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Biological characteristics and clinical management of uveal and conjunctival melanoma

Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kaŠTELAN ANA DIDOVIĆpaVIČIĆ DARIA paŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai Wong ka Ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

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Evolution of Mother-to-Child HIV-1 Transmission Rate in Mali from 2009 to 2018

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Advances in Microbiology 2024年第5期14卷 256-267页

作者： Alou Sanogo Mohamed Ag Baraïka Maïga Aminata Demba Koita Mahamadou Abdou Mamadou guindo Clémentine N’Diaye Fatoumata Namoudou Traoré Abdoulaye Bagayoko Youssouf Diallo Flabou Bougoudogo Ibrehima guindo National Institute for Public Health Bamako Mali Faculty of Pharmacy (FAPH) University of Science of Technical and Technology de Bamako Bamako Mali University Hospital Center (CHU)-Point g Bamako Mali Faculty of Medecine and Odonto-Stomatology University of Science of Technical and Technology de Bamako Bamako Mali Sector Unit for the Fight against AIDS Tuberculosis and Hepatitis Bamako Mali UNICEF (United Nations Children’ s Fund) Bamako Mali

Despite enormous efforts to achieve the goal of eliminating mother-to-child transmission of HIV-1, it remains a major challenge for many countries in sub-Saharan Africa, particularly Mali. Our objective is to assess changes in the rate of mother-to-child transmission of HIV-1. We conducted a cross-sectional study between January 1, 2009 to December 31, 2018 (10 years) of early diagnosis activity in newborns and children born to HIV-1-positive mothers at the National Institute for Public Health (INSP). The samples came from health and referral centers in mali. All samples were received at the Laboratory of Molecular Biology at the INSP. Proviral DNA extraction was performed from a blood spot sample with a Roche DNA kit, Cobas AmpliPrep/Cobas TaqMan HIV-1 qualitative Test, V2.0 (Roche Molecular System, Inc, USA) following the company procedures. Molecular diagnosis was performed using the same kits using an algorithm of three identical PCRs. The Epi Info version 7 software was used for data analysis with a significance threshold of 5%. A total of 10,714 samples of infants and children born to HIV-positive mothers were analyzed by PCR. Ninety-six percent of mothers were on ARV prophylaxis (AZT 3TC NVP and AZT NVP) and 60% of newborns received the same ARV prophylaxis. Of these children, 956 tested positive with an overall transmission rate of 8.92%, varying between 7.27% in 2009 and 08.01% in 2018. This rate was relatively low among children receiving prophylaxis at 2.04% and remained high for children who received breastfeeding at 5.62%. However, the transmission rate remains low for those who have benefited from mixed and artificial breastfeeding at 1.58% and 1.27% respectively. A significant proportion of children remained infected by their mothers during pregnancy, childbirth or breastfeeding. This study shows the importance of early diagnosis of HIV in children using molecular technology.

关键词： Early Diagnosis Mothers-to-Child Newborns PCR DNA HIV-1

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Ultra-low temperature cofired ceramics based on Li_(2)WO_(4)as perspective substrate materials for terahertz frequencies

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Journal of Advanced Ceramics 2023年第3期12卷 526-538页

作者： Dorota Szwagierczak Beata Synkiewicz-Musialska Jan Kulawik Elżbieta Czerwińska Norbert pałka Kraków Division Łukasiewicz Research Network-Institute of Microelectronics and PhotonicsKraków 30-701Poland Institute of Optoelectronics Military University of TechnologyWarszawa 00-908Poland

With the development of low dielectric permittivity materials having an ultra-low sintering temperature,testing their dielectric properties at terahertz frequencies suitable for 6g communication systems and implementation of the fabricated materials in ultra-low temperature cofired ceramics(ULTCC)were the main goals of the *** tungstate Li_(2)WO_(4)was synthesized by a solid-state reaction and used for the preparation of green tapes and test structures with cofired internal conductive layers,which are destined for substrates of microwave and submillimeter wave *** behavior,thermal effects,and mass changes of the green tapes during heating were studied using a hot-stage microscope,differential thermal analysis,and thermogravimetry.A single-phase composition was revealed for being undoped and doped with AlF3–CaB_(4)O_(7)*** impact of frequency,temperature,the addition of AlF3–CaB_(4)O_(7)and CuBi_(2)O_(4)dopants,and sintering temperature was the subject of in-depth characterization of dielectric properties in a terahertz region.A glass-free composition,ultra-low sintering temperature of 590–630℃,low roughness of the green tapes,dense microstructure,compatibility with Ag conductors,low and stable dielectric permittivity of 5.0–5.8 in a broad range of 0.2–2 THz,and low dielectric loss of 0.008–0.01 at 1 THz are the main advantages of the developed ULTCC substrates.

关键词： Li_(2)WO_(4) ultra-low temperature cofired ceramics(ULTCC) tape casting dielectric properties terahertz frequency range

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Microstructure and Property Relationships in Resistance Spot Weld between 7114 Interstitial Free Steel and 304 Austenitic Stainless Steel

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Journal of Materials Science & Technology 2006年第3期22卷 375-381页

作者： Ahmet Hasanba■o■lu Ramazan kaar Department of Metal Education karabük Technical Education Faculty Karabük 78100 Turkey

Due to the differences in physical, chemical and mechanical properties of the base metals, the resistance spot welding of dissimilar materials is generally more challenging than that of similar materials. The influence of the primary welding parameters affecting the heat input such as peak current on the morphology, microhardness, and tensile shear load bearing capacity of dissimilar welds between 304 grades austenitic and 7114 grade interstitial free steel has been investigated in this study. The optimum welding parameters producing maximum joint strength were established at a peak current of 9 ka, where the electrode force is kept 6×10^-5 pa and weld time is kept constant 17 cycles, respectively. The primary cause of weakening the weldment is identified as the excessive grain growing region of heat affected zone （HAZ） in case of 7114 grade interstitial free steel.

关键词： Resistance spot weld Interstitial free steel Austenitic stainless steel

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The effect of severe plastic deformation on the Mg properties after CEC deformation

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Journal of Magnesium and Alloys 2020年第3期8卷 761-768页

作者： B.Suikowski M.Janoska g.Boczkal R.Chulist M.Mroczkowski P.paika Department of Non-Ferrous Metals Engineering Faculty of Non-Ferrous MetalsAGH University of Science and Technology30 Mickiewicza Av.Krakow 30-059Poland Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta St.Krakow 30-059Poland

In this study,the effect of severe plastic deformation on the Mg grain refinement and recovery mechanism was *** pure magnesium was deformed at room temperature by cycling extrusion-compression(CEC)process up to large *** steps of deformation have been used by applying 1,2 and 4 passes of CEC giving a total effective plastic strain ofε=*** and structural properties of Mg in initial state and the states after successive steps of deformation were *** mechanical properties were determined by microhardness and compression tests at room *** structural investigations involved light microscope observations,electron back scattered diffraction and texture measurements by X-ray *** was found that the CEC process refines the grain size down to 6.4μm and reduces strong rolling texture ***,only the first two passes had a strong effect on mechanical properties while a larger number of CEC cycles(above 4)led to failure of the samples with a small effect on *** observation correlates with texture evolution indicating a more random orientation distribution that slows down the typical for hep metals rapid work *** was found that the CEC process activated twin dynamic recrystallization in deformed *** process led to the formation of new randomly oriented grains inside the twinned areas and as a consequence it reduced the strong rolling texture components.

关键词： Magnesium Cyclic extrusion compression Texture Microhardness

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geodesic metrics on fractals and applications to heat kernel estimates

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Science China Mathematics 2023年第5期66卷 907-934页

作者： Qingsong gu ka-Sing Lau Hua Qiu Huo-Jun Ruan Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics The Chinese University of Hong KongHong KongChina Department of Mathematics University of PittsburghPittsburghPA 15217USA School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China

It is well known that for a Brownian motion, if we change the medium to be inhomogeneous by a measure μ, then the new motion(the time-changed process) will diffuse according to a different metric D(·, ·).In 2009, Kigami initiated a general scheme to construct such metrics through some self-similar weight functions g on the symbolic space. In order to provide concrete models to Kigami’s theoretical construction, in this paper,we give a thorough study of his metric on two classes of fractals of primary importance: the nested fractals and the generalized Sierpinski carpets;we further assume that the weight functions g := ga are generated by“symmetric” weights a. Let M be the domain of a such that Dgadefines a metric, and let S be the boundary of M. One of our main results is that the metrics from ga satisfy the metric chain condition if and only if a ∈ *** determine M and S, we provide a recursive weight transfer construction on the nested fractals, and a basic symmetric argument on the Sierpinski carpet. As an application, we use the metric chain condition to obtain the lower estimate of the sub-gaussian heat kernel. This together with the upper estimate obtained by Kigami allows us to have a concrete class of metrics for the time change, and the two-sided sub-gaussian heat kernel estimate on the fundamental fractals.

关键词： Brownian motion heat kernel metric chain condition nested fractal quasisymmetry resistance metric Sierpinski carpet weight function

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FR-Ⅲ型矫治器对不同生长发育期Ⅲ类错牙合颅面结构的影响

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临床口腔医学杂志 2024年第7期40卷 402-406页

作者：王晨林沅佑陈嘉婷赵立星口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院正畸科四川成都610041

目的:对不同生长发育期的安氏Ⅲ类错牙合畸形,根据颈椎骨龄分期分组,通过对正畸治疗前后头颅侧位片的测量分析,比较不同生长发育期开展FR-Ⅲ型矫治器治疗的颅面部效果差异。方法:选取34例使用FR-Ⅲ型矫治器治疗,处于生长发育期的安氏Ⅲ... 详细信息

目的:对不同生长发育期的安氏Ⅲ类错牙合畸形,根据颈椎骨龄分期分组,通过对正畸治疗前后头颅侧位片的测量分析,比较不同生长发育期开展FR-Ⅲ型矫治器治疗的颅面部效果差异。方法:选取34例使用FR-Ⅲ型矫治器治疗,处于生长发育期的安氏Ⅲ类患者,根据颈椎骨龄分期分组:生长发育高峰前期组(CVMⅠ~Ⅱ期)、生长发育高峰期组(CVMⅢ~Ⅳ期)。使用Dolphin 11.8软件对患者颅面结构进行X线头影测量分析。结果:治疗后SNA角、ANB角、U1-SN角、U1-APog距和覆盖、NA-pa角均显著增大(Pg′角、N′-Sn-Pog′角和IMpa角显著减小(P<0.01)。比较生长发育高峰前期组和高峰期组FR-Ⅲ型矫治器矫治前后的差值,高峰期组SNB角、MP-SN差值绝对值显著大于高峰前期组(P<0.05)。结论:FR-Ⅲ型矫治器可促进上颌骨向前生长,改善软组织侧貌,但没有显著抑制下颌骨生长。在生长发育高峰前期矫治,促进上颌骨向前生长的可能性更大,在高峰期矫治会引起下颌骨顺时针旋转。

关键词：安氏Ⅲ类错牙合 FR-Ⅲ型矫治器颈椎骨龄

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Evaluation of natural forest regeneration as a part of land restoration in the Khentii massif,Mongolia

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Journal of Forestry Research 2020年第5期31卷 1773-1786页

作者： David Juricka Antonın Kusbach Jana parılkova Jakub Houska pavlına Ambrozova Vaclav Pecina Zdena Rosicka Martin Brtnicky Jindrich Kynicky Department of geology and Pedology Faculty of Forestry and Wood TechnologyMendel UniversityZemedelska 161300 BrnoCzech Republic Department of Forest Botany Dendrology and GeobiocoenologyFaculty of Forestry and Wood TechnologyMendel UniversityZemedelska161300 BrnoCzech Republic Faculty of Civil Engineering Institute of Water StructuresBrno University of TechnologyZizkova 1760200 BrnoCzech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 656/12361200 BrnoCzech Republic

Forest stands in the semi-arid environment of northern Mongolia have an essential role in controlling ongoing desertification in the surrounding *** the last decade,the total forest area has decreased *** aim of this study was to evaluate the potential of natural regeneration as an essential element for ensuring sustainability of these *** on field measurements from 120 plots in six sites,our assessment tool revealed five qualitative categories of forest regeneration,allowing us to assess impacts of both grazing and environmental conditions on the regeneration *** is a crucial factor and adversely affects *** sites with relatively low grazing intensity,low soil moisture levels represent the main reason for reduced *** approach to classification proposed in this study allows for the identification and interpretation of stand conditions where natural regeneration has *** study provides an important foundation to inform decisionmaking related to land protection and restoration *** findings could be used in comparative studies and,importantly,may aid further mapping of Mongolian forests.

关键词： Mongolia Natural forest regeneration Seedlings Larix sibirica Land restoration Desertification

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抑制火电机组超低频振荡的一次调频建模及仿真

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自动化与仪器仪表 2024年第9期 177-180,185页

作者：张顺李生鹏姚洪宇柏建华曹士保国网甘肃省电力公司电力科学研究院兰州730050 兰州陇能电力科技有限公司兰州730070

近年来,火电机组因调速系统稳定性变差引发超低频振荡现象时有发生,对电网的安全稳定运行带来较大影响。文章基于这一背景,通过分析某电网发生的超低频振荡案例,研究火电机组超振荡现象与调速系统中一次调频动作之间的关联性,设计一种... 详细信息

近年来,火电机组因调速系统稳定性变差引发超低频振荡现象时有发生,对电网的安全稳定运行带来较大影响。文章基于这一背景,通过分析某电网发生的超低频振荡案例,研究火电机组超振荡现象与调速系统中一次调频动作之间的关联性,设计一种能够高度识别低频振荡发生甄别策略,以及基于广义滤波的一次调频优化控制策略。建模仿真及优化应用结果表明,该方案既能够有效抑制因机组调速系统不稳定引发的超低频振荡事件的发生,又能够显著提升调频动作积分电量,从而提高电力系统的本质安全。

关键词：火电机组超低频振荡一次调频建模仿真

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