s. -A. chen 王亭忠(译) 杜媛(校) 不详 Division of cardiology Taipei Veterans General Hospital 201 Sec. 2 Shih-PaiRoad Taipei Taiwan

OBJEcTIVEs: This study sought to investigate the regional frequency distributi on from multiple bi-atrial sites in different types of paroxysmal atrial fibril lation(AF). BAcKGROUND: A previous study showed a left atrium(LA) to right atriu m(RA) frequency gradient in patients with paroxysmal AF. METHODs: Forty-four pa tients(age=60±16, male patients=27) with paroxysmal AF originating from the pul monary veins(PVs)(n=31) or superior vena cava(sVc)(n=13) were included. Frequenc y analysis was performed on the intracardiac electrograms(7 s, 1 kHz/channel) re corded from PV, posterior LA, coronary sinus(cs), posterolateral RA, and sVc. Th e largest peak frequency was identified as the dominant frequency(DF). REsULTs: In the PV-AF patients, there was a frequency gradient from the PV ostium to the LA, RA, and sVc(8.5±3.3 Hz vs. 5.9±1.1 Hz vs. 5.2±0.85 Hz vs. 5.5±0.48 Hz, respectively, pst DFs were mostly located at the arrhythmogen ic PV ostium(58%). The DFs of the arrhythmogenic PV and PV ostium were signific antly higher than those of the non-arrhythmogenic PVs and PV ostia(psVc-AF patients, there was a frequency gradient from the sVc to the RA, LA , and PV(8.0±2.4 Hz vs. 5.9±1.1 Hz vs. 5.9±0.7 Hz vs. 5.8±0.7 Hz, respective ly, p=0.001). The highest DFs were mostly located inside the sVc(77%) instead o f the sVc ostium(as compared with PV-AF patients, p=0.035). cONcLUsIONs: The lo cation of the highest DF depended on the arrhythmogenic PV or sVc. A frequency g radient was present between the arrhythmogenic thoracic vein and atrium in all p atients.

关键词：阵发性房颤频率分析同类型致心律失常性 sVc 心内心电图频率分布上腔静脉

Exposure to cuticular bacteria can alter host behavior in a funnel-weaving spider

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current Zoology 2018年第3期64卷 721-726页

作者： Olivia B.paRKs Krishna s.KOTHAmasU Michael J.ZIEMBA Morgan BENNER madison cRIsTINZIANO serena KANTZ Daniel LEGER John LI Devanshi paTEL William RABUsE samantha sUTTON Amandi WILsON Priyanka BAIREDDY Aditi A.KAmaT mariah J.cALLAs matthew J.BORGEs marysa N.scALIA Emily KLENK Gabrielle scHERER maria M.maRTINEZ sarah R.GRUBs Nancy KAUFmaNN Jonathan N.PRUITT carl N.KEIsER Department of Biological sciences University of PittsburghPittsburghPA 15260USA Department of Ecology Evolutionand Marine BiologyUniversity of CaliforniaSanta BarbaraCA 93106USA Rice University Academy of Fellows Rice UniversityHoustonTX 77005USA Department of Biosciences Rice UniversityHoustonTX 77005USA

contact with environmental microbes are arguably the most common species interaction in which any animal *** have noted diverse relationships between hosts and resident microbes,which can have strong consequences for host development,physiology,and behavior. many of these studies focus specifically on pathogens or beneficial microbes,while the benign microbes,of which the majority of bacteria could be described,are often ***,we explore the nature of the relationships between the grass spider Agelenopsis pennsylvanica and bacteria collected from their cuticles in ***,using culture-based methods,we identified a portion of the cuticular bacterial communities that are naturally associated with these ***,we topically exposed spiders to a subset of these bacterial monocultures to estimate how bacterial exposure may alter 3 host behavioral traits:boldness,aggressiveness,and activity *** conducted these behavioral assays 3 times before and 3 times after topical application,and compared the changes observed in each trait with spiders that were exposed to a sterile control *** identified 9 species of bacteria from the cuticles of 36 spiders and exposed groups of 20 spiders to 1 of 4 species of cuticular *** found that exposure to Dermacoccus nishinomiyaensis and staphylococcus saprophyticus was associated with a lo-fold decrease in the foraging aggressiveness of spiders toward prey in their *** bacterial exposure did not have survival consequences for hosts,these data suggest that interactions with cuticular bacteria,even non- pathogenic bacteria,could alter host behavior.

关键词： Agelenopsis pennsylvanica aggressiveness Araneae cuticular bacteria personality

减肥期间低糖负荷饮食对静息能量消耗和心脏病危险因素的作用

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 21-21页

作者： Pereira M. A. swain J. Goldfine A. B. D. s. Ludwig 王亭忠 Department of Medicine Children's Hospital 300 Longwood Ave Boston MA 02115 United States Dr.

context: Weight loss elicits physiological adaptations relating to energy inta ke and expenditure that antagonize ongoing weight loss. Objective: To test wheth er dietary composition affects the physiological adaptations to weight loss, as assessed by resting energy expenditure. Design, study, and participants: A rando mized paralleldesign study of 39 over-weight or obese young adults aged 18 to 4 0 years who received an energy-restricted diet, either low-glycemic load or lo w-fat. participants were studied in the General clinical Research centers of th e Brigham and Women’s Hospital and the children’s Hospital, Boston, mass, befo re and after 10%weightless. The study was conducted from January 4,2001, to may 6, 2003. main Outcome Measures: Resting energy expenditure measured in the fast ing state by indirect calorimetry, body composition by dual-energy X-ray absor ptiometry, cardiovascular disease risk factors, and self-reported hunger. Resul ts: Resting energy expenditure decreased less with the low-glycemic load diet t han with the low-fat diet, expressed in absolute terms(mean[sE], 96 [24] vs 176 [27] kcal/d; P=.04) or as a proportion(5.9%[1.5%] vs 10.6%[1.7%]; P=.05). pa rticipants receiving the low-glycemic load diet reported less hunger than those receiving the low-fat diet(P=.04). Insulin resistance(P=.01), serum triglyceri des(P=.01), c-reac-tive protein(P=.03), and blood pressure(P=.07 for both syst olic and diastolic) improved more with the low-gly-cemic load diet. changes in body composition (fat and lean mass) in both groups were very similar(P=.85 and P=.45, respectively). conclusions: changes in dietary composition within prevai ling norms can affect physiological adaptations that defend body weight. Reducti on in glycemic load may aid in the prevention or treatment of obesity, cardiovas cular disease, and diabetes mellitus.

关键词：糖负荷静息能量消耗低脂饮食生理性代偿反应饥饿感空腹状态胰岛素抵抗临床研究中心儿童医院心血管疾病