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Journal of Intelligent and Connected Vehicles 2024年第2期7卷 151-161页

作者： Miklós Lukovics Szabolcs prónay Barbara Nagy Faculty of Economics and Business Administration University of SzegedSzeged H-6726Hungary

previous studies have identified trust as one of the key factors in the technology acceptance of autonomousvehicles. As these studies mostly investigated the population in general, little is known about segment-specific ***, the widely used survey methods are less able to capture the deeper forms of trust—which neuroscientificmethods are much better suited to capture. The main objective of our research is to study trust as one of the key factors oftechnology acceptance related to autonomous vehicles by using neuroscientific methods for specific consumer ***-time eye-tracking tests were applied to a sample of 113 participants, combined with a posttest self-report. The testswere carried out under laboratory conditions during which our subjects watched videos recorded with the internal camerasof autonomous vehicles. Based on the fixation count, total fixation duration, and pupil dilation, we empirically verified thatthe trust level of all five identified segments is relatively low, while the trust level of the “traditional rejecting” segment is thelowest. An increase in trust level can be shown if the subjects receive extra information about the journey. Anotherimportant finding is that the self-reported trust level is not always congruent with the eye-tracking analysis results;therefore,combined approaches can lead to greater measurement validity.

关键词： autonomous vehicles(AVs) technology acceptance trust eye-tracking

(Bio)electrochemistry for the environment,ready for ignition?

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Environmental Science and Ecotechnology 2024年第1期17卷 1-3页

作者： Xiaofei Wang Kun Guo Korneel Rabaey Antonin prévoteau Center for Microbial Ecology and Technology Ghent UniversityBelgium CAPTUREFrieda Saeysstraat 19000 GhentBelgium Department of Chemical Engineering Xi'an Jiaotong UniversityChina Department of Biotechnology Ghent UniversityBelgium CAPTUREFrieda Saeysstraat 19000 GhentBelgium

We are facing multiple environmental challenges and a degrading ecosystem due to ever-increasing anthropogenic activities and the release of unwanted chemicals into the *** pollutants remain in the environment due to a lack of an appropriate electron donor or *** processes can provide this need through the supply and uptake of electrons in a very versatile and environmentally compatible *** two decades,we know that bacteria can also perform the role of electrocatalysts,coupling electrons to complex *** the framework of the electrification of the world,electrochemistry stands up as one of the most relevant and rapidly growing vectors to make use of renewable energy sources to carry on useful,“chemical-free”*** such,a diversity of new concepts involving electrodes have been developed and proposed for environmental remediation,waste treatment,resource recovery(water,metals,nutrients,electric power),environmental sensing,and sustainable production of commodity chemicals.

关键词： versatile carry chemicals

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek próchniak Chrystian Droste Jan Kownacki Maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

Antagonizing amyloid-β/calcium-sensing receptor signaling in human astrocytes and neurons: a key to halt Alzheimer's disease progression?

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Neural Regeneration Research 2015年第2期10卷 213-218页

作者： Ilaria Dal prà Anna Chiarini Ubaldo Armato Histology & Embryology Section Department of Life & Reproduction Sciences University of Verona Medical School

Astrocytes＇ roles in late-onset Alzheimer＇s disease （LOAD） promotion are important, since they survive soluble or fibrillar amyloid-β peptides （Aβs） neurotoxic effects, undergo alterations of intracellular and intercellular Ca2＋ signaling and gliotransmitters release via the Aβ/a7-nAChR （αT-nicotinic acetylcholine receptor） signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/CaSR （calcium-sensing receptor） signaling. Recently, it was suggested that the NMDAR （N-methyl-D-aspartate receptor） inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-nAChR signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric CaSR antagonist （calcilytic）.

关键词： Alzheimer's disease amyloid-β astrocytes Ca2+ calcilytic calcium-sensing receptor nitromemantine NPS 2143 aT-nicotinic acetylcholine receptor

Investigation of the Compressible Flow through the Tip-Section Turbine Blade Cascade with Supersonic Inlet

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Journal of Thermal Science 2016年第2期25卷 138-144页

作者： Martin Luxa Jaromír príhoda David Simurda Petr Straka Jaroslav Synác Institute of Thermomechanics AS CR v.v.i. Dolejskova 1402/5 18200 Prague Czech Republic Aerospace Research and Test Establishment Plc Beranovych 130 19905 Prague Czech Republic Doosan Skoda Power Co. Ltd. Tylova 1/57 30128 Pilsen Czech Republic

The contribution deals with the experimental and numerical investigation of compressible flow through the tip-section turbine blade cascade with the blade 54″ long. Experimental investigations by means of optical(interferometry and schlieren method) and pneumatic measurements provide more information about the behaviour and nature of basic phenomena occurring in the profile cascade flow field. The numerical simulation was carried out by means of the EARSM turbulence model according to Hellsten [5] completed by the bypass transition model with the algebraic equation for the intermittency coefficient proposed by Straka and P?íhoda [6] and implemented into the in-house numerical code. The investigation was focused particularly on the effect of shock waves on the shear layer development including the laminar/turbulent transition. Interactions of shock waves with shear layers on both sides of the blade result usually in the transition in attached and/ or separated flow and so to the considerable impact to the flow structure and energy losses in the blade cascade.

关键词： long turbine rotor blade supersonic tip section optical methods transition modelling CFD

Organic matter produced by algae and cyanobacteria: Quantitative and qualitative characterization

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Journal of Environmental Sciences 2013年第6期25卷 1089-1097页

作者： Maud Leloup Rudy Nicolau Virginie Pallier Claude Yprmian Geneviève Feuillade-Cathalifaud University of Limoges EA 4330Groupement de Recherche EauSolEnvironnement(GRESE)ENSILParc d'ESTER Technople16 rue AtlantisF-87068 Limoges CedexFrance UMR 7245 MCAM MNHN-CNRS Equipe CyanobactériesCyanotoxines et EnvironnementMuséum National d'Histoire NaturelleCase 3912 rue BuffonF-75231 Paris Cedex 05France

This work aims at characterizing organic matter produced by an alga Euglena gracil~ and a cyanobacteria Microcystis aeruginosa and assessing the evolution of its characteristics during growth. A culture medium was optimized. The species growth phases were monitored using both visible spectrophotometry and flow cytometry cell counting. Organic matter fractionation according to hydrophobicity and specific UV absorbance （SUVA） index were used to specifically characterize the produced algal organic matter （AOM）. The AOM characteristics were both growth phase and species dependent. However, a similar evolution was observed. The hydrophilic fraction （HPI） was the major fraction whatever the growth phases and was almost the only one produced during lag and exponential phases. It represented around 75% of AOM during exponential phase and then decreased when the stationary phase appeared. It represented 46% and 60% of the AOM during late decline phase for the cyanobacteria and the alga respectively. The hydrophobic （HPO） and transphilic （TPH） fractions started to appear from the beginning of the stationary phase with more hydrophobic compounds coming from intracellular organic material of dying cells. HPO and TPH percentages still increased during the decline phase probably because of two additional processes： photo-dissolution and leaching of particulate organic matter from cells fragments. A comparison of AOM during late decline phase and natural organic matter （NOM） from Glane River （France） underlined that AOM was more fiydrophilic and presented a lower SUVA for each fractions than NOM. However, the difference between NOM and AOM hydrophobicity narrowed during decline phase.

关键词： algae cyanobacteria organic matter XAD fractionation SUVA flow cytometry

A versatile approach for temporary storage and shipping of in vitro cultured cells,cell sheets and tissue engineered constructs-a preliminary report

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Engineered Regeneration 2022年第3期3卷 283-291页

作者： Anju MS Athira RK Ramesh Babu V Anil Kumar pr Naresh Kasoju Division of Tissue Culture Department of Applied BiologyBiomedical Technology WingSree Chitra Tirunal Institute for Medical Science and TechnologyThiruvananthapuram 695012KeralaIndia Division of precision Fabrication Department of Medical Devices EngineeringBiomedical Technology WingSree Chitra Tirunal Institute for Medical Science and TechnologyThiruvananthapuram 695012KeralaIndia

Temporary storage/shipping of cell/tissue engineering products from bench to bedside is a key aspect of re-generative *** current proof-of-concept study presents a multipurpose device for temporary storage/shipping of cell culture dishes containing cell/tissue *** device,made with readily available raw ma-terials,contains three elements viz.a specialized lid,polymeric plates having grooves and a set of nuts and *** part of the performance evaluation,the device was first subjected to a simulated storage/shipping process,wherein the leak-proof and aseptic containment of the contents was ***,the setup was used for temporary storage/shipping of dishes having(a)L929 cell monolayers cultured on treated surfaces,(b)SIRC,HaCaT and A549 cell sheets cultured on thermo-responsive surfaces,(c)HOS-cell encapsulated agar gels and(d)HOS-cell seeded silk fibroin *** results showed that the health of cell monolayers/cell sheets/tissue constructs after the process was comparable to that before the *** device was scalable,simple to handle,can be made for a single or multi-use purpose,and can be resizable to load other culture *** design of the storage/shipping device described in this report thus offers versatile features and applications.

关键词： Tissue engineering Scaffolds Tissue equivalents Translational medicine

Interaction between climate and management on beta diversity components of vegetation in relation to soil properties in arid and semi-arid oak forests, Iran

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Journal of Arid Land 2019年第1期11卷 43-57页

作者： Heydari MEHDI Aazami FATEMEH Faramarzi MARZBAN Omidipour REZA Bazgir MASOUD Pothier DAVID prévosto BERNARD Department of Forest Science College of Agriculture Ilam University Department of Rangeland and Watershed Management College of Agriculture Ilam University Department of Rangeland and Watershed Management College of Natural Resources and Earth Sciences Shahrekord University Department of Soil Science College of Agriculture Ilam University Department of Wood and Forest Sciences Centre for Forest Research Laval University Irstea-National Research Institute of Science and Technology for Environment and Agriculture

This study aimed to investigate the interaction between regions with different climatic conditions(arid vs. semi-arid) and management(protected vs. unprotected) on the turnover and nestedness of vegetation in relation to physical, chemical and biological properties of soils in the Ilam province of Iran. In each of the two regions, we sampled 8 sites(4 managed and 4 unmanaged sites) within each of which we established 4 circular plots(1000 m^2) that were used to investigate woody species, while two micro-plots(1 m×1 m) were established in each 1000-m^2 plot to analyze herbaceous species. In each sample unit, we also extracted three soil samples(0–20 cm depth) for measuring soil properties. The results indicated that the interaction between region and conservational management significantly affected the percent of canopy cover of Persian oak(Quercus brantii Linddl), soil respiration, substrate-induced respiration, as well as beta and gamma diversities and turnover of plant species. The percent of oak canopy cover was positively correlated with soil silt, electrical conductivity, available potassium, and alpha diversity, whereas it was negatively correlated with plant turnover. In addition, plant turnover was positively related to available phosphorus, while nestedness of species was positively related to organic carbon and total nitrogen. According to these results, we concluded that physical, chemical, and biological characteristics of limited ecological niche generally influenced plant diversity. Also, this study demonstrated the major contribution of the beta diversity on gamma diversity, especially in semi-arid region, because of the higher heterogeneity of vegetation in this area.

关键词： climatic conditions conservation management beta diversity oak forests physical-chemical property semi-arid region