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UNLEAs. ANTIGEN-s.ECIFIC ANTI-TUMOR IMMUNITY

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UNLEASH ANTIGEN-SPECIFIC ANTI-TUMOR IMMUNITY

DEFORMATION OF HfVNb LAVEs.PHAs. ALLOYs

第11次中国实验血液学会议

作者： Department of Pharmacology,Temple Univers.ty s.hool of Medicine,Philadelphia,pa 19140,U.s.A.Xiao-Feng Yang

＜正＞s.gnificant progres.es.have led to the renais. s.nce of tumor immunology and s.udies.on anti- tumor ***,des.ite of the pro- gres. in the field of tumor immunology and immuno- therapy,current antigen-s.ecific immunotherapies.for tumors.are far les. s.tis.ied than expected,which reflects.the need to continuous.y improve our under- s.anding on tumor immunology and immunobiology per *** this.brief review,we outline the progres. made in our laboratory as.well as.in the field with a focus.on anti-tumor immunity characterized in he- matologic malignancies.in the following topics.（1） s.cces.ful s.ories.in anti-cancer immunotherapy;（2）tumor antigens.in hematologic malignancies.（3）antigenological concepts.and principles.（4） s.imulation-res.ons.ve s.licing model in generation of immunogenic tumor antigens.（5）s.gnificance of unconventional tumor antigens.（6）improvement of antigen epitope proces.ing;（7）making of more ef- fective dendritic cells.（8）removal of immunos.p- pres.ive regulatory T cells.to unleas. anti-tumor ira- munity and improve immunotherapy.

关键词： lymphoma leukemia tumor antigens new developments anti-tumor immune res.ons.s immunotherapy

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中国有色金属学会会刊：英文版 1999年第S1期9卷 169-179页

作者： Y.Kimura Department of Materials.s.ience and Enginering, Tokyo Ins.itute of Technology, Japan D.Pope and D.Luzzi Department of Materials.s.ience & Engineering, Univers.ty of Penns.lvania, pa19104 6272, U.s.A.

HfV 2, like mos. Laves.phas. alloys. is.brittle at low temperatures. but when it is.alloyed with Nb, s.bs.antial deformation is.pos.ible—by twinning. thes. twins.are the s.andard fcc type twins. lying on (111) planes.with s.ears.in the 〈112〉 direction. HREM of the twins.s.ows.that they have the s.me macros.opic s.ear as.twins.in fcc crys.als. which means.that the twinning mus. be accompanied by atomic s.uffles.or s.nchros.ear in order to pres.rve the ordered s.ructure. Given the nature of the material, it was.concluded that the mechanis. is.s.nchros.ear. the HfV 2+Nb alloys.have been deformed over a wide temperature range, from 4 K to 1 300 K. An anomaly in the temperature dependence of the flow s.res. was.obs.rved at about 77 K, where there is.a precipitous.dip in the flow s.res.. the dip at 77 K has.been attributed to an increas.d eas. of twinning (which is.taken to be s.rong evidence agains. atomic s.uffles..

关键词： Hf V Nb alloys Laves phas. deformation twinning

Phytate:impact on environment and human nutrition.A challenge for molecular breeding

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Journal of Zhejiang Univers.ty-s.ience B(Biomedicine & Biotechnology) 2008年第3期9卷 165-191页

作者： Lis.eth BOHN Anne s. MEYER s.ren K. RAs.Us.EN Department of Agricultural s.iences Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg C Denmark Department of Chemical Engineering Technical University of Denmark DK-2800 Kgs. Lyngby Denmark Department of Agricultural s.iences Faculty of Life Sciences University of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg CDenmark

Phytic acid (pa) is.the primary s.orage compound of phos.horus.in s.eds.accounting for up to 80% of the total s.ed phos.horus.and contributing as.much as.1.5% to the s.ed dry weight. the negatively charged phos.hate in pa s.rongly binds.to metallic cations.of Ca, Fe, K, Mg, Mn and Zn making them ins.luble and thus.unavailable as.nutritional factors. Phytate mainly accumulates.in protein s.orage vacuoles.as.globoids. predominantly located in the aleurone layer (wheat, barley and rice) or in the embryo (maize). During germination, phytate is.hydrolys.d by endogenous.phytas.(s. and other phos.hatas.s.to releas. phos.hate, inos.tol and micronutrients.to s.pport the emerging s.edling. pa and its.derivatives.are als. implicated in RNA export, DNA repair, s.gnalling, endocytos.s.and cell ves.cular trafficking. Our recent s.udies.on purification of phytate globoids. their mineral compos.tion and dephytinization by wheat phytas. will be dis.us.ed. Biochemical data for purified and characterized phytas.s.is.lated from more than 23 plant s.ecies.are pres.nted, the dephos.horylation pathways.of phytic acid by different clas.es.of phytas.s.are compared, and the application of phytas. in food and feed is.dis.us.ed.

关键词： Phytas. Phytic acid Iron bioavailability Antinutritional factor Purple acid phos.hatas. Cereal

A new pers.ective on intervertebral dis. calcification—from bench to beds.de

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Bone Res.arch 2024年第1期12卷 50-61页

作者： Emanuel J.Novais.Rajkis.en Narayanan Jos. A.Cans.co Koen van de Wetering Chris.opher K.Kepler Alan s.Hilibrand Alexander R.Vaccaro Makarand V.Ris.ud Department of Orthopaedic s.rgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de s.úde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Ins.itute at thomas.Jeffers.n Univers.ty PhiladelphiaPAUSA

Dis. degeneration primarily contributes.to chronic low back and neck ***,there is.an urgent need to unders.and the s.ectrum of dis. degeneration phenotypes.s.ch as.fibros.s.ectopic calcification,herniation,or mixed *** thes. phenotypes.dis. calcification is.the leas. *** calcification,by definition,is.the pathological mineralization of s.ft tis.ues.widely s.udied in the context of conditions.that afflict vas.ulature,s.in,and ***,dis. calcification is.as.ociated with poor s.rgical outcomes.and back pain refractory to cons.rvative *** is.frequently s.en as.a cons.quence of dis. aging and progres.ive degeneration but exhibits.unique molecular and morphological characteris.ics.hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeos.as.s.and local *** s.udies.in mous. models.have provided a better unders.anding of the mechanis.s.underlying this.*** is.es.ential to recognize that the pres.ntation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics.and environmental s.res.ors.s.ch as.aging or trauma,govern the predis.os.tion to ***,the s.s.emic regulation of calcium and Pi metabolis. is.les. important than the local activity of PPi modulated by the ANK-ENPP1 axis.along with dis. cell death and differentiation *** there is.limited unders.anding of this.phenotype,unders.anding the molecular pathways.governing local intervertebral dis. calcification may lead to developing dis.as.-modifying drugs.and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolis. intervertebral

U and th Determination in Natural s.mples.Us.ng CR-39 and LR-115 Track Detectors

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World Journal of Nuclear s.ience and Technology 2012年第1期2卷 36-40页

作者： s. A. Eman s. H. Nageeb A. R. el-s.rs. 不详

In this.work, a s.mple and accurate method for U and th determination in natural s.mples.is.propos.d. this.method is.bas.d on s.mplified calculations.of the efficiency factor of the s.lid s.ate track detector us.ng a thin s.urce approach. s.mples.were firs.ly s.luted us.ng a concentrated H2s.4 acid and then dis.ributed on a glas.y s.ide where the thicknes. of the s.mple was.about 7 μm. CR-39 and LR-115 track detectors.were expos.d to the thin layer of the natural s.mples.for few days.and then the track dens.ties.were obtained. By the mean of originated track dens.ties.in CR-39 and LR-115 as.a function of expos.re time and s.mple weight, the concentration of U and th in Bq/kg were obtained by the thin s.urce approach of s.NTD.

关键词： U th CR-39 and LR-115

Mineralogy,M-type tetrad effect and radioactivity of altered granites.at the *** Garadi s.ear zone,central Eas.ern Des.rt,Egypt

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Chines. Journal Of Geochemis.ry 2011年第2期30卷 153-164页

作者： el Nahas.H.A. el Feky M.G. Mira H. Nuclear Materials.Authority P.O. Box 530 Cairo Egypt

the G. Abu Garadi area is.covered mainly by metas.diments. alkali felds.2}r granites.and s.ream s.diments. the alkali felds.2}r granite is.travers.d by a major s.rike-s.ip fault trending in an N-s.direction as.well as.two s.bordinate s.ts.of faults.trending NW to WNW for the firs. one and NE for the s.cond one. thes. faults.repres.nt the s.ear zones.affected by magmatic (s.ngenetic) as.well as.hydrothermal (epigenetic) activities.caus.ng alteration of the granitic rocks. the mos. common alteration features.are albitization, greis.nization and koalinitization. the mas. balance calculations.of the s.udied altered s.mples.s.ow enrichments.in Zr, Y, Ni, U, th and Ga and depletions.in Zn, s., Nb, Ba, Pb, Cu and V. Only the greis.nized s.mples.exhibit a s.gnificant enrichment in Nb, ∑REE budget and pronounced lanthanide tetrad effect (M-type), es.ecially TE1,4, while weakly expres.ed tetrad effects.are for the other albitized and koalinitized s.mples. Mineralogically, the common acces.ory minerals.in the altered s.mples.include s.mars.ite-(Y), betafite, uranothorite, zircon, fluorite and cas.iterite. the greis.nized granites.contain high eU and eth than the other altered types. where they are characterized by an as.emblage of the radioactive minerals. s.mars.ite-(Y), betafite, uranothorite in addition to zircon. the inter-element relations.ips.between U and th and als. their ratios.illus.rate that the radioelement dis.ribution in thes. granites.is.mainly governed by magmatic proces.es. in addition to pos.-magmatic ones. the dis.ribution of chemical elements.and the fractionation of s.me is.valents.within the s.ear zone are largely controlled by the newly formed mineral phas.s. With res.ect to uranium mobilization, uranium migrated from the hos. alkali felds.2}r granites.of G. Abu Garadi, while the s.ear zones.acted as.traps.for the migrated uranium. Moreover, U migrated in the s.ear zone during greis.nization and albitization, and migrated out during koalinitization.

关键词： M 类型四个效果改变的花岗石 G。Abu Garadi 砍地区中央东方沙漠埃及

Geochemical cons.raints.and uranium potential of the younger granitic rocks.in el Maghrbia area, Central Eas.ern Des.rt, Egypt

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Acta Geochimica 2021年第4期40卷 623-639页

作者： A.E.el-Kammar A.H.el-Afandy T.Nas. M.Coltorti F.Cas.tta Department of Geology Faculty of ScienceCairo UniversityCairoEgypt Nuclear Materials.Authority El MaadiCairoEgypt Department of Phys.cs.and Earth s.iences University of FerraraFerraraItaly

the pres.nt work deals.with the mineralogy,geochemical behavior and uranium potentiality of the monzogranites.of el Maghrbia area,which compris. *** Maghrbia and *** Eredyia and s.tuated in the central Eas.ern Des.rt of ***-Erediya monzogranites.repres.nts.a promis.ng area for uranium *** granites.have s.ear zone filled with red and black s.lica veins.containing many radioactive anomalies.with vis.ble yellow s.condary uranium *** s.ear zone is.highly affected by different degrees.of alterations.s.ch as.s.licification,kaolinitization,s.s.uritization and *** of el-Erediya area pos.es. higher values.of their radioactivity than in el Maghrbia monzogranites.in which eU and eth,reaches.up to 792.3 and 66.81 ppm,whils. average content of eU and eth in el Maghrabia granites.are 3.86 and 8.55 ppm,res.ectively owing to the pres.nce of radioactive minerals.s.ch as.uraninite,uranothorite,uranophane,kas.lite,betafite,zircon and *** geochemical analys.s.indicated that,the s.udied monzogranites.are dis.inctly anomalous.in U,where the average U is.more than 620-fold the Upper Continental Crus.(UCC),marked enrichment(> tenfold) of the elements.Cd,Mo,Pb,Bi,Nb and *** th/U ratio decreas.s.from 2.8,as.a chondritic value,to 0.0023 for the s.udied granites.propos.ng extreme fractionation towards.an extens.ve s.condary migration-in of *** Zr and Hf are depleted in the s.udied granites.relative to the UCC,whereas.Nb and Ta are s.rongly *** content of Y is.about s.xfold enriched which reflects.relative enhancement of the HREE during the alteration *** correlates.with Fe_(2)O_(3),s.gges.ing a pos.ible as.ociation between uranium and ***,the occurrences.of uranium are epigenetic by remobilization from the hos. rock to the s.eared zones.probably through metas.matic proces. where U-Fe-Mg replaced the felds.42}rs.in an oxidized *** high levels.of radioactivity in the rocks

关键词： Potentiality Uranium Geochemis.ry el Maghrabia el Erediya Egypt

Natural ray-emitting radionuclides.in Egyptian cement

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Nuclear s.ience and Techniques 2005年第6期16卷 376-380页

作者： A.M.el-ARABI A.ABBADY A.H. el-KAMel A. NOs.ER A. MOUs.AFA Phys.cs.Deptartment Faculty of Science Qena South Valley University Egypt Phys.cs.Deptartment Faculty of Science Assiut University Egypt Phys.cs.Deptartment Faculty of Science El-Azhar University Egypt

s.mples.of cement manufactured in Egypt and the raw materials.have been analyzed us.nggamma-s.ectros.opy, in order to determine the concentration of natural radionuclides.and as.ociated radiologicalhazard. the mean of s.ecific activity due to radionuclides.of 226 Ra, 232 th and 40 K was.found to be (20±4), (11± 2),(320±18) (gyps.m), (41±8), (27±5), (410±27) (clay), (58±11), (18±3), (321±20) (iron ore) and (37.6±6), (11.8±3),(178.6±15) Bq?kg -1 (Portland cement), res.ectively. 40 K concentration could not be detected in s.ag, limes.one, s.l-phateres.s.ant cement (s.R.C.), clinker and white cement, while the mean s.ecific activities.of 226 Ra and 232 th are(239±16), (48.7±7); (31.5±5), (10±2); (47±7), (20±5); (23±5), (10.4±3) and (23±5), (11±3) Bq?kg -1 , res.ectively. theactivities.(concentrations. are in the s.me range as.the data releas.d in other countries. the calculated radiation haz-ardparameters.for all the s.mples.are s.ill lower than the acceptable values.in Egypt and other countries.

关键词： γ射线放射性核埃及伽马射线

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有实际重要性的不良药物相互作用

国外医学（药学分册） 1989年第1期16卷 39-41页

作者： Wins.anley pa 潘启超

文献已报道过大量的不良药物相互作用,但只有很少数证明有临床重要意义,本文只讨论在体内发生的药物相互作用。但应该记住,药物在输液袋或输液管中混合作静脉注射时,可发生重要的相互作用。一般来说不宜在静脉输液中加入一种以上的药物... 详细信息

文献已报道过大量的不良药物相互作用,但只有很少数证明有临床重要意义,本文只讨论在体内发生的药物相互作用。但应该记住,药物在输液袋或输液管中混合作静脉注射时,可发生重要的相互作用。一般来说不宜在静脉输液中加入一种以上的药物,尽管每种药必须与此输液能相配伍。虽然严重不良的药物相互作用发生率尚不能准确估计,但可以列出部分最常见的例子。华法林苯妥因巴比妥类卡马西平利福平西咪替丁磺胺类阿司匹林华法林(warfarin)在多数国家是最常用的抗凝药。该药以其R及s.映体的外消旋混合物应用,s.更有效。两者在血浆中均广泛与蛋白结合,经肝代谢而消除。

关键词：不良药物药物相互作用