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Alteration in the expression of microRNA-21 regulated target genes:Role in breast cancer

BIOCELL 2022年第2期46卷 309-324页

作者： priyanka thakur REENA V.SAINI ANIL K.CHHILLAR NEERAJ K.SAINI VIJAY KUMAR thakur SAMARJEET SINGH SIWAL ADESH K.SAINI Faculty of Sciences Shoolini UniversitySolan173229India Department of Biotechnology MMECMaharishi Markandeshwar(Deemed to be University)Ambala133207India Maharishi Markandeshwar University Solan173229India Centre of Biotechnology Maharshi Dayanand UniversityRohtak124001India School of Biotechnology Jawaharlal Nehu UniversityNew Delhi110067India Biorefining and Advanced Materials Research Center Scotland’s Rural College(SRUC)EdinburghEH93JGUK Department of Chemistry MMECMaharishi Markandeshwar(Deemed to be University)Ambala133207India

Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of *** diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early ***(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and *** dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer ***-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target *** upregulation of miR-21 is observed in many instances of breast *** review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target *** discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its *** will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care.

关键词： Non-coding RNA microRNAs Breast cancer Tumor suppression Biomarker

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Müllerian duct anomalies and their effect on the radiotherapeutic management of cervical cancer

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Chinese Journal of Cancer 2013年第8期32卷 434-440页

作者： Madhup Rastogi Swaroop Revannasiddaiah Pragyat thakur priyanka thakur Manish Gupta Manoj K Gupta Rajeev K Seam Department of Radiotherapy & Oncology Regional Cancer Centre Department of Radiation Oncology HCG-Bangalore Institute of Oncology

Radiotherapy plays a major role in the treatment of cervical cancer. A successful radiotherapy program integrates both external beam and brachytherapy components. The principles of radiotherapy are strongly based on the anatomy of the organ and patterns of local and nodal spread. However, in patients with distorted anatomy, several practical issues arise in the delivery of optimal radiotherapy, especially with brachytherapy. Müllerian duct anomalies result in congenital malformations of the female genital tract. Though being very commonly studied for their deleterious effects on fertility and pregnancy, they have not been recognized for their potential to interfere with the delivery of radiotherapy among patients with cervical cancer. Here, we discuss the management of cervical cancer among patients with Müllerian duct anomalies and review the very sparse amount of published literature on this topic.

关键词：放射治疗宫颈癌管理异常管道先天畸形传播模式解剖结构

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Hodgkin's lymphoma involving extranodal sites:potential association with HIV infection and the implications for clinical management

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Chinese Journal of Cancer 2013年第2期32卷 102-102,F0003页

作者： Swaroop Revannasiddaiah Sridhar Papaiah Susheela priyanka thakur Madhup Rastogi Department of Radiation Therapy & Oncology HCG Bangalore Institute of Oncology Department of Radiation Therapy & Oncology Regional Cancer CenterIndira Gandhi Medical College

We commend Li et al.[1]for their article "Clinical characteristics of the patients with Hodgkin’s lymphoma involving extranodal sites" (published in the Chinese Journal of Cancer in July 2012). We agree that in comparison with extranodal non-Hodgkin’s lymphoma(NHL), the incidence of extranodal Hodgkin’s lymphoma(HL) is much rarer and thus described much

关键词：淋巴瘤艾滋病毒感染临床管理部位金关联临床特点发病率

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