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Social Advantage with Mixed Entangled States

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Journal of Quantum Information Science 2020年第2期10卷 11-22页

作者： Aritra Das pratyusha chowdhury Department of Physics Indian Institute of Technology Kanpur Uttar Pradesh India Department of Physics St. Xavier’s College Kolkata West Bengal India

It has been extensively shown in past literature that Bayesian game theory and quantum non-locality have strong ties between them. Pure entangled states have been used, in both common and conflict interest games, to gain advantageous payoffs, both at the individual and social level. In this paper, we construct a game for a mixed entangled state such that this state gives higher payoffs than classically possible, both at the individual level and the social level. Also, we use the I-3322 inequality so that states that aren’t useful advice for the Bell-CHSH1 inequality can also be used. Finally, the measurement setting we use is a restricted social welfare strategy (given this particular state).

关键词： Non-Local Games Mixed Entangled States Social-Welfare-Solution

Enhancing Critical Path Problem in Neutrosophic Environment Using Python

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2957-2976页

作者： M.Navya pratyusha Ranjan Kumar VIT-AP University InavoluBesides AP SecretariatAmaravati APIndia

In the real world,one of the most common problems in project management is the unpredictability of resources and *** efficient way to resolve uncertainty problems and overcome such obstacles is through an extended fuzzy approach,often known as neutrosophic *** rigorous proposed model has led to the creation of an advanced technique for computing the triangular single-valued neutrosophic *** innovative approach evaluates the inherent uncertainty in project durations of the planning phase,which enhances the potential significance of the decision-making process in the *** proposed method,for the first time in the neutrosophic set literature,not only solves existing problems but also introduces a new set of problems not yet explored in previous research.A comparative study using Python programming was conducted to examine the effectiveness of responsive and adaptive planning,as well as their differences from other existing models such as the classical critical path problem and the fuzzy critical path *** study highlights the use of neutrosophic logic in handling complex projects by illustrating an innovative dynamic programming framework that is robust and flexible,according to the derived results,and sets the stage for future discussions on its scalability and application across different industries.

关键词： Classical critical path problem fuzzy critical path problem uncertainty neutrosophic triangular single-valued neutrosophic number neutrosophic critical path problem python programming languag

Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis

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World Journal of Gastroenterology 2017年第7期23卷 1278-1288页

作者： Harsha Moole Harsha Tathireddy Sirish Dharmapuri Vishnu Moole Raghuveer Boddireddy pratyusha Yedama Sowmya Dharmapuri Achuta Uppu Naveen Bondalapati Abhiram Duvvuri Department of Medicine University of Illinois College of Medicine Department of Medicine Wilkes-Barre Veterans Affairs Medical Center Department of Medicine NTR University of Health Sciences Department of Medicine Albert Einstein College of Medicine Department of Medicine Barnes Jewish Christian Medical GroupChristian Hospital Division of Gastroenterology and Hepatology Kansas City Veteran Affairs Medical Center

To perform a systematic review and meta-analysis on clinical outcomes of photodynamic therapy (PDT) in non-resectable *** studies compared outcomes with photodynamic therapy and biliary stenting (PDT group) vs biliary stenting only (BS group) in palliation of non-resectable cholangiocarcinoma. Articles were searched in MEDLINE, PubMed, and EMBASE. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 *** studies (n = 402) that met inclusion criteria were included in this analysis. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. Pooled odds ratio for successful biliary drainage (decrease in bilirubin level > 50% within 7days after stenting) in PDT vs BS group was 4.39 (95%CI: 2.35-8.19). Survival period in PDT and BS groups were 413.04 d (95%CI: 349.54-476.54) and 183.41 (95%CI: 136.81-230.02) respectively. The change in Karnofsky performance scores after intervention in PDT and BS groups were +6.99 (95%CI: 4.15-9.82) and -3.93 (95%CI: -8.63-0.77) respectively. Odds ratio for post-intervention cholangitis in PDT vs BS group was 0.57 (95%CI: 0.35-0.94). In PDT group, 10.51% (95%CI: 6.94-14.72) had photosensitivity reactions that were self-limiting. Subgroup analysis of prospective studies showed similar results, except the incidence of cholangitis was comparable in both *** palliation of unresectable cholangiocarcinoma, PDT seems to be significantly superior to BS alone. PDT should be used as an adjunct to biliary stenting in these patients.

关键词： Photodynamic therapy Biliary stenting Unresectable cholangiocarcinoma Outcome Systematic review Meta-analysis

Progression from low-grade dysplasia to malignancy in patients with Barrett's esophagus diagnosed by two or more pathologists

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World Journal of Gastroenterology 2016年第39期22卷 8831-8843页

作者： Harsha Moole Jaymon Patel Zohair Ahmed Abhiram Duvvuri Sreekar Vennelaganti Vishnu Moole Sowmya Dharmapuri Raghuveer Boddireddy pratyusha Yedama Naveen Bondalapati Achuta Uppu Prashanth Vennelaganti Srinivas Puli Department of Medicine University of Illinois College of Medicine at Peoria Division of Gastro-enterology and Hepatology Kansas City Veteran Affairs Medical Center Department of Medicine Apogee Medical Group Department of Medicine NTR University of Health Sciences Department of Medicine Barnes Jewish Christian Medical Group Christian Hospital Department of Medicine Albert Einstein College of Medicine Division of Gastroenterology and Hepatology University of Kansas Medical Center Division of Gastroenterology and Hepatology University of Illinois College of Medicine at Peoria

AIM To evaluate annual incidence of low grade dysplasia(LGD) progression to high grade dysplasia(HGD) and/or esophageal adenocarcinoma(EAC) when diagnosis was made by two or more expert *** Studies evaluating the progression of LGD to HGD or EAC were included. The diagnosis of LGD must be made by consensus of two or more expert gastrointestinal pathologists. Articles were searched in Medline, Pubmed, and Embase. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic. RESULTS Initial search identified 721 reference articles, of which 53 were selected and reviewed. Twelve studies(n = 971) that met the inclusion criteria were included in this analysis. Among the total original LGD diagnoses in the included studies, only 37.49% reached the consensus LGD diagnosis after review by two or more expert pathologists. Total follow up period was 1532 patient-years. In the pooled consensus LGD patients, the annual incidence rate(AIR) of progression to HGD and or EAC was 10.35%(95%CI: 7.56-13.13) and progression to EAC was 5.18%(95%CI: 3.43-6.92). Among the patients down staged from original LGD diagnosis to No-dysplasia Barrett's esophagus, the AIR of progression to HGD and EAC was 0.65%(95%CI: 0.49-0.80). Among the patients down staged to Indefinite for dysplasia, the AIR of progression to HGD and EAC was 1.42%(95%CI: 1.19-1.65). In patients with consensus HGD diagnosis, the AIR of progression to EAC was 28.63%(95%CI: 13.98-43.27). CONCLUSION When LGD is diagnosed by consensus agreement of two or more expert pathologists, its progression towards malignancy seems to be at least three times the current estimates, however it could be up to 20 times the current estimates. Biopsies of all Barrett's esophagus patients with LGD should be reviewed by two expert gastroenterology pathologists. Follow-up strict surveillance programs should be in place for these patients.

关键词： Barrett’s esophagus Low grade dysplasia High grade dysplasia Esophageal adenocarcinoma Annual incidence of progression Systematic review Meta-analysis

Comparative study of outcomes following laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy in morbidly obese patients: A case control study

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World Journal of Gastrointestinal Endoscopy 2017年第4期9卷 162-170页

作者： Harshit Garg pratyusha Priyadarshini Sandeep Aggarwal Samagra Agarwal Rachna Chaudhary Department of Surgical Disciplines All India Institute of Medical Sciences Department of Medicine All India Institute of Medical Sciences

To compare the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) on weight loss and obesity related comorbidities over two year follow-up via case control study design. METHODSForty patients undergoing LRYGB, who completed their two year follow-up were matched with 40 patients undergoing LSG for age, gender, body mass index and presence of type 2 diabetes mellitus (T2DM). Data of these patients was retrospectively reviewed to compare the outcome in terms of weight loss and improvement in comorbidities, i.e., T2DM, hypertension (HTN), obstructive sleep apnea syndrome (OSAS), hypothyroidism and gastroesophageal reflux disease (GERD). RESULTSPercentage excess weight loss (EWL%) was similar in LRYGB and LSG groups at one year follow-up (70.5% vs 66.5%, P = 0.36) while it was significantly greater for LRYGB group after two years as compared to LSG group (76.5% vs 67.9%, P = 0.04). The complication rate after LRYGB and LSG was similar (10% vs 7.5%, P = 0.99). The median duration of T2DM and mean number of oral hypoglycemic agents were higher in LRYGB group than LSG group (7 years vs 5 years and 2.2 vs 1.8 respectively, P < 0.05). Both LRYGB and LSG had significant but similar improvement in T2DM, HTN, OSAS and hypothyroidism. However, GERD resolved in all patients undergoing LRYGB while it resolved in only 50% cases with LSG. Eight point three percent patients developed new-onset GERD after LSG. CONCLUSIONLRYGB has better outcomes in terms of weight loss two years after surgery as compared to LSG. The impact of LRYGB and LSG on T2DM, HTN, OSAS and hypothyroidism is similar. However, LRYGB has significant resolution of GERD as compared to LSG.

关键词： Bariatric surgery Laparoscopic sleeve gastrectomy Laparoscopic Roux-en-Y gastric bypass Weight loss Comorbidities

A targetable pathway to eliminate TRA-1-60^(+)/TRA-1-81^(+)chemoresistant cancer cells

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Journal of Molecular Cell Biology 2023年第6期15卷 25-39页

作者： Lei Tan Xiaohua Duan pratyusha Mutyala Ting Zhou Sadaf Amin Tuo Zhang Brian Herbst Gokce Askan Tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman Christine AIacobuzio-Donahue Steven DLeach Todd Evans Shuibing Chen Department of Surgery Weill Cornell MedicineNew YorkNY 10065USA Center for Energy Metabolism and Reproduction Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Genomic Health Weill Cornell MedicineNew YorkNY 10065USA The SKI Stem Cell Research Facility The Center for Stem Cell Biology and Developmental Biology ProgramMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Genomic Resource Core Facility Weill Cornell Medical CollegeNew YorkNY 10065USA Rubenstein Center for Pancreatic Cancer Research Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Division of Regenerative Medicine Hartman Institute for Therapeutic Organ RegenerationAnsary Stem Cell InstituteDepartment of MedicineWeill Cornell MedicineNew YorkNY 10065USA Dartmouth Cancer Center Darmouth CollegeHanoverNH 03755USA

Chemoresistance is a primary cause of treatment failure in pancreatic *** cell surface markers specifically expressed in chemoresistant cancer cells(CCCs)could facilitate targeted therapies to overcome *** performed an antibody-based screen and found that TRA-1-60 and TRA-1-81,two‘stemness’cell surface markers,are highly enriched in ***-more,TRA-1-60^(+)/TRA-1-81^(+)cells are chemoresistant compared to TRA-1-60^(-)/TRA-1-81^(-)*** profiling identified UGT1A10,shown to be both necessary and sufficient to maintain TRA-1-60/TRA-1-81 expression and *** a high-content chemical screen,we identified Cymarin,which downregulates UGT1A10,eliminates TRA-1-60/TRA-1-81 expression,and increases chemosensitivity both in vitro and in ***,TRA-1-60/TRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted ***,we discovered a novel CCC surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway.

关键词： pancreatic cancer TRA-1-60/TRA-1-81 chemoresistance UGT1A10 Cymarin

Varied presentations, magnitude, and outcome of traumatic neck injuries at a level I trauma center

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Emergency and Critical Care Medicine 2022年第2期2卷 45-49页

作者： Parvez Mohi Ud Din Dar Jogendra Boddeda Supreet Kaur pratyusha Priyadarshini Abhinav Kumar Dinesh Bagaria Narendra Choudhary Junaid Alam Sushma Sagar Subodh Kumar Amit Gupta Biplab Mishra Division of Trauma Surgery and Critical Care Jai Prakash Narayan Apex Trauma CentreAll India Institute of Medical Sciences(AIIMS)New DelhiIndia Department of General Surgery All India Institute of Medical Sciences(AIIMS)JodhpurRajasthanIndia

Introduction:Traumatic neck injuries(TNIs)constitute 5%–10%of all trauma *** injuries can be caused by either penetrating or blunt *** can have a varied presentation like cut injury over the neck,bleeding,neck swelling,breathing difficulty,dysphagia,***:This was a retrospective observational study conducted at a level I trauma center in India from January 2016 to March *** hundred thirty patients who required admission and intervention due to TNIs were included in this ***:One hundred thirty patients with neck injuries were included in this *** were predominant(91.5%)with the age ranging from 10 to *** most common mechanism of injury was physical assault(40.7%),followed by road traffic injury(23.8%)and self-inflicted injuries(18.4%).Penetrating trauma was *** neck wound with bleeding was the most common presenting *** II injuries were more common(83.8%)followed by zone I(12.3%)and zone III(3.8%).Soft tissue injury including skin,platysma breach,and strap muscle injury was present in 46.9% of *** injury was present in 13.8%,tracheal injury in 28.5%,vascular injury in 13.8%,and esophageal injury in 4.6% of ***:Penetrating neck trauma is more common than blunt in developing countries like *** Trauma Life Support(ATLS)protocol guides the initial *** definitive management depends on the type and mechanism of injury,anatomical level,severity,and the organ injured.

关键词： Bleeding Neck trauma Resuscitation Trachea Vascular injury

Enantiomeric Separation of S-Epichlorohydrin and R-Epichlorohydrin by Capillary Gas Chromatography with FID Detector

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American Journal of Analytical Chemistry 2016年第11期7卷 772-784页

作者： Cholleti Vijay Kumar Pavan Kumar Vasa Y. Ravindra Kumar Pasula Aparna Padi pratyusha Dr. Reddy’s Laboratories Ltd. Active Pharmaceutical Ingredients IPDO Hyderabad India Department of Chemistry J.N.T. University Hyderabad India Department of Pediatrics SUNY Stony Brook Medical Center Stony Brook New York USA

The aim of this study was to develop a simple and derivatization free method for the Quantification of S-Epichlorohydrin in R-Epichlorohydrin by using a gas chromatography coupled with flame ionization detector (FID). Enantiopure epichlorohydrin was a valuable epoxide key starting material for preparing optically active Rivaroxaban. The enantiomeric separations of S-Epichlorohydrin and R-Epichlorohydrin were achieved on Gamaa-Dex-225 (30 meters × 0.25 mm I.D, 0.25 μm) column with a total run time of 30 min. Nitrogen was used as a carrier gas with constant pressure 25.0 psi. The critical experimental parameters such as, column selection, flow rate, injection volume and diluent were studied and optimized. Excellent correlation coeffient between peak responses and concentrations was >0.9998. The recoveries of S-Epichlorohydrin spiked in R-Epichlorohydrin were in the range from 98.2% to 102.8%. Limit of quantitation for S-Epichlorohydrin was sufficiently lower than limits specified by ICH. The method has validated as per International Conference on Harmonization (ICH) guidelines. A precise, accurate, linear and robust Gas Chromatography method was developed for the quantification of S-Epichlorohydrin in R-Epichlorohydrin for Rivaroxaban.

关键词： S-Epichlorohydrin R-Epichlorohydrin Method Development ICH Guidelines Method Validation Gas Chromatography

Management and outcome of pancreatic trauma:a 6-year experience at a level I trauma center

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Emergency and Critical Care Medicine 2023年第1期3卷 6-11页

作者： Abhinav Anand Parvez Mohi Ud Din Dar Preksha Rani Supreet Kaur Joses Dany James Junaid Alam pratyusha Priyadarshini Abhinav Kumar Dinesh Bagaria Narendra Choudhary Subodh Kumar Amit Gupta Sushma Sagar Biplab Mishra Division of Trauma Surgery and Critical Care Jai Prakash Narayan Apex Trauma CentreAll India Institute of Medical Sciences(AIIMS)New DelhiIndia Department of Trauma and Emergency Medicine All India Institute of Medical Science(AIIMS)VijaypurJammuJammu and KashmirIndia Department of General Surgery All India Institute of Medical Science(AIIMS)JodhpurRajasthanIndia

Background: Pancreatic trauma (PT) accounts for less than 1% of all trauma admissions. Occasionally, PT is undetected during theprimary survey and becomes apparent only when complications arise. It occurs in up to 5% of blunt abdominal trauma cases and 12%of individuals with penetrating abdominal injuries. Management is determined by the status of the main pancreatic duct and ***: This was an ambispective study conducted at the Jai Prakash Narayan Apex Trauma Center, All India Institute ofMedical Sciences,New Delhi, from January 2015 to December 2017 (retrospective), and January 2019 to December 2020 (prospective). In total, 113patients with PT were included in this ***:We analyzed the data of 113 patients with PT included in this study, of whichmales predominated (93.7%). Blunt PT was presentin 101 patients (89.4%) and penetrating PT in 12 patients (10.6%). Half of the patients (51.3%) had the American Association for theSurgery of Trauma grade III PT, followed by grade II (18.6%), and grade I (15%). Of the total 113 patients, 68 (60.2%) were treated withoperative management, and 45 (39.8%) with nonoperative management. Distal pancreatectomy, with or without splenectomy, was themost common procedure performed in our study, followed by drainage. There were 27 mortalities (23.8%) during the study period, ofwhich 7 were directly related to PT and 20 were due to other organ-related sepsis and hemorrhagic ***: Pancreatic trauma is rare but challenging for trauma surgeons, with persistent management controversies. Early diagnosisis important for favorable results;however, a delay in diagnosis has been associated with higher morbidity and mortality. Low-grade pancreaticinjuries can be successfully managed nonoperatively, whereas high-grade pancreatic injuries require surgical intervention.

关键词： Abdominal trauma Distal pancreatectomy Management Pancreatic trauma