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一例临床药师参与卵巢癌患者使用帕博利珠单抗致免疫相关性肺炎和心肌炎的病例分析

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中国处方药 2024年第7期22卷 126-129页

作者：陈春梅崔朴梅吴吉进昆明理工大学附属安宁市第一人民医院药学部昆明650300 昆明理工大学附属安宁市第一人民医院肿瘤科昆明650300

目的分析1例帕博利珠单抗致免疫相关性肺炎和心肌炎的临床特点、发生机制及诊治方案。方法临床药师检索相关文献,总结帕博利珠单抗治疗卵巢癌癌诱发免疫相关性肺炎和心肌炎的临床特点、发生机制,并协助诊治。结果经积极治疗后,患者转归... 详细信息

目的分析1例帕博利珠单抗致免疫相关性肺炎和心肌炎的临床特点、发生机制及诊治方案。方法临床药师检索相关文献,总结帕博利珠单抗治疗卵巢癌癌诱发免疫相关性肺炎和心肌炎的临床特点、发生机制,并协助诊治。结果经积极治疗后,患者转归较好。结论临床药师参考免疫毒性管理指南对不良反应进行分级,给出治疗建议,转归较好,体现了临床药师的服务价值。

关键词：铂耐药卵巢癌免疫相关性肺炎免疫相关性心肌炎病例分析

高等农业院校现代色谱分析课程思政探索与实践

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遵义师范学院学报 2024年第1期26卷 123-125页

作者：薄丽丽蒲陆梅年芳甘肃农业大学理学院甘肃兰州730070

课程思政建设是当前加强高校思想政治工作和专业课程教学改革的重要内容,是构建全方位育人格局,将其他课程与思政课同向同行,协同育人,以最终实现“立德树人”根本教育任务的一种综合教育理念。现代色谱分析是高等农业院校化学、农学、... 详细信息

课程思政建设是当前加强高校思想政治工作和专业课程教学改革的重要内容,是构建全方位育人格局,将其他课程与思政课同向同行,协同育人,以最终实现“立德树人”根本教育任务的一种综合教育理念。现代色谱分析是高等农业院校化学、农学、食品科学、动物药学、动物医学等专业研究生的必修课程。该课程开课专业广、修读人数多,是开展课程思政教育的重要载体。作者以高等农业院校现代色谱分析课程为例,介绍了实施课程思政的重要意义,课程思政元素的挖掘及思政内容与专业内容的融合,希望能为相关学科课程思政教学提供有益参考。

关键词：课程思政现代色谱分析资源发掘有效实施

基于多任务学习的改性双基推进剂的综合性能预测

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化学研究与应用 2024年第3期36卷 608-615页

作者：郭延芝吴艳玲徐司雨蒲雪梅赵凤起四川大学化学学院四川成都610064 西安近代化学研究所含能材料全国重点实验室陕西西安710065

为满足改性双基推进剂多性能的综合预测需求,本研究提出基于多任务学习的机器学习策略,综合考虑推进剂组分、含量、压强和的粒度对目标性能的影响,首次构建了包含燃速、比冲、特征速度、摩擦感度和撞击感度在内的RDX-CMDB推进剂综合性... 详细信息

为满足改性双基推进剂多性能的综合预测需求,本研究提出基于多任务学习的机器学习策略,综合考虑推进剂组分、含量、压强和的粒度对目标性能的影响,首次构建了包含燃速、比冲、特征速度、摩擦感度和撞击感度在内的RDX-CMDB推进剂综合性能预测模型。通过网格寻参模式优化模型,结合十折交叉验证法比较了十种机器学习算法的建模效果。其中,极限梯度提升回归模型预测性能最优,平均R^(2)可达0.9997;在对6个外部样本的测试中,该模型对5个目标性能的预测误差均在5%以内。结果表明,本研究提出的多任务机器学习模型可在试验样本量不足的情况下,实现推进剂的多个目标性能准确预测,对推进剂的综合性能优化和配方设计具有理论指导意义。

关键词：改性双基推进剂综合性能多任务学习定量预测

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枸杞叶片酚酸类物质的自毒作用分析

江苏农业学报 2024年第2期40卷 213-222页

作者：宋燕芳彭彤马少兰马彩霞高娜李凯乐张传继蒲美运纳小凡兰州大学生命科学学院甘肃兰州730000 细胞活动与逆境适应教育部重点实验室甘肃兰州730000 彭阳县第一中学宁夏固原756500 宁夏大学生命科学学院宁夏银川750021

自毒作用是植物连作障碍形成的主要原因之一,严重影响植物生长和粮食生产。前期研究结果表明,土壤微生物多样性下降、土传病害加重是枸杞园连作障碍形成的重要原因,但枸杞残体的自毒作用及其物质基础目前仍不明确。为探讨自毒物质的主... 详细信息

自毒作用是植物连作障碍形成的主要原因之一,严重影响植物生长和粮食生产。前期研究结果表明,土壤微生物多样性下降、土传病害加重是枸杞园连作障碍形成的重要原因,但枸杞残体的自毒作用及其物质基础目前仍不明确。为探讨自毒物质的主要来源,本研究对比分析了枸杞(Lycium barbarum L.)叶、茎、根等组织浸提液对枸杞幼苗生长的影响。浓度梯度试验结果表明,叶片浸提液的抑制效应高于根、老根皮及茎浸提液。向无枸杞种植历史的农田土壤中添加枸杞叶片干粉能够显著抑制枸杞幼苗生长及叶片光合作用,证实了枸杞叶片具有自毒作用。联合UPLC-QTOF-MS和GC-TOF-MS技术对生长季末期枸杞叶片进行代谢组分析,共鉴定出有机酸112种、醇类41种、氨基酸37种、醛酮类28种和糖类48种。对其中24种有机酸及衍生物的分析发现,20种有机物能够不同程度抑制枸杞幼苗初生根生长。其中水杨酸、邻苯二甲酸、对羟基苯甲酸和香豆素在浓度低至10μmol/L时仍具显著抑制效应。UPLC结果进一步显示,长期连作导致枸杞园土壤香豆素、水杨酸、苯甲酸、阿魏酸和香豆酸积累。此外,土壤总酚酸含量也随种植年限增加显著增加。这些结果表明土壤中枸杞叶片酚酸能够在长期连作下积累并诱发自毒作用,这为进一步探索枸杞连作障碍形成机制提供了研究基础。

关键词：枸杞连作障碍自毒物质叶片酚酸

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The rice miR171b–SCL6-IIs module controls blast resistance,grain yield,and flowering

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The Crop Journal 2022年第1期10卷 117-127页

作者： Yan Li Ying Tong Xiaorong He Yong Zhu Tingting Li Xiaoyu Lin Wei Mao Zeeshan Ghulam Nabi Gishkori Zhixue Zhao Jiwei Zhang Yanyan Huang mei pu Jing Fan Jing Wang Wenming Wang State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Rice Research Institute and Key Lab for Major Crop Diseases Sichuan Agricultural UniversityChengdu 611130SichuanChina

Micro RNAs(mi RNAs)act as regulators of plant development and multiple stress *** we demonstrate that the rice mi R171 b-SCL6-IIs module regulates the balance between blast resistance,grain yield,and *** R171 b-overexpressing rice plants(OX171 b)displayed increased rice blast resistance accompanied with enhanced defense responses and late heading,whereas blocking mi R171 b expression in rice(MIM171)led to greater susceptibility to blast disease,associated with compromised defense responses and early *** overexpressing or silencing of mi R171 b significantly affected plant height and number of filled seeds per panicle(seed-setting rate),resulting in decreased grain *** R171 b targets SCL6-IIa,SCL6-IIb,and SCL6-IIc,whose expression was suppressed in OX171 b but increased in *** of SCL6-IIa,SCL6-IIb,and SCL6-IIc all displayed phenotypes like that of OX171 b,including markedly increased blast disease resistance,slightly decreased grain yield,and delayed *** of mi R171 b increased gradually in leaves during the vegetative stage but decreased gradually in panicles during the reproductive stage,whereas SCL6-IIs displayed the reverse expression ***,these results suggest that the expression of mi R171 b was time-and space-dependent during the rice growth period and regulated the balance between rice blast disease resistance,grain yield,and flowering via SCL6-IIs,and that appropriate accumulation of mi R171 b is essential for rice development.

关键词： miR171b SCL6-IIs Blast disease resistance Yield trait Flowering

Effects of Non-specific and Specific Solvation on Adsorption of BPTI on Au Surface： Insight from Molecular Dynamics Simulation

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Chinese Journal of Chemical Physics 2013年第5期26卷 558-568,I0003,I0004页

作者： Wei Yang Li-yun Zhang Meng-long Li Xue-mei pu Nan-rong Zhao Faculty of Chemistry Sichuan University Chengdu 610064 China

Proteins adsorption at solid surfaces are of paramount important for many natural processes. However, the role of specific water in influencing the adsorption process has not been well understood. We used molecular dynamics simulation to study the adsorption of BPTI on Au surface in three water environments (dielectric constant model, partial and full solvation models). The result shows that a fast and strong adsorption can occur in the dielectric environment, which leads to significant structure changes, as confirmed by great deviation from the crystal structure, largely spreading along the Au surface, rapid lose in all secondary structures and the great number of atoms in contact with the surface. Compared to the dielectric model, slower adsorption and fewer changes in the calculated properties above are observed in the partial solvation system since the specific water layer weakens the adsorption effects. However, in the partial solvation system, the adsorption of polar Au surface causes a significant decrease in the specific hydration around the protein, which still results in large structure changes similar to the dielectric system, but with much less adsorption extent. Enough water molecules in the full solvation system could allow the protein to rotate, and to large extent preserve the protein native structure, thus leading to the slowest and weakest adsorption. On the whole, the effects of non‐specific and specific solvation on the protein structure and adsorption dynamics are significantly different, highlighting the importance of the specific water molecule in the protein adsorption.

关键词：分子动力学模拟蛋白质吸附非特异性固体表面溶剂化 Au 晶体结构介电常数

Experimental and simulation study on shear stress-induced erythrocyte damage based on vortex oscillator

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Biomedical Engineering Communications 2024年第1期3卷 23-30页

作者： Xu mei Li-pu Zhao Lian Hou Ying-Ying Zhong State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Mechanical and Electrical Engineering Silicon Lake Vocational and Technical CollegeSuzhou 215006China College of Education Central China Normal UniversityWuhan 430079China

Background:Shear stress-induced erythrocyte damage,namely hemolysis,is an important problem in the development of blood-contacting medical devices such as mechanical circulatory support *** fluid dynamics simulation combined with hemolysis prediction models have been widely used to predict *** the development of hemolysis prediction models,the new hemolysis prediction model requires more experimental data to *** addition,the difference of in vitro blood-shearing device also affect the accuracy of hemolysis ***:To address these problems,a new in vitro blood-shearing device(vortex oscillator)was used to further verify the accuracy of the hemolysis prediction models,and to guide the optimal design of blood-contacting medical devices such as mechanical circulatory support ***,the flow field information such as wall stress and velocity of the vortex oscillator under different speeds was ***,different hemolysis prediction models were used to calculate hemolysis,and the predicted data was compared with the experimental *** and Conclusion:In this study,the flow field information inside the vortex oscillator at high rotational speeds was systematically investigated,and the prediction of hemolysis was carried *** results showed that the predicted data of hemolysis was significantly different from the experimental data,which indicated that it was urgent to establish a standardized in vitro blood-shearing platform to provide a reference for accurate hemolysis prediction.

关键词： CFD Hemolysis prediction model Vortex oscillator Shear stress

Comparative experimental study on inhibiting gas explosion using ABC dry powder and diatomite powder

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Journal of Coal Science & Engineering(China) 2012年第2期18卷 138-142页

作者： DENG Jun pu Guang-mei LUO Zhen-min CHENG Fang-ming School of Energy Engineering Xi'an University of Science and TechnologyXi'an 710054China Key Laboratory of Western Mine Exploitation and Hazard Prevention Ministry of EducationXi'an 710054China

Using a 20 L spherical explosion suppressing test system, the largest gas explosion pressure and maximum pressure rising rate with additives of ultra-fine ABC dry powder and diatomite powder were tested and compared, and the explosion suppression effect of the two kinds of powder was analyzed. Experimental results show that both powders can suppress gas explosion and ABC dry powder is superior to diatomite powder. Adding two powders under the same experimental conditions, when methane concentration is 7.0%, the maximum explosion pressure decreased 39% and 4%, respectively, while the rising rate of the maximum pressure decreased 80% and 53%, respectively. When methane concentration is 9.5%, the maximum explosion pressure decreased 14% and 12%, respectively, the rising rate of maximum pressure decreased 62% and 27%, respectively, the maximum explosion pressure decreased 23% and 18%, respectively, while the rising rate of the maximum pressure decreased 77% and 70%, respectively. When methane concentration is 12.0%, the explosion suppression effect of ultra-fine ABC dry powder is not affected by the methane concentration, and the explosion suppression effect of diatomite powder under high methane concentrations is more obvious.

关键词：粉末添加剂气体爆炸对比实验硅藻土 ABC 干粉最大压力上升速率最大爆炸压力

Chemoenzymatic Synthesis of Cellular Adhesion Tripeptide RGD Precursor in Organic Media

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Chemical Research in Chinese Universities 2006年第6期22卷 721-726页

作者： WANG Hua ZHAO Mi-feng pu Li-mei DING Wei HUANG Yi-bing HOU Rui-zhen ZENG Hong-bin XU Li ZHANG Xue-zhong Key Laboratory of Molecular Enzymology and Engineering Jilin University Changchun 130021 P. R. China China-Japan Union Hospital Jilin University Changchun 130033 P. R. China First Hospital Jilin University Changchun 130021 P. R. China

Chemoenzymatic synthesis of tripeptide Bz-RGD-（OEt）2 was conducted in this study. First, the free dipeptide Gly-Asp was synthesized via a novel chemical method, wherein only L-aspaxtic acid was used and was followed by the esterification of Gly-Asp. The formation of the linkage between the third amino acid Bz-Arg-OEt and Gly-Asp-（OEt）2 was completed by using the enzymatic method in organic media. The effects of several factors such as pH, the water content, triethylamine （TEA）, the molar ratio of the substrates, and the reaction time on the yield of Bz-RGD- （OEt）2 were examined. It was obtained that the optimum conditions for Bz-RGD-（OEt）2 synthesis in an ethanol/ Tris-HC1 buffer system （ volume ratio 93： 7 ） were as follows ： pH = 8.0 ; temperature, 30 ℃ ; reaction time, 7 h. The tripeptide yield was 75.2%.

关键词： RGD Synthesis Trypsin Organic solvent