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Photonics Research 2019年第4期7卷 416-422页

作者： SUNG-WEN HUANG CHEN CHIH-CHIANG SHEN TINGZHU WU ZHEN-YOU LIAO lee-FENG CHEN JIA-ROU ZHOU CHUN-FU lee CHIH-HAO LIN CHIEN-CHUNG LIN CHIN-WEI SHER po-tsung lee AN-JYE TZOU ZHONG CHEN HAO-CHUNG KUO Institute of Electro-Optical Engineering Taiwan Chiao Tung University Department of Electronic Science Fujian Engineering Research Center for Solid-State Lighting Xiamen University Institute of Photonics System Taiwan Chiao Tung University HKUST Fok Ying Tung Research Institute Department of Electrical Engineering and Computer Sciences and TBSI University of California at Berkeley

Full-color displays based on micro light-emitting diodes(μLEDs) can be fabricated on monolithic epitaxial wafers. Nanoring(NR) structures were fabricated on a green LED epitaxial wafer; the color of NR-μLEDs was tuned from green to blue through strain relaxation. An Al_2O_3 layer was deposited on the sidewall of NR-μLEDs,which improved the photoluminescence intensity by 143.7%. Coupling with the exposed multiple quantum wells through nonradiative resonant energy transfer, red quantum dots were printed to NR-μLEDs for a full-color display. To further improve the color purity of the red light, a distributed Bragg reflector is developed to reuse the excitation light.

关键词： Full-color displays epitaxial wafers

Full-color micro-LED display with high color stability using semipolar(20-21) InGaN LEDs and quantum-dot photoresist

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Photonics Research 2020年第5期8卷 630-636页

作者： SUNG-WEN HUANG CHEN YU-MING HUANG KONTHOUJAM JAMES SINGH YU-CHIEN HSU FANG-JYUN LIOU JIE SONG JOOWON CHOI po-tsung lee CHIEN-CHUNG LIN ZHONG CHEN JUNG HAN TINGZHU WU HAO-CHUNG KUO Department of Photonics&Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringTaiwan Chiao Tung UniversityHsinchu 30010China Institute of Photonic System Taiwan Chiao Tung UniversityTainan 71150China Saphlux Inc. BranfordConnecticut 06405USA Departm ent of Electronic Science Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Departm ent of Electrical Engineering Yale UniversityNew HavenConnecticut 06520USA

Red-green-blue(RGB)full-color micro light-emitting diodes(μ-LEDs)fabricated from semipolar(20-21)wafers,with a quantum-dot photoresist color-conversion layer,were *** semipolar(20-21)In Ga N/Ga Nμ-LEDs were fabricated on large(4 in.)patterned sapphire substrates by orientation-controlled *** semipolarμ-LEDs showed a 3.2 nm peak wavelength shift and a 14.7%efficiency droop under 200 A∕cm2injected current density,indicating significant amelioration of the quantum-confined Stark *** of the semipolarμ-LEDs’emission-wavelength stability,the RGB pixel showed little color shift with current density and achieved a wide color gamut(114.4%NTSC space and 85.4%Rec.2020).

关键词： LEDs photoresist sapphire

850/940-nm VCSEL for optical communication and 3D sensing

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Opto-Electronic Advances 2018年第3期1卷 11-21页

作者： Chih-Hsien Cheng Chih-Chiang Shen Hsuan-Yun Kao Dan-Hua Hsieh Huai-Yung Wang Yen-Wei Yeh Yun-Ting Lu Sung-Wen Huang Chen Cheng-Ting Tsai Yu-Chieh Chi tsung Sheng Kao Chao-Hsin Wu Hao-Chung Kuo po-tsung lee Gong-Ru Lin Graduate Institute of Photonics and Optoelectronics Department of Electrical Engineering Taiwan University Taipei 10617 China Department of Photonics & Graduate Institute of Electro-Optical Engineering College of Electrical and Computer Engineering Chiao Tung UniversityHsinchu 30100 China Department of Electrical Engineering Taiwan University Taipei 10617 China.

This paper is going to review the state-of-the-art of the high-speed 850/940-nm vertical cavity surface emitting laser（VCSEL）, discussing the structural design, mode control and the related data transmission performance. InGaAs/AlGaAsmultiple quantum well （MQW） was used to increase the differential gain and photon density in VCSEL. The multiple oxidelayers and oxide-confined aperture were well designed in VCSEL to decrease the parasitic capacitance and generate single mode （SM） VCSEL. The maximal modulation bandwidth of 30 GHz was achieved with well-designed VCSEL structure. At the end of the paper, other applications of the near-infrared VCSELs are discussed.

关键词： vertical cavity surface emitting laser 3D sensing optical communication LiDAR virtual reality augmented reality

Hybrid-type white LEDs based on inorganic halide perovskite QDs: candidates for wide color gamut display backlights

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Photonics Research 2019年第5期7卷 579-585页

作者： Chih-Hao Lin Akta Verma Chieh-Yu Kang Yung-Min Pai Tzu-Yu Chen Jin-Jia Yang Chin-Wei Sher Ya-Zhu Yang po-tsung lee Chien-Chung Lin Yu-Chuan Wu S. K. Sharma Tingzhu Wu Shu-Ru Chung Hao-Chung Kuo Department of Photonics and Institute of Electro-Optical Engineering College of Electrical and Computer Engineering Taiwan Chiao Tung University Hsinchu 30010 China Department of Applied Physics Indian Institute of Technology (Indian School of Mines) Dhanbad-826004 India Fok Ying Tung Research Institute Hong Kong University of Science and Technology Hong Kong China Department of Materials Science and Engineering Taiwan Formosa University Yunlin 63201 China Institute of Photonic System College of Photonics Taiwan Chiao Tung University Tainan 711 China Department of Materials and Mineral Resources Engineering Taiwan Taipei University of Technology Taipei 10608 China Department of Chemical and Materials Engineering Chinese Culture University Taipei 11114 China Department of Electronic Science Fujian Engineering Research Center for Solid-state Lighting Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Xiamen University Xiamen 361005 China

We demonstrate inorganic halide perovskite quantum-dots-based white light-emitting diodes via three different geometries, including liquid, solid, and hybrid types. Problems of fast anion exchange and aggregation in the cases of liquidand solid-type devices are discussed in detail and push us to move towards the fabrication of a hybrid-type device structure. The experiment results illustrate that a hybrid-type device has the highest luminance efficiency(51 lm/W) and a wide color gamut(122% of NTSC and 91% of Rec. 2020). Therefore, we conclude that a hybrid-type device can provide an outstanding color gamut for high color gamut display applications.

关键词： LEDs QDs wide color gamut display backlights

Recurrent inverted papilloma coexisted with skull base lymphoma: A case report

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World Journal of Clinical Cases 2021年第2期9卷 516-520页

作者： Heng Juei Hsu Chi Chen Huang Ming tsung Chuang Chih Hao Tien Jung Shun lee po-Hsuan lee Section of Neurosurgery Department of SurgeryTainan Sin Lau HospitalTainan 70144Taiwan Section of Neurosurgery Department of SurgeryNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Department of Medical Imaging National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Department of Cell Biology and Anatomy College of MedicineNational Cheng Kung UniversityTainan 701Taiwan

BACKGROUND Inverted papilloma is an uncommon neoplasm in the nasal *** is a histologically benign tumor,but has a high recurrence and local invasion *** addition,nasal or skull base lymphoma is another rare *** coexistence of these two tumors in one case makes the diagnosis and related treatment *** SUMMARY We report a case of an immunocompetent patient,who had a history of inverted papilloma 20 years *** patient presented with an infiltrated mass lesion in the nasal cavity with extension to the frontal *** repeated biopsies revealed inverted papilloma without any malignant *** the patient underwent a frontobasal craniotomy with total tumor excision,the final pathological examination revealed nasal inverted papilloma coexisting with diffuse large B-cell lymphoma of the skull *** Based on this case report,while managing a case of an aggressive recurrent inverted papilloma,not only squamous cell carcinoma transformation,but also other invasive malignancy,such as lymphoma,should be considered.

关键词： Coexisting tumors Inverted papilloma Primary central nervous system lymphoma Skull base Squamous cell carcinoma Case report

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Assessment of highway slope failure using neural networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 101-108页

作者： tsung-lin lee Hung-ming LIN Yuh-pin LU 1Department of Construction and Facility Management Department of Resource and Environment Leader University

An artificial intelligence technique of back-propagation neural networks is used to assess the slope ***-site slope failure data from the South Cross-Island Highway in southern Taiwan are used to test the performance of the neural network *** numerical results demonstrate the effectiveness of artificial neural networks in the evaluation of slope failure potential based on five major factors,such as the slope gradient angle,the slope height,the cumulative precipitation,daily rainfall and strength of materials.

关键词： Neural network Prediction Highway Slope failure

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing