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A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

Petroleum Science 2024年第3期21卷 1865-1874页

作者： Ji Wang ning Qi Hong-Yao Yin Yu-jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDpa.,and examined compa.atively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDpa.for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDpa.20 wt%HCl solution maintains stable viscosity of 90 m pa.s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m pa.s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDpa.remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDpa.HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDpa.to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,pa.ing a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

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Mechanism of pa.hymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du Jian-jun Zhao Xia Li Shi-Cong Huang Na ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND pa.hymic acid(pa.is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of pa.in gastric cancer(GC)remains *** To investigate the mechanism of pa.in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the pa.*** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompa.sing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pa.hway is likely to be the mechanism by which pa.effectively treats GC,according to KEGG enrichment *** experimental findings showed that pa.could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pa.se the cell *** Network pharmacology demonstrated that pa.could treat GC by controlling a variety of signaling pa.hways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： pa.hymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

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Evolution of pore systems in low-maturity oil shales during thermal upgrading--Quantified by dynamic SEM and machine learning

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Petroleum Science 2024年第3期21卷 1739-1750页

作者： jun Liu Xue Bai Derek Elsworth Key Laboratory of Deep Underground Science and Engineering(Ministry of Education) Institute of New Energy and Low-Carbon TechnologySichuan UniversityChengdu610065SichuanChina International Quantum Academy Shenzhen518048GuangdongChina Shenzhen Institute of Advanced Electronic Materials Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055GuangdongChina Depa.tment of Energy and Mineral Engineering Pennsylvania State University ParkPA 16802USA

In-situ upgrading by heating is feasible for low-maturity shale oil,where the pore spa.e dynamically *** characterize this response for a heated substrate concurrently imaged by *** systematically follow the evolution of pore quantity,size(length,width and cross-sectional area),orientation,shape(aspect ratio,roundness and solidity)and their anisotropy—interpreted by machine *** indicate that heating generates new pores in both organic matter and inorganic ***,the newly formed pores are smaller than the original pores and thus reduce average lengths and widths of the bedding-pa.allel pore ***,the average pore lengths and widths are increased in the bedding-perpendicular ***,heating increases the cross-sectional area of pores in low-maturity oil shales,where this growth tendency fluctuates at300℃.In addition,the orientation and shape of the newly-formed heating-induced pores follow the habit of the original pores and follow the initial probability distributions of pore orientation and ***,limited anisotropy is detected in pore direction and shape,indicating similar modes of evolution both bedding-pa.allel and *** propose a straightforward but robust model to describe evolution of pore system in low-maturity oil shales during heating.

关键词： Low-maturity oil shale Pore elongation Organic matter pyrolysis In-situthermal upgrading Scanning electron microscopy(SEM) Machine learning

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Interpretation of Chinese Expert Consensus on the Diagnosis and Management Strategy of pa.ients with Statin Intolerance: A guiding file for helping to lipid management for Chinese population

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Journal of Geriatric Cardiology 2024年第7期21卷 713-715页

作者： Jian-jun LI Cardiometabolic Center National Center for Cardiovascular DiseaseChinese Academy of Medical ScienceFuwai HospitalBeijingChina

It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,which has created a new era for ASCVD ***,statin intolerance is not clinically uncommon,which there are several issues with confu-sion and ***,a file named Chinese Expert Consensus on the Diagnosis and Management Strategy of pa.tients With Statin Intolerance,like a navigator,has recently been published written by a team of experts from the Cardiovascular Metabolic Medicine Professional Committee,Expert Committee of the National Center for Cardiovascular Diseases aiming to en-hance the standardized clinical application of statins and improve the prevention and clinical *** this article,author briefly summarized the key points of above consensus in order to helping to comprehending the content of the consensus sugges-tions.

关键词： Expert Strategy corners

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A triangular architectural relation model among sustainability,beauty,and power

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Frontiers of Architectural Research 2024年第4期13卷 699-711页

作者： Ján Legény RobertŠpa.ek TomášHubinský Lucia Benkovičová Faculty of Architecture and Design Slovak University of Technology in BratislavaBratislavaSlovakia

Sustainability,beauty,and power are notions that hit our contemporary perception every ***,they have been an integral pa.t of architecture and urban planning in various forms since the *** pa.er presents their fundamental descriptions,followed by an assessment of their mutual relations and impa.t on architecture through a triangular architectural relation model developed by the authors of the *** the theoretical thought experiment,it highlights eight boundary models along with their main characteristics,in pa.ticular,the implosion,explosion,shared-control,utilitarian,no-control,supremacy,inside-forced,and outside-forced architectural related *** models can help predict future events,explain pa.t events,make decisions,and plan strategies,or reveal problems and propose new *** applications include determination of the causes of certain results or finding out the responsibility and mechanisms that led to *** authors are of the opinion that the mutual denominator of sustainability,beauty,and power represents ethics that should be forced in architectural education and practice.

关键词： Triangular architectural relation model Sustainability Beauty Power Thought experiment Interpretation

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Construction and performance test of charged pa.ticle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Depa.tment for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged pa.ticle array named MATE-pa.which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged pa.ticles that penetrate the active volume of the *** performance of MATE-pa.has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good sepa.ation of light-charged pa.ticles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-pa.improves pa.ticle identification and increases the dynamic range of the kinetic energy of charged pa.ticles,pa.ticularly that of theαpa.ticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

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Genes & Diseases 2024年第3期11卷 248-263页

作者： Shuo Li Tiande Zou jun Chen Jiaming Li Jinming You Jiangxi Province Key Laboratory of Animal Nutrition Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Fibroblast growth factor 21(FGF21)was originally identified as an important meta-bolic regulator which plays a crucial physiological role in regulating a variety of metabolic pa.rameters through the metabolic *** a novel multifunctional endocrine growth factor,the role of FGF21 in the metabolic network warrants extensive *** insight was obtained from the observation that the FGF21-dependent mechanism that regulates lipid metabolism,glycogen transformation,and biological effectiveness occurs through the coordi-nated pa.ticipa.ion of the liver,adipose tissue,central nervous system,and sympa.hetic *** review focuses on the role of FGF21-uncoupling protein 1(UCP1)signaling in lipid metabolism and how FGF21 alleviates non-alcoholic fatty liver disease(NAFLD).Additionally,this review reveals the mechanism by which FGF21 governs glucolipid *** research on the role of FGF21 in the metabolic network has mostly focused on the crucial pa.hway of glucolipid ***21 has been shown to have multiple regulatory roles in the metabolic *** an adequate understanding of the concrete regulatory pa.h-ways of FGF21 in the metabolic network has not been attained,this review sheds new light on the metabolic mechanisms of FGF21,explores how FGF21 engages different tissues and organs,and lays a theoretical foundation for future in-depth research on FGF21-targeted treatment of metabolic diseases.

关键词： Adipose FGF21 Insulin homeostasis Lipid metabolism Liver Metabolicnetwork

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Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires:A novel application in urinary flow measurement

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Nanotechnology and Precision Engineering 2024年第3期7卷 1-12页

作者： Ben-Song Wang Ang Gao Song-Wei Huang Qi-Hong ning Cheng Zhou Qi-Xiang Song Da-XiangCui School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Depa.tment of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Flexible pressure sensors are lightweight and highly sensitive,making them suitable for use in small portable devices to achieve precise measurements of tiny *** article introduces a low-cost and easy-fabrication strategy for piezoresistive flexible pressure *** embedding silver nanowires into a polydimethylsiloxane layer with micro-pyramids on its surface,a flexible pressure sensor is created that can detect low pressure (17.3 pa. with fast response (pa.1).Furthermore,the pressure sensor exhibits a sensitive and stable response to a small amount of water flowing on its *** this basis,the flexible pressure sensor is innovatively combined with a micro-rotor to fabricate a novel urinary flow-rate meter (uroflowmeter),and results from a simulated human urination experiment show that the uroflowmeter accurately captured all the essential shape characteristics that were present in the pump-simulated urination *** ahead,this research provides a new reference for using flexible pressure sensors in urinary flow-rate monitoring.

关键词： Flexible pressure sensor Silver nanowires Portable device Uroﬂowmeter Healthcare

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Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

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Petroleum Science 2024年第3期21卷 1875-1888页

作者： Yong-Ping Huang Yong Hu Chang-Long Liu Yi-ning Wu Chen-Wei Zou Li-Yuan Zhang Ming-Wei Zhao Cai-Li Dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China)Qingdao 266580ShandongPR China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206PR China CNOOC China Co Ltd Tianjin BranchTianjin300459PR China

A gel based on polyacrylamide,exhibiting delayed crosslinking characteristics,emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong *** viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppa.t suspension properties before *** into account both the cost and the potential damage to reservoirs,polymers with lower concentrations and molecular weights are generally *** this work,the supramolecular action was integrated into the polymer,resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer *** double network gel,which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker,effectively resists temperature while minimizing permeability damage to the *** results indicate that the supramolecular polymer system with a molecular weight of(268—380)×10^(4)g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt%due to the supramolecular interaction between polymers,compa.ed to the 0.6 wt%traditional polymer(hydrolyzed polyacrylamide,molecular weight of 1078×10^(4)g/mol).The supramolecular polymer system possessed excellent proppa.t suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%,whereas the0.6 wt%traditional polymer had a rate of 0.57 cm/*** compa.ison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt%and an elastic modulus of 7.77 pa.the double network gel with a higher elastic modulus(9.00 pa.could be formed only at 0.1 wt%Zr-crosslinker,which greatly reduced the amount of residue of the fluid after *** viscosity of the double network gel was66 m pa.s after 2 h shearing,whereas the traditional gel only reached 27 m pa.s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppa.t suspension property

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Computing Resource Allocation for Blockchain-Based Mobile Edge Computing

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 863-885页

作者： Wanbo Zhang Yuqi Fan jun Zhang Xu Ding jung Yoon Kim School of Computer Science and Information Engineering Intelligent Interconnected Systems Laboratory of Anhui ProvinceHefei University of TechnologyHefei230601China Anhui Province Key Lab of Aerospa.e Structural pa.ts Forming Technology and Equipment Hefei University of TechnologyHefei230009China College of Future Industry Gachon UniversitySeongnam13120South Korea

Users and edge servers are not fullymutually trusted inmobile edge computing(MEC),and hence blockchain can be introduced to provide *** blockchain-basedMEC,each edge server functions as a node in bothMEC and blockchain,processing users’tasks and then uploading the task related information to the *** is,each edge server runs both users’offloaded tasks and blockchain tasks *** that there is a trade-off between the resource allocation for MEC and blockchain ***,the allocation of the resources of edge servers to the blockchain and theMEC is crucial for the processing delay of blockchain-based *** of the existing research tackles the problem of resource allocation in either blockchain or MEC,which leads to unfavorable performance of the blockchain-based MEC *** this pa.er,we study how to allocate the computing resources of edge servers to the MEC and blockchain tasks with the aimtominimize the total systemprocessing *** the problem,we propose a computing resource Allocation algorithmfor Blockchain-based MEC(ABM)which utilizes the Slater’s condition,Karush-Kuhn-Tucker(KKT)conditions,pa.tial derivatives of the Lagrangian function and subgradient projection method to obtain the *** results show that ABM converges and effectively reduces the processing delay of blockchain-based MEC.

关键词： Mobile edge computing blockchain resource allocation

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