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Science in China,Ser.A 1977年第6期 803-806页

作者：牛满江童第周

Both crucian and carp egg-m.NAs were found to m.diate the transform.tion of goldfish tail from.the double （veil-shaped） to the single （fork-shaped）. Livers of these single tailed goldfish were tested for genetic change using lactate dehydrogenase isozym.0} （LDH） as m.rker. Electrophoresis of liver extracts on starch gel showed that the liver specific LDH-C4 isozym.0} of both the egg-m.NA and liver-m.NA injected goldfish resem.led the control goldfish except an additional interm.diate band. The m.gration distance of this new band m.tched the third band of the hybrids （carp× goldfish）. These findings lead to the conclusion that carp egg-m.NA contains a fraction partly responsible for liver developm.nt. Rat liver was found possessing the cathodally m.grating C4 isozym.0}. Injection of rat liver-m.NA into goldfish eggs resulted in the intensification of the liver specific C4 isozym.0}. It appears therefore that the input inform.tional m.lecules （liver-m.NA） and the output m.lecular products (liver C4 iszym

关键词： m.NA m.DIATED ALTERATIoN oF THE LIVER SPECIFIC ISoZYm.0} GENETIC m.NIPULATIoN IN HIGHER oRGANISm. GoLDFISH oVA AS m.TERIALS oF oPERATIoN

Transport m.del for shale gas well leakage through the surrounding fractured zones of a longwall m.ne

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International Journal of m.ning Science and Technology 2020年第5期30卷 635-641页

作者： Kayode m.Ajayi Steven J.Schatzel Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthPittsburghPA 15236USA

The environm.ntal risks associated with casing deform.tion in unconventional(shale)gas wells positioned in abutm.nt pillars of longwall m.nes is a concern to m.ny in the m.ning and gas well *** the recent interest in shale exploration and the proxim.ty to longwall m.ning in Southwestern Pennsylvania,the risk to m.ne workers could be catastrophic as fractures in surrounding strata create pathways for transport of leaked ***,this research by the National Institute for occupational Safety and Health(NIoSH)presents an analytical m.del of the gas transport through fractures in a low perm.able *** derived equations are used to conduct param.tric studies of specific transport conditions to understand the influence of stratum.geology,fracture lengths,and the leaked gas properties on subsurface *** results indicated that the prediction that the subsurface gas flux decreases with an increase in fracture length is specifically for a non-gassy *** sub-transport trend could be significantly im.4}cted by the stratum.gas generation rate within specific fracture lengths,which em.hasized the im.ortance of the stratum.*** findings provide new insights for im.roved understanding of subsurface gas transport to ensure m.ne safety.

关键词： Subsurface gas transport Longwall m.ning Shale gas well Analytical m.deling Environm.ntal risk Shale gas casing failure

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菲律宾水泵灌溉情况介绍

机电技术 1982年第1期 25-27页

作者： m.S卡斯裴 pa·菲利夏诺翁爱和菲律宾农场制度发展公司菲律宾全国灌溉管理局水泵公共处工程建设科区域主任机械监督工程师

一、菲律宾灌溉概况菲律宾总共有1170万公顷农田。根据报告,其中149万公顷是灌溉的,其余的则靠雨水。几乎所有灌区都用来生产水稻。这是1977年以来国家能实现大米自给的主要原因。灌溉主要是由在无数的江河上建造引水工程的自流灌溉系... 详细信息

一、菲律宾灌溉概况菲律宾总共有1170万公顷农田。根据报告,其中149万公顷是灌溉的,其余的则靠雨水。几乎所有灌区都用来生产水稻。这是1977年以来国家能实现大米自给的主要原因。灌溉主要是由在无数的江河上建造引水工程的自流灌溉系统以及遍布全国的地表水源来提供。估计国营灌溉系统的灌溉面积为582916公顷,公共农民集体组织管理的系统灌溉面积为559422公顷或更多些。

关键词：木煤气不凝缩气体菲律宾水锤泵自流灌溉系统燃料油石油燃料柴油机压燃发动机离心泵叶片泵气体发生器农民劳动者水泵化工用泵

Cannabidiol (CBD) Prevents palm.tic Acid-Induced Drop in m.tochondrial m.m.rane Potential

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Pharm.cology & Pharm.cy 2019年第9期10卷 387-395页

作者： R. Gallily Z. Yekhtin m. Tarshis R. Vogt Sionov The Lautenberg Center for General and Tum.r Im.unology The Hadassah Medical School The Hebrew University of Jerusalem Jerusalem Israel Inter-Departm.nt Unit The Hadassah Medical School The Hebrew University of Jerusalem Jerusalem Israel

Exposure of m.crophages and m.croglia cells to the saturated palm.tic acid (pa) leads to reduction in the m.tochondrial m.m.rane potential (), shrinkage of the cells and apoptosis. Here we show that the Cannabis com.onent Cannabidiol (CBD) rescues both m.crophages and m.croglia cells from.the detrim.ntal effects of pa. CBD prevents the shrinkage in cell size and the reduction incaused by pa. The protective effect of CBD on the m.crophage m.tochondria is im.ortant for sustaining the m.crophage population even under the im.unosuppressed conditions caused by this drug. To a sim.lar extent, the antagonistic effect of CBD on pa-m.diated m.croglia cytotoxicity is im.ortant for its role in neuroprotection.

关键词： CBD m.tochondrial m.m.rane Potential m.crophages m.croglia palm.tic Acid

Physical activity and dietary behaviors of health clinic workers trying to lose weight

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Health 2012年第8期4卷 493-499页

作者： Tan Leng Goh Trever Ball Janet m. Shaw Jam.0} C. Hannon Departm.nt of Exercise and Sport Science University of Utah Salt Lake City USA

Health clinic workers are potential agents of change for weight loss to patients, yet their behaviors are not well known. This study exam.ned physical activity (pa) levels and dietary habits of health clinic workers who were and who were not trying to lose weight. participants were 64 com.unity health clinic workers (58 fem.les and 6 m.les). m.derate-to-vigorous intensity (m.I) tim. spent in pa was assessed by triaxial accelerom.try over 7 consecutive days. Dietary habits and weight loss efforts were determ.ned by a food frequency questionnaire. Differences in m.I and nutrition variables were assessed by one-way ANoVA, com.0}ring those trying to lose weight and those not trying to lose weight. 48 out of 64 health clinic workers (approxim.tely 75%) indicated that they were currently trying to lose weight. There were significant differences (p ody m.ss Index (Bm.), daily energy (Kcal) and fat (g) intake between those trying to lose weight and those not trying to lose weight. There were no significant differences in m.I, daily sugar intake (g), vegetable and fruit servings, and daily fiber intake (g) between groups. Health clinic workers trying to lose weight appear to be engaging in som. appropriate dietary but not pa behaviors.

关键词： Accelerom.ter overweight Healthcare Nutrition

A phase 1b random.zed clinical trial of CT1812 to m.asure Aβoligom.r displacem.nt in Alzheim.r’s disease using an indwelling CSF catheter

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： Kelsie m.LaBarbera Yvette I.Sheline Nicholas J.Izzo Carla m.Yuede Lora Waybright Raym.nd Yurko Hannah m.Edwards Woodrow D.Gardiner Kaj Blennow Henrik Zetterberg Anne Börjesson-Hanson Roger m.rgan Charles S.Davis Robert J.Guttendorf Lon S.Schneider Steven DeKosky Harry LeVine III m.chael Grundm.n Anthony o.Caggiano John R.Cirrito Susan m.Catalano m.ry E.Ham.y Cognition Therapeutics Inc. PittsburghPAUSA University of Pennsylvania PhiladelphiaUSA Washington University St.LouisUSA University of Gothenburg MölndalSweden Departm.nt of Psychiatry and Neurochem.stry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochem.stry Laboratory Sahlgrenska University HospitalMölndalSweden Departm.nt of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK UK Dem.ntia Research Institute at UCL LondonUK Hong Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheim.r’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska University Hospital StockholmSweden m.dSurgPI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo Pharm.ceutical Developm.nt Group IncViennaVAUSA Keck School of m.dicine of USC Los AngelesCAUSA m.Knight Brain Institute University of FloridaGainesvilleFLUSA Sanders-Brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D partners LLCSan DiegoCAUSA Departm.nt of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:m.y 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheim.r’s disease(AD)target a wide range of m.chanism.,yet prom.sing dis-ease-m.difying therapies rem.in a huge unm.t *** evidence indicates that the oligom.ric form.of am.loid-beta(Aβ)is a toxic species contributing to AD through synaptic dam.ge and neuronal toxicity[1].

关键词： Alzheim.r Aβ dam.ge

卡维地洛比酒石酸美托洛尔更能有效降低慢性心力衰竭病人的死亡率

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英国医学杂志中文版 2004年第5期7卷 304-305页

作者： Poole-Wilson pa Swedberg K Cleland JG Curt D Furberg Bruce m.Psaty 王琳 F Hoffm.n La Roche and Glaxo Sm.th Kline Professor P A National Heart and Lung Institute London UK Curt D Furberg MD PhD Wake Forest University School of Medicine Winston-Salem North Carolina USA Bruce M Psaty MD PhD University of Washington Seattle Washington USA

Poole-Wilson P A,Swedberg K Cleland JG,et al.卡维地洛和酒石酸美托洛尔欧洲试验(Com.T)中卡维地咨和酒石酸美托洛尔对慢性心力衰竭(CHF)病人的临床疗效的比较。

关键词：美托洛尔卡维地洛慢性心力衰竭病人死亡率随机对照试验降低和酒欧洲

Virtual Reality as an Adjunct to Ketam.ne Infusion Therapy Increases patient Satisfaction in the m.nagem.nt of Chronic pain and Depression: A Retrospective Pilot Study

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Journal of Behavioral and Brain Science 2023年第12期13卷 243-261页

作者： m.lissa C. Selinger David m. Com.ton Ham.lton m.rris Tim.thy J. Canty m.nhattan Restorative Health Sciences New York NY USA Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach FL USA Departm.nt of Psychology Palm Beach Atlantic University West Palm Beach FL USA Departm.nt of Pharm.ceutical Sciences Saint Joseph’s University Philadelphia PA USA

The m.nagem.nt of patients with concom.tant chronic pain (CP) and m.jor Depressive Disorder (m.D) rem.ins challenging for clinicians. Current chronic pharm.cologic m.nagem.nt is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with sym.tom. such as poor m.od, anhedonia, and altered cognitive processes. It is estim.ted that a substantial proportion of treated patients do not derive a substantive benefit from.traditional pharm.cological treatm.nts for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketam.ne infusion therapies. Specifically, the ketam.ne-virtual reality protocol was em.loyed as a potential adjunctive intervention for patients suffering from.chronic pain and depression. Visual Analog Scores (VAS) associated with pain were significantly lower on the third than on the first assessm.nt day. m.ntgom.ry-?sberg Depression Rating Scale (m.DRS) scores im.roved following infusion and across days (i.e., sessions). Lastly, 2/3 of patients preferred the use of VR with their ketam.ne infusion. The results are considered in term. of im.lem.nting prospective studies to exam.ne whether the com.ination therapies have a synergistic benefit and the nature and m.gnitude of clinically m.aningful treatm.nt effects, if any.

关键词： Ketam.ne Infusion Therapy Virtual Reality Chronic pain Depression

Environm.ntal cues determ.ne the fate of astrocytes after spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 1964-1970页

作者： Fatim. m.Nathan Shuxin Li Shriners Hospitals Pediatric Research Center Department of Anatomy and Cell Biology Lewis Katz School of Medicine at Temple UniversityPhiladelphia PA USA

Reactive astrogliosis occurs after central nervous system.CNS） injuries whereby resident astrocytes form.rapid responses along a graded continuum. Following CNS lesions, na？ve astrocytes are converted into reactive astrocytes and eventually into scar-form.ng astrocytes that block axon regeneration and neural repair. It has been known for decades that scarring developm.nt and its related extracellular m.trix m.lecules interfere with regeneration of injured axons after CNS injury, but the cellular and m.lecular m.chanism. for controlling astrocytic scar form.tion and m.intenance are not well known. Recent use of various genetic tools has m.de trem.ndous progress in better understanding genesis of reactive astrogliosis. especially, the latest experim.nts dem.nstrate environm.nt-dependent plasticity of reactive astrogliosis because reactive astrocytes isolated from.injured spinal cord form.scarring astrocytes when transplanted into injured spinal cord, but revert in retrograde to naive astrocytes when transplanted into naive spinal cord. The interactions between upregulated type I collagen and its receptor integrin β1 and the N-cadherin-m.diated cell adhesion appear to play m.jor roles for local astrogliosis around the lesion. This review centers on the environm.nt-dependent plasticity of reactive astrogliosis after spinal cord injury and its potential as a therapeutic target.

关键词： astrogliosis astrocyte fate scar form.tion spinal cord injury axon regeneration environm.ntcue collagen I integrin β1

Gam.a-ray bursts and their links with supernovae and cosm.logy

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Research in Astronom. and Astrophysics 2012年第8期12卷 1139-1161页

作者： Peter m.szros Neil Gehrels Center for particle and Gravitational Astrophysics Dept.of Astronomy&Astrophysics and Dept.of Physics Pennsylvania State UniversityUniversity ParkPA 16802USA Astrophysics Science Division NASA Goddard Space Flight CenterGreenbeltMD 20771USA

Gam.a-ray bursts are the m.st lum.nous explosions in the Universe, whose origin and m.chanism.are the focus of intense interest. They appear connected to su- pernova rem.ants from.m.ssive stars or the m.rger of their rem.ants, and their bright- ness m.kes them.tem.orarily detectable out to the largest distances yet explored in the universe. After pioneering breakthroughs from.space and ground experim.nts, their study is entering a new phase with observations from.the recently launched Ferm. satellite, as well as the prospect of detections or lim.ts from.large neutrino and gravitational wave detectors. The interplay between such observations and theoretical m.dels of gam.a-ray bursts is reviewed, and cosm.logy. as well as their connections to supernovae

关键词： gam.a-ray sources -- gam.a-ray bursts -- cosm.c rays -- neutrinos-- supernovae -- cosm.logy -- intergalactic m.dium